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Neurocognitive and observational markers: prediction of autism spectrum disorder from infancy to mid-childhood / Rachael BEDFORD in Molecular Autism, 8 (2017)
[article]
Titre : Neurocognitive and observational markers: prediction of autism spectrum disorder from infancy to mid-childhood Type de document : Texte imprimé et/ou numérique Auteurs : Rachael BEDFORD, Auteur ; T. GLIGA, Auteur ; E. SHEPHARD, Auteur ; M. ELSABBAGH, Auteur ; A. PICKLES, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur Article en page(s) : 49p. Langues : Anglais (eng) Mots-clés : Autism Diagnosis High risk Infants Neurocognitive Prediction Siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: Prospective studies of infants at high familial risk for autism spectrum disorder (ASD) have identified a number of putative early markers that are associated with ASD outcome at 3 years of age. However, some diagnostic changes occur between toddlerhood and mid-childhood, which raises the question of whether infant markers remain associated with diagnosis into mid-childhood. METHODS: First, we tested whether infant neurocognitive markers (7-month neural response to eye gaze shifts and 14-month visual disengagement latencies) as well as an observational marker of emerging ASD behaviours (the Autism Observation Scale for Infants; AOSI) predicted ASD outcome in high-risk (HR) 7-year-olds with and without an ASD diagnosis (HR-ASD and HR-No ASD) and low risk (LR) controls. Second, we tested whether the neurocognitive markers offer predictive power over and above the AOSI. RESULTS: Both neurocognitive markers distinguished children with an ASD diagnosis at 7 years of age from those in the HR-No ASD and LR groups. Exploratory analysis suggested that neurocognitive markers may further differentiate stable versus lost/late diagnosis across the 3 to 7 year period, which will need to be tested in larger samples. At both 7 and 14 months, combining the neurocognitive marker with the AOSI offered a significantly improved model fit over the AOSI alone. CONCLUSIONS: Infant neurocognitive markers relate to ASD in mid-childhood, improving predictive power over and above an early observational marker. The findings have implications for understanding the neurodevelopmental mechanisms that lead from risk to disorder and for identification of potential targets of pre-emptive intervention. En ligne : http://dx.doi.org/10.1186/s13229-017-0167-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 8 (2017) . - 49p.[article] Neurocognitive and observational markers: prediction of autism spectrum disorder from infancy to mid-childhood [Texte imprimé et/ou numérique] / Rachael BEDFORD, Auteur ; T. GLIGA, Auteur ; E. SHEPHARD, Auteur ; M. ELSABBAGH, Auteur ; A. PICKLES, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur . - 49p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 49p.
Mots-clés : Autism Diagnosis High risk Infants Neurocognitive Prediction Siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: Prospective studies of infants at high familial risk for autism spectrum disorder (ASD) have identified a number of putative early markers that are associated with ASD outcome at 3 years of age. However, some diagnostic changes occur between toddlerhood and mid-childhood, which raises the question of whether infant markers remain associated with diagnosis into mid-childhood. METHODS: First, we tested whether infant neurocognitive markers (7-month neural response to eye gaze shifts and 14-month visual disengagement latencies) as well as an observational marker of emerging ASD behaviours (the Autism Observation Scale for Infants; AOSI) predicted ASD outcome in high-risk (HR) 7-year-olds with and without an ASD diagnosis (HR-ASD and HR-No ASD) and low risk (LR) controls. Second, we tested whether the neurocognitive markers offer predictive power over and above the AOSI. RESULTS: Both neurocognitive markers distinguished children with an ASD diagnosis at 7 years of age from those in the HR-No ASD and LR groups. Exploratory analysis suggested that neurocognitive markers may further differentiate stable versus lost/late diagnosis across the 3 to 7 year period, which will need to be tested in larger samples. At both 7 and 14 months, combining the neurocognitive marker with the AOSI offered a significantly improved model fit over the AOSI alone. CONCLUSIONS: Infant neurocognitive markers relate to ASD in mid-childhood, improving predictive power over and above an early observational marker. The findings have implications for understanding the neurodevelopmental mechanisms that lead from risk to disorder and for identification of potential targets of pre-emptive intervention. En ligne : http://dx.doi.org/10.1186/s13229-017-0167-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 Parent-delivered early intervention in infants at risk for ASD: Effects on electrophysiological and habituation measures of social attention / Emily J. H. JONES in Autism Research, 10-5 (May 2017)
[article]
Titre : Parent-delivered early intervention in infants at risk for ASD: Effects on electrophysiological and habituation measures of social attention Type de document : Texte imprimé et/ou numérique Auteurs : Emily J. H. JONES, Auteur ; Geraldine DAWSON, Auteur ; Jean KELLY, Auteur ; Annette ESTES, Auteur ; Sara JANE WEBB, Auteur Article en page(s) : p.961-972 Langues : Anglais (eng) Mots-clés : autism ASD infant high-risk neurocognitive social attention promoting first relationships Index. décimale : PER Périodiques Résumé : Prospective longitudinal studies of infants with older siblings with autism spectrum disorder (ASD) have indicated that differences in the neurocognitive systems underlying social attention may emerge prior to the child meeting ASD diagnostic criteria. Thus, targeting social attention with early intervention might have the potential to alter developmental trajectories for infants at high risk for ASD. Electrophysiological and habituation measures of social attention were collected at 6, 12, and 18 months in a group of high-risk infant siblings of children with ASD (N?=?33). Between 9 and 11 months of age, infant siblings received a parent-delivered intervention, promoting first relationships (PFR), (n?=?19) or on-going assessment without intervention (n?=?14). PFR has been previously shown to increase parental responsivity to infant social communicative cues and infant contingent responding. Compared to infants who only received assessment and monitoring, infants who received the intervention showed improvements in neurocognitive metrics of social attention, as reflected in a greater reduction in habituation times to face versus object stimuli between 6 and 12 months, maintained at 18 months; a greater increase in frontal EEG theta power between 6 and 12 months; and a more comparable P400 response to faces and objects at 12 months. The high-risk infants who received the intervention showed a pattern of responses that appeared closer to the normative responses of two groups of age-matched low-risk control participants. Though replication is necessary, these results suggest that early parent-mediated intervention has the potential to impact the brain systems underpinning social attention in infants at familial risk for ASD. En ligne : http://dx.doi.org/10.1002/aur.1754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307
in Autism Research > 10-5 (May 2017) . - p.961-972[article] Parent-delivered early intervention in infants at risk for ASD: Effects on electrophysiological and habituation measures of social attention [Texte imprimé et/ou numérique] / Emily J. H. JONES, Auteur ; Geraldine DAWSON, Auteur ; Jean KELLY, Auteur ; Annette ESTES, Auteur ; Sara JANE WEBB, Auteur . - p.961-972.
Langues : Anglais (eng)
in Autism Research > 10-5 (May 2017) . - p.961-972
Mots-clés : autism ASD infant high-risk neurocognitive social attention promoting first relationships Index. décimale : PER Périodiques Résumé : Prospective longitudinal studies of infants with older siblings with autism spectrum disorder (ASD) have indicated that differences in the neurocognitive systems underlying social attention may emerge prior to the child meeting ASD diagnostic criteria. Thus, targeting social attention with early intervention might have the potential to alter developmental trajectories for infants at high risk for ASD. Electrophysiological and habituation measures of social attention were collected at 6, 12, and 18 months in a group of high-risk infant siblings of children with ASD (N?=?33). Between 9 and 11 months of age, infant siblings received a parent-delivered intervention, promoting first relationships (PFR), (n?=?19) or on-going assessment without intervention (n?=?14). PFR has been previously shown to increase parental responsivity to infant social communicative cues and infant contingent responding. Compared to infants who only received assessment and monitoring, infants who received the intervention showed improvements in neurocognitive metrics of social attention, as reflected in a greater reduction in habituation times to face versus object stimuli between 6 and 12 months, maintained at 18 months; a greater increase in frontal EEG theta power between 6 and 12 months; and a more comparable P400 response to faces and objects at 12 months. The high-risk infants who received the intervention showed a pattern of responses that appeared closer to the normative responses of two groups of age-matched low-risk control participants. Though replication is necessary, these results suggest that early parent-mediated intervention has the potential to impact the brain systems underpinning social attention in infants at familial risk for ASD. En ligne : http://dx.doi.org/10.1002/aur.1754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307