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Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study / A. HAVDAHL in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)
[article]
Titre : Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study Type de document : Texte imprimé et/ou numérique Auteurs : A. HAVDAHL, Auteur ; C. FARMER, Auteur ; Synnve SCHJØLBERG, Auteur ; A. S. ØYEN, Auteur ; P. SURÉN, Auteur ; T. REICHBORN-KJENNERUD, Auteur ; P. MAGNUS, Auteur ; Michaeline BRESNAHAN, Auteur ; M. HORNIG, Auteur ; E. SUSSER, Auteur ; W. I. LIPKIN, Auteur ; C. LORD, Auteur ; C. STOLTENBERG, Auteur ; A. THURM, Auteur ; Somer L. BISHOP, Auteur Article en page(s) : p.1070-1078 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology Child Cohort Studies Humans Intellectual Disability/epidemiology Neurodevelopmental Disorders/epidemiology Walking Intellectual disability MoBa epidemiology gross motor milestones late walking All profits from their research are donated to charity. The other authors report no conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Delayed walking is common in intellectual disability (ID) but may be less common when ID occurs with autism spectrum disorder (ASD). Previous studies examining this were limited by reliance on clinical samples and exclusion of children with severe motor deficits. OBJECTIVE: To examine in a population-based sample if age of walking is differentially related to intellectual ability in children with ASD versus other neurodevelopmental disorders (NDD). METHODS: Participants were from the nested Autism Birth Cohort Study of the Norwegian Mother, Father and Child Cohort Study (MoBa). Cox proportional hazards regression assessed if diagnosis (ASD n = 212 vs. NDD n = 354), continuous nonverbal IQ, and their interaction, were associated with continuous age of walking. RESULTS: The relationship between nonverbal IQ and age of walking was stronger for NDD than for ASD (Group × nonverbal IQ interaction, ?(2) = 13.93, p = .0002). This interaction was characterized by a 21% decrease in the likelihood of walking onset at any given time during the observation period per 10-point decrease in nonverbal IQ (hazard ratio = 0.79, 95% CI: 0.78-0.85) in the NDD group compared to 8% (hazard ratio = 0.92, 95% CI: 0.86-0.98) in the ASD group. CONCLUSIONS: The finding that age of walking is less strongly related to low intellectual ability in children with ASD than in children without other NDDs supports the hypothesis that ID in ASD may result from heterogeneous developmental pathways. Late walking may be a useful stratification variable in etiological research focused on ASD and other NDDs. En ligne : http://dx.doi.org/10.1111/jcpp.13369 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1070-1078[article] Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study [Texte imprimé et/ou numérique] / A. HAVDAHL, Auteur ; C. FARMER, Auteur ; Synnve SCHJØLBERG, Auteur ; A. S. ØYEN, Auteur ; P. SURÉN, Auteur ; T. REICHBORN-KJENNERUD, Auteur ; P. MAGNUS, Auteur ; Michaeline BRESNAHAN, Auteur ; M. HORNIG, Auteur ; E. SUSSER, Auteur ; W. I. LIPKIN, Auteur ; C. LORD, Auteur ; C. STOLTENBERG, Auteur ; A. THURM, Auteur ; Somer L. BISHOP, Auteur . - p.1070-1078.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1070-1078
Mots-clés : Autism Spectrum Disorder/epidemiology Child Cohort Studies Humans Intellectual Disability/epidemiology Neurodevelopmental Disorders/epidemiology Walking Intellectual disability MoBa epidemiology gross motor milestones late walking All profits from their research are donated to charity. The other authors report no conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Delayed walking is common in intellectual disability (ID) but may be less common when ID occurs with autism spectrum disorder (ASD). Previous studies examining this were limited by reliance on clinical samples and exclusion of children with severe motor deficits. OBJECTIVE: To examine in a population-based sample if age of walking is differentially related to intellectual ability in children with ASD versus other neurodevelopmental disorders (NDD). METHODS: Participants were from the nested Autism Birth Cohort Study of the Norwegian Mother, Father and Child Cohort Study (MoBa). Cox proportional hazards regression assessed if diagnosis (ASD n = 212 vs. NDD n = 354), continuous nonverbal IQ, and their interaction, were associated with continuous age of walking. RESULTS: The relationship between nonverbal IQ and age of walking was stronger for NDD than for ASD (Group × nonverbal IQ interaction, ?(2) = 13.93, p = .0002). This interaction was characterized by a 21% decrease in the likelihood of walking onset at any given time during the observation period per 10-point decrease in nonverbal IQ (hazard ratio = 0.79, 95% CI: 0.78-0.85) in the NDD group compared to 8% (hazard ratio = 0.92, 95% CI: 0.86-0.98) in the ASD group. CONCLUSIONS: The finding that age of walking is less strongly related to low intellectual ability in children with ASD than in children without other NDDs supports the hypothesis that ID in ASD may result from heterogeneous developmental pathways. Late walking may be a useful stratification variable in etiological research focused on ASD and other NDDs. En ligne : http://dx.doi.org/10.1111/jcpp.13369 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 Commentary: A longitudinal exploration of the effects of the COVID-19 lockdowns for adolescents both with and without neurodevelopmental disorders - a reflection on Houghton et al. (2022) / Charlotte FIELD in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)
[article]
Titre : Commentary: A longitudinal exploration of the effects of the COVID-19 lockdowns for adolescents both with and without neurodevelopmental disorders - a reflection on Houghton et al. (2022) Type de document : Texte imprimé et/ou numérique Auteurs : Charlotte FIELD, Auteur Article en page(s) : p.1344-1346 Langues : Anglais (eng) Mots-clés : Adolescent Humans covid-19 Pandemics/prevention & control Communicable Disease Control Neurodevelopmental Disorders/epidemiology Loneliness/psychology Index. décimale : PER Périodiques Résumé : The lockdowns during the COVID-19 pandemic had and continue to have severe and wide-ranging effects worldwide on mental health and loneliness. In this commentary, I summarise Houghton et al. (2022) who explored these effects longitudinally in adolescents in Western Australia, with and without a Neurodevelopmental Disorder (NDD), considering the strengths and weaknesses of the article and its importance to the field. Adolescents with NDD, who already had a high baseline rate of loneliness and mental health difficulties, did not find that this increased during COVID-19 lockdowns. However, adolescents without NDD, who began with a much lower baseline rate, found that this was elevated. There was variability in terms of different types of NDD, with adolescents who had ADHD reporting some positive effects of the COVID-19 lockdowns. These findings highlight the importance of support for adolescents both with NDD and those without as the world emerges out of the pandemic. En ligne : http://dx.doi.org/10.1111/jcpp.13661 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1344-1346[article] Commentary: A longitudinal exploration of the effects of the COVID-19 lockdowns for adolescents both with and without neurodevelopmental disorders - a reflection on Houghton et al. (2022) [Texte imprimé et/ou numérique] / Charlotte FIELD, Auteur . - p.1344-1346.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1344-1346
Mots-clés : Adolescent Humans covid-19 Pandemics/prevention & control Communicable Disease Control Neurodevelopmental Disorders/epidemiology Loneliness/psychology Index. décimale : PER Périodiques Résumé : The lockdowns during the COVID-19 pandemic had and continue to have severe and wide-ranging effects worldwide on mental health and loneliness. In this commentary, I summarise Houghton et al. (2022) who explored these effects longitudinally in adolescents in Western Australia, with and without a Neurodevelopmental Disorder (NDD), considering the strengths and weaknesses of the article and its importance to the field. Adolescents with NDD, who already had a high baseline rate of loneliness and mental health difficulties, did not find that this increased during COVID-19 lockdowns. However, adolescents without NDD, who began with a much lower baseline rate, found that this was elevated. There was variability in terms of different types of NDD, with adolescents who had ADHD reporting some positive effects of the COVID-19 lockdowns. These findings highlight the importance of support for adolescents both with NDD and those without as the world emerges out of the pandemic. En ligne : http://dx.doi.org/10.1111/jcpp.13661 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study / A. S. E. LEE in Autism Research, 14-12 (December 2021)
[article]
Titre : Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : A. S. E. LEE, Auteur ; Y. JI, Auteur ; R. RAGHAVAN, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; C. PEARSON, Auteur ; G. MIROLLI, Auteur ; E. BIND, Auteur ; A. STEFFENS, Auteur ; J. MUKHERJEE, Auteur ; D. HALTMEIER, Auteur ; Z. T. FAN, Auteur ; X. WANG, Auteur Article en page(s) : p.2533-2543 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity Autism Spectrum Disorder/epidemiology Birth Cohort Cohort Studies Female Humans Neurodevelopmental Disorders/epidemiology Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Selenium attention deficit-hyperactivity disorder children environmental risk factors epigenetics gene-environment interaction pediatrics pre- and perinatal risk factors Index. décimale : PER Périodiques Résumé : Selenium (Se) is an essential trace element involved in various biological processes, including neurodevelopment. Available literature indicates that both Se deficiency and excess may be detrimental to health. It is also known that Se can cross the placenta from maternal to fetal circulation. To date, the role of maternal Se status in child long-term neurodevelopment is largely unexplored. This study investigated the temporal and dose-response associations between maternal Se status and child risk of neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It consisted of 1550 mother-infant dyads from the Boston Birth Cohort. Maternal red blood cell (RBC) Se levels were measured in samples collected within 72?h of delivery (biomarker of third trimester Se status). Pediatric neurodevelopmental diagnoses were obtained from electronic medical records. Data analyses showed that maternal RBC Se levels were positively associated with child risk of developing ASD, with an adjusted odds ratio of 1.49 for ASD (95% CI: 1.09, 2.02) per IQR increase in Se. There was also a positive association between maternal Se and ADHD (OR: 1.29; 95% CI: 1.04, 1.56, per IQR increase in Se). These associations remained robust even after adjusting for pertinent covariables; and there was no significant interaction between Se and these covariables. Our findings suggest that prenatal exposure to high maternal Se levels may adversely affect child neurodevelopment. Our findings warrant further investigation; if confirmed, optimizing maternal prenatal Se levels may be necessary to maximize its health benefits while preventing undue risk. LAY SUMMARY: Selenium (Se) is an essential nutrient for the health of the pregnant mother and her baby. While Se can readily cross the placenta from maternal to fetal circulation, little is known about maternal Se status on her child's neurodevelopmental outcomes. We studied over 1500 mother-child dyads from birth to school age of the child. We found that babies born from mothers with high blood Se levels may be at increased risk of developing autism spectrum disorder or attention deficit hyperactivity disorder. Given this is the first study of the kind, more study is needed to confirm our findings. En ligne : http://dx.doi.org/10.1002/aur.2617 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-12 (December 2021) . - p.2533-2543[article] Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study [Texte imprimé et/ou numérique] / A. S. E. LEE, Auteur ; Y. JI, Auteur ; R. RAGHAVAN, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; C. PEARSON, Auteur ; G. MIROLLI, Auteur ; E. BIND, Auteur ; A. STEFFENS, Auteur ; J. MUKHERJEE, Auteur ; D. HALTMEIER, Auteur ; Z. T. FAN, Auteur ; X. WANG, Auteur . - p.2533-2543.
Langues : Anglais (eng)
in Autism Research > 14-12 (December 2021) . - p.2533-2543
Mots-clés : Attention Deficit Disorder with Hyperactivity Autism Spectrum Disorder/epidemiology Birth Cohort Cohort Studies Female Humans Neurodevelopmental Disorders/epidemiology Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Selenium attention deficit-hyperactivity disorder children environmental risk factors epigenetics gene-environment interaction pediatrics pre- and perinatal risk factors Index. décimale : PER Périodiques Résumé : Selenium (Se) is an essential trace element involved in various biological processes, including neurodevelopment. Available literature indicates that both Se deficiency and excess may be detrimental to health. It is also known that Se can cross the placenta from maternal to fetal circulation. To date, the role of maternal Se status in child long-term neurodevelopment is largely unexplored. This study investigated the temporal and dose-response associations between maternal Se status and child risk of neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It consisted of 1550 mother-infant dyads from the Boston Birth Cohort. Maternal red blood cell (RBC) Se levels were measured in samples collected within 72?h of delivery (biomarker of third trimester Se status). Pediatric neurodevelopmental diagnoses were obtained from electronic medical records. Data analyses showed that maternal RBC Se levels were positively associated with child risk of developing ASD, with an adjusted odds ratio of 1.49 for ASD (95% CI: 1.09, 2.02) per IQR increase in Se. There was also a positive association between maternal Se and ADHD (OR: 1.29; 95% CI: 1.04, 1.56, per IQR increase in Se). These associations remained robust even after adjusting for pertinent covariables; and there was no significant interaction between Se and these covariables. Our findings suggest that prenatal exposure to high maternal Se levels may adversely affect child neurodevelopment. Our findings warrant further investigation; if confirmed, optimizing maternal prenatal Se levels may be necessary to maximize its health benefits while preventing undue risk. LAY SUMMARY: Selenium (Se) is an essential nutrient for the health of the pregnant mother and her baby. While Se can readily cross the placenta from maternal to fetal circulation, little is known about maternal Se status on her child's neurodevelopmental outcomes. We studied over 1500 mother-child dyads from birth to school age of the child. We found that babies born from mothers with high blood Se levels may be at increased risk of developing autism spectrum disorder or attention deficit hyperactivity disorder. Given this is the first study of the kind, more study is needed to confirm our findings. En ligne : http://dx.doi.org/10.1002/aur.2617 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450