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An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder / A. S. LEWIS in Journal of Autism and Developmental Disorders, 48-8 (August 2018)
[article]
Titre : An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; M. O. LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; M. R. PICCIOTTO, Auteur ; D. G. SUKHODOLSKY, Auteur Article en page(s) : p.2748-2757 Langues : Anglais (eng) Mots-clés : Adult Aggression Autism spectrum disorder Irritability Nicotine Nicotinic acetylcholine receptor Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367
in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757[article] An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; M. O. LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; M. R. PICCIOTTO, Auteur ; D. G. SUKHODOLSKY, Auteur . - p.2748-2757.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757
Mots-clés : Adult Aggression Autism spectrum disorder Irritability Nicotine Nicotinic acetylcholine receptor Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder / Gerrit I. VAN SCHALKWYK in Journal of Autism and Developmental Disorders, 45-9 (September 2015)
[article]
Titre : Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Gerrit I. VAN SCHALKWYK, Auteur ; Alan S. LEWIS, Auteur ; Zheala QAYYUM, Auteur ; Kourtney KOSLOSKY, Auteur ; Marina R. PICCIOTTO, Auteur ; Fred R. VOLKMAR, Auteur Article en page(s) : p.3061-3066 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Developmental disorder Aggression Irritability Nicotine Nicotine patch Nicotinic acetylcholine receptor Index. décimale : PER Périodiques Résumé : Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-015-2471-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267
in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3061-3066[article] Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Gerrit I. VAN SCHALKWYK, Auteur ; Alan S. LEWIS, Auteur ; Zheala QAYYUM, Auteur ; Kourtney KOSLOSKY, Auteur ; Marina R. PICCIOTTO, Auteur ; Fred R. VOLKMAR, Auteur . - p.3061-3066.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3061-3066
Mots-clés : Autism spectrum disorder Developmental disorder Aggression Irritability Nicotine Nicotine patch Nicotinic acetylcholine receptor Index. décimale : PER Périodiques Résumé : Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-015-2471-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267