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Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study / H. DEN BAKKER in Molecular Autism, 9 (2018)
[article]
Titre : Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study Type de document : Texte imprimé et/ou numérique Auteurs : H. DEN BAKKER, Auteur ; M. S. SIDOROV, Auteur ; Z. FAN, Auteur ; D. J. LEE, Auteur ; L. M. BIRD, Auteur ; C. J. CHU, Auteur ; B. D. PHILPOT, Auteur Article en page(s) : 32p. Langues : Anglais (eng) Mots-clés : Angelman Syndrome/physiopathology Case-Control Studies Child Delta Rhythm Female Gamma Rhythm Humans Male Sleep Stages Angelman syndrome Biomarker Coherence eeg Spindles UBE3A Index. décimale : PER Périodiques Résumé : Background: Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, speech and motor impairments, epilepsy, abnormal sleep, and phenotypic overlap with autism. Individuals with AS display characteristic EEG patterns including high-amplitude rhythmic delta waves. Here, we sought to quantitatively explore EEG architecture in AS beyond known spectral power phenotypes. We were motivated by studies of functional connectivity and sleep spindles in autism to study these EEG readouts in children with AS. Methods: We analyzed retrospective wake and sleep EEGs from children with AS (age 4-11) and age-matched neurotypical controls. We assessed long-range and short-range functional connectivity by measuring coherence across multiple frequencies during wake and sleep. We quantified sleep spindles using automated and manual approaches. Results: During wakefulness, children with AS showed enhanced long-range EEG coherence across a wide range of frequencies. During sleep, children with AS showed increased long-range EEG coherence specifically in the gamma band. EEGs from children with AS contained fewer sleep spindles, and these spindles were shorter in duration than their neurotypical counterparts. Conclusions: We demonstrate two quantitative readouts of dysregulated sleep composition in children with AS-gamma coherence and spindles-and describe how functional connectivity patterns may be disrupted during wakefulness. Quantitative EEG phenotypes have potential as biomarkers and readouts of target engagement for future clinical trials and provide clues into how neural circuits are dysregulated in children with AS. En ligne : https://dx.doi.org/10.1186/s13229-018-0214-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Molecular Autism > 9 (2018) . - 32p.[article] Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study [Texte imprimé et/ou numérique] / H. DEN BAKKER, Auteur ; M. S. SIDOROV, Auteur ; Z. FAN, Auteur ; D. J. LEE, Auteur ; L. M. BIRD, Auteur ; C. J. CHU, Auteur ; B. D. PHILPOT, Auteur . - 32p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 32p.
Mots-clés : Angelman Syndrome/physiopathology Case-Control Studies Child Delta Rhythm Female Gamma Rhythm Humans Male Sleep Stages Angelman syndrome Biomarker Coherence eeg Spindles UBE3A Index. décimale : PER Périodiques Résumé : Background: Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, speech and motor impairments, epilepsy, abnormal sleep, and phenotypic overlap with autism. Individuals with AS display characteristic EEG patterns including high-amplitude rhythmic delta waves. Here, we sought to quantitatively explore EEG architecture in AS beyond known spectral power phenotypes. We were motivated by studies of functional connectivity and sleep spindles in autism to study these EEG readouts in children with AS. Methods: We analyzed retrospective wake and sleep EEGs from children with AS (age 4-11) and age-matched neurotypical controls. We assessed long-range and short-range functional connectivity by measuring coherence across multiple frequencies during wake and sleep. We quantified sleep spindles using automated and manual approaches. Results: During wakefulness, children with AS showed enhanced long-range EEG coherence across a wide range of frequencies. During sleep, children with AS showed increased long-range EEG coherence specifically in the gamma band. EEGs from children with AS contained fewer sleep spindles, and these spindles were shorter in duration than their neurotypical counterparts. Conclusions: We demonstrate two quantitative readouts of dysregulated sleep composition in children with AS-gamma coherence and spindles-and describe how functional connectivity patterns may be disrupted during wakefulness. Quantitative EEG phenotypes have potential as biomarkers and readouts of target engagement for future clinical trials and provide clues into how neural circuits are dysregulated in children with AS. En ligne : https://dx.doi.org/10.1186/s13229-018-0214-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Relation of Melatonin to Sleep Architecture in Children with Autism / Roberta M. LEU in Journal of Autism and Developmental Disorders, 41-4 (April 2011)
[article]
Titre : Relation of Melatonin to Sleep Architecture in Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Roberta M. LEU, Auteur ; Liya BEYDERMAN, Auteur ; Emmanuel J. BOTZOLAKIS, Auteur ; Kyla SURDYKA, Auteur ; Lily WANG, Auteur ; Beth A. MALOW, Auteur Année de publication : 2011 Article en page(s) : p.427-433 Langues : Anglais (eng) Mots-clés : 6-Sulfatoxymelatonin 6-SM Sleep stages Children’s Sleep Habits Questionnaire Parental Concerns Questionnaire Polysomnography Index. décimale : PER Périodiques Résumé : Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM). We therefore investigated the relationship between 6-SM levels and sleep architecture in children with autism spectrum disorders (ASD). Twenty-three children, aged 4–10 years, completed two nights of polysomnography and one overnight urine collection for measurement of urinary 6-SM excretion rate. Parents completed the Children’s Sleep Habits Questionnaire. We found that higher urinary 6-SM excretion rates were associated with increased N3 sleep, decreased N2 sleep, and decreased daytime sleepiness. The results warrant further examination to examine the effects of supplemental melatonin on sleep architecture and daytime sleepiness. En ligne : http://dx.doi.org/10.1007/s10803-010-1072-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119
in Journal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.427-433[article] Relation of Melatonin to Sleep Architecture in Children with Autism [Texte imprimé et/ou numérique] / Roberta M. LEU, Auteur ; Liya BEYDERMAN, Auteur ; Emmanuel J. BOTZOLAKIS, Auteur ; Kyla SURDYKA, Auteur ; Lily WANG, Auteur ; Beth A. MALOW, Auteur . - 2011 . - p.427-433.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.427-433
Mots-clés : 6-Sulfatoxymelatonin 6-SM Sleep stages Children’s Sleep Habits Questionnaire Parental Concerns Questionnaire Polysomnography Index. décimale : PER Périodiques Résumé : Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM). We therefore investigated the relationship between 6-SM levels and sleep architecture in children with autism spectrum disorders (ASD). Twenty-three children, aged 4–10 years, completed two nights of polysomnography and one overnight urine collection for measurement of urinary 6-SM excretion rate. Parents completed the Children’s Sleep Habits Questionnaire. We found that higher urinary 6-SM excretion rates were associated with increased N3 sleep, decreased N2 sleep, and decreased daytime sleepiness. The results warrant further examination to examine the effects of supplemental melatonin on sleep architecture and daytime sleepiness. En ligne : http://dx.doi.org/10.1007/s10803-010-1072-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119