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Détail de l'auteur
Auteur Beth A. MALOW
Documents disponibles écrits par cet auteur



Erratum to: Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes / Beth A. MALOW in Journal of Autism and Developmental Disorders, 42-8 (August 2012)
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Genetic Variation in Melatonin Pathway Enzymes in Children with Autism Spectrum Disorder and Comorbid Sleep Onset Delay / Olivia J. VEATCH in Journal of Autism and Developmental Disorders, 45-1 (January 2015)
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[article]
in Journal of Autism and Developmental Disorders > 45-1 (January 2015) . - p.100-110
Titre : Genetic Variation in Melatonin Pathway Enzymes in Children with Autism Spectrum Disorder and Comorbid Sleep Onset Delay Type de document : texte imprimé Auteurs : Olivia J. VEATCH, Auteur ; Julie S. PENDERGAST, Auteur ; Melissa J. ALLEN, Auteur ; Roberta M. LEU, Auteur ; Carl Hirschie JOHNSON, Auteur ; Sarah H. ELSEA, Auteur ; Beth A. MALOW, Auteur Article en page(s) : p.100-110 Langues : Anglais (eng) Mots-clés : Comorbidities Genetic analyses Phenotyping Phenotypic subgroups Biomarkers Endophenotypes Index. décimale : PER Périodiques Résumé : Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically unique ASD subgroup, consisting solely of children with comorbid expression of sleep onset delay. We evaluated variation in two melatonin pathway genes, acetylserotonin O-methyltransferase (ASMT) and cytochrome P450 1A2 (CYP1A2). We observed higher frequencies than currently reported (p < 0.04) for variants evidenced to decrease ASMT expression and related to decreased CYP1A2 enzyme activity (p ? 0.0007). We detected a relationship between genotypes in ASMT and CYP1A2 (r2 = 0.63). Our results indicate that expression of sleep onset delay relates to melatonin pathway genes. En ligne : http://dx.doi.org/10.1007/s10803-014-2197-4 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2581 [article] Genetic Variation in Melatonin Pathway Enzymes in Children with Autism Spectrum Disorder and Comorbid Sleep Onset Delay [texte imprimé] / Olivia J. VEATCH, Auteur ; Julie S. PENDERGAST, Auteur ; Melissa J. ALLEN, Auteur ; Roberta M. LEU, Auteur ; Carl Hirschie JOHNSON, Auteur ; Sarah H. ELSEA, Auteur ; Beth A. MALOW, Auteur . - p.100-110.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-1 (January 2015) . - p.100-110
Mots-clés : Comorbidities Genetic analyses Phenotyping Phenotypic subgroups Biomarkers Endophenotypes Index. décimale : PER Périodiques Résumé : Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically unique ASD subgroup, consisting solely of children with comorbid expression of sleep onset delay. We evaluated variation in two melatonin pathway genes, acetylserotonin O-methyltransferase (ASMT) and cytochrome P450 1A2 (CYP1A2). We observed higher frequencies than currently reported (p < 0.04) for variants evidenced to decrease ASMT expression and related to decreased CYP1A2 enzyme activity (p ? 0.0007). We detected a relationship between genotypes in ASMT and CYP1A2 (r2 = 0.63). Our results indicate that expression of sleep onset delay relates to melatonin pathway genes. En ligne : http://dx.doi.org/10.1007/s10803-014-2197-4 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2581 Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes / Beth A. MALOW in Journal of Autism and Developmental Disorders, 42-8 (August 2012)
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[article]
in Journal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1729-1737
Titre : Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes Type de document : texte imprimé Auteurs : Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Susan G. McGREW, Auteur ; Lily WANG, Auteur ; Suzanne E. GOLDMAN, Auteur ; Diane FAWKES, Auteur ; Courtney BURNETTE, Auteur Année de publication : 2012 Article en page(s) : p.1729-1737 Langues : Anglais (eng) Catégories : AUTISM DIAGNOSIS OBSERVATION SCHEDULE (ADOS)
ESSAI CLINIQUE
MELATONINE
PHARMACOLOGIE
QUESTIONNAIRE
TROUBLE DU SOMMEILMots-clés : Melatonin Insomnia Actigraphy Clinical trial Children’s sleep habits questionnaire Child behavior checklist Autism diagnostic observation schedule Index. décimale : PER Périodiques Résumé : Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose–response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population. En ligne : http://dx.doi.org/10.1007/s10803-011-1418-3 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1784 [article] Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes [texte imprimé] / Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Susan G. McGREW, Auteur ; Lily WANG, Auteur ; Suzanne E. GOLDMAN, Auteur ; Diane FAWKES, Auteur ; Courtney BURNETTE, Auteur . - 2012 . - p.1729-1737.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1729-1737
Catégories : AUTISM DIAGNOSIS OBSERVATION SCHEDULE (ADOS)
ESSAI CLINIQUE
MELATONINE
PHARMACOLOGIE
QUESTIONNAIRE
TROUBLE DU SOMMEILMots-clés : Melatonin Insomnia Actigraphy Clinical trial Children’s sleep habits questionnaire Child behavior checklist Autism diagnostic observation schedule Index. décimale : PER Périodiques Résumé : Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose–response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population. En ligne : http://dx.doi.org/10.1007/s10803-011-1418-3 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1784 Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep / Suzanne E. GOLDMAN in Journal of Autism and Developmental Disorders, 44-10 (October 2014)
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[article]
in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2525-2535
Titre : Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep Type de document : texte imprimé Auteurs : Suzanne E. GOLDMAN, Auteur ; Karen W. ADKINS, Auteur ; M. Wade CALCUTT, Auteur ; Melissa D. CARTER, Auteur ; Robert L. GOODPASTER, Auteur ; Lily WANG, Auteur ; Yaping SHI, Auteur ; Helen J. BURGESS, Auteur ; David L. HACHEY, Auteur ; Beth A. MALOW, Auteur Article en page(s) : p.2525-2535 Langues : Anglais (eng) Mots-clés : Insomnia N-acetylserotonin Dim light melatonin onset Index. décimale : PER Périodiques Résumé : Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (C max) and time to peak concentration (T max) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin. En ligne : http://dx.doi.org/10.1007/s10803-014-2123-9 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2409 [article] Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep [texte imprimé] / Suzanne E. GOLDMAN, Auteur ; Karen W. ADKINS, Auteur ; M. Wade CALCUTT, Auteur ; Melissa D. CARTER, Auteur ; Robert L. GOODPASTER, Auteur ; Lily WANG, Auteur ; Yaping SHI, Auteur ; Helen J. BURGESS, Auteur ; David L. HACHEY, Auteur ; Beth A. MALOW, Auteur . - p.2525-2535.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2525-2535
Mots-clés : Insomnia N-acetylserotonin Dim light melatonin onset Index. décimale : PER Périodiques Résumé : Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (C max) and time to peak concentration (T max) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin. En ligne : http://dx.doi.org/10.1007/s10803-014-2123-9 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2409 Parent-Based Sleep Education for Children with Autism Spectrum Disorders / Beth A. MALOW in Journal of Autism and Developmental Disorders, 44-1 (January 2014)
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[article]
in Journal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.216-228
Titre : Parent-Based Sleep Education for Children with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Ann REYNOLDS, Auteur ; Shelly K. WEISS, Auteur ; Alvin LOH, Auteur ; Diane FAWKES, Auteur ; Terry KATZ, Auteur ; Suzanne E. GOLDMAN, Auteur ; Niru MADDURI, Auteur ; Rachel J. HUNDLEY, Auteur ; Traci E. CLEMONS, Auteur Article en page(s) : p.216-228 Langues : Anglais (eng) Mots-clés : Insomnia Actigraphy Children’s Sleep Habits Questionnaire Repetitive Behavior Scale-Revised Child Behavior Checklist Index. décimale : PER Périodiques Résumé : This study provided sleep education to parents of children with autism spectrum disorder (ASD) to determine whether an individual or group format was more effective in improving sleep and aspects of daytime behavior and family functioning. Eighty children, ages 2–10 years, with ASD and sleep onset delay completed the study. Actigraphy and parent questionnaires were collected at baseline and 1 month after treatment. Mode of education did not affect outcomes. Sleep latency, insomnia subscales on the Children’s Sleep Habits Questionnaire, and other outcomes related to child and family functioning improved with treatment. Parent-based sleep education, delivered in relatively few sessions, was associated with improved sleep onset delay in children with ASD. Group versus individualized education did not affect outcome. En ligne : http://dx.doi.org/10.1007/s10803-013-1866-z Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2207 [article] Parent-Based Sleep Education for Children with Autism Spectrum Disorders [texte imprimé] / Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Ann REYNOLDS, Auteur ; Shelly K. WEISS, Auteur ; Alvin LOH, Auteur ; Diane FAWKES, Auteur ; Terry KATZ, Auteur ; Suzanne E. GOLDMAN, Auteur ; Niru MADDURI, Auteur ; Rachel J. HUNDLEY, Auteur ; Traci E. CLEMONS, Auteur . - p.216-228.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.216-228
Mots-clés : Insomnia Actigraphy Children’s Sleep Habits Questionnaire Repetitive Behavior Scale-Revised Child Behavior Checklist Index. décimale : PER Périodiques Résumé : This study provided sleep education to parents of children with autism spectrum disorder (ASD) to determine whether an individual or group format was more effective in improving sleep and aspects of daytime behavior and family functioning. Eighty children, ages 2–10 years, with ASD and sleep onset delay completed the study. Actigraphy and parent questionnaires were collected at baseline and 1 month after treatment. Mode of education did not affect outcomes. Sleep latency, insomnia subscales on the Children’s Sleep Habits Questionnaire, and other outcomes related to child and family functioning improved with treatment. Parent-based sleep education, delivered in relatively few sessions, was associated with improved sleep onset delay in children with ASD. Group versus individualized education did not affect outcome. En ligne : http://dx.doi.org/10.1007/s10803-013-1866-z Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2207 Parental Sleep Concerns in Autism Spectrum Disorders: Variations from Childhood to Adolescence / Suzanne E. GOLDMAN in Journal of Autism and Developmental Disorders, 42-4 (April 2012)
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PermalinkRelation of Melatonin to Sleep Architecture in Children with Autism / Roberta M. LEU in Journal of Autism and Developmental Disorders, 41-4 (April 2011)
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PermalinkRelationship Between Subtypes of Restricted and Repetitive Behaviors and Sleep Disturbance in Autism Spectrum Disorder / Rachel J. HUNDLEY in Journal of Autism and Developmental Disorders, 46-11 (November 2016)
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PermalinkShorter sleep duration is associated with social impairment and comorbidities in ASD / Olivia J. VEATCH in Autism Research, 10-7 (July 2017)
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PermalinkSleep is associated with problem behaviors in children and adolescents with Autism Spectrum Disorders / Suzanne E. GOLDMAN in Research in Autism Spectrum Disorders, 5-3 (July-September 2011)
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Centre d'Information et de Documentationdu CRA Rhône-Alpes
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