2373 recherche sur le mot-clé 'disorders'

A 3D approach to understanding heterogeneity in early developing autisms / Veronica MANDELLI in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 41p. Titre : A 3D approach to understanding heterogeneity in early developing autisms Type de document : texte imprimé Auteurs : Veronica MANDELLI, Auteur ; Ines SEVERINO, Auteur ; Lisa T. EYLER, Auteur ; Karen PIERCE, Auteur ; Eric COURCHESNE, Auteur ; Michael V. LOMBARDO, Auteur Article en page(s) : 41p. Langues : Anglais (eng) Mots-clés : Humans  Child, Preschool  Autistic Disorder/diagnostic imaging/diagnosis  Female  Male  Child  Phenotype  Imaging, Three-Dimensional  Clustering  Gene expression  Stratification  Subtypes  fMRI  for the Collection in this journal entitled 'Neuroimaging in Autism Spectrum  Disorders'. All other authors have no competing interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Phenotypic heterogeneity in early language, intellectual, motor, and adaptive functioning (LIMA) features are amongst the most striking features that distinguish different types of autistic individuals. Yet the current diagnostic criteria uses a single label of autism and implicitly emphasizes what individuals have in common as core social-communicative and restricted repetitive behavior difficulties. Subtype labels based on the non-core LIMA features may help to more meaningfully distinguish types of autisms with differing developmental paths and differential underlying biology. METHODS: Unsupervised data-driven subtypes were identified using stability-based relative clustering validation on publicly available Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS) data (n = 615; age = 24-68 months) from the National Institute of Mental Health Data Archive (NDA). Differential developmental trajectories between subtypes were tested on longitudinal data from NDA and from an independent in-house dataset from UCSD. A subset of the UCSD dataset was also tested for subtype differences in functional and structural neuroimaging phenotypes and relationships with blood gene expression. The current subtyping model was also compared to early language outcome subtypes derived from past work. RESULTS: Two autism subtypes can be identified based on early phenotypic LIMA features. These data-driven subtypes are robust in the population and can be identified in independent data with 98% accuracy. The subtypes can be described as Type I versus Type II autisms differentiated by relatively high versus low scores on LIMA features. These two types of autisms are also distinguished by different developmental trajectories over the first decade of life. Finally, these two types of autisms reveal striking differences in functional and structural neuroimaging phenotypes and their relationships with gene expression and may highlight unique biological mechanisms. LIMITATIONS: Sample sizes for the neuroimaging and gene expression dataset are relatively small and require further independent replication. The current work is also limited to subtyping based on MSEL and VABS phenotypic measures. CONCLUSIONS: This work emphasizes the potential importance of stratifying autism by a Type I versus Type II distinction focused on LIMA features and which may be of high prognostic and biological significance. En ligne : https://dx.doi.org/10.1186/s13229-024-00613-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] A 3D approach to understanding heterogeneity in early developing autisms [texte imprimé] / Veronica MANDELLI, Auteur ; Ines SEVERINO, Auteur ; Lisa T. EYLER, Auteur ; Karen PIERCE, Auteur ; Eric COURCHESNE, Auteur ; Michael V. LOMBARDO, Auteur . - 41p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 41p. Mots-clés : Humans  Child, Preschool  Autistic Disorder/diagnostic imaging/diagnosis  Female  Male  Child  Phenotype  Imaging, Three-Dimensional  Clustering  Gene expression  Stratification  Subtypes  fMRI  for the Collection in this journal entitled 'Neuroimaging in Autism Spectrum  Disorders'. All other authors have no competing interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Phenotypic heterogeneity in early language, intellectual, motor, and adaptive functioning (LIMA) features are amongst the most striking features that distinguish different types of autistic individuals. Yet the current diagnostic criteria uses a single label of autism and implicitly emphasizes what individuals have in common as core social-communicative and restricted repetitive behavior difficulties. Subtype labels based on the non-core LIMA features may help to more meaningfully distinguish types of autisms with differing developmental paths and differential underlying biology. METHODS: Unsupervised data-driven subtypes were identified using stability-based relative clustering validation on publicly available Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS) data (n = 615; age = 24-68 months) from the National Institute of Mental Health Data Archive (NDA). Differential developmental trajectories between subtypes were tested on longitudinal data from NDA and from an independent in-house dataset from UCSD. A subset of the UCSD dataset was also tested for subtype differences in functional and structural neuroimaging phenotypes and relationships with blood gene expression. The current subtyping model was also compared to early language outcome subtypes derived from past work. RESULTS: Two autism subtypes can be identified based on early phenotypic LIMA features. These data-driven subtypes are robust in the population and can be identified in independent data with 98% accuracy. The subtypes can be described as Type I versus Type II autisms differentiated by relatively high versus low scores on LIMA features. These two types of autisms are also distinguished by different developmental trajectories over the first decade of life. Finally, these two types of autisms reveal striking differences in functional and structural neuroimaging phenotypes and their relationships with gene expression and may highlight unique biological mechanisms. LIMITATIONS: Sample sizes for the neuroimaging and gene expression dataset are relatively small and require further independent replication. The current work is also limited to subtyping based on MSEL and VABS phenotypic measures. CONCLUSIONS: This work emphasizes the potential importance of stratifying autism by a Type I versus Type II distinction focused on LIMA features and which may be of high prognostic and biological significance. En ligne : https://dx.doi.org/10.1186/s13229-024-00613-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Ethiopian community health workers' beliefs and attitudes towards children with autism: Impact of a brief training intervention / Dejene TILAHUN in Autism, 23-1 (January 2019)  

Public ISBD [article]  inAutism > 23-1 (January 2019) . - p.39-49 Titre : Ethiopian community health workers' beliefs and attitudes towards children with autism: Impact of a brief training intervention Type de document : texte imprimé Auteurs : Dejene TILAHUN, Auteur ; Abebaw FEKADU, Auteur ; Bethlehem TEKOLA, Auteur ; Mesfin ARAYA, Auteur ; Ilona ROTH, Auteur ; Basiro DAVEY, Auteur ; Charlotte HANLON, Auteur ; Rosa A. HOEKSTRA, Auteur Article en page(s) : p.39-49 Langues : Anglais (eng) Mots-clés : attitude  autism spectrum disorder  community health workers  developing  countries  developmental disabilities  Ethiopia  stigma  mental-health  low-income  illness  disorders  africa  guangzhou  knowledge  people  staff  Psychology Index. décimale : PER Périodiques Résumé : There is a severe shortage of services for children with autism in Ethiopia; access to services is further impeded by negative beliefs and stigmatising attitudes towards affected children and their families. To increase access to services, care provision is decentralised through task-shifted care by community health extension workers. This study aimed to examine the impact of a brief training (Health Education and Training; HEAT) for Ethiopian rural health extension workers and comprised three groups: (1) health extension workers who completed a basic mental health training module (HEAT group, N = 104); (2) health extension workers who received enhanced training, comprising basic HEAT as well as video-based training on developmental disorders and a mental health pocket guide (HEAT+ group, N = 97); and (3) health extension workers untrained in mental health (N = 108). All participants completed a questionnaire assessing beliefs and social distance towards children with autism. Both the HEAT and HEAT+ group showed fewer negative beliefs and decreased social distance towards children with autism compared to the untrained health extension worker group, with the HEAT+ group outperforming the HEAT group. However, HEAT+ trained health extension workers were less likely to have positive expectations about children with autism than untrained health extension workers. These findings have relevance for task-sharing and scale up of autism services in low-resource settings worldwide. En ligne : http://dx.doi.org/10.1177/1362361317730298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379 [article] Ethiopian community health workers' beliefs and attitudes towards children with autism: Impact of a brief training intervention [texte imprimé] / Dejene TILAHUN, Auteur ; Abebaw FEKADU, Auteur ; Bethlehem TEKOLA, Auteur ; Mesfin ARAYA, Auteur ; Ilona ROTH, Auteur ; Basiro DAVEY, Auteur ; Charlotte HANLON, Auteur ; Rosa A. HOEKSTRA, Auteur . - p.39-49. Langues : Anglais (eng) in Autism > 23-1 (January 2019) . - p.39-49 Mots-clés : attitude  autism spectrum disorder  community health workers  developing  countries  developmental disabilities  Ethiopia  stigma  mental-health  low-income  illness  disorders  africa  guangzhou  knowledge  people  staff  Psychology Index. décimale : PER Périodiques Résumé : There is a severe shortage of services for children with autism in Ethiopia; access to services is further impeded by negative beliefs and stigmatising attitudes towards affected children and their families. To increase access to services, care provision is decentralised through task-shifted care by community health extension workers. This study aimed to examine the impact of a brief training (Health Education and Training; HEAT) for Ethiopian rural health extension workers and comprised three groups: (1) health extension workers who completed a basic mental health training module (HEAT group, N = 104); (2) health extension workers who received enhanced training, comprising basic HEAT as well as video-based training on developmental disorders and a mental health pocket guide (HEAT+ group, N = 97); and (3) health extension workers untrained in mental health (N = 108). All participants completed a questionnaire assessing beliefs and social distance towards children with autism. Both the HEAT and HEAT+ group showed fewer negative beliefs and decreased social distance towards children with autism compared to the untrained health extension worker group, with the HEAT+ group outperforming the HEAT group. However, HEAT+ trained health extension workers were less likely to have positive expectations about children with autism than untrained health extension workers. These findings have relevance for task-sharing and scale up of autism services in low-resource settings worldwide. En ligne : http://dx.doi.org/10.1177/1362361317730298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379

Looking good but feeling bad: "Camouflaging" behaviors and mental health in women with autistic traits / Jonathan S. BECK in Autism, 24-4 (May 2020)  

Public ISBD [article]  inAutism > 24-4 (May 2020) . - p.809-821 Titre : Looking good but feeling bad: "Camouflaging" behaviors and mental health in women with autistic traits Type de document : texte imprimé Auteurs : Jonathan S. BECK, Auteur ; Rebecca A. LUNDWALL, Auteur ; Terisa P. GABRIELSEN, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur Article en page(s) : p.809-821 Langues : Anglais (eng) Mots-clés : autism spectrum  camouflage  diagnosis  disorders  female  mental health  women Index. décimale : PER Périodiques Résumé : Women who try to hide or "camouflage" their autistic traits are likely to report that they feel distressed, think of suicide, and/or struggle to function in everyday life. We asked 58 women with autistic traits to complete questionnaires about camouflaging and mental health. Most of these women did not have a formal diagnosis of autism, yet a majority reported that they camouflaged autistic traits, and a large majority reported significant mental health challenges. Some researchers have suggested that women with autistic traits are more likely than autistic men to experience mental health challenges because women may try more to "fit in" socially by camouflaging their autistic traits. Analyses showed that camouflaging was associated with feeling distressed (depressed, anxious, and/or stressed). For women who reported above-average levels of camouflaging, camouflaging was also associated with having thoughts about suicide and struggling to function in everyday life. Trying to camouflage autistic traits was associated with mental health challenges, regardless of whether those traits were very mild or more severe. The findings of this study may influence how mental health professionals evaluate and treat women with autistic traits. En ligne : http://dx.doi.org/10.1177/1362361320912147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 [article] Looking good but feeling bad: "Camouflaging" behaviors and mental health in women with autistic traits [texte imprimé] / Jonathan S. BECK, Auteur ; Rebecca A. LUNDWALL, Auteur ; Terisa P. GABRIELSEN, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur . - p.809-821. Langues : Anglais (eng) in Autism > 24-4 (May 2020) . - p.809-821 Mots-clés : autism spectrum  camouflage  diagnosis  disorders  female  mental health  women Index. décimale : PER Périodiques Résumé : Women who try to hide or "camouflage" their autistic traits are likely to report that they feel distressed, think of suicide, and/or struggle to function in everyday life. We asked 58 women with autistic traits to complete questionnaires about camouflaging and mental health. Most of these women did not have a formal diagnosis of autism, yet a majority reported that they camouflaged autistic traits, and a large majority reported significant mental health challenges. Some researchers have suggested that women with autistic traits are more likely than autistic men to experience mental health challenges because women may try more to "fit in" socially by camouflaging their autistic traits. Analyses showed that camouflaging was associated with feeling distressed (depressed, anxious, and/or stressed). For women who reported above-average levels of camouflaging, camouflaging was also associated with having thoughts about suicide and struggling to function in everyday life. Trying to camouflage autistic traits was associated with mental health challenges, regardless of whether those traits were very mild or more severe. The findings of this study may influence how mental health professionals evaluate and treat women with autistic traits. En ligne : http://dx.doi.org/10.1177/1362361320912147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425

A multi-method examination of sluggish cognitive tempo in relation to adolescent sleep, daytime sleepiness, and circadian preference / Joseph W. FREDRICK in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1658-1667 Titre : A multi-method examination of sluggish cognitive tempo in relation to adolescent sleep, daytime sleepiness, and circadian preference Type de document : texte imprimé Auteurs : Joseph W. FREDRICK, Auteur ; Kiley M. YEAMAN, Auteur ; Xiaoqian YU, Auteur ; Joshua M. LANGBERG, Auteur ; Stephen P. BECKER, Auteur Article en page(s) : p.1658-1667 Langues : Anglais (eng) Mots-clés : Adolescent  Female  Humans  Male  Attention Deficit Disorder with Hyperactivity  Research Design  Sluggish Cognitive Tempo  Sleep  Disorders of Excessive Somnolence  Adhd  adolescence  circadian function  circadian preference  daytime sleepiness Index. décimale : PER Périodiques Résumé : BACKGROUND: The field's understanding of the association between sluggish cognitive tempo (SCT) and sleep is severely limited by the lack of multi-method and multi-informant research designs that move beyond global ratings, often focused on a limited number of sleep-related domains, such as daytime sleepiness. The current study begins to address these limitations by using actigraphy, daily sleep diary, and self- and parent-report global ratings of sleep in adolescents, a developmental period marked by changes in SCT, sleep, and circadian function. As SCT and sleep are also associated with ADHD symptoms, we tested these associations in a sample of adolescents with and without ADHD. METHODS: Adolescents (N=302; M age=13.17 years, 44.7% female) with (n=162) and without ADHD (n=140) and parents completed global ratings of sleep and daytime sleepiness, and adolescents completed a measure of circadian preference. Adolescents also wore actigraphs for approximately two weeks, during which daily diaries were completed. RESULTS: Above and beyond demographic characteristics (i.e., sex, race, and family income), pubertal development, medication use, and ADHD group status, adolescents' self-reported SCT symptoms were uniquely associated with shorter sleep duration and later sleep onset per both actigraphy and daily diary. SCT symptoms were also uniquely associated with longer sleep onset latency and poorer overall sleep (per daily diary), more sleep/wake problems and daytime sleepiness (per adolescent rating), more difficulties initiating and maintaining sleep (per parent rating), and later eveningness preference (per adolescent rating). Nearly all significant effects remained in sensitivity analyses controlling for adolescent- or parent-reported ADHD symptom dimensions. CONCLUSIONS: Findings provide the strongest evidence to date for SCT being uniquely linked to poorer sleep, greater daytime sleepiness, and a later evening circadian preference across subjective and objective measures. Longitudinal studies are needed to evaluate predictive and bidirectional associations. En ligne : http://dx.doi.org/10.1111/jcpp.13568 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] A multi-method examination of sluggish cognitive tempo in relation to adolescent sleep, daytime sleepiness, and circadian preference [texte imprimé] / Joseph W. FREDRICK, Auteur ; Kiley M. YEAMAN, Auteur ; Xiaoqian YU, Auteur ; Joshua M. LANGBERG, Auteur ; Stephen P. BECKER, Auteur . - p.1658-1667. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1658-1667 Mots-clés : Adolescent  Female  Humans  Male  Attention Deficit Disorder with Hyperactivity  Research Design  Sluggish Cognitive Tempo  Sleep  Disorders of Excessive Somnolence  Adhd  adolescence  circadian function  circadian preference  daytime sleepiness Index. décimale : PER Périodiques Résumé : BACKGROUND: The field's understanding of the association between sluggish cognitive tempo (SCT) and sleep is severely limited by the lack of multi-method and multi-informant research designs that move beyond global ratings, often focused on a limited number of sleep-related domains, such as daytime sleepiness. The current study begins to address these limitations by using actigraphy, daily sleep diary, and self- and parent-report global ratings of sleep in adolescents, a developmental period marked by changes in SCT, sleep, and circadian function. As SCT and sleep are also associated with ADHD symptoms, we tested these associations in a sample of adolescents with and without ADHD. METHODS: Adolescents (N=302; M age=13.17 years, 44.7% female) with (n=162) and without ADHD (n=140) and parents completed global ratings of sleep and daytime sleepiness, and adolescents completed a measure of circadian preference. Adolescents also wore actigraphs for approximately two weeks, during which daily diaries were completed. RESULTS: Above and beyond demographic characteristics (i.e., sex, race, and family income), pubertal development, medication use, and ADHD group status, adolescents' self-reported SCT symptoms were uniquely associated with shorter sleep duration and later sleep onset per both actigraphy and daily diary. SCT symptoms were also uniquely associated with longer sleep onset latency and poorer overall sleep (per daily diary), more sleep/wake problems and daytime sleepiness (per adolescent rating), more difficulties initiating and maintaining sleep (per parent rating), and later eveningness preference (per adolescent rating). Nearly all significant effects remained in sensitivity analyses controlling for adolescent- or parent-reported ADHD symptom dimensions. CONCLUSIONS: Findings provide the strongest evidence to date for SCT being uniquely linked to poorer sleep, greater daytime sleepiness, and a later evening circadian preference across subjective and objective measures. Longitudinal studies are needed to evaluate predictive and bidirectional associations. En ligne : http://dx.doi.org/10.1111/jcpp.13568 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Sleep patterns, sluggish cognitive tempo, and daytime sleepiness - a commentary on Fredrick et al. (2022) / Dena SADEGHI-BAHMANI in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1668-1670 Titre : Sleep patterns, sluggish cognitive tempo, and daytime sleepiness - a commentary on Fredrick et al. (2022) Type de document : texte imprimé Auteurs : Dena SADEGHI-BAHMANI, Auteur ; Serge BRAND, Auteur Article en page(s) : p.1668-1670 Langues : Anglais (eng) Mots-clés : Adolescent  Child  Humans  Attention Deficit Disorder with Hyperactivity/complications  Cross-Sectional Studies  Sluggish Cognitive Tempo  Sleep/physiology  Disorders of Excessive Somnolence  Cognition/physiology Index. décimale : PER Périodiques Résumé : Fredrick et al. (Journal of Child Psychology and Psychiatry, 2022) showed in their cross-sectional and observational study that higher Sluggish Cognitive Tempo (SCT) traits were associated with more impaired subjective and objective sleep parameters. Importantly, data were gathered from adolescents and their parents, thus, enhancing the validity of the findings. In addition, the observed pattern of associations was unrelated to ADHD traits, age, sex, medication, or pubertal development. In the present commentary, we acknowledge the scientific value and practical and clinical implications of these findings. For future studies, we propose seven research avenues, which might help to further clarify the neurophysiological, psychological, and behavioral associations between SCT traits and sleep patterns. En ligne : http://dx.doi.org/10.1111/jcpp.13693 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Sleep patterns, sluggish cognitive tempo, and daytime sleepiness - a commentary on Fredrick et al. (2022) [texte imprimé] / Dena SADEGHI-BAHMANI, Auteur ; Serge BRAND, Auteur . - p.1668-1670. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1668-1670 Mots-clés : Adolescent  Child  Humans  Attention Deficit Disorder with Hyperactivity/complications  Cross-Sectional Studies  Sluggish Cognitive Tempo  Sleep/physiology  Disorders of Excessive Somnolence  Cognition/physiology Index. décimale : PER Périodiques Résumé : Fredrick et al. (Journal of Child Psychology and Psychiatry, 2022) showed in their cross-sectional and observational study that higher Sluggish Cognitive Tempo (SCT) traits were associated with more impaired subjective and objective sleep parameters. Importantly, data were gathered from adolescents and their parents, thus, enhancing the validity of the findings. In addition, the observed pattern of associations was unrelated to ADHD traits, age, sex, medication, or pubertal development. In the present commentary, we acknowledge the scientific value and practical and clinical implications of these findings. For future studies, we propose seven research avenues, which might help to further clarify the neurophysiological, psychological, and behavioral associations between SCT traits and sleep patterns. En ligne : http://dx.doi.org/10.1111/jcpp.13693 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Social (Pragmatic) Communication Disorder: Another name for the Broad Autism Phenotype? / Judy F. FLAX in Autism, 23-8 (November 2019)  

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Speaking genes or genes for speaking? Deciphering the genetics of speech and language / Elena L. GRIGORENKO in Journal of Child Psychology and Psychiatry, 50-1-2 (January/February 2009)  

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(1)H-NMR-based metabolomics reveals metabolic alterations in early development of a mouse model of Angelman syndrome / Pooja Kri GUPTA in Molecular Autism, 15 (2024)  

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2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam / Shirley H.F. LEE in Journal of Autism and Developmental Disorders, 51-12 (December 2021)  

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2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study / Lynnea MYERS in Journal of Autism and Developmental Disorders, 48-9 (September 2018)  

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