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Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development / Tania L. ROTH in Journal of Child Psychology and Psychiatry, 52-4 (April 2011)
[article]
Titre : Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development Type de document : Texte imprimé et/ou numérique Auteurs : Tania L. ROTH, Auteur ; J. David SWEATT, Auteur Année de publication : 2011 Article en page(s) : p.398-408 Langues : Anglais (eng) Mots-clés : Early-life experience maternal care epigenetic DNA methylation histone modification Index. décimale : PER Périodiques Résumé : Experiences during early development profoundly affect development of the central nervous system (CNS) to impart either risk for or resilience to later psychopathology. Work in the developmental neuroscience field is providing compelling data that epigenetic marking of the genome may underlie aspects of this process. Experiments in rodents continue to show that experiences during sensitive periods of development influence DNA methylation patterns of several genes. These experience-induced DNA methylation patterns represent stable epigenetic modifications that alter gene transcription throughout the lifespan and promote specific behavioral outcomes. We discuss the relevance of these findings to humans, and also briefly discuss these findings in the broader contexts of cognition and psychiatric disorder. We conclude by discussing the implications of these observations for future research. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02282.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119
in Journal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.398-408[article] Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development [Texte imprimé et/ou numérique] / Tania L. ROTH, Auteur ; J. David SWEATT, Auteur . - 2011 . - p.398-408.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.398-408
Mots-clés : Early-life experience maternal care epigenetic DNA methylation histone modification Index. décimale : PER Périodiques Résumé : Experiences during early development profoundly affect development of the central nervous system (CNS) to impart either risk for or resilience to later psychopathology. Work in the developmental neuroscience field is providing compelling data that epigenetic marking of the genome may underlie aspects of this process. Experiments in rodents continue to show that experiences during sensitive periods of development influence DNA methylation patterns of several genes. These experience-induced DNA methylation patterns represent stable epigenetic modifications that alter gene transcription throughout the lifespan and promote specific behavioral outcomes. We discuss the relevance of these findings to humans, and also briefly discuss these findings in the broader contexts of cognition and psychiatric disorder. We conclude by discussing the implications of these observations for future research. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02282.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 Annual Research Review: Critical windows - the microbiota-gut-brain axis in neurocognitive development / Caitlin S. M. COWAN in Journal of Child Psychology and Psychiatry, 61-3 (March 2020)
[article]
Titre : Annual Research Review: Critical windows - the microbiota-gut-brain axis in neurocognitive development Type de document : Texte imprimé et/ou numérique Auteurs : Caitlin S. M. COWAN, Auteur ; Timothy G. DINAN, Auteur ; John F. CRYAN, Auteur Article en page(s) : p.353-371 Langues : Anglais (eng) Mots-clés : Cognitive development child development early-life experience environmental exposures neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : The gut microbiota is a vast, complex, and fascinating ecosystem of microorganisms that resides in the human gastrointestinal tract. As an integral part of the microbiota-gut-brain axis, it is now being recognized that the microbiota is a modulator of brain and behavior, across species. Intriguingly, periods of change in the microbiota coincide with the development of other body systems and particularly the brain. We hypothesize that these times of parallel development are biologically relevant, corresponding to 'sensitive periods' or 'critical windows' in the development of the microbiota-gut-brain axis. Specifically, signals from the microbiota during these periods are hypothesized to be crucial for establishing appropriate communication along the axis throughout the life span. In other words, the microbiota is hypothesized to act like an expected input to calibrate the development of the microbiota-gut-brain axis. The absence or disruption of the microbiota during specific developmental windows would therefore be expected to have a disproportionate effect on specific functions or potentially for regulation of the system as a whole. Evidence for microbial modulation of neurocognitive development and neurodevelopmental risk is discussed in light of this hypothesis, finishing with a focus on the challenges that lay ahead for the future study of the microbiota-gut-brain axis during development. En ligne : http://dx.doi.org/10.1111/jcpp.13156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420
in Journal of Child Psychology and Psychiatry > 61-3 (March 2020) . - p.353-371[article] Annual Research Review: Critical windows - the microbiota-gut-brain axis in neurocognitive development [Texte imprimé et/ou numérique] / Caitlin S. M. COWAN, Auteur ; Timothy G. DINAN, Auteur ; John F. CRYAN, Auteur . - p.353-371.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-3 (March 2020) . - p.353-371
Mots-clés : Cognitive development child development early-life experience environmental exposures neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : The gut microbiota is a vast, complex, and fascinating ecosystem of microorganisms that resides in the human gastrointestinal tract. As an integral part of the microbiota-gut-brain axis, it is now being recognized that the microbiota is a modulator of brain and behavior, across species. Intriguingly, periods of change in the microbiota coincide with the development of other body systems and particularly the brain. We hypothesize that these times of parallel development are biologically relevant, corresponding to 'sensitive periods' or 'critical windows' in the development of the microbiota-gut-brain axis. Specifically, signals from the microbiota during these periods are hypothesized to be crucial for establishing appropriate communication along the axis throughout the life span. In other words, the microbiota is hypothesized to act like an expected input to calibrate the development of the microbiota-gut-brain axis. The absence or disruption of the microbiota during specific developmental windows would therefore be expected to have a disproportionate effect on specific functions or potentially for regulation of the system as a whole. Evidence for microbial modulation of neurocognitive development and neurodevelopmental risk is discussed in light of this hypothesis, finishing with a focus on the challenges that lay ahead for the future study of the microbiota-gut-brain axis during development. En ligne : http://dx.doi.org/10.1111/jcpp.13156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420