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Abnormalities in brain systems supporting individuation and enumeration in autism / Kirsten O'HEARN in Autism Research, 9-1 (January 2016)
[article]
Titre : Abnormalities in brain systems supporting individuation and enumeration in autism Type de document : Texte imprimé et/ou numérique Auteurs : Kirsten O'HEARN, Auteur ; Katerina VELANOVA, Auteur ; Andrew LYNN, Auteur ; Catherine WRIGHT, Auteur ; Michael HALLQUIST, Auteur ; Nancy MINSHEW, Auteur ; Beatriz LUNA, Auteur Article en page(s) : p.82-96 Langues : Anglais (eng) Mots-clés : autism spectrum disorder fMRI parietal number subitizing counting Index. décimale : PER Périodiques Résumé : Previous work indicates that adults with autism display a decreased capacity when rapidly enumerating small sets of elements (i.e., subitizing), compared to typically developing (TD) individuals. This ability is crucial for fundamental visual functions such as object individuation and parallel processing. Thus, the deficit in autism suggests limits in these skills. To examine the neural basis of this limitation, adults with and without high functioning autism rapidly enumerated 1 to 8 randomly located squares during a neuroimaging study. Typically, adults are thought to use parallel visual processes to quantify up to three or four elements, and serial processes to enumerate more (5+) elements. We hypothesized that parietal lobe regions associated with counting would be recruited with smaller sets of elements in adults with autism, compared to TD adults. Consistent with this hypothesis, activation in parietal regions increased with smaller set sizes in adults with autism compared to TD adults. Increased activation for three elements was evident in several regions, including those thought to underlie subitizing. In addition, regions specific to the counting range in TD adults were often equally active for set sizes in the subitizing range in the adults with autism. Finally, significant deactivation was evident in TD adults, presumably reflecting relative suppression of regions specialized for competing processes, but was not apparent in adults with autism. These differences in brain function in adults with autism on a simple enumeration task suggest atypical brain organization and function that is likely to impact most visual tasks, especially those with multiple elements. En ligne : http://dx.doi.org/10.1002/aur.1498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-1 (January 2016) . - p.82-96[article] Abnormalities in brain systems supporting individuation and enumeration in autism [Texte imprimé et/ou numérique] / Kirsten O'HEARN, Auteur ; Katerina VELANOVA, Auteur ; Andrew LYNN, Auteur ; Catherine WRIGHT, Auteur ; Michael HALLQUIST, Auteur ; Nancy MINSHEW, Auteur ; Beatriz LUNA, Auteur . - p.82-96.
Langues : Anglais (eng)
in Autism Research > 9-1 (January 2016) . - p.82-96
Mots-clés : autism spectrum disorder fMRI parietal number subitizing counting Index. décimale : PER Périodiques Résumé : Previous work indicates that adults with autism display a decreased capacity when rapidly enumerating small sets of elements (i.e., subitizing), compared to typically developing (TD) individuals. This ability is crucial for fundamental visual functions such as object individuation and parallel processing. Thus, the deficit in autism suggests limits in these skills. To examine the neural basis of this limitation, adults with and without high functioning autism rapidly enumerated 1 to 8 randomly located squares during a neuroimaging study. Typically, adults are thought to use parallel visual processes to quantify up to three or four elements, and serial processes to enumerate more (5+) elements. We hypothesized that parietal lobe regions associated with counting would be recruited with smaller sets of elements in adults with autism, compared to TD adults. Consistent with this hypothesis, activation in parietal regions increased with smaller set sizes in adults with autism compared to TD adults. Increased activation for three elements was evident in several regions, including those thought to underlie subitizing. In addition, regions specific to the counting range in TD adults were often equally active for set sizes in the subitizing range in the adults with autism. Finally, significant deactivation was evident in TD adults, presumably reflecting relative suppression of regions specialized for competing processes, but was not apparent in adults with autism. These differences in brain function in adults with autism on a simple enumeration task suggest atypical brain organization and function that is likely to impact most visual tasks, especially those with multiple elements. En ligne : http://dx.doi.org/10.1002/aur.1498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 ADHD-related sex differences in fronto-subcortical intrinsic functional connectivity and associations with delay discounting / K. S. ROSCH in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)
[article]
Titre : ADHD-related sex differences in fronto-subcortical intrinsic functional connectivity and associations with delay discounting Type de document : Texte imprimé et/ou numérique Auteurs : K. S. ROSCH, Auteur ; S. H. MOSTOFSKY, Auteur ; M. B. NEBEL, Auteur Année de publication : 2018 Article en page(s) : 34 p. Langues : Anglais (eng) Mots-clés : Adhd Delay discounting Functional connectivity Ica Resting-state Reward Temporal discounting fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with atypical fronto-subcortical neural circuitry and heightened delay discounting, or a stronger preference for smaller, immediate rewards over larger, delayed rewards. Recent evidence of ADHD-related sex differences in brain structure and function suggests anomalies in fronto-subcortical circuitry may differ among girls and boys with ADHD. The current study examined whether the functional connectivity (FC) within fronto-subcortical neural circuitry differs among girls and boys with ADHD compared to same-sex typically developing (TD) controls and relates to delay discounting. METHODS: Participants include 8-12-year-old children with ADHD (n = 72, 20 girls) and TD controls (n = 75, 21 girls). Fronto-subcortical regions of interest were functionally defined by applying independent component analysis to resting-state fMRI data. Intrinsic FC between subcortical components, including the striatum and amygdala, and prefrontal components, including ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), and anterior dorsolateral prefrontal cortex (dlPFC), was compared across diagnostic groups overall and within sex. Correlations between intrinsic FC of the six fronto-subcortical pairs and delay discounting were also examined. RESULTS: Both girls and boys with ADHD show atypical FC between vmPFC and subcortical regions including the striatum (stronger positive FC in ADHD) and amygdala (weaker negative FC in ADHD), with the greatest diagnostic effects among girls. In addition, girls with ADHD show atypical intrinsic FC between the striatum and dlPFC components, including stronger positive FC with ACC and stronger negative FC with dlPFC. Further, girls but not boys, with ADHD, show heightened real-time delay discounting. Brain-behavior correlations suggest (1) stronger negative FC between the striatal and dlPFC components correlated with greater money delay discounting across all participants and (2) stronger FC between the amygdala with both the dlPFC and ACC components was differentially related to heightened real-time discounting among girls and boys with and without ADHD. CONCLUSIONS: Our findings suggest fronto-subcortical functional networks are affected in children with ADHD, particularly girls, and relate to delay discounting. These results also provide preliminary evidence of greater disruptions in fronto-subcortical FC among girls with ADHD that is not due to elevated inattention symptom severity, intellectual reasoning ability, age, or head motion. En ligne : http://dx.doi.org/10.1186/s11689-018-9254-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386
in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 34 p.[article] ADHD-related sex differences in fronto-subcortical intrinsic functional connectivity and associations with delay discounting [Texte imprimé et/ou numérique] / K. S. ROSCH, Auteur ; S. H. MOSTOFSKY, Auteur ; M. B. NEBEL, Auteur . - 2018 . - 34 p.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 34 p.
Mots-clés : Adhd Delay discounting Functional connectivity Ica Resting-state Reward Temporal discounting fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with atypical fronto-subcortical neural circuitry and heightened delay discounting, or a stronger preference for smaller, immediate rewards over larger, delayed rewards. Recent evidence of ADHD-related sex differences in brain structure and function suggests anomalies in fronto-subcortical circuitry may differ among girls and boys with ADHD. The current study examined whether the functional connectivity (FC) within fronto-subcortical neural circuitry differs among girls and boys with ADHD compared to same-sex typically developing (TD) controls and relates to delay discounting. METHODS: Participants include 8-12-year-old children with ADHD (n = 72, 20 girls) and TD controls (n = 75, 21 girls). Fronto-subcortical regions of interest were functionally defined by applying independent component analysis to resting-state fMRI data. Intrinsic FC between subcortical components, including the striatum and amygdala, and prefrontal components, including ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), and anterior dorsolateral prefrontal cortex (dlPFC), was compared across diagnostic groups overall and within sex. Correlations between intrinsic FC of the six fronto-subcortical pairs and delay discounting were also examined. RESULTS: Both girls and boys with ADHD show atypical FC between vmPFC and subcortical regions including the striatum (stronger positive FC in ADHD) and amygdala (weaker negative FC in ADHD), with the greatest diagnostic effects among girls. In addition, girls with ADHD show atypical intrinsic FC between the striatum and dlPFC components, including stronger positive FC with ACC and stronger negative FC with dlPFC. Further, girls but not boys, with ADHD, show heightened real-time delay discounting. Brain-behavior correlations suggest (1) stronger negative FC between the striatal and dlPFC components correlated with greater money delay discounting across all participants and (2) stronger FC between the amygdala with both the dlPFC and ACC components was differentially related to heightened real-time discounting among girls and boys with and without ADHD. CONCLUSIONS: Our findings suggest fronto-subcortical functional networks are affected in children with ADHD, particularly girls, and relate to delay discounting. These results also provide preliminary evidence of greater disruptions in fronto-subcortical FC among girls with ADHD that is not due to elevated inattention symptom severity, intellectual reasoning ability, age, or head motion. En ligne : http://dx.doi.org/10.1186/s11689-018-9254-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 Adolescents' neural reactivity to acute psychosocial stress: dysfunctional regulation habits are linked to temporal gyrus response / Sabrina GOLDE in Development and Psychopathology, 35-1 (February 2023)
[article]
Titre : Adolescents' neural reactivity to acute psychosocial stress: dysfunctional regulation habits are linked to temporal gyrus response Type de document : Texte imprimé et/ou numérique Auteurs : Sabrina GOLDE, Auteur ; Tobias GLEICH, Auteur ; Lydia ROMUND, Auteur ; Anna STIPPL, Auteur ; Patricia PELZ, Auteur ; Diana RAUFELDER, Auteur ; Robert C. LORENZ, Auteur ; Anne BECK, Auteur Article en page(s) : p.332-344 Langues : Anglais (eng) Mots-clés : emotion regulation strategies fMRI mid-adolescence Montreal imaging stress task (MIST) psychosocial stress Index. décimale : PER Périodiques Résumé : Mid-adolescence is a critical time for the development of stress-related disorders and it is associated with significant social vulnerability. However, little is known about normative neural processes accompanying psychosocial stress at this time. Previous research found that emotion regulation strategies critically influence the relationship between stress and the development of psychiatric symptoms during adolescence. Using functional magnetic resonance imaging (fMRI), we examined neural responses to acute stress and analyzed whether the tendency to use adaptive or maladaptive emotion regulation strategies is related to neural and autonomic stress responses. Results show large linear activation increases from low to medium to high stress levels mainly in medial prefrontal, insulae and temporal areas. Caudate and subgenual anterior cingulate cortex, neural areas related to reward and affective valuations, showed linearly decreasing activation. In line with our hypothesis, the current adolescent neural stress profile resembled social rejection and was characterized by pronounced activation in insula, angular and temporal cortices. Moreover, results point to an intriguing role of the anterior temporal gyrus. Stress-related activity in the anterior temporal gyrus was positively related to maladaptive regulation strategies and stress-induced autonomic activity. Maladaptive coping might increase the social threat and reappraisal load of a stressor, relating to higher stress sensitivity of anterior temporal cortices. En ligne : https://doi.org/10.1017/S0954579421000572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499
in Development and Psychopathology > 35-1 (February 2023) . - p.332-344[article] Adolescents' neural reactivity to acute psychosocial stress: dysfunctional regulation habits are linked to temporal gyrus response [Texte imprimé et/ou numérique] / Sabrina GOLDE, Auteur ; Tobias GLEICH, Auteur ; Lydia ROMUND, Auteur ; Anna STIPPL, Auteur ; Patricia PELZ, Auteur ; Diana RAUFELDER, Auteur ; Robert C. LORENZ, Auteur ; Anne BECK, Auteur . - p.332-344.
Langues : Anglais (eng)
in Development and Psychopathology > 35-1 (February 2023) . - p.332-344
Mots-clés : emotion regulation strategies fMRI mid-adolescence Montreal imaging stress task (MIST) psychosocial stress Index. décimale : PER Périodiques Résumé : Mid-adolescence is a critical time for the development of stress-related disorders and it is associated with significant social vulnerability. However, little is known about normative neural processes accompanying psychosocial stress at this time. Previous research found that emotion regulation strategies critically influence the relationship between stress and the development of psychiatric symptoms during adolescence. Using functional magnetic resonance imaging (fMRI), we examined neural responses to acute stress and analyzed whether the tendency to use adaptive or maladaptive emotion regulation strategies is related to neural and autonomic stress responses. Results show large linear activation increases from low to medium to high stress levels mainly in medial prefrontal, insulae and temporal areas. Caudate and subgenual anterior cingulate cortex, neural areas related to reward and affective valuations, showed linearly decreasing activation. In line with our hypothesis, the current adolescent neural stress profile resembled social rejection and was characterized by pronounced activation in insula, angular and temporal cortices. Moreover, results point to an intriguing role of the anterior temporal gyrus. Stress-related activity in the anterior temporal gyrus was positively related to maladaptive regulation strategies and stress-induced autonomic activity. Maladaptive coping might increase the social threat and reappraisal load of a stressor, relating to higher stress sensitivity of anterior temporal cortices. En ligne : https://doi.org/10.1017/S0954579421000572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 Affective neural response to restricted interests in autism spectrum disorders / Carissa J. CASCIO in Journal of Child Psychology and Psychiatry, 55-2 (February 2014)
[article]
Titre : Affective neural response to restricted interests in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Carissa J. CASCIO, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Jessica L. HEACOCK, Auteur ; Kimberly B. SCHAUDER, Auteur ; Whitney A. LORING, Auteur ; Baxter P. ROGERS, Auteur ; Jennifer R. PRYWELLER, Auteur ; Cassandra R. NEWSOM, Auteur ; Jurnell COCKHREN, Auteur ; Aize CAO, Auteur ; Scott BOLTON, Auteur Article en page(s) : p.162-171 Langues : Anglais (eng) Mots-clés : Autism restricted interests reward repetitive behavior fMRI insula salience Index. décimale : PER Périodiques Résumé : Background Restricted interests are a class of repetitive behavior in autism spectrum disorders (ASD) whose intensity and narrow focus often contribute to significant interference with daily functioning. While numerous neuroimaging studies have investigated executive circuits as putative neural substrates of repetitive behavior, recent work implicates affective neural circuits in restricted interests. We sought to explore the role of affective neural circuits and determine how restricted interests are distinguished from hobbies or interests in typical development. Methods We compared a group of children with ASD to a typically developing (TD) group of children with strong interests or hobbies, employing parent report, an operant behavioral task, and functional imaging with personalized stimuli based on individual interests. Results While performance on the operant task was similar between the two groups, parent report of intensity and interference of interests was significantly higher in the ASD group. Both the ASD and TD groups showed increased BOLD response in widespread affective neural regions to the pictures of their own interest. When viewing pictures of other children's interests, the TD group showed a similar pattern, whereas BOLD response in the ASD group was much more limited. Increased BOLD response in the insula and anterior cingulate cortex distinguished the ASD from the TD group, and parent report of the intensity and interference with daily life of the child's restricted interest predicted insula response. Conclusions While affective neural network response and operant behavior are comparable in typical and restricted interests, the narrowness of focus that clinically distinguishes restricted interests in ASD is reflected in more interference in daily life and aberrantly enhanced insula and anterior cingulate response to individuals’ own interests in the ASD group. These results further support the involvement of affective neural networks in repetitive behaviors in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221
in Journal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.162-171[article] Affective neural response to restricted interests in autism spectrum disorders [Texte imprimé et/ou numérique] / Carissa J. CASCIO, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Jessica L. HEACOCK, Auteur ; Kimberly B. SCHAUDER, Auteur ; Whitney A. LORING, Auteur ; Baxter P. ROGERS, Auteur ; Jennifer R. PRYWELLER, Auteur ; Cassandra R. NEWSOM, Auteur ; Jurnell COCKHREN, Auteur ; Aize CAO, Auteur ; Scott BOLTON, Auteur . - p.162-171.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.162-171
Mots-clés : Autism restricted interests reward repetitive behavior fMRI insula salience Index. décimale : PER Périodiques Résumé : Background Restricted interests are a class of repetitive behavior in autism spectrum disorders (ASD) whose intensity and narrow focus often contribute to significant interference with daily functioning. While numerous neuroimaging studies have investigated executive circuits as putative neural substrates of repetitive behavior, recent work implicates affective neural circuits in restricted interests. We sought to explore the role of affective neural circuits and determine how restricted interests are distinguished from hobbies or interests in typical development. Methods We compared a group of children with ASD to a typically developing (TD) group of children with strong interests or hobbies, employing parent report, an operant behavioral task, and functional imaging with personalized stimuli based on individual interests. Results While performance on the operant task was similar between the two groups, parent report of intensity and interference of interests was significantly higher in the ASD group. Both the ASD and TD groups showed increased BOLD response in widespread affective neural regions to the pictures of their own interest. When viewing pictures of other children's interests, the TD group showed a similar pattern, whereas BOLD response in the ASD group was much more limited. Increased BOLD response in the insula and anterior cingulate cortex distinguished the ASD from the TD group, and parent report of the intensity and interference with daily life of the child's restricted interest predicted insula response. Conclusions While affective neural network response and operant behavior are comparable in typical and restricted interests, the narrowness of focus that clinically distinguishes restricted interests in ASD is reflected in more interference in daily life and aberrantly enhanced insula and anterior cingulate response to individuals’ own interests in the ASD group. These results further support the involvement of affective neural networks in repetitive behaviors in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 Age group differences in executive network functional connectivity and relationships with social behavior in men with autism spectrum disorder / Melissa J. M. WALSH in Research in Autism Spectrum Disorders, 63 (July 2019)
[article]
Titre : Age group differences in executive network functional connectivity and relationships with social behavior in men with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Melissa J. M. WALSH, Auteur ; Leslie C. BAXTER, Auteur ; Christopher J. SMITH, Auteur ; B. Blair BRADEN, Auteur Article en page(s) : p.63-77 Langues : Anglais (eng) Mots-clés : Aging Autism Spectrum Disorder fMRI Social behavior Executive network Executive functions Index. décimale : PER Périodiques Résumé : Background Research suggests adults with autism spectrum disorder (ASD) may use executive functions to compensate for social difficulties. Given hallmark age-related declines in executive functioning and the executive brain network in normal aging, there is concern that older adults with ASD may experience further declines in social functioning as they age. In a male-only sample, we hypothesized: 1) older adults with ASD would demonstrate greater ASD-related social behavior than young adults with ASD, 2) adults with ASD would demonstrate a greater age group reduction in connectivity of the executive brain network than neurotypical (NT) adults, and 3) that behavioral and neural mechanisms of executive functioning would predict ASD-related social difficulties in adults with ASD. Methods Participants were a cross-sectional sample of non-intellectually disabled young (ages 18–25) and middle-aged (ages 40-70) adult men with ASD and NT development (young adult ASD: n?=?24; middle-age ASD: n?=?25; young adult NT: n?=?15; middle-age NT: n?=?21). We assessed ASD-related social behavior via the self-report Social Responsiveness Scale-2 (SRS-2) Total Score, with exploratory analyses of the Social Cognition Subscale. We assessed neural executive function via connectivity of the resting-state executive network (EN) as measured by independent component analysis. Correlations were investigated between SRS-2 Total Scores (with exploratory analyses of the Social Cognition Subscale), EN functional connectivity of the dorsolateral prefrontal cortex (dlPFC), and a behavioral measure of executive function, Tower of London (ToL) Total Moves. Results We did not confirm a significant age group difference for adults with ASD on the SRS-2 Total Score; however, exploratory analysis revealed middle-age men with ASD had higher scores on the SRS-2 Social Cognition Subscale than young adult men with ASD. Exacerbated age group reductions in EN functional connectivity were confirmed (left dlPFC) in men with ASD compared to NT, such that older adults with ASD demonstrated the greatest levels of hypoconnectivity. A significant correlation was confirmed between dlPFC connectivity and the SRS-2 Total Score in middle-age men with ASD, but not young adult men with ASD. Furthermore, exploratory analysis revealed a significant correlation with the SRS-2 Social Cognition Subscale for young and middle-aged ASD groups and ToL Total Moves. Conclusion Our findings suggest that ASD-related difficulties in social cognition and EN hypoconnectivity may get worse with age in men with ASD and is related to executive functioning. Further, exacerbated EN hypoconnectivity associated with older age in ASD may be a mechanism of increased ASD-related social cognition difficulties in older adults with ASD. Given the cross-sectional nature of this sample, longitudinal replication is needed. En ligne : https://doi.org/10.1016/j.rasd.2019.02.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=394
in Research in Autism Spectrum Disorders > 63 (July 2019) . - p.63-77[article] Age group differences in executive network functional connectivity and relationships with social behavior in men with autism spectrum disorder [Texte imprimé et/ou numérique] / Melissa J. M. WALSH, Auteur ; Leslie C. BAXTER, Auteur ; Christopher J. SMITH, Auteur ; B. Blair BRADEN, Auteur . - p.63-77.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 63 (July 2019) . - p.63-77
Mots-clés : Aging Autism Spectrum Disorder fMRI Social behavior Executive network Executive functions Index. décimale : PER Périodiques Résumé : Background Research suggests adults with autism spectrum disorder (ASD) may use executive functions to compensate for social difficulties. Given hallmark age-related declines in executive functioning and the executive brain network in normal aging, there is concern that older adults with ASD may experience further declines in social functioning as they age. In a male-only sample, we hypothesized: 1) older adults with ASD would demonstrate greater ASD-related social behavior than young adults with ASD, 2) adults with ASD would demonstrate a greater age group reduction in connectivity of the executive brain network than neurotypical (NT) adults, and 3) that behavioral and neural mechanisms of executive functioning would predict ASD-related social difficulties in adults with ASD. Methods Participants were a cross-sectional sample of non-intellectually disabled young (ages 18–25) and middle-aged (ages 40-70) adult men with ASD and NT development (young adult ASD: n?=?24; middle-age ASD: n?=?25; young adult NT: n?=?15; middle-age NT: n?=?21). We assessed ASD-related social behavior via the self-report Social Responsiveness Scale-2 (SRS-2) Total Score, with exploratory analyses of the Social Cognition Subscale. We assessed neural executive function via connectivity of the resting-state executive network (EN) as measured by independent component analysis. Correlations were investigated between SRS-2 Total Scores (with exploratory analyses of the Social Cognition Subscale), EN functional connectivity of the dorsolateral prefrontal cortex (dlPFC), and a behavioral measure of executive function, Tower of London (ToL) Total Moves. Results We did not confirm a significant age group difference for adults with ASD on the SRS-2 Total Score; however, exploratory analysis revealed middle-age men with ASD had higher scores on the SRS-2 Social Cognition Subscale than young adult men with ASD. Exacerbated age group reductions in EN functional connectivity were confirmed (left dlPFC) in men with ASD compared to NT, such that older adults with ASD demonstrated the greatest levels of hypoconnectivity. A significant correlation was confirmed between dlPFC connectivity and the SRS-2 Total Score in middle-age men with ASD, but not young adult men with ASD. Furthermore, exploratory analysis revealed a significant correlation with the SRS-2 Social Cognition Subscale for young and middle-aged ASD groups and ToL Total Moves. Conclusion Our findings suggest that ASD-related difficulties in social cognition and EN hypoconnectivity may get worse with age in men with ASD and is related to executive functioning. Further, exacerbated EN hypoconnectivity associated with older age in ASD may be a mechanism of increased ASD-related social cognition difficulties in older adults with ASD. Given the cross-sectional nature of this sample, longitudinal replication is needed. En ligne : https://doi.org/10.1016/j.rasd.2019.02.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=394 Age-related changes in neural responses to sensory stimulation in autism: a cross-sectional study / Kaitlin K. CUMMINGS ; Susan Y. BOOKHEIMER ; Mirella DAPRETTO ; Shulamite A. GREEN in Molecular Autism, 14 (2023)
PermalinkAltered Medial Frontal and Superior Temporal Response to Implicit Processing of Emotions in Autism / Rajesh K. KANA in Autism Research, 9-1 (January 2016)
PermalinkAltered neural response to rejection-related words in children exposed to maltreatment / Vanessa B. PUETZ in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)
PermalinkAn examination of maternal prenatal BMI and human fetal brain development / Megan E. NORR in Journal of Child Psychology and Psychiatry, 62-4 (April 2021)
PermalinkAn fMRI study of facial emotion processing in children and adolescents with 22q11.2 deletion syndrome / R. AZUMA in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)
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