722 recherche sur le mot-clé 'genetic-risk'

Association of polygenic scores for autism with volumetric MRI phenotypes in cerebellum and brainstem in adults / Salahuddin MOHAMMAD in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 34p. Titre : Association of polygenic scores for autism with volumetric MRI phenotypes in cerebellum and brainstem in adults Type de document : texte imprimé Auteurs : Salahuddin MOHAMMAD, Auteur ; Mélissa GENTREAU, Auteur ; Manon DUBOL, Auteur ; Gull RUKH, Auteur ; Jessica MWINYI, Auteur ; Helgi B. SCHIÖTH, Auteur Article en page(s) : 34p. Langues : Anglais (eng) Mots-clés : Humans  Cerebellum/diagnostic imaging/pathology  Brain Stem/diagnostic imaging/pathology  Magnetic Resonance Imaging  Male  Female  Phenotype  Adult  Multifactorial Inheritance  Genetic Predisposition to Disease  Organ Size  Middle Aged  Autistic Disorder/genetics/diagnostic imaging  Genome-Wide Association Study  Autism Spectrum Disorder/genetics/diagnostic imaging  Gray Matter/diagnostic imaging/pathology  Case-Control Studies  Autism  Brain MRI  Brainstem  Cerebellum  Polygenic risk score Index. décimale : PER Périodiques Résumé : Previous research on autism spectrum disorders (ASD) have showed important volumetric alterations in the cerebellum and brainstem. Most of these studies are however limited to case-control studies with small clinical samples and including mainly children or adolescents. Herein, we aimed to explore the association between the cumulative genetic load (polygenic risk score, PRS) for ASD and volumetric alterations in the cerebellum and brainstem, as well as global brain tissue volumes of the brain among adults at the population level. We utilized the latest genome-wide association study of ASD by the Psychiatric Genetics Consortium (18,381 cases, 27,969 controls) and constructed the ASD PRS in an independent cohort, the UK Biobank. Regression analyses controlled for multiple comparisons with the false-discovery rate (FDR) at 5% were performed to investigate the association between ASD PRS and forty-four brain magnetic resonance imaging (MRI) phenotypes among ~ 31,000 participants. Primary analyses included sixteen MRI phenotypes: total volumes of the brain, cerebrospinal fluid (CSF), grey matter (GM), white matter (WM), GM of whole cerebellum, brainstem, and ten regions of the cerebellum (I_IV, V, VI, VIIb, VIIIa, VIIIb, IX, X, CrusI and CrusII). Secondary analyses included twenty-eight MRI phenotypes: the sub-regional volumes of cerebellum including the GM of the vermis and both left and right lobules of each cerebellar region. ASD PRS were significantly associated with the volumes of seven brain areas, whereby higher PRS were associated to reduced volumes of the whole brain, WM, brainstem, and cerebellar regions I-IV, IX, and X, and an increased volume of the CSF. Three sub-regional volumes including the left cerebellar lobule I-IV, cerebellar vermes VIIIb, and X were significantly and negatively associated with ASD PRS. The study highlights a substantial connection between susceptibility to ASD, its underlying genetic etiology, and neuroanatomical alterations of the adult brain. En ligne : https://dx.doi.org/10.1186/s13229-024-00611-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Association of polygenic scores for autism with volumetric MRI phenotypes in cerebellum and brainstem in adults [texte imprimé] / Salahuddin MOHAMMAD, Auteur ; Mélissa GENTREAU, Auteur ; Manon DUBOL, Auteur ; Gull RUKH, Auteur ; Jessica MWINYI, Auteur ; Helgi B. SCHIÖTH, Auteur . - 34p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 34p. Mots-clés : Humans  Cerebellum/diagnostic imaging/pathology  Brain Stem/diagnostic imaging/pathology  Magnetic Resonance Imaging  Male  Female  Phenotype  Adult  Multifactorial Inheritance  Genetic Predisposition to Disease  Organ Size  Middle Aged  Autistic Disorder/genetics/diagnostic imaging  Genome-Wide Association Study  Autism Spectrum Disorder/genetics/diagnostic imaging  Gray Matter/diagnostic imaging/pathology  Case-Control Studies  Autism  Brain MRI  Brainstem  Cerebellum  Polygenic risk score Index. décimale : PER Périodiques Résumé : Previous research on autism spectrum disorders (ASD) have showed important volumetric alterations in the cerebellum and brainstem. Most of these studies are however limited to case-control studies with small clinical samples and including mainly children or adolescents. Herein, we aimed to explore the association between the cumulative genetic load (polygenic risk score, PRS) for ASD and volumetric alterations in the cerebellum and brainstem, as well as global brain tissue volumes of the brain among adults at the population level. We utilized the latest genome-wide association study of ASD by the Psychiatric Genetics Consortium (18,381 cases, 27,969 controls) and constructed the ASD PRS in an independent cohort, the UK Biobank. Regression analyses controlled for multiple comparisons with the false-discovery rate (FDR) at 5% were performed to investigate the association between ASD PRS and forty-four brain magnetic resonance imaging (MRI) phenotypes among ~ 31,000 participants. Primary analyses included sixteen MRI phenotypes: total volumes of the brain, cerebrospinal fluid (CSF), grey matter (GM), white matter (WM), GM of whole cerebellum, brainstem, and ten regions of the cerebellum (I_IV, V, VI, VIIb, VIIIa, VIIIb, IX, X, CrusI and CrusII). Secondary analyses included twenty-eight MRI phenotypes: the sub-regional volumes of cerebellum including the GM of the vermis and both left and right lobules of each cerebellar region. ASD PRS were significantly associated with the volumes of seven brain areas, whereby higher PRS were associated to reduced volumes of the whole brain, WM, brainstem, and cerebellar regions I-IV, IX, and X, and an increased volume of the CSF. Three sub-regional volumes including the left cerebellar lobule I-IV, cerebellar vermes VIIIb, and X were significantly and negatively associated with ASD PRS. The study highlights a substantial connection between susceptibility to ASD, its underlying genetic etiology, and neuroanatomical alterations of the adult brain. En ligne : https://dx.doi.org/10.1186/s13229-024-00611-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs / Cen CHEN in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1513-1522 Titre : Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs Type de document : texte imprimé Auteurs : Cen CHEN, Auteur ; Yi LU, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Erik PETTERSSON, Auteur Article en page(s) : p.1513-1522 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Twins, Dizygotic  Longitudinal Studies  Psychopathology  Mental Disorders/epidemiology/genetics  Risk Factors  Attention Deficit Disorder with Hyperactivity/epidemiology  General factor of psychopathology  genetic nurture  multi-polygenic score  polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. METHODS: The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n=2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (ÃŽ2) and then within DZ twin pairs (ÃŽ2(w) ), which controls for indirect pathways. RESULTS: In childhood, the PRS for ADHD predicted general psychopathology (ÃŽ2=0.09, 95% CI: [0.06, 0.12]; ÃŽ2(w) =0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (ÃŽ2=0.04 [0.00, 0.08]; ÃŽ2(w) =0.09 [0.01, 0.17]) and specific hyperactivity (ÃŽ2=0.07 [0.04, 0.11]; ÃŽ2(w) =0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (ÃŽ2=0.08 [0.03, 0.13]; ÃŽ2(w) =0.19 [0.08, 0.30]) and specific inattention problems (ÃŽ2=0.05 [0.01, 0.09]; ÃŽ2(w) =0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (ÃŽ2=0.06 [0.02, 0.10]; ÃŽ2(w) =0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. CONCLUSIONS: This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology. En ligne : http://dx.doi.org/10.1111/jcpp.13605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs [texte imprimé] / Cen CHEN, Auteur ; Yi LU, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Erik PETTERSSON, Auteur . - p.1513-1522. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1513-1522 Mots-clés : Adolescent  Humans  Twins, Dizygotic  Longitudinal Studies  Psychopathology  Mental Disorders/epidemiology/genetics  Risk Factors  Attention Deficit Disorder with Hyperactivity/epidemiology  General factor of psychopathology  genetic nurture  multi-polygenic score  polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. METHODS: The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n=2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (ÃŽ2) and then within DZ twin pairs (ÃŽ2(w) ), which controls for indirect pathways. RESULTS: In childhood, the PRS for ADHD predicted general psychopathology (ÃŽ2=0.09, 95% CI: [0.06, 0.12]; ÃŽ2(w) =0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (ÃŽ2=0.04 [0.00, 0.08]; ÃŽ2(w) =0.09 [0.01, 0.17]) and specific hyperactivity (ÃŽ2=0.07 [0.04, 0.11]; ÃŽ2(w) =0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (ÃŽ2=0.08 [0.03, 0.13]; ÃŽ2(w) =0.19 [0.08, 0.30]) and specific inattention problems (ÃŽ2=0.05 [0.01, 0.09]; ÃŽ2(w) =0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (ÃŽ2=0.06 [0.02, 0.10]; ÃŽ2(w) =0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. CONCLUSIONS: This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology. En ligne : http://dx.doi.org/10.1111/jcpp.13605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms / Gisela SUGRANYES in Journal of Child Psychology and Psychiatry, 62-6 (June 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.780-789 Titre : Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms Type de document : texte imprimé Auteurs : Gisela SUGRANYES, Auteur ; Elena DE LA SERNA, Auteur ; Daniel ILZARBE, Auteur ; Jose Carlos PARIENTE, Auteur ; Roger BORRAS, Auteur ; Soledad ROMERO, Auteur ; Mireia ROSA, Auteur ; Inmaculada BAEZA, Auteur ; Maria Dolores MORENO, Auteur ; Miguel BERNARDO, Auteur ; Eduard VIETA, Auteur ; Josefina CASTRO-FORNIELES, Auteur Article en page(s) : p.780-789 Langues : Anglais (eng) Mots-clés : Adolescent  Bipolar Disorder/diagnostic imaging  Brain/diagnostic imaging  Cross-Sectional Studies  Genetic Predisposition to Disease  Humans  Magnetic Resonance Imaging  Psychotic Disorders/diagnostic imaging  Schizophrenia/diagnostic imaging/genetics  High-risk studies  bipolar  psychosis  schizophrenia  structural MRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The evaluation of child and adolescent offspring of patients with schizophrenia (SzO) or bipolar disorder (BpO) may help understand changes taking place in the brain in individuals at heightened risk for disease during a key developmental period. METHODS: One hundred twenty-eight individuals (33 SzO and 46 BpO, considered jointly as 'Familial High Risk' (FHR), and 49 controls) aged 6-17 years underwent clinical, cognitive and neuroimaging assessment at baseline, 2- and 4-year follow-up. Twenty FHR participants (11 SzO and 9 BpO) developed psychotic spectrum symptoms during follow-up, while 59 FHR participants did not. Magnetic resonance imaging was performed on a 3Tesla scanner; cortical surface reconstruction was applied to measure cortical thickness, surface area and grey matter volume. RESULTS: FHR participants who developed psychotic spectrum symptoms over time showed greater time-related mean cortical thinning than those who did not and than controls. By subgroups, this effect was present in both BpO and SzO in the occipital cortex. At baseline, FHR participants who developed psychotic spectrum symptoms over time had smaller total surface area and grey matter volume than those who did not and than controls. Over time, all FHR participants showed less longitudinal decrease in surface area than controls. In those who developed psychotic spectrum symptoms over time, this effect was driven by BpO, while in those who did not, this was due to SzO, who also showed less grey matter volume reduction. CONCLUSION: The emergence of psychotic spectrum symptoms in FHR was indexed by smaller cross-sectional surface area and progressive cortical thinning. Relative preservation of surface area over time may signal different processes according to familial risk. These findings lay the foundation for future studies aimed at stratification of FHR youth. En ligne : http://dx.doi.org/10.1111/jcpp.13321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms [texte imprimé] / Gisela SUGRANYES, Auteur ; Elena DE LA SERNA, Auteur ; Daniel ILZARBE, Auteur ; Jose Carlos PARIENTE, Auteur ; Roger BORRAS, Auteur ; Soledad ROMERO, Auteur ; Mireia ROSA, Auteur ; Inmaculada BAEZA, Auteur ; Maria Dolores MORENO, Auteur ; Miguel BERNARDO, Auteur ; Eduard VIETA, Auteur ; Josefina CASTRO-FORNIELES, Auteur . - p.780-789. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.780-789 Mots-clés : Adolescent  Bipolar Disorder/diagnostic imaging  Brain/diagnostic imaging  Cross-Sectional Studies  Genetic Predisposition to Disease  Humans  Magnetic Resonance Imaging  Psychotic Disorders/diagnostic imaging  Schizophrenia/diagnostic imaging/genetics  High-risk studies  bipolar  psychosis  schizophrenia  structural MRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The evaluation of child and adolescent offspring of patients with schizophrenia (SzO) or bipolar disorder (BpO) may help understand changes taking place in the brain in individuals at heightened risk for disease during a key developmental period. METHODS: One hundred twenty-eight individuals (33 SzO and 46 BpO, considered jointly as 'Familial High Risk' (FHR), and 49 controls) aged 6-17 years underwent clinical, cognitive and neuroimaging assessment at baseline, 2- and 4-year follow-up. Twenty FHR participants (11 SzO and 9 BpO) developed psychotic spectrum symptoms during follow-up, while 59 FHR participants did not. Magnetic resonance imaging was performed on a 3Tesla scanner; cortical surface reconstruction was applied to measure cortical thickness, surface area and grey matter volume. RESULTS: FHR participants who developed psychotic spectrum symptoms over time showed greater time-related mean cortical thinning than those who did not and than controls. By subgroups, this effect was present in both BpO and SzO in the occipital cortex. At baseline, FHR participants who developed psychotic spectrum symptoms over time had smaller total surface area and grey matter volume than those who did not and than controls. Over time, all FHR participants showed less longitudinal decrease in surface area than controls. In those who developed psychotic spectrum symptoms over time, this effect was driven by BpO, while in those who did not, this was due to SzO, who also showed less grey matter volume reduction. CONCLUSION: The emergence of psychotic spectrum symptoms in FHR was indexed by smaller cross-sectional surface area and progressive cortical thinning. Relative preservation of surface area over time may signal different processes according to familial risk. These findings lay the foundation for future studies aimed at stratification of FHR youth. En ligne : http://dx.doi.org/10.1111/jcpp.13321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations / Evangeline C. KURTZ-NELSON in Journal of Autism and Developmental Disorders, 51-9 (September 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3365-3373 Titre : Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations Type de document : texte imprimé Auteurs : Evangeline C. KURTZ-NELSON, Auteur ; See Wan THAM, Auteur ; Kaitlyn AHLERS, Auteur ; Daniel CHO, Auteur ; Arianne S. WALLACE, Auteur ; Evan E. EICHLER, Auteur ; Raphael A. BERNIER, Auteur ; Rachel K. EARL, Auteur Article en page(s) : p.3365-3373 Langues : Anglais (eng) Mots-clés : Abdominal Pain/genetics  Autism Spectrum Disorder/epidemiology/genetics  Humans  Mutation  Risk Factors  Self-Injurious Behavior/epidemiology/genetics  Abdominal pain  Autism spectrum disorder  Intellectual disability  Rare genetic disorders  Self-injurious behavior  Inc. The remaining authors have no conflicts of interest to report. Index. décimale : PER Périodiques Résumé : Self-injurious behaviors (SIB) are elevated in autism spectrum disorder (ASD) and related genetic disorders, but the genetic and biological mechanisms that contribute to SIB in ASD are poorly understood. This study examined rates and predictors of SIB in 112 individuals with disruptive mutations to ASD-risk genes. Current SIB were reported in 30% of participants and associated with poorer cognitive and adaptive skills. History of severe abdominal pain predicted higher rates of SIB and SIB severity after controlling for age and adaptive behavior; individuals with a history of severe abdominal pain were eight times more likely to exhibit SIB than those with no history. Future research is needed to examine associations between genetic risk, pain, and SIB in this population. En ligne : http://dx.doi.org/10.1007/s10803-020-04774-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations [texte imprimé] / Evangeline C. KURTZ-NELSON, Auteur ; See Wan THAM, Auteur ; Kaitlyn AHLERS, Auteur ; Daniel CHO, Auteur ; Arianne S. WALLACE, Auteur ; Evan E. EICHLER, Auteur ; Raphael A. BERNIER, Auteur ; Rachel K. EARL, Auteur . - p.3365-3373. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3365-3373 Mots-clés : Abdominal Pain/genetics  Autism Spectrum Disorder/epidemiology/genetics  Humans  Mutation  Risk Factors  Self-Injurious Behavior/epidemiology/genetics  Abdominal pain  Autism spectrum disorder  Intellectual disability  Rare genetic disorders  Self-injurious behavior  Inc. The remaining authors have no conflicts of interest to report. Index. décimale : PER Périodiques Résumé : Self-injurious behaviors (SIB) are elevated in autism spectrum disorder (ASD) and related genetic disorders, but the genetic and biological mechanisms that contribute to SIB in ASD are poorly understood. This study examined rates and predictors of SIB in 112 individuals with disruptive mutations to ASD-risk genes. Current SIB were reported in 30% of participants and associated with poorer cognitive and adaptive skills. History of severe abdominal pain predicted higher rates of SIB and SIB severity after controlling for age and adaptive behavior; individuals with a history of severe abdominal pain were eight times more likely to exhibit SIB than those with no history. Future research is needed to examine associations between genetic risk, pain, and SIB in this population. En ligne : http://dx.doi.org/10.1007/s10803-020-04774-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Brief Report: Clusters and Trajectories Across the Autism and/or ADHD Spectrum / Sonja LABIANCA in Journal of Autism and Developmental Disorders, 48-10 (October 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3629-3636 Titre : Brief Report: Clusters and Trajectories Across the Autism and/or ADHD Spectrum Type de document : texte imprimé Auteurs : Sonja LABIANCA, Auteur ; Anne Katrine PAGSBERG, Auteur ; Klaus Damgaard JAKOBSEN, Auteur ; A.B. DEMUR, Auteur ; M. BARTALAN, Auteur ; Jette LABIANCA, Auteur ; Thomas WERGE, Auteur Article en page(s) : p.3629-3636 Langues : Anglais (eng) Mots-clés : ASD  ADHD  Co-morbidity  Genetic risk  Clusters of life trajectories  National Health Register Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) frequently co-occur and show high genetic correlation. With the introduction of DSM-5, there is a new concept of an ASD and/or ADHD spectrum (ASD/ADHD). This study aimed to identify predictors of severity and need of healthcare within this spectrum. 39 families with multiple individuals affected by ASD/ADHD were recruited from a psychiatric clinic. Diagnoses, functional and demographic characteristics were retrieved from journals while hospital admissions were identified in the Danish health register. An estimated fraction of 31% ASD/ADHD patients had never been hospitalized and 35% remained undiagnosed despite hospitalization. Cluster analysis identified trajectories that discriminate age of diagnosis, educational attainment to degree of severity, need of hospitalization and genetic risk. En ligne : https://doi.org/10.1007/s10803-018-3618-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Brief Report: Clusters and Trajectories Across the Autism and/or ADHD Spectrum [texte imprimé] / Sonja LABIANCA, Auteur ; Anne Katrine PAGSBERG, Auteur ; Klaus Damgaard JAKOBSEN, Auteur ; A.B. DEMUR, Auteur ; M. BARTALAN, Auteur ; Jette LABIANCA, Auteur ; Thomas WERGE, Auteur . - p.3629-3636. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3629-3636 Mots-clés : ASD  ADHD  Co-morbidity  Genetic risk  Clusters of life trajectories  National Health Register Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) frequently co-occur and show high genetic correlation. With the introduction of DSM-5, there is a new concept of an ASD and/or ADHD spectrum (ASD/ADHD). This study aimed to identify predictors of severity and need of healthcare within this spectrum. 39 families with multiple individuals affected by ASD/ADHD were recruited from a psychiatric clinic. Diagnoses, functional and demographic characteristics were retrieved from journals while hospital admissions were identified in the Danish health register. An estimated fraction of 31% ASD/ADHD patients had never been hospitalized and 35% remained undiagnosed despite hospitalization. Cluster analysis identified trajectories that discriminate age of diagnosis, educational attainment to degree of severity, need of hospitalization and genetic risk. En ligne : https://doi.org/10.1007/s10803-018-3618-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data / Olivia J. VEATCH in Journal of Neurodevelopmental Disorders, 14 (2022)  

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Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated / Steven R.H. BEACH in Development and Psychopathology, 33-3 (August 2021)  

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Childhood developmental disorders: an academic and clinical convergence point for psychiatry, neurology, psychology and pediatrics / Allan L. REISS in Journal of Child Psychology and Psychiatry, 50-1-2 (January/February 2009)  

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Commentary: Insights from across diagnostic boundaries: ADHD in the RDoC era – a commentary on Scerif and Baker () / Alysa E. DOYLE in Journal of Child Psychology and Psychiatry, 56-3 (March 2015)  

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Consanguinity in India and Its Association With Autism Spectrum Disorder / Madhu P. MAMIDALA in Autism Research, 8-2 (April 2015)  

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