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Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations / E. C. KURTZ-NELSON in Journal of Autism and Developmental Disorders, 51-9 (September 2021)
[article]
Titre : Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations Type de document : Texte imprimé et/ou numérique Auteurs : E. C. KURTZ-NELSON, Auteur ; S. W. THAM, Auteur ; K. AHLERS, Auteur ; D. CHO, Auteur ; Arianne S. WALLACE, Auteur ; E. E. EICHLER, Auteur ; Raphael BERNIER, Auteur ; R. K. EARL, Auteur Article en page(s) : p.3365-3373 Langues : Anglais (eng) Mots-clés : Abdominal Pain/genetics Autism Spectrum Disorder/epidemiology/genetics Humans Mutation Risk Factors Self-Injurious Behavior/epidemiology/genetics Abdominal pain Autism spectrum disorder Intellectual disability Rare genetic disorders Self-injurious behavior Inc. The remaining authors have no conflicts of interest to report. Index. décimale : PER Périodiques Résumé : Self-injurious behaviors (SIB) are elevated in autism spectrum disorder (ASD) and related genetic disorders, but the genetic and biological mechanisms that contribute to SIB in ASD are poorly understood. This study examined rates and predictors of SIB in 112 individuals with disruptive mutations to ASD-risk genes. Current SIB were reported in 30% of participants and associated with poorer cognitive and adaptive skills. History of severe abdominal pain predicted higher rates of SIB and SIB severity after controlling for age and adaptive behavior; individuals with a history of severe abdominal pain were eight times more likely to exhibit SIB than those with no history. Future research is needed to examine associations between genetic risk, pain, and SIB in this population. En ligne : http://dx.doi.org/10.1007/s10803-020-04774-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3365-3373[article] Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations [Texte imprimé et/ou numérique] / E. C. KURTZ-NELSON, Auteur ; S. W. THAM, Auteur ; K. AHLERS, Auteur ; D. CHO, Auteur ; Arianne S. WALLACE, Auteur ; E. E. EICHLER, Auteur ; Raphael BERNIER, Auteur ; R. K. EARL, Auteur . - p.3365-3373.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3365-3373
Mots-clés : Abdominal Pain/genetics Autism Spectrum Disorder/epidemiology/genetics Humans Mutation Risk Factors Self-Injurious Behavior/epidemiology/genetics Abdominal pain Autism spectrum disorder Intellectual disability Rare genetic disorders Self-injurious behavior Inc. The remaining authors have no conflicts of interest to report. Index. décimale : PER Périodiques Résumé : Self-injurious behaviors (SIB) are elevated in autism spectrum disorder (ASD) and related genetic disorders, but the genetic and biological mechanisms that contribute to SIB in ASD are poorly understood. This study examined rates and predictors of SIB in 112 individuals with disruptive mutations to ASD-risk genes. Current SIB were reported in 30% of participants and associated with poorer cognitive and adaptive skills. History of severe abdominal pain predicted higher rates of SIB and SIB severity after controlling for age and adaptive behavior; individuals with a history of severe abdominal pain were eight times more likely to exhibit SIB than those with no history. Future research is needed to examine associations between genetic risk, pain, and SIB in this population. En ligne : http://dx.doi.org/10.1007/s10803-020-04774-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 One-year course and predictors of abdominal pain in children with autism spectrum disorders: The role of anxiety and sensory over-responsivity / Micah O. MAZUREK in Research in Autism Spectrum Disorders, 8-11 (November 2014)
[article]
Titre : One-year course and predictors of abdominal pain in children with autism spectrum disorders: The role of anxiety and sensory over-responsivity Type de document : Texte imprimé et/ou numérique Auteurs : Micah O. MAZUREK, Auteur ; Amy KEEFER, Auteur ; Amy SHUI, Auteur ; Roma A. VASA, Auteur Article en page(s) : p.1508-1515 Langues : Anglais (eng) Mots-clés : Abdominal pain Gastrointestinal problems Anxiety Sensory problems Autism Autism spectrum disorder Index. décimale : PER Périodiques Résumé : AbstractObjectives To examine the one-year course of parent-reported abdominal pain in children with autism spectrum disorder (ASD), and to determine whether anxiety and sensory over-responsivity (SOR) contribute to the onset or remission of abdominal pain. Methods Participants included 225 children (ages 2–17) with ASD enrolled in the Autism Speaks Autism Treatment Network. Primary measures included the parent-reported GI Symptom Inventory Questionnaire, Child Behavior Checklist, and Short Sensory Profile. Results One-fourth (25.8%) experienced chronic abdominal pain (duration ?3 months) at baseline, persisting at one-year follow-up for 86.7%. New onset pain occurred for 23.8% of those without baseline pain. Anxiety, SOR, and chronic abdominal pain were associated at baseline. SOR significantly predicted new onset pain, but neither anxiety nor SOR were predictors of pain remission. Conclusions Abdominal pain appears to be common and persistent among children with ASD. The relations among SOR, anxiety and abdominal pain offer information about potential underlying mechanisms. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.07.018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Research in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1508-1515[article] One-year course and predictors of abdominal pain in children with autism spectrum disorders: The role of anxiety and sensory over-responsivity [Texte imprimé et/ou numérique] / Micah O. MAZUREK, Auteur ; Amy KEEFER, Auteur ; Amy SHUI, Auteur ; Roma A. VASA, Auteur . - p.1508-1515.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1508-1515
Mots-clés : Abdominal pain Gastrointestinal problems Anxiety Sensory problems Autism Autism spectrum disorder Index. décimale : PER Périodiques Résumé : AbstractObjectives To examine the one-year course of parent-reported abdominal pain in children with autism spectrum disorder (ASD), and to determine whether anxiety and sensory over-responsivity (SOR) contribute to the onset or remission of abdominal pain. Methods Participants included 225 children (ages 2–17) with ASD enrolled in the Autism Speaks Autism Treatment Network. Primary measures included the parent-reported GI Symptom Inventory Questionnaire, Child Behavior Checklist, and Short Sensory Profile. Results One-fourth (25.8%) experienced chronic abdominal pain (duration ?3 months) at baseline, persisting at one-year follow-up for 86.7%. New onset pain occurred for 23.8% of those without baseline pain. Anxiety, SOR, and chronic abdominal pain were associated at baseline. SOR significantly predicted new onset pain, but neither anxiety nor SOR were predictors of pain remission. Conclusions Abdominal pain appears to be common and persistent among children with ASD. The relations among SOR, anxiety and abdominal pain offer information about potential underlying mechanisms. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.07.018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study / O. W. H. WONG in Autism Research, 14-10 (October 2021)
[article]
Titre : An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study Type de document : Texte imprimé et/ou numérique Auteurs : O. W. H. WONG, Auteur ; A. M. W. LAM, Auteur ; Kelly Y. C. LAI, Auteur ; S. L. MA, Auteur ; S. F. HUNG, Auteur ; S. CHAN, Auteur ; S. WONG, Auteur ; P. W. L. LEUNG, Auteur Article en page(s) : p.2131-2142 Langues : Anglais (eng) Mots-clés : Anxiety/complications Autism Spectrum Disorder/complications/epidemiology Autistic Disorder/complications/epidemiology Case-Control Studies Child Child, Preschool Gastrointestinal Diseases/complications/epidemiology Humans Male abdominal pain anxiety autism constipation functional gastrointestinal disorder gut-brain axis nausea Index. décimale : PER Périodiques Résumé : Children with autism commonly suffer from comorbid functional gastrointestinal disorders (FGID) and anxiety. The raised prevalence of both conditions in autism suggests complex reciprocal relationships, which are seldom explored in non-treatment-seeking FGID. The relationships between subtypes of FGID and anxiety are also unclear. This study recruited boys with autism and age-matched typically developing (TD) boys, aged 4-11?years, who were not actively seeking help for gastrointestinal problems. Their parents completed the Rome IV Diagnostic Questionnaires for Pediatric FGID. Four groups of children with and without autism/FGID were identified and compared on their anxiety level using the Spence children's anxiety scale. In 69 boys with autism and 69 age-matched TD boys, FGID were identified in 22 and 16 boys, respectively. ANCOVA demonstrated a significant interaction effect of autism and FGID on anxiety (F[1, 129] = 5.43, p = 0.021), while conditional logistic regression identified an interaction effect of autism and anxiety on the odds of FGID (OR 1.038, 95% CI 1.002-1.075, p = 0.038). Explorative post hoc analysis showed higher anxiety in functional nausea and vomiting disorder (p = 0.033) and functional abdominal pain disorder (p = 0.029) among boys with autism than TD boys with the same respective subtypes of FGID. In summary, among prepubertal boys with autism, the presence of FGID that are non-treatment-seeking in nature, has a significantly stronger association with higher levels of anxiety than TD boys. The strength of association may be more prominent in subtypes of FGID. Possible pathomechanisms including the underlying microbiota spectra and inflammatory paths should be explored in future studies. LAY SUMMARY: Anxiety and gastrointestinal problems are common symptoms in autism. Given that gut health could be linked to emotions, their association in young boys with autism was studied. The presence of nausea vomiting, or abdominal pain were associated with raised anxiety among boys with autism, yet this was not observed in typically developing boys. This suggests that anxiety among autistic children could be partly explained by the presence of FGID. En ligne : http://dx.doi.org/10.1002/aur.2555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-10 (October 2021) . - p.2131-2142[article] An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study [Texte imprimé et/ou numérique] / O. W. H. WONG, Auteur ; A. M. W. LAM, Auteur ; Kelly Y. C. LAI, Auteur ; S. L. MA, Auteur ; S. F. HUNG, Auteur ; S. CHAN, Auteur ; S. WONG, Auteur ; P. W. L. LEUNG, Auteur . - p.2131-2142.
Langues : Anglais (eng)
in Autism Research > 14-10 (October 2021) . - p.2131-2142
Mots-clés : Anxiety/complications Autism Spectrum Disorder/complications/epidemiology Autistic Disorder/complications/epidemiology Case-Control Studies Child Child, Preschool Gastrointestinal Diseases/complications/epidemiology Humans Male abdominal pain anxiety autism constipation functional gastrointestinal disorder gut-brain axis nausea Index. décimale : PER Périodiques Résumé : Children with autism commonly suffer from comorbid functional gastrointestinal disorders (FGID) and anxiety. The raised prevalence of both conditions in autism suggests complex reciprocal relationships, which are seldom explored in non-treatment-seeking FGID. The relationships between subtypes of FGID and anxiety are also unclear. This study recruited boys with autism and age-matched typically developing (TD) boys, aged 4-11?years, who were not actively seeking help for gastrointestinal problems. Their parents completed the Rome IV Diagnostic Questionnaires for Pediatric FGID. Four groups of children with and without autism/FGID were identified and compared on their anxiety level using the Spence children's anxiety scale. In 69 boys with autism and 69 age-matched TD boys, FGID were identified in 22 and 16 boys, respectively. ANCOVA demonstrated a significant interaction effect of autism and FGID on anxiety (F[1, 129] = 5.43, p = 0.021), while conditional logistic regression identified an interaction effect of autism and anxiety on the odds of FGID (OR 1.038, 95% CI 1.002-1.075, p = 0.038). Explorative post hoc analysis showed higher anxiety in functional nausea and vomiting disorder (p = 0.033) and functional abdominal pain disorder (p = 0.029) among boys with autism than TD boys with the same respective subtypes of FGID. In summary, among prepubertal boys with autism, the presence of FGID that are non-treatment-seeking in nature, has a significantly stronger association with higher levels of anxiety than TD boys. The strength of association may be more prominent in subtypes of FGID. Possible pathomechanisms including the underlying microbiota spectra and inflammatory paths should be explored in future studies. LAY SUMMARY: Anxiety and gastrointestinal problems are common symptoms in autism. Given that gut health could be linked to emotions, their association in young boys with autism was studied. The presence of nausea vomiting, or abdominal pain were associated with raised anxiety among boys with autism, yet this was not observed in typically developing boys. This suggests that anxiety among autistic children could be partly explained by the presence of FGID. En ligne : http://dx.doi.org/10.1002/aur.2555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 The association between emotional and behavioral problems and gastrointestinal symptoms among children with high-functioning autism / Carla A. MAZEFSKY in Autism, 18-5 (July 2014)
[article]
Titre : The association between emotional and behavioral problems and gastrointestinal symptoms among children with high-functioning autism Type de document : Texte imprimé et/ou numérique Auteurs : Carla A. MAZEFSKY, Auteur ; Dana R. SCHREIBER, Auteur ; Thomas M. OLINO, Auteur ; Nancy J. MINSHEW, Auteur Article en page(s) : p.493-501 Langues : Anglais (eng) Mots-clés : abdominal pain autism spectrum disorder behavior Child Behavior Checklist gastrointestinal Index. décimale : PER Périodiques Résumé : This study investigated the association between gastrointestinal symptoms and a broad set of emotional and behavioral concerns in 95 children with high-functioning autism and IQ scores ? 80. Gastrointestinal symptoms were assessed via the Autism Treatment Network’s Gastrointestinal Symptom Inventory, and data were gathered on autism symptom severity, adaptive behavior, and multiple internalizing and externalizing problems. The majority (61%) of children had at least one reported gastrointestinal symptom. Emotional and behavioral problems were also common but with a high degree of variability. Children with and without gastrointestinal problems did not differ in autism symptom severity, adaptive behavior, or total internalizing or externalizing problem scores. However, participants with gastrointestinal problems had significantly higher levels of affective problems. This finding is consistent with a small body of research noting a relationship between gastrointestinal problems, irritability, and mood problems in autism spectrum disorder. More research to identify the mechanisms underlying this relationship in autism spectrum disorder is warranted. Future research should include a medical assessment of gastrointestinal concerns, longitudinal design, and participants with a range of autism spectrum disorder severity in order to clarify the directionality of this relationship and to identify factors that may impact heterogeneity in the behavioral manifestation of gastrointestinal concerns. En ligne : http://dx.doi.org/10.1177/1362361313485164 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233
in Autism > 18-5 (July 2014) . - p.493-501[article] The association between emotional and behavioral problems and gastrointestinal symptoms among children with high-functioning autism [Texte imprimé et/ou numérique] / Carla A. MAZEFSKY, Auteur ; Dana R. SCHREIBER, Auteur ; Thomas M. OLINO, Auteur ; Nancy J. MINSHEW, Auteur . - p.493-501.
Langues : Anglais (eng)
in Autism > 18-5 (July 2014) . - p.493-501
Mots-clés : abdominal pain autism spectrum disorder behavior Child Behavior Checklist gastrointestinal Index. décimale : PER Périodiques Résumé : This study investigated the association between gastrointestinal symptoms and a broad set of emotional and behavioral concerns in 95 children with high-functioning autism and IQ scores ? 80. Gastrointestinal symptoms were assessed via the Autism Treatment Network’s Gastrointestinal Symptom Inventory, and data were gathered on autism symptom severity, adaptive behavior, and multiple internalizing and externalizing problems. The majority (61%) of children had at least one reported gastrointestinal symptom. Emotional and behavioral problems were also common but with a high degree of variability. Children with and without gastrointestinal problems did not differ in autism symptom severity, adaptive behavior, or total internalizing or externalizing problem scores. However, participants with gastrointestinal problems had significantly higher levels of affective problems. This finding is consistent with a small body of research noting a relationship between gastrointestinal problems, irritability, and mood problems in autism spectrum disorder. More research to identify the mechanisms underlying this relationship in autism spectrum disorder is warranted. Future research should include a medical assessment of gastrointestinal concerns, longitudinal design, and participants with a range of autism spectrum disorder severity in order to clarify the directionality of this relationship and to identify factors that may impact heterogeneity in the behavioral manifestation of gastrointestinal concerns. En ligne : http://dx.doi.org/10.1177/1362361313485164 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233