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Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors? / Maryam M. ABDULLAH in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
[article]
Titre : Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors? Type de document : Texte imprimé et/ou numérique Auteurs : Maryam M. ABDULLAH, Auteur ; Agnes R. LY, Auteur ; Wendy A. GOLDBERG, Auteur ; K. Alison CLARKE-STEWART, Auteur ; John V. DUDGEON, Auteur ; Christopher G. MULL, Auteur ; Tony J. CHAN, Auteur ; Erin E. KENT, Auteur ; Andrew Z. MASON, Auteur ; Jonathon E. ERICSON, Auteur Année de publication : 2012 Article en page(s) : p.929-936 Langues : Anglais (eng) Mots-clés : Autism ADHD Metal Lead Mercury Manganese Index. décimale : PER Périodiques Résumé : To examine possible links between neurotoxicant exposure and neuropsychological disorders and child behavior, relative concentrations of lead, mercury, and manganese were examined in prenatal and postnatal enamel regions of deciduous teeth from children with Autism Spectrum Disorders (ASDs), high levels of disruptive behavior (HDB), and typically developing (TD) children. Using laser ablation inductively coupled plasma mass spectrometry, we found no significant differences in levels of these neurotoxicants for children with ASDs compared with TD children, but there was marginal significance indicating that children with ASDs have lower manganese levels. No significant differences emerged between children with HDB and TD children. The current findings challenge the notion that perinatal heavy metal exposure is a major contributor to the development of ASDs and HDB. En ligne : http://dx.doi.org/10.1007/s10803-011-1318-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.929-936[article] Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors? [Texte imprimé et/ou numérique] / Maryam M. ABDULLAH, Auteur ; Agnes R. LY, Auteur ; Wendy A. GOLDBERG, Auteur ; K. Alison CLARKE-STEWART, Auteur ; John V. DUDGEON, Auteur ; Christopher G. MULL, Auteur ; Tony J. CHAN, Auteur ; Erin E. KENT, Auteur ; Andrew Z. MASON, Auteur ; Jonathon E. ERICSON, Auteur . - 2012 . - p.929-936.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.929-936
Mots-clés : Autism ADHD Metal Lead Mercury Manganese Index. décimale : PER Périodiques Résumé : To examine possible links between neurotoxicant exposure and neuropsychological disorders and child behavior, relative concentrations of lead, mercury, and manganese were examined in prenatal and postnatal enamel regions of deciduous teeth from children with Autism Spectrum Disorders (ASDs), high levels of disruptive behavior (HDB), and typically developing (TD) children. Using laser ablation inductively coupled plasma mass spectrometry, we found no significant differences in levels of these neurotoxicants for children with ASDs compared with TD children, but there was marginal significance indicating that children with ASDs have lower manganese levels. No significant differences emerged between children with HDB and TD children. The current findings challenge the notion that perinatal heavy metal exposure is a major contributor to the development of ASDs and HDB. En ligne : http://dx.doi.org/10.1007/s10803-011-1318-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156 Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? / Kerrie SHANDLEY in Autism Research, 7-5 (October 2014)
[article]
Titre : Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Kerrie SHANDLEY, Auteur ; David W. AUSTIN, Auteur ; Jahar L. BHOWMIK, Auteur Article en page(s) : p.535-542 Langues : Anglais (eng) Mots-clés : porphyrins biomarker ASD diagnosis ASD severity heavy metals mercury Index. décimale : PER Périodiques Résumé : A fundamental challenge to the timely diagnosis of Autism Spectrum Disorder (ASD) is the reliance on the observation of a set of aberrant behavior. Consequently, the diagnostic process requires that the child reach an age where the behaviors would typically be exhibited. The identification of a reliable biological marker (biomarker) could be of considerable benefit to the diagnostic process. As a diagnostic biomarker, porphyrins present an attractive prospect as previous studies have reported consistent findings of children with ASD showing significant elevations in porphyrin levels in contrast to controls. Furthermore, there is some evidence that ASD severity may be associated with porphyrins, which would be a valuable characteristic of any ASD biomarker. Importantly, for practical use, porphyrins can be tested non-invasively via a sample of urine. The present study sought to investigate whether porphyrin profiles can reliably be used to (a) differentiate ASD cases from healthy controls; and (b) predict ASD severity. The study compared the porphyrin levels of three groups of children aged 2–6 years: Group 1—children diagnosed with ASD (n?=?70); Group 2—healthy, normally developing siblings of children diagnosed with ASD (n?=?36); and Group 3—healthy, normally developing children with no known blood relative diagnosed with ASD (n?=?54). The results of logistic regression analyses failed to find support for the hypotheses that porphyrin levels could be used as a valid tool to detect ASD cases or predict severity. Autism Res 2014, 7: 535–542. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Autism Research > 7-5 (October 2014) . - p.535-542[article] Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? [Texte imprimé et/ou numérique] / Kerrie SHANDLEY, Auteur ; David W. AUSTIN, Auteur ; Jahar L. BHOWMIK, Auteur . - p.535-542.
Langues : Anglais (eng)
in Autism Research > 7-5 (October 2014) . - p.535-542
Mots-clés : porphyrins biomarker ASD diagnosis ASD severity heavy metals mercury Index. décimale : PER Périodiques Résumé : A fundamental challenge to the timely diagnosis of Autism Spectrum Disorder (ASD) is the reliance on the observation of a set of aberrant behavior. Consequently, the diagnostic process requires that the child reach an age where the behaviors would typically be exhibited. The identification of a reliable biological marker (biomarker) could be of considerable benefit to the diagnostic process. As a diagnostic biomarker, porphyrins present an attractive prospect as previous studies have reported consistent findings of children with ASD showing significant elevations in porphyrin levels in contrast to controls. Furthermore, there is some evidence that ASD severity may be associated with porphyrins, which would be a valuable characteristic of any ASD biomarker. Importantly, for practical use, porphyrins can be tested non-invasively via a sample of urine. The present study sought to investigate whether porphyrin profiles can reliably be used to (a) differentiate ASD cases from healthy controls; and (b) predict ASD severity. The study compared the porphyrin levels of three groups of children aged 2–6 years: Group 1—children diagnosed with ASD (n?=?70); Group 2—healthy, normally developing siblings of children diagnosed with ASD (n?=?36); and Group 3—healthy, normally developing children with no known blood relative diagnosed with ASD (n?=?54). The results of logistic regression analyses failed to find support for the hypotheses that porphyrin levels could be used as a valid tool to detect ASD cases or predict severity. Autism Res 2014, 7: 535–542. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241