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Quantitative Gait Analysis in Duplication 15q Syndrome and Nonsyndromic ASD / Rujuta B. WILSON in Autism Research, 13-7 (July 2020)
[article]
Titre : Quantitative Gait Analysis in Duplication 15q Syndrome and Nonsyndromic ASD Type de document : Texte imprimé et/ou numérique Auteurs : Rujuta B. WILSON, Auteur ; David ELASHOFF, Auteur ; Arnaud GOUELLE, Auteur ; Beth A. SMITH, Auteur ; Andrew M. WILSON, Auteur ; Abigail DICKINSON, Auteur ; Tabitha SAFARI, Auteur ; Carly HYDE, Auteur ; Shafali S. JESTE, Auteur Article en page(s) : p.1102-1110 Langues : Anglais (eng) Mots-clés : autism spectrum disorder duplication 15q syndrome gait function genetic syndrome motor impairments quantitative gait analysis Index. décimale : PER Périodiques Résumé : Motor impairments occur frequently in genetic syndromes highly penetrant for autism spectrum disorder (syndromic ASD) and in individuals with ASD without a genetic diagnosis (nonsyndromic ASD). In particular, abnormalities in gait in ASD have been linked to language delay, ASD severity, and likelihood of having a genetic disorder. Quantitative measures of motor function can improve our ability to evaluate motor differences in individuals with syndromic and nonsyndromic ASD with varying levels of intellectual disability and adaptive skills. To evaluate this methodology, we chose to use quantitative gait analysis to study duplication 15q syndrome (dup15q syndrome), a genetic disorder highly penetrant for motor delays, intellectual disability, and ASD. We evaluated quantitative gait variables in individuals with dup15q syndrome (n = 39) and nonsyndromic ASD (n = 21) and compared these data to a reference typically developing cohort. We found a gait pattern of slow pace, poor postural control, and large gait variability in dup15q syndrome. Our findings improve characterization of motor function in dup15q syndrome and nonsyndromic ASD. Quantitative gait analysis can be used as a translational method and can improve our identification of clinical endpoints to be used in treatment trials for these syndromes. Autism Res 2020, 13: 1102-1110. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Motor impairments, particularly abnormalities in walking, occur frequently in genetic syndromes highly penetrant for autism spectrum disorder (syndromic ASD). Here, using quantitative gait analysis, we find that individuals with duplication 15q syndrome have an atypical gait pattern that differentiates them from typically developing and nonsyndromic ASD individuals. Our findings improve motor characterization in dup15q syndrome and nonsyndromic ASD. En ligne : http://dx.doi.org/10.1002/aur.2298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429
in Autism Research > 13-7 (July 2020) . - p.1102-1110[article] Quantitative Gait Analysis in Duplication 15q Syndrome and Nonsyndromic ASD [Texte imprimé et/ou numérique] / Rujuta B. WILSON, Auteur ; David ELASHOFF, Auteur ; Arnaud GOUELLE, Auteur ; Beth A. SMITH, Auteur ; Andrew M. WILSON, Auteur ; Abigail DICKINSON, Auteur ; Tabitha SAFARI, Auteur ; Carly HYDE, Auteur ; Shafali S. JESTE, Auteur . - p.1102-1110.
Langues : Anglais (eng)
in Autism Research > 13-7 (July 2020) . - p.1102-1110
Mots-clés : autism spectrum disorder duplication 15q syndrome gait function genetic syndrome motor impairments quantitative gait analysis Index. décimale : PER Périodiques Résumé : Motor impairments occur frequently in genetic syndromes highly penetrant for autism spectrum disorder (syndromic ASD) and in individuals with ASD without a genetic diagnosis (nonsyndromic ASD). In particular, abnormalities in gait in ASD have been linked to language delay, ASD severity, and likelihood of having a genetic disorder. Quantitative measures of motor function can improve our ability to evaluate motor differences in individuals with syndromic and nonsyndromic ASD with varying levels of intellectual disability and adaptive skills. To evaluate this methodology, we chose to use quantitative gait analysis to study duplication 15q syndrome (dup15q syndrome), a genetic disorder highly penetrant for motor delays, intellectual disability, and ASD. We evaluated quantitative gait variables in individuals with dup15q syndrome (n = 39) and nonsyndromic ASD (n = 21) and compared these data to a reference typically developing cohort. We found a gait pattern of slow pace, poor postural control, and large gait variability in dup15q syndrome. Our findings improve characterization of motor function in dup15q syndrome and nonsyndromic ASD. Quantitative gait analysis can be used as a translational method and can improve our identification of clinical endpoints to be used in treatment trials for these syndromes. Autism Res 2020, 13: 1102-1110. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Motor impairments, particularly abnormalities in walking, occur frequently in genetic syndromes highly penetrant for autism spectrum disorder (syndromic ASD). Here, using quantitative gait analysis, we find that individuals with duplication 15q syndrome have an atypical gait pattern that differentiates them from typically developing and nonsyndromic ASD individuals. Our findings improve motor characterization in dup15q syndrome and nonsyndromic ASD. En ligne : http://dx.doi.org/10.1002/aur.2298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 Sensorimotor skills in autism spectrum disorder: A meta-analysis / Sarah-Maude COLL in Research in Autism Spectrum Disorders, 76 (August 2020)
[article]
Titre : Sensorimotor skills in autism spectrum disorder: A meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Sarah-Maude COLL, Auteur ; Nicholas E. V. FOSTER, Auteur ; Alexa MEILLEUR, Auteur ; Simona M. BRAMBATI, Auteur ; Krista L. HYDE, Auteur Article en page(s) : p.101570 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Sensorimotor skills Motor coordination Motor impairments Index. décimale : PER Périodiques Résumé : Background Sensorimotor skills are often reported as atypical in individuals with autism spectrum disorder (ASD). Little is known about how sensorimotor skills in ASD may vary across development and with symptom severity. The main objective of this study was to conduct a comprehensive quantitative meta-analysis of sensorimotor skills in ASD. The specific aims were: to assess impairment of gross and fine sensorimotor skills in ASD, to examine the effect of age on sensorimotor skills in ASD and to examine the relationship between sensorimotor skills and ASD symptom severity. Method An exhaustive search was conducted in Psycnet, PubMed, Web of Science and Cochrane Database to identify studies in ASD from 1980 to 2018 that involved quantitative evaluations of motor coordination, motor impairments, arm movement, gait, postural stability, visuomotor or auditory motor integration. A total of 139 studies were included and this represent 3436 individuals with ASD. Results Results strongly support the presence of deficits in overall sensorimotor abilities in ASD (Hedges’ g?=?1.22, p? 0.001) and these atypicalities extended to fine and gross sensorimotor abilities. Sensorimotor abilities increased with age, but did not appear to covary with symptom severity. Conclusions These results highlight the importance to target these deficits in future interventions and consider the impact of sensorimotor impairments across research, therapy, and educational settings. En ligne : https://doi.org/10.1016/j.rasd.2020.101570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429
in Research in Autism Spectrum Disorders > 76 (August 2020) . - p.101570[article] Sensorimotor skills in autism spectrum disorder: A meta-analysis [Texte imprimé et/ou numérique] / Sarah-Maude COLL, Auteur ; Nicholas E. V. FOSTER, Auteur ; Alexa MEILLEUR, Auteur ; Simona M. BRAMBATI, Auteur ; Krista L. HYDE, Auteur . - p.101570.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 76 (August 2020) . - p.101570
Mots-clés : Autism spectrum disorder Sensorimotor skills Motor coordination Motor impairments Index. décimale : PER Périodiques Résumé : Background Sensorimotor skills are often reported as atypical in individuals with autism spectrum disorder (ASD). Little is known about how sensorimotor skills in ASD may vary across development and with symptom severity. The main objective of this study was to conduct a comprehensive quantitative meta-analysis of sensorimotor skills in ASD. The specific aims were: to assess impairment of gross and fine sensorimotor skills in ASD, to examine the effect of age on sensorimotor skills in ASD and to examine the relationship between sensorimotor skills and ASD symptom severity. Method An exhaustive search was conducted in Psycnet, PubMed, Web of Science and Cochrane Database to identify studies in ASD from 1980 to 2018 that involved quantitative evaluations of motor coordination, motor impairments, arm movement, gait, postural stability, visuomotor or auditory motor integration. A total of 139 studies were included and this represent 3436 individuals with ASD. Results Results strongly support the presence of deficits in overall sensorimotor abilities in ASD (Hedges’ g?=?1.22, p? 0.001) and these atypicalities extended to fine and gross sensorimotor abilities. Sensorimotor abilities increased with age, but did not appear to covary with symptom severity. Conclusions These results highlight the importance to target these deficits in future interventions and consider the impact of sensorimotor impairments across research, therapy, and educational settings. En ligne : https://doi.org/10.1016/j.rasd.2020.101570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429