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Gene–environment interactions in genome-wide association studies: current approaches and new directions / Stacey J. WINHAM in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)
[article]
Titre : Gene–environment interactions in genome-wide association studies: current approaches and new directions Type de document : Texte imprimé et/ou numérique Auteurs : Stacey J. WINHAM, Auteur ; Joanna M. BIERNACKA, Auteur Article en page(s) : p.1120-1134 Langues : Anglais (eng) Mots-clés : Gene–environment interaction gene-level pathway gene-set data-mining Index. décimale : PER Périodiques Résumé : Background Complex psychiatric traits have long been thought to be the result of a combination of genetic and environmental factors, and gene–environment interactions are thought to play a crucial role in behavioral phenotypes and the susceptibility and progression of psychiatric disorders. Candidate gene studies to investigate hypothesized gene–environment interactions are now fairly common in human genetic research, and with the shift toward genome-wide association studies, genome-wide gene–environment interaction studies are beginning to emerge. Methods We summarize the basic ideas behind gene–environment interaction, and provide an overview of possible study designs and traditional analysis methods in the context of genome-wide analysis. We then discuss novel approaches beyond the traditional strategy of analyzing the interaction between the environmental factor and each polymorphism individually. Results Two-step filtering approaches that reduce the number of polymorphisms tested for interactions can substantially increase the power of genome-wide gene–environment studies. New analytical methods including data-mining approaches, and gene-level and pathway-level analyses, also have the capacity to improve our understanding of how complex genetic and environmental factors interact to influence psychologic and psychiatric traits. Such methods, however, have not yet been utilized much in behavioral and mental health research. Conclusions Although methods to investigate gene–environment interactions are available, there is a need for further development and extension of these methods to identify gene–environment interactions in the context of genome-wide association studies. These novel approaches need to be applied in studies of psychology and psychiatry. En ligne : http://dx.doi.org/10.1111/jcpp.12114 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212
in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1120-1134[article] Gene–environment interactions in genome-wide association studies: current approaches and new directions [Texte imprimé et/ou numérique] / Stacey J. WINHAM, Auteur ; Joanna M. BIERNACKA, Auteur . - p.1120-1134.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1120-1134
Mots-clés : Gene–environment interaction gene-level pathway gene-set data-mining Index. décimale : PER Périodiques Résumé : Background Complex psychiatric traits have long been thought to be the result of a combination of genetic and environmental factors, and gene–environment interactions are thought to play a crucial role in behavioral phenotypes and the susceptibility and progression of psychiatric disorders. Candidate gene studies to investigate hypothesized gene–environment interactions are now fairly common in human genetic research, and with the shift toward genome-wide association studies, genome-wide gene–environment interaction studies are beginning to emerge. Methods We summarize the basic ideas behind gene–environment interaction, and provide an overview of possible study designs and traditional analysis methods in the context of genome-wide analysis. We then discuss novel approaches beyond the traditional strategy of analyzing the interaction between the environmental factor and each polymorphism individually. Results Two-step filtering approaches that reduce the number of polymorphisms tested for interactions can substantially increase the power of genome-wide gene–environment studies. New analytical methods including data-mining approaches, and gene-level and pathway-level analyses, also have the capacity to improve our understanding of how complex genetic and environmental factors interact to influence psychologic and psychiatric traits. Such methods, however, have not yet been utilized much in behavioral and mental health research. Conclusions Although methods to investigate gene–environment interactions are available, there is a need for further development and extension of these methods to identify gene–environment interactions in the context of genome-wide association studies. These novel approaches need to be applied in studies of psychology and psychiatry. En ligne : http://dx.doi.org/10.1111/jcpp.12114 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 Investigating multilevel pathways of developmental consequences of maltreatment / Carrie E. DEPASQUALE in Development and Psychopathology, 31-4 (October 2019)
[article]
Titre : Investigating multilevel pathways of developmental consequences of maltreatment Type de document : Texte imprimé et/ou numérique Auteurs : Carrie E. DEPASQUALE, Auteur ; E. D. HANDLEY, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.1227-1236 Langues : Anglais (eng) Mots-clés : cortisol externalizing maltreatment pathway social Index. décimale : PER Périodiques Résumé : The impact of maltreatment spreads across many developmental domains and extends across the entire life span. Identifying unidirectional or bidirectional drivers of developmental cascades of the effects of maltreatment experiences is critical to efficiently employing interventions to promote resilient development in maltreated children. This 1-year longitudinal study utilized a multiple-levels approach, investigating "bottom-up" and "top-down" cascades using structural equation modeling between cortisol regulation, externalizing behavior, and peer aggression. Neither a bottom-up model driven by cortisol regulation nor a top-down model driven by peer aggression fit the data well. Instead, lower rates of externalizing behavior at Year 1 most strongly predicted improvements at all levels of analysis (reduced cortisol, externalizing behavior, and peer aggression) at Year 2. These results provide initial indication of a mechanism through which interventions for maltreated children may be most effective and result in the most substantial positive changes across developmental domains. En ligne : http://dx.doi.org/10.1017/s0954579418000834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406
in Development and Psychopathology > 31-4 (October 2019) . - p.1227-1236[article] Investigating multilevel pathways of developmental consequences of maltreatment [Texte imprimé et/ou numérique] / Carrie E. DEPASQUALE, Auteur ; E. D. HANDLEY, Auteur ; Dante CICCHETTI, Auteur . - p.1227-1236.
Langues : Anglais (eng)
in Development and Psychopathology > 31-4 (October 2019) . - p.1227-1236
Mots-clés : cortisol externalizing maltreatment pathway social Index. décimale : PER Périodiques Résumé : The impact of maltreatment spreads across many developmental domains and extends across the entire life span. Identifying unidirectional or bidirectional drivers of developmental cascades of the effects of maltreatment experiences is critical to efficiently employing interventions to promote resilient development in maltreated children. This 1-year longitudinal study utilized a multiple-levels approach, investigating "bottom-up" and "top-down" cascades using structural equation modeling between cortisol regulation, externalizing behavior, and peer aggression. Neither a bottom-up model driven by cortisol regulation nor a top-down model driven by peer aggression fit the data well. Instead, lower rates of externalizing behavior at Year 1 most strongly predicted improvements at all levels of analysis (reduced cortisol, externalizing behavior, and peer aggression) at Year 2. These results provide initial indication of a mechanism through which interventions for maltreated children may be most effective and result in the most substantial positive changes across developmental domains. En ligne : http://dx.doi.org/10.1017/s0954579418000834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406