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Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder / Daniel VON RHEIN in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)
[article]
Titre : Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Daniel VON RHEIN, Auteur ; Marianne OLDEHINKEL, Auteur ; Christian F. BECKMANN, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Catharina A. HARTMAN, Auteur ; Pieter J. HOEKSTRA, Auteur ; Barbara FRANKE, Auteur ; Roshan COOLS, Auteur ; Jan K. BUITELAAR, Auteur ; Maarten MENNES, Auteur Article en page(s) : p.697-705 Langues : Anglais (eng) Mots-clés : Resting-state fMRI functional connectivity attention-deficit/hyperactivity disorder cortico-striatal networks striatum putamen Index. décimale : PER Périodiques Résumé : Background Task-based and resting-state functional Magnetic Resonance Imaging (fMRI) studies report attention-deficit/hyperactivity disorder (ADHD)-related alterations in brain regions implicated in cortico-striatal networks. We assessed whether ADHD is associated with changes in the brain's global cortico-striatal functional architecture, or whether ADHD-related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico-striatal functional architecture we computed whole-brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico-striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico-striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289
in Journal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.697-705[article] Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Daniel VON RHEIN, Auteur ; Marianne OLDEHINKEL, Auteur ; Christian F. BECKMANN, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Catharina A. HARTMAN, Auteur ; Pieter J. HOEKSTRA, Auteur ; Barbara FRANKE, Auteur ; Roshan COOLS, Auteur ; Jan K. BUITELAAR, Auteur ; Maarten MENNES, Auteur . - p.697-705.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.697-705
Mots-clés : Resting-state fMRI functional connectivity attention-deficit/hyperactivity disorder cortico-striatal networks striatum putamen Index. décimale : PER Périodiques Résumé : Background Task-based and resting-state functional Magnetic Resonance Imaging (fMRI) studies report attention-deficit/hyperactivity disorder (ADHD)-related alterations in brain regions implicated in cortico-striatal networks. We assessed whether ADHD is associated with changes in the brain's global cortico-striatal functional architecture, or whether ADHD-related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico-striatal functional architecture we computed whole-brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico-striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico-striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders / Krissy A. R. DOYLE-THOMAS in Research in Autism Spectrum Disorders, 8-1 (January 2014)
[article]
Titre : Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Krissy A. R. DOYLE-THOMAS, Auteur ; Dallas CARD, Auteur ; Latha V. SOORYA, Auteur ; A. TING WANG, Auteur ; Jin FAN, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.44-51 Langues : Anglais (eng) Mots-clés : Magnetic resonance spectroscopy Autism spectrum disorders Deep gray matter Caudate nucleus Putamen Thalamus and social cognition Index. décimale : PER Périodiques Résumé : Abstract Structural neuroimaging studies in autism report atypical volume in deep brain structures which are related to symptomatology. Little is known about metabolic changes in these regions, and how they vary with age and sex, and/or relate to clinical behaviors. Using magnetic resonance spectroscopy we measured N-acetylaspartate, choline, creatine, myoinositol and glutamate in the caudate, putamen, and thalamus of 20 children with autism and 16 typically developing controls (7–18 years). Relative to controls, individuals with autism had elevated glutamate/creatine in the putamen. In addition, both groups showed age-related increases in glutamate in this region. Boys, relative to girls had increased choline/creatine in the thalamus. Lastly, there were correlations between glutamate, choline, and myoinositol in all three regions, and behavioral scores in the ASD group. These findings suggest changes in deep gray matter neurochemistry, which are sensitive to diagnosis, age and sex, and are associated with behavioral differences. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.10.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220
in Research in Autism Spectrum Disorders > 8-1 (January 2014) . - p.44-51[article] Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders [Texte imprimé et/ou numérique] / Krissy A. R. DOYLE-THOMAS, Auteur ; Dallas CARD, Auteur ; Latha V. SOORYA, Auteur ; A. TING WANG, Auteur ; Jin FAN, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.44-51.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-1 (January 2014) . - p.44-51
Mots-clés : Magnetic resonance spectroscopy Autism spectrum disorders Deep gray matter Caudate nucleus Putamen Thalamus and social cognition Index. décimale : PER Périodiques Résumé : Abstract Structural neuroimaging studies in autism report atypical volume in deep brain structures which are related to symptomatology. Little is known about metabolic changes in these regions, and how they vary with age and sex, and/or relate to clinical behaviors. Using magnetic resonance spectroscopy we measured N-acetylaspartate, choline, creatine, myoinositol and glutamate in the caudate, putamen, and thalamus of 20 children with autism and 16 typically developing controls (7–18 years). Relative to controls, individuals with autism had elevated glutamate/creatine in the putamen. In addition, both groups showed age-related increases in glutamate in this region. Boys, relative to girls had increased choline/creatine in the thalamus. Lastly, there were correlations between glutamate, choline, and myoinositol in all three regions, and behavioral scores in the ASD group. These findings suggest changes in deep gray matter neurochemistry, which are sensitive to diagnosis, age and sex, and are associated with behavioral differences. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.10.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 Processing of Real-World, Dynamic Natural Stimuli in Autism is Linked to Corticobasal Function / Paula J. WEBSTER in Autism Research, 13-4 (April 2020)
[article]
Titre : Processing of Real-World, Dynamic Natural Stimuli in Autism is Linked to Corticobasal Function Type de document : Texte imprimé et/ou numérique Auteurs : Paula J. WEBSTER, Auteur ; Chris FRUM, Auteur ; Amy KUROWSKI-BURT, Auteur ; Christopher E. BAUER, Auteur ; Sijin WEN, Auteur ; Jad H. RAMADAN, Auteur ; Kathryn A. BAKER, Auteur ; James W. LEWIS, Auteur Article en page(s) : p.539-549 Langues : Anglais (eng) Mots-clés : autism spectrum disorder biological motion globus pallidus hypoactivation intraparietal sulcus lentiform nucleus magnetic resonance imaging putamen Index. décimale : PER Périodiques Résumé : Many individuals with autism spectrum disorder (ASD) have been shown to perceive everyday sensory information differently compared to peers without autism. Research examining these sensory differences has primarily utilized nonnatural stimuli or natural stimuli using static photos with few having utilized dynamic, real-world nonverbal stimuli. Therefore, in this study, we used functional magnetic resonance imaging to characterize brain activation of individuals with high-functioning autism when viewing and listening to a video of a real-world scene (a person bouncing a ball) and anticipating the bounce. We investigated both multisensory and unisensory processing and hypothesized that individuals with ASD would show differential activation in (a) primary auditory and visual sensory cortical and association areas, and in (b) cortical and subcortical regions where auditory and visual information is integrated (e.g. temporal-parietal junction, pulvinar, superior colliculus). Contrary to our hypotheses, the whole-brain analysis revealed similar activation between the groups in these brain regions. However, compared to controls the ASD group showed significant hypoactivation in the left intraparietal sulcus and left putamen/globus pallidus. We theorize that this hypoactivation reflected underconnectivity for mediating spatiotemporal processing of the visual biological motion stimuli with the task demands of anticipating the timing of the bounce event. The paradigm thus may have tapped into a specific left-lateralized aberrant corticobasal circuit or loop involved in initiating or inhibiting motor responses. This was consistent with a dual "when versus where" psychophysical model of corticobasal function, which may reflect core differences in sensory processing of real-world, nonverbal natural stimuli in ASD. Autism Res 2020, 13: 539-549. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: To understand how individuals with autism perceive the real-world, using magnetic resonance imaging we examined brain activation in individuals with autism while watching a video of someone bouncing a basketball. Those with autism had similar activation to controls in auditory and visual sensory brain regions, but less activation in an area that processes information about body movements and in a region involved in modulating movements. These areas are important for understanding the actions of others and developing social skills. En ligne : http://dx.doi.org/10.1002/aur.2250 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421
in Autism Research > 13-4 (April 2020) . - p.539-549[article] Processing of Real-World, Dynamic Natural Stimuli in Autism is Linked to Corticobasal Function [Texte imprimé et/ou numérique] / Paula J. WEBSTER, Auteur ; Chris FRUM, Auteur ; Amy KUROWSKI-BURT, Auteur ; Christopher E. BAUER, Auteur ; Sijin WEN, Auteur ; Jad H. RAMADAN, Auteur ; Kathryn A. BAKER, Auteur ; James W. LEWIS, Auteur . - p.539-549.
Langues : Anglais (eng)
in Autism Research > 13-4 (April 2020) . - p.539-549
Mots-clés : autism spectrum disorder biological motion globus pallidus hypoactivation intraparietal sulcus lentiform nucleus magnetic resonance imaging putamen Index. décimale : PER Périodiques Résumé : Many individuals with autism spectrum disorder (ASD) have been shown to perceive everyday sensory information differently compared to peers without autism. Research examining these sensory differences has primarily utilized nonnatural stimuli or natural stimuli using static photos with few having utilized dynamic, real-world nonverbal stimuli. Therefore, in this study, we used functional magnetic resonance imaging to characterize brain activation of individuals with high-functioning autism when viewing and listening to a video of a real-world scene (a person bouncing a ball) and anticipating the bounce. We investigated both multisensory and unisensory processing and hypothesized that individuals with ASD would show differential activation in (a) primary auditory and visual sensory cortical and association areas, and in (b) cortical and subcortical regions where auditory and visual information is integrated (e.g. temporal-parietal junction, pulvinar, superior colliculus). Contrary to our hypotheses, the whole-brain analysis revealed similar activation between the groups in these brain regions. However, compared to controls the ASD group showed significant hypoactivation in the left intraparietal sulcus and left putamen/globus pallidus. We theorize that this hypoactivation reflected underconnectivity for mediating spatiotemporal processing of the visual biological motion stimuli with the task demands of anticipating the timing of the bounce event. The paradigm thus may have tapped into a specific left-lateralized aberrant corticobasal circuit or loop involved in initiating or inhibiting motor responses. This was consistent with a dual "when versus where" psychophysical model of corticobasal function, which may reflect core differences in sensory processing of real-world, nonverbal natural stimuli in ASD. Autism Res 2020, 13: 539-549. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: To understand how individuals with autism perceive the real-world, using magnetic resonance imaging we examined brain activation in individuals with autism while watching a video of someone bouncing a basketball. Those with autism had similar activation to controls in auditory and visual sensory brain regions, but less activation in an area that processes information about body movements and in a region involved in modulating movements. These areas are important for understanding the actions of others and developing social skills. En ligne : http://dx.doi.org/10.1002/aur.2250 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421