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Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes / Tanya L. PROCYSHYN in Autism Research, 10-5 (May 2017)
[article]
Titre : Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes Type de document : Texte imprimé et/ou numérique Auteurs : Tanya L. PROCYSHYN, Auteur ; Peter L. HURD, Auteur ; Bernard CRESPI, Auteur Article en page(s) : p.750-756 Langues : Anglais (eng) Mots-clés : attention autism quotient autism spectrum avpr1a microsatellite analysis rs1 rs3 vasopressin Index. décimale : PER Périodiques Résumé : Variation in the AVPR1a gene, which codes for a receptor for the neurohormone vasopressin, has been found to relate to autism risk. Interestingly, variation in this gene also relates to differences in social behaviour in non-clinical populations. Variation in this gene may affect expression of AVPR1a receptors in brain areas involved in social behaviour. Here, we tested whether AVPR1a variation was associated with Autism Quotient (AQ) scores, a questionnaire that measures non-clinical manifestations of autism, in a population of 873 healthy university students. The AVPR1a RS1 and RS3 microsatellites were examined, and variants were categorized as “long” or “short”. The RS3 long/long genotype was significantly associated with a higher AQ score (i.e., a more autistic-like phenotype) for the combined population and for females only. Further examination showed that this relationship was due to a specific RS3 variant, termed the “target allele”, which previous research has linked to reduced altruism and increased marital problems in healthy individuals. We also observed that the relationship between RS3 genotype and AQ score was mainly due to the “attention switching” (the ability to shift attention from one task to another) component of the questionnaire; this ability is commonly impaired in autism spectrum disorders. Overall, our study establishes continuity between the existing AVPR1a research in clinical and non-clinical populations. Our results suggest that vasopressin may exert its effects on social behaviour in part by modulating attentional focus between social and non-social cues. En ligne : http://dx.doi.org/10.1002/aur.1716 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307
in Autism Research > 10-5 (May 2017) . - p.750-756[article] Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes [Texte imprimé et/ou numérique] / Tanya L. PROCYSHYN, Auteur ; Peter L. HURD, Auteur ; Bernard CRESPI, Auteur . - p.750-756.
Langues : Anglais (eng)
in Autism Research > 10-5 (May 2017) . - p.750-756
Mots-clés : attention autism quotient autism spectrum avpr1a microsatellite analysis rs1 rs3 vasopressin Index. décimale : PER Périodiques Résumé : Variation in the AVPR1a gene, which codes for a receptor for the neurohormone vasopressin, has been found to relate to autism risk. Interestingly, variation in this gene also relates to differences in social behaviour in non-clinical populations. Variation in this gene may affect expression of AVPR1a receptors in brain areas involved in social behaviour. Here, we tested whether AVPR1a variation was associated with Autism Quotient (AQ) scores, a questionnaire that measures non-clinical manifestations of autism, in a population of 873 healthy university students. The AVPR1a RS1 and RS3 microsatellites were examined, and variants were categorized as “long” or “short”. The RS3 long/long genotype was significantly associated with a higher AQ score (i.e., a more autistic-like phenotype) for the combined population and for females only. Further examination showed that this relationship was due to a specific RS3 variant, termed the “target allele”, which previous research has linked to reduced altruism and increased marital problems in healthy individuals. We also observed that the relationship between RS3 genotype and AQ score was mainly due to the “attention switching” (the ability to shift attention from one task to another) component of the questionnaire; this ability is commonly impaired in autism spectrum disorders. Overall, our study establishes continuity between the existing AVPR1a research in clinical and non-clinical populations. Our results suggest that vasopressin may exert its effects on social behaviour in part by modulating attentional focus between social and non-social cues. En ligne : http://dx.doi.org/10.1002/aur.1716 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307