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Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder / H. BOZKURT in Autism Research, 14-10 (October 2021)
[article]
Titre : Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : H. BOZKURT, Auteur ; ? ?IM?EK, Auteur ; S. ?AHIN, Auteur Article en page(s) : p.2078-2084 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder Biomarkers Brain Brain-Derived Neurotrophic Factor Child Child, Preschool Humans Hydrocortisone Male Tissue Plasminogen Activator autism brain-derived neurotrophic factor cortisol Index. décimale : PER Périodiques Résumé : Several studies demonstrated biological effects of cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) on human metabolism and central nervous system. Our study investigated the serum levels of tPA along with BDNF and cortisol in children with autism spectrum disorder (ASD). Thirty three male children with ASD ranging in age from 2 to 15?years were selected for the study group and 27 age-matched healthy male children were selected for the control group. The ASD severity was determined by the score on the Autism Behavior Checklist (ABC). The mean cortisol levels for the study group and the control group were 79.1?±?30.2 ng/ml and 60.0?±?25.1 ng/ml, respectively. The mean BDNF levels for the study group and the control group were 5.9?±?2.8 ng/ml and 3.7?±?1.8 ng/ml, respectively. The mean tPA levels for the study group and the control group were 32.9?±?18.5 ng/ml and 25.5?±?15.1 ng/ml, respectively. Cortisol, BDNF and tPA levels were significantly higher in the study group compared to the control group (p?0.001). There was no statistically significant effect in terms of age, ABC total and subscale scores on serum cortisol, BDNF and tPA levels in the study group (p?>?0.05). It may be suggested that elevations may indicate a role in the pathogenesis of ASD or it may be the case that ASD may alter the levels or pathways of these metabolic factors. LAY SUMMARY: The underlying mechanism or a specific metabolic target relevant to autism spectrum disorder (ASD) has not yet been identified. Cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) have biological effects on neuroplasticity but little is known about the role of cortisol and tPA-BDNF pathway in ASD. In the present study focused on male children with ASD, we have found higher blood levels of cortisol, BDNF and tPA than their healthy peers. This is the first clinical study to evaluate the serum tPA levels along with BDNF and cortisol in ASD. The results suggest that several neurotrophic and other related markers should be born in mind while examining children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2582 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-10 (October 2021) . - p.2078-2084[article] Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder [Texte imprimé et/ou numérique] / H. BOZKURT, Auteur ; ? ?IM?EK, Auteur ; S. ?AHIN, Auteur . - p.2078-2084.
Langues : Anglais (eng)
in Autism Research > 14-10 (October 2021) . - p.2078-2084
Mots-clés : Adolescent Autism Spectrum Disorder Biomarkers Brain Brain-Derived Neurotrophic Factor Child Child, Preschool Humans Hydrocortisone Male Tissue Plasminogen Activator autism brain-derived neurotrophic factor cortisol Index. décimale : PER Périodiques Résumé : Several studies demonstrated biological effects of cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) on human metabolism and central nervous system. Our study investigated the serum levels of tPA along with BDNF and cortisol in children with autism spectrum disorder (ASD). Thirty three male children with ASD ranging in age from 2 to 15?years were selected for the study group and 27 age-matched healthy male children were selected for the control group. The ASD severity was determined by the score on the Autism Behavior Checklist (ABC). The mean cortisol levels for the study group and the control group were 79.1?±?30.2 ng/ml and 60.0?±?25.1 ng/ml, respectively. The mean BDNF levels for the study group and the control group were 5.9?±?2.8 ng/ml and 3.7?±?1.8 ng/ml, respectively. The mean tPA levels for the study group and the control group were 32.9?±?18.5 ng/ml and 25.5?±?15.1 ng/ml, respectively. Cortisol, BDNF and tPA levels were significantly higher in the study group compared to the control group (p?0.001). There was no statistically significant effect in terms of age, ABC total and subscale scores on serum cortisol, BDNF and tPA levels in the study group (p?>?0.05). It may be suggested that elevations may indicate a role in the pathogenesis of ASD or it may be the case that ASD may alter the levels or pathways of these metabolic factors. LAY SUMMARY: The underlying mechanism or a specific metabolic target relevant to autism spectrum disorder (ASD) has not yet been identified. Cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) have biological effects on neuroplasticity but little is known about the role of cortisol and tPA-BDNF pathway in ASD. In the present study focused on male children with ASD, we have found higher blood levels of cortisol, BDNF and tPA than their healthy peers. This is the first clinical study to evaluate the serum tPA levels along with BDNF and cortisol in ASD. The results suggest that several neurotrophic and other related markers should be born in mind while examining children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2582 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder / ?eref ?IMSEK in Autism Research, 9-12 (December 2016)
[article]
Titre : Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : ?eref ?IMSEK, Auteur ; ?hsan ÇETIN, Auteur ; Abdullah ÇIM, Auteur ; Sava? KAYA, Auteur Article en page(s) : p.1241-1247 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder inflammation selectin tissue plasminogen activator sPECAM-1 Index. décimale : PER Périodiques Résumé : Although the etiopathology of autism spectrum disorder (ASD) is not clear, immune dysfunction has been proposed as a mechanism for the pathophysiology of ASD. The purpose of this study is to examine serum levels of tissue plasminogen activator (t-PA) and some adhesion molecules in children with ASD that have not been investigated previously in detail. The study group included 35 male children aged from 2 to 9 diagnosed with ASD according to DSM-V criteria. Soluble platelet endothelial adhesion molecule-1 (sPECAM-1), P-selectin, E-selectin, and t-PA in the serum were determined with enzyme-linked immunosorbent assay. Autism behavior check list (ABC) is used for the assessment of ASD severity. The levels of t-PA (P?=?0.025) and E-selectin (P?=?0.007) was detected significantly higher in children with ASD than control group. Serum levels of sPECAM-1 showed statistically significant negative correlation with sensory, body and object-use, language, social, and self-help and total scores in the patient group (r?=??0.349, P?=?0.04; r?=??0.411, P?=?0.01; r?=??0.412, P?=?0.01; r?=??0.417, P?=?0.01, and r?=??0.531, P?0.01, respectively). Serum levels of P-selectin levels showed statistically significant negative correlation with ABC total score in the patient group (r?=??0.378, P?=?0.03). It may be suggested that t-PA, E-selectin, P-selectin, and sPECAM-1 a crucial role in inflammatory conditions in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1638 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
in Autism Research > 9-12 (December 2016) . - p.1241-1247[article] Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder [Texte imprimé et/ou numérique] / ?eref ?IMSEK, Auteur ; ?hsan ÇETIN, Auteur ; Abdullah ÇIM, Auteur ; Sava? KAYA, Auteur . - p.1241-1247.
Langues : Anglais (eng)
in Autism Research > 9-12 (December 2016) . - p.1241-1247
Mots-clés : Autism spectrum disorder inflammation selectin tissue plasminogen activator sPECAM-1 Index. décimale : PER Périodiques Résumé : Although the etiopathology of autism spectrum disorder (ASD) is not clear, immune dysfunction has been proposed as a mechanism for the pathophysiology of ASD. The purpose of this study is to examine serum levels of tissue plasminogen activator (t-PA) and some adhesion molecules in children with ASD that have not been investigated previously in detail. The study group included 35 male children aged from 2 to 9 diagnosed with ASD according to DSM-V criteria. Soluble platelet endothelial adhesion molecule-1 (sPECAM-1), P-selectin, E-selectin, and t-PA in the serum were determined with enzyme-linked immunosorbent assay. Autism behavior check list (ABC) is used for the assessment of ASD severity. The levels of t-PA (P?=?0.025) and E-selectin (P?=?0.007) was detected significantly higher in children with ASD than control group. Serum levels of sPECAM-1 showed statistically significant negative correlation with sensory, body and object-use, language, social, and self-help and total scores in the patient group (r?=??0.349, P?=?0.04; r?=??0.411, P?=?0.01; r?=??0.412, P?=?0.01; r?=??0.417, P?=?0.01, and r?=??0.531, P?0.01, respectively). Serum levels of P-selectin levels showed statistically significant negative correlation with ABC total score in the patient group (r?=??0.378, P?=?0.03). It may be suggested that t-PA, E-selectin, P-selectin, and sPECAM-1 a crucial role in inflammatory conditions in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1638 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298