Effects of repetitive transcranial magnetic stimulation in performing eye–hand integration tasks: Four preliminary studies with children showing low-functioning autism / Simonetta PANERAI in Autism, 18-6 (August 2014)  

Public ISBD [article]  inAutism > 18-6 (August 2014) . - p.638-650 Titre : Effects of repetitive transcranial magnetic stimulation in performing eye–hand integration tasks: Four preliminary studies with children showing low-functioning autism Type de document : Texte imprimé et/ou numérique Auteurs : Simonetta PANERAI, Auteur ; Domenica TASCA, Auteur ; Bartolo LANUZZA, Auteur ; Grazia TRUBIA, Auteur ; Raffaele FERRI, Auteur ; Sabrina MUSSO, Auteur ; Giovanna ALAGONA, Auteur ; Giuseppe DI GUARDO, Auteur ; Concetta BARONE, Auteur ; Maria P. GAGLIONE, Auteur ; Maurizio ELIA, Auteur Article en page(s) : p.638-650 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  premotor cortex  rehabilitation  transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : This report, based on four studies with children with low-functioning autism, aimed at evaluating the effects of repetitive transcranial magnetic stimulation delivered on the left and right premotor cortices on eye–hand integration tasks; defining the long-lasting effects of high-frequency repetitive transcranial magnetic stimulation; and investigating the real efficacy of high-frequency repetitive transcranial magnetic stimulation by comparing three kinds of treatments (high-frequency repetitive transcranial magnetic stimulation, a traditional eye–hand integration training, and both treatments combined). Results showed a significant increase in eye–hand performances only when high-frequency repetitive transcranial magnetic stimulation was delivered on the left premotor cortex; a persistent improvement up to 1 h after the end of the stimulation; better outcomes in the treatment combining high-frequency repetitive transcranial magnetic stimulation and eye–hand integration training. Based on these preliminary findings, further evaluations on the usefulness of high-frequency repetitive transcranial magnetic stimulation in rehabilitation of children with autism are strongly recommended. En ligne : http://dx.doi.org/10.1177/1362361313495717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237 [article] Effects of repetitive transcranial magnetic stimulation in performing eye–hand integration tasks: Four preliminary studies with children showing low-functioning autism [Texte imprimé et/ou numérique] / Simonetta PANERAI, Auteur ; Domenica TASCA, Auteur ; Bartolo LANUZZA, Auteur ; Grazia TRUBIA, Auteur ; Raffaele FERRI, Auteur ; Sabrina MUSSO, Auteur ; Giovanna ALAGONA, Auteur ; Giuseppe DI GUARDO, Auteur ; Concetta BARONE, Auteur ; Maria P. GAGLIONE, Auteur ; Maurizio ELIA, Auteur . - p.638-650. Langues : Anglais (eng) in Autism > 18-6 (August 2014) . - p.638-650 Mots-clés : autism spectrum disorders  premotor cortex  rehabilitation  transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : This report, based on four studies with children with low-functioning autism, aimed at evaluating the effects of repetitive transcranial magnetic stimulation delivered on the left and right premotor cortices on eye–hand integration tasks; defining the long-lasting effects of high-frequency repetitive transcranial magnetic stimulation; and investigating the real efficacy of high-frequency repetitive transcranial magnetic stimulation by comparing three kinds of treatments (high-frequency repetitive transcranial magnetic stimulation, a traditional eye–hand integration training, and both treatments combined). Results showed a significant increase in eye–hand performances only when high-frequency repetitive transcranial magnetic stimulation was delivered on the left premotor cortex; a persistent improvement up to 1 h after the end of the stimulation; better outcomes in the treatment combining high-frequency repetitive transcranial magnetic stimulation and eye–hand integration training. Based on these preliminary findings, further evaluations on the usefulness of high-frequency repetitive transcranial magnetic stimulation in rehabilitation of children with autism are strongly recommended. En ligne : http://dx.doi.org/10.1177/1362361313495717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237

Long-term Cognitive and Behavioral Therapies, Combined with Augmentative Communication, are Related to Uncinate Fasciculus Integrity in Autism / Matteo PARDINI in Journal of Autism and Developmental Disorders, 42-4 (April 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.585-592 Titre : Long-term Cognitive and Behavioral Therapies, Combined with Augmentative Communication, are Related to Uncinate Fasciculus Integrity in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Matteo PARDINI, Auteur ; Maurizio ELIA, Auteur ; Francesco GARACI, Auteur ; Silvia GUIDA, Auteur ; Filadelfo CONIGLIONE, Auteur ; Frank KRUEGER, Auteur ; Francesca BENASSI, Auteur ; Leonardo EMBERTI GIALLORETI, Auteur Année de publication : 2012 Article en page(s) : p.585-592 Langues : Anglais (eng) Mots-clés : Diffusion Tensor Imaging  Autism  Uncinate fasciculus  Cognitive therapy  Long-term rehabilitation Index. décimale : PER Périodiques Résumé : Recent evidence points to white-matter abnormalities as a key factor in autism physiopathology. Using Diffusion Tensor Imaging, we studied white-matter structural properties in a convenience sample of twenty-two subjects with low-functioning autism exposed to long-term augmentative and alternative communication, combined with sessions of cognitive and behavioral therapy. Uncinate fasciculus structural properties correlated significantly with therapy length and early onset, as well as to clinical outcome, independently from IQ, age or symptoms severity at therapy onset. Moreover, adherence to therapy was linked with better clinical outcome and uncinate fasciculus structural integrity. The results point to the capability of a long-term rehabilitation of subjects with low-functioning autism to produce white-matter structural modifications, which could thus play a role in the rehabilitative outcome. En ligne : http://dx.doi.org/10.1007/s10803-011-1281-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Long-term Cognitive and Behavioral Therapies, Combined with Augmentative Communication, are Related to Uncinate Fasciculus Integrity in Autism [Texte imprimé et/ou numérique] / Matteo PARDINI, Auteur ; Maurizio ELIA, Auteur ; Francesco GARACI, Auteur ; Silvia GUIDA, Auteur ; Filadelfo CONIGLIONE, Auteur ; Frank KRUEGER, Auteur ; Francesca BENASSI, Auteur ; Leonardo EMBERTI GIALLORETI, Auteur . - 2012 . - p.585-592. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.585-592 Mots-clés : Diffusion Tensor Imaging  Autism  Uncinate fasciculus  Cognitive therapy  Long-term rehabilitation Index. décimale : PER Périodiques Résumé : Recent evidence points to white-matter abnormalities as a key factor in autism physiopathology. Using Diffusion Tensor Imaging, we studied white-matter structural properties in a convenience sample of twenty-two subjects with low-functioning autism exposed to long-term augmentative and alternative communication, combined with sessions of cognitive and behavioral therapy. Uncinate fasciculus structural properties correlated significantly with therapy length and early onset, as well as to clinical outcome, independently from IQ, age or symptoms severity at therapy onset. Moreover, adherence to therapy was linked with better clinical outcome and uncinate fasciculus structural integrity. The results point to the capability of a long-term rehabilitation of subjects with low-functioning autism to produce white-matter structural modifications, which could thus play a role in the rehabilitative outcome. En ligne : http://dx.doi.org/10.1007/s10803-011-1281-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Principal pathogenetic components and biological endophenotypes in autism spectrum disorders / Roberto SACCO in Autism Research, 3-5 (October 2010)  

Public ISBD [article]  inAutism Research > 3-5 (October 2010) . - p.237-252 Titre : Principal pathogenetic components and biological endophenotypes in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Roberto SACCO, Auteur ; Paolo CURATOLO, Auteur ; Barbara MANZI, Auteur ; Roberto MILITERNI, Auteur ; Carmela BRAVACCIO, Auteur ; Alessandro FROLLI, Auteur ; Carlo LENTI, Auteur ; Monica SACCANI, Auteur ; Maurizio ELIA, Auteur ; Karl-Ludvig REICHELT, Auteur ; Tiziana PASCUCCI, Auteur ; Stefano PUGLISI-ALLEGRA, Auteur ; Antonio M. PERSICO, Auteur Année de publication : 2010 Article en page(s) : p.237-252 Langues : Anglais (eng) Mots-clés : autistic disorder  macrocephaly  neurodevelopment  pervasive developmental disorders  principal component analysis  serotonin Index. décimale : PER Périodiques Résumé : Autism is a complex neurodevelopmental disorder, likely encompassing multiple pathogenetic components. The aim of this study is to begin identifying at least some of these components and to assess their association with biological endophenotypes. To address this issue, we recruited 245 Italian patients with idiopathic autism spectrum disorders and their first-degree relatives. Using a stepwise approach, patient and family history variables were analyzed using principal component analysis (“exploratory phase”), followed by intra- and inter-component cross-correlation analyses (“follow-up phase”), and by testing for association between each component and biological endophenotypes, namely head circumference, serotonin blood levels, and global urinary peptide excretion rates (“biological correlation phase”). Four independent components were identified, namely “circadian & sensory dysfunction,” “immune dysfunction,” “neurodevelopmental delay,” and “stereotypic behavior,” together representing 74.5% of phenotypic variance in our sample. Marker variables in the latter three components are positively associated with macrocephaly, global peptiduria, and serotonin blood levels, respectively. These four components point toward at least four processes associated with autism, namely (I) a disruption of the circadian cycle associated with behavioral and sensory abnormalities, (II) dysreactive immune processes, surprisingly linked both to prenatal obstetric complications and to excessive postnatal body growth rates, (III) a generalized developmental delay, and (IV) an abnormal neural circuitry underlying stereotypies and early social behaviors. En ligne : http://dx.doi.org/10.1002/aur.151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Principal pathogenetic components and biological endophenotypes in autism spectrum disorders [Texte imprimé et/ou numérique] / Roberto SACCO, Auteur ; Paolo CURATOLO, Auteur ; Barbara MANZI, Auteur ; Roberto MILITERNI, Auteur ; Carmela BRAVACCIO, Auteur ; Alessandro FROLLI, Auteur ; Carlo LENTI, Auteur ; Monica SACCANI, Auteur ; Maurizio ELIA, Auteur ; Karl-Ludvig REICHELT, Auteur ; Tiziana PASCUCCI, Auteur ; Stefano PUGLISI-ALLEGRA, Auteur ; Antonio M. PERSICO, Auteur . - 2010 . - p.237-252. Langues : Anglais (eng) in Autism Research > 3-5 (October 2010) . - p.237-252 Mots-clés : autistic disorder  macrocephaly  neurodevelopment  pervasive developmental disorders  principal component analysis  serotonin Index. décimale : PER Périodiques Résumé : Autism is a complex neurodevelopmental disorder, likely encompassing multiple pathogenetic components. The aim of this study is to begin identifying at least some of these components and to assess their association with biological endophenotypes. To address this issue, we recruited 245 Italian patients with idiopathic autism spectrum disorders and their first-degree relatives. Using a stepwise approach, patient and family history variables were analyzed using principal component analysis (“exploratory phase”), followed by intra- and inter-component cross-correlation analyses (“follow-up phase”), and by testing for association between each component and biological endophenotypes, namely head circumference, serotonin blood levels, and global urinary peptide excretion rates (“biological correlation phase”). Four independent components were identified, namely “circadian & sensory dysfunction,” “immune dysfunction,” “neurodevelopmental delay,” and “stereotypic behavior,” together representing 74.5% of phenotypic variance in our sample. Marker variables in the latter three components are positively associated with macrocephaly, global peptiduria, and serotonin blood levels, respectively. These four components point toward at least four processes associated with autism, namely (I) a disruption of the circadian cycle associated with behavioral and sensory abnormalities, (II) dysreactive immune processes, surprisingly linked both to prenatal obstetric complications and to excessive postnatal body growth rates, (III) a generalized developmental delay, and (IV) an abnormal neural circuitry underlying stereotypies and early social behaviors. En ligne : http://dx.doi.org/10.1002/aur.151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

Special Education Versus Inclusive Education: The Role of the TEACCH Program / Simonetta PANERAI in Journal of Autism and Developmental Disorders, 39-6 (June 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-6 (June 2009) . - p.874-882 Titre : Special Education Versus Inclusive Education: The Role of the TEACCH Program Type de document : Texte imprimé et/ou numérique Auteurs : Simonetta PANERAI, Auteur ; Marinella ZINGALE, Auteur ; Grazia TRUBIA, Auteur ; Maria FINOCCHIARO, Auteur ; Rosa ZUCCARELLO, Auteur ; Raffaele FERRI, Auteur ; Maurizio ELIA, Auteur Année de publication : 2009 Article en page(s) : p.874-882 Langues : Anglais (eng) Mots-clés : Autistic-disorder Parent-training Individualized-educational-program Inclusion Index. décimale : PER Périodiques Résumé : Our study aimed at comparing, over a period of 3 years, the effectiveness of three different educational approaches addressed to children with autism and severe mental retardation. The first one was a treatment and education of autistic and related communication handicapped children (TEACCH) program implemented in a residential center; the second was a TEACCH program implemented at home and at mainstream schools, after a specific parent psychoeducational training; the third approach referred to inclusive education in mainstream schools, in which a nonspecific approach was implemented. Each subject was assessed twice, using the Psycho-Educational Profile-Revised (PEP-R) and Vineland Adaptive Behavior Scale (VABS)-survey form. Effectiveness of TEACCH appeared to be confirmed, showing positive outcomes in the natural setting, and revealing its inclusive value. En ligne : http://dx.doi.org/10.1007/s10803-009-0696-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=758 [article] Special Education Versus Inclusive Education: The Role of the TEACCH Program [Texte imprimé et/ou numérique] / Simonetta PANERAI, Auteur ; Marinella ZINGALE, Auteur ; Grazia TRUBIA, Auteur ; Maria FINOCCHIARO, Auteur ; Rosa ZUCCARELLO, Auteur ; Raffaele FERRI, Auteur ; Maurizio ELIA, Auteur . - 2009 . - p.874-882. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-6 (June 2009) . - p.874-882 Mots-clés : Autistic-disorder Parent-training Individualized-educational-program Inclusion Index. décimale : PER Périodiques Résumé : Our study aimed at comparing, over a period of 3 years, the effectiveness of three different educational approaches addressed to children with autism and severe mental retardation. The first one was a treatment and education of autistic and related communication handicapped children (TEACCH) program implemented in a residential center; the second was a TEACCH program implemented at home and at mainstream schools, after a specific parent psychoeducational training; the third approach referred to inclusive education in mainstream schools, in which a nonspecific approach was implemented. Each subject was assessed twice, using the Psycho-Educational Profile-Revised (PEP-R) and Vineland Adaptive Behavior Scale (VABS)-survey form. Effectiveness of TEACCH appeared to be confirmed, showing positive outcomes in the natural setting, and revealing its inclusive value. En ligne : http://dx.doi.org/10.1007/s10803-009-0696-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=758

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