
- <Centre d'Information et de documentation du CRA Rhône-Alpes
- CRA
- Informations pratiques
-
Adresse
Centre d'information et de documentation
Horaires
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexLundi au Vendredi
Contact
9h00-12h00 13h30-16h00Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Adresse
|
[n° ou bulletin]
[n° ou bulletin]
3-5 - October 2010 [Texte imprimé et/ou numérique] . - 2010.
|
Exemplaires (1)
Code-barres | Cote | Support | Localisation | Section | Disponibilité |
---|---|---|---|---|---|
PER0000511 | PER ARI | Périodique | Centre d'Information et de Documentation du CRA Rhône-Alpes | PER - Périodiques | Exclu du prêt |
Dépouillements


White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults / Oswald J.N. BLOEMEN in Autism Research, 3-5 (October 2010)
![]()
[article]
Titre : White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults Type de document : Texte imprimé et/ou numérique Auteurs : Oswald J.N. BLOEMEN, Auteur ; Quinton DEELEY, Auteur ; Fred SUNDRAM, Auteur ; Eileen DALY, Auteur ; Gareth J. BARKER, Auteur ; Derek K. JONES, Auteur ; Therese A.M.J. VAN AMELSVOORT, Auteur ; Nicole SCHMITZ, Auteur ; Dene ROBERTSON, Auteur ; Kieran C. MURPHY, Auteur ; Declan G. MURPHY, Auteur Année de publication : 2010 Article en page(s) : p.203-213 Langues : Anglais (eng) Mots-clés : autism Asperger syndrome white matter DTI connectivity Index. décimale : PER Périodiques Résumé : Background: Autistic Spectrum Disorder (ASD), including Asperger syndrome and autism, is a highly genetic neurodevelopmental disorder. There is a consensus that ASD has a biological basis, and it has been proposed that it is a “connectivity” disorder. Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) allows measurement of the microstructural integrity of white matter (a proxy measure of “connectivity”). However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome. Methods: We measured the fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) of white matter, using DT-MRI, in 13 adults with Asperger syndrome and 13 controls. The groups did not differ significantly in overall intelligence and age. FA, MD and RD were assessed using whole brain voxel-based techniques. Results: Adults with Asperger syndrome had a significantly lower FA than controls in 13 clusters. These were largely bilateral and included white matter in the internal capsule, frontal, temporal, parietal and occipital lobes, cingulum and corpus callosum. Conclusions: Adults with Asperger syndrome have widespread significant differences from controls in white matter microstructural integrity. En ligne : http://dx.doi.org/10.1002/aur.146 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.203-213[article] White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults [Texte imprimé et/ou numérique] / Oswald J.N. BLOEMEN, Auteur ; Quinton DEELEY, Auteur ; Fred SUNDRAM, Auteur ; Eileen DALY, Auteur ; Gareth J. BARKER, Auteur ; Derek K. JONES, Auteur ; Therese A.M.J. VAN AMELSVOORT, Auteur ; Nicole SCHMITZ, Auteur ; Dene ROBERTSON, Auteur ; Kieran C. MURPHY, Auteur ; Declan G. MURPHY, Auteur . - 2010 . - p.203-213.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.203-213
Mots-clés : autism Asperger syndrome white matter DTI connectivity Index. décimale : PER Périodiques Résumé : Background: Autistic Spectrum Disorder (ASD), including Asperger syndrome and autism, is a highly genetic neurodevelopmental disorder. There is a consensus that ASD has a biological basis, and it has been proposed that it is a “connectivity” disorder. Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) allows measurement of the microstructural integrity of white matter (a proxy measure of “connectivity”). However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome. Methods: We measured the fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) of white matter, using DT-MRI, in 13 adults with Asperger syndrome and 13 controls. The groups did not differ significantly in overall intelligence and age. FA, MD and RD were assessed using whole brain voxel-based techniques. Results: Adults with Asperger syndrome had a significantly lower FA than controls in 13 clusters. These were largely bilateral and included white matter in the internal capsule, frontal, temporal, parietal and occipital lobes, cingulum and corpus callosum. Conclusions: Adults with Asperger syndrome have widespread significant differences from controls in white matter microstructural integrity. En ligne : http://dx.doi.org/10.1002/aur.146 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Perception of emotion in musical performance in adolescents with autism spectrum disorders / Anjali BHATARA in Autism Research, 3-5 (October 2010)
![]()
[article]
Titre : Perception of emotion in musical performance in adolescents with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Anjali BHATARA, Auteur ; Eve-Marie QUINTIN, Auteur ; Bianca LEVY, Auteur ; Ursula BELLUGI, Auteur ; Eric FOMBONNE, Auteur ; Daniel J. LEVITIN, Auteur Année de publication : 2010 Article en page(s) : p.214-225 Langues : Anglais (eng) Mots-clés : autism spectrum disorders Asperger syndrome Williams syndrome music emotion perception auditory perception Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) are impaired in understanding the emotional undertones of speech, many of which are communicated through prosody. Musical performance also employs a form of prosody to communicate emotion, and the goal of this study was to examine the ability of adolescents with ASD to understand musical emotion. We designed an experiment in which each musical stimulus served as its own control while we varied the emotional expressivity by manipulating timing and amplitude variation. We asked children and adolescents with ASD and matched controls as well as individuals with Williams syndrome (WS) to rate how emotional these excerpts sounded. Results show that children and adolescents with ASD are impaired relative to matched controls and individuals with WS at judging the difference in emotionality among the expressivity levels. Implications for theories of emotion in autism are discussed in light of these findings. En ligne : http://dx.doi.org/10.1002/aur.147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.214-225[article] Perception of emotion in musical performance in adolescents with autism spectrum disorders [Texte imprimé et/ou numérique] / Anjali BHATARA, Auteur ; Eve-Marie QUINTIN, Auteur ; Bianca LEVY, Auteur ; Ursula BELLUGI, Auteur ; Eric FOMBONNE, Auteur ; Daniel J. LEVITIN, Auteur . - 2010 . - p.214-225.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.214-225
Mots-clés : autism spectrum disorders Asperger syndrome Williams syndrome music emotion perception auditory perception Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) are impaired in understanding the emotional undertones of speech, many of which are communicated through prosody. Musical performance also employs a form of prosody to communicate emotion, and the goal of this study was to examine the ability of adolescents with ASD to understand musical emotion. We designed an experiment in which each musical stimulus served as its own control while we varied the emotional expressivity by manipulating timing and amplitude variation. We asked children and adolescents with ASD and matched controls as well as individuals with Williams syndrome (WS) to rate how emotional these excerpts sounded. Results show that children and adolescents with ASD are impaired relative to matched controls and individuals with WS at judging the difference in emotionality among the expressivity levels. Implications for theories of emotion in autism are discussed in light of these findings. En ligne : http://dx.doi.org/10.1002/aur.147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Prototypical category learning in high-functioning autism / Tony VLADUSICH in Autism Research, 3-5 (October 2010)
![]()
[article]
Titre : Prototypical category learning in high-functioning autism Type de document : Texte imprimé et/ou numérique Auteurs : Tony VLADUSICH, Auteur ; Olufemi OLU-LAFE, Auteur ; Dae-Shik KIM, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Stephen GROSSBERG, Auteur Année de publication : 2010 Article en page(s) : p.226-236 Langues : Anglais (eng) Mots-clés : autism category learning prototype exemplar memory attention vigilance adaptive resonance theory Index. décimale : PER Périodiques Résumé : An ongoing debate in developmental cognitive neuroscience is whether individuals with autism are able to learn prototypical category representations from multiple exemplars. Prototype learning and memory were examined in a group of high-functioning autistic boys and young men, using a classic paradigm in which participants learned to classify novel dot patterns into one of two categories. Participants were trained on distorted versions of category prototypes until they reached a criterion level of performance. During transfer testing, participants were shown the training items together with three novel stimulus sets manifesting variable levels of physical distortion (low, medium, or high distortion) relative to the unseen prototypes. Two experiments were conducted, differing only in the manner in which the physical distortions were defined. In the first experiment, a subset of autistic individuals learned categories more slowly than controls, accompanied by an overall diminution in transfer-testing performance. The autism group did, however, manifest a typical pattern of performance across the testing conditions, relative to controls. In the second experiment, group means did not differ statistically in either the training or testing phases. Taken together, these data indicate that high-functioning autistic individuals do not manifest gross deficits in prototypical category learning. A theoretical discussion is given in terms of how perceptual grouping may interact with category learning. En ligne : http://dx.doi.org/10.1002/aur.148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.226-236[article] Prototypical category learning in high-functioning autism [Texte imprimé et/ou numérique] / Tony VLADUSICH, Auteur ; Olufemi OLU-LAFE, Auteur ; Dae-Shik KIM, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Stephen GROSSBERG, Auteur . - 2010 . - p.226-236.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.226-236
Mots-clés : autism category learning prototype exemplar memory attention vigilance adaptive resonance theory Index. décimale : PER Périodiques Résumé : An ongoing debate in developmental cognitive neuroscience is whether individuals with autism are able to learn prototypical category representations from multiple exemplars. Prototype learning and memory were examined in a group of high-functioning autistic boys and young men, using a classic paradigm in which participants learned to classify novel dot patterns into one of two categories. Participants were trained on distorted versions of category prototypes until they reached a criterion level of performance. During transfer testing, participants were shown the training items together with three novel stimulus sets manifesting variable levels of physical distortion (low, medium, or high distortion) relative to the unseen prototypes. Two experiments were conducted, differing only in the manner in which the physical distortions were defined. In the first experiment, a subset of autistic individuals learned categories more slowly than controls, accompanied by an overall diminution in transfer-testing performance. The autism group did, however, manifest a typical pattern of performance across the testing conditions, relative to controls. In the second experiment, group means did not differ statistically in either the training or testing phases. Taken together, these data indicate that high-functioning autistic individuals do not manifest gross deficits in prototypical category learning. A theoretical discussion is given in terms of how perceptual grouping may interact with category learning. En ligne : http://dx.doi.org/10.1002/aur.148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Principal pathogenetic components and biological endophenotypes in autism spectrum disorders / Roberto SACCO in Autism Research, 3-5 (October 2010)
![]()
[article]
Titre : Principal pathogenetic components and biological endophenotypes in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Roberto SACCO, Auteur ; Paolo CURATOLO, Auteur ; Barbara MANZI, Auteur ; Roberto MILITERNI, Auteur ; Carmela BRAVACCIO, Auteur ; Alessandro FROLLI, Auteur ; Carlo LENTI, Auteur ; Monica SACCANI, Auteur ; Maurizio ELIA, Auteur ; Karl-Ludvig REICHELT, Auteur ; Tiziana PASCUCCI, Auteur ; Stefano PUGLISI-ALLEGRA, Auteur ; Antonio M. PERSICO, Auteur Année de publication : 2010 Article en page(s) : p.237-252 Langues : Anglais (eng) Mots-clés : autistic disorder macrocephaly neurodevelopment pervasive developmental disorders principal component analysis serotonin Index. décimale : PER Périodiques Résumé : Autism is a complex neurodevelopmental disorder, likely encompassing multiple pathogenetic components. The aim of this study is to begin identifying at least some of these components and to assess their association with biological endophenotypes. To address this issue, we recruited 245 Italian patients with idiopathic autism spectrum disorders and their first-degree relatives. Using a stepwise approach, patient and family history variables were analyzed using principal component analysis (“exploratory phase”), followed by intra- and inter-component cross-correlation analyses (“follow-up phase”), and by testing for association between each component and biological endophenotypes, namely head circumference, serotonin blood levels, and global urinary peptide excretion rates (“biological correlation phase”). Four independent components were identified, namely “circadian & sensory dysfunction,” “immune dysfunction,” “neurodevelopmental delay,” and “stereotypic behavior,” together representing 74.5% of phenotypic variance in our sample. Marker variables in the latter three components are positively associated with macrocephaly, global peptiduria, and serotonin blood levels, respectively. These four components point toward at least four processes associated with autism, namely (I) a disruption of the circadian cycle associated with behavioral and sensory abnormalities, (II) dysreactive immune processes, surprisingly linked both to prenatal obstetric complications and to excessive postnatal body growth rates, (III) a generalized developmental delay, and (IV) an abnormal neural circuitry underlying stereotypies and early social behaviors. En ligne : http://dx.doi.org/10.1002/aur.151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.237-252[article] Principal pathogenetic components and biological endophenotypes in autism spectrum disorders [Texte imprimé et/ou numérique] / Roberto SACCO, Auteur ; Paolo CURATOLO, Auteur ; Barbara MANZI, Auteur ; Roberto MILITERNI, Auteur ; Carmela BRAVACCIO, Auteur ; Alessandro FROLLI, Auteur ; Carlo LENTI, Auteur ; Monica SACCANI, Auteur ; Maurizio ELIA, Auteur ; Karl-Ludvig REICHELT, Auteur ; Tiziana PASCUCCI, Auteur ; Stefano PUGLISI-ALLEGRA, Auteur ; Antonio M. PERSICO, Auteur . - 2010 . - p.237-252.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.237-252
Mots-clés : autistic disorder macrocephaly neurodevelopment pervasive developmental disorders principal component analysis serotonin Index. décimale : PER Périodiques Résumé : Autism is a complex neurodevelopmental disorder, likely encompassing multiple pathogenetic components. The aim of this study is to begin identifying at least some of these components and to assess their association with biological endophenotypes. To address this issue, we recruited 245 Italian patients with idiopathic autism spectrum disorders and their first-degree relatives. Using a stepwise approach, patient and family history variables were analyzed using principal component analysis (“exploratory phase”), followed by intra- and inter-component cross-correlation analyses (“follow-up phase”), and by testing for association between each component and biological endophenotypes, namely head circumference, serotonin blood levels, and global urinary peptide excretion rates (“biological correlation phase”). Four independent components were identified, namely “circadian & sensory dysfunction,” “immune dysfunction,” “neurodevelopmental delay,” and “stereotypic behavior,” together representing 74.5% of phenotypic variance in our sample. Marker variables in the latter three components are positively associated with macrocephaly, global peptiduria, and serotonin blood levels, respectively. These four components point toward at least four processes associated with autism, namely (I) a disruption of the circadian cycle associated with behavioral and sensory abnormalities, (II) dysreactive immune processes, surprisingly linked both to prenatal obstetric complications and to excessive postnatal body growth rates, (III) a generalized developmental delay, and (IV) an abnormal neural circuitry underlying stereotypies and early social behaviors. En ligne : http://dx.doi.org/10.1002/aur.151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Multisensory processing in children with autism: high-density electrical mapping of auditory–somatosensory integration / Natalie RUSSO in Autism Research, 3-5 (October 2010)
![]()
[article]
Titre : Multisensory processing in children with autism: high-density electrical mapping of auditory–somatosensory integration Type de document : Texte imprimé et/ou numérique Auteurs : Natalie RUSSO, Auteur ; John J. FOXE, Auteur ; Alice B. BRANDWEIN, Auteur ; Ted ALTSCHULER, Auteur ; Hilary GOMES, Auteur ; Sophie MOLHOLM, Auteur Année de publication : 2010 Article en page(s) : p.253-267 Langues : Anglais (eng) Mots-clés : autism spectrum disorders electrophysiology multisensory integration auditory processing somatosensory processing development Index. décimale : PER Périodiques Résumé : Successful integration of signals from the various sensory systems is crucial for normal sensory–perceptual functioning, allowing for the perception of coherent objects rather than a disconnected cluster of fragmented features. Several prominent theories of autism suggest that automatic integration is impaired in this population, but there have been few empirical tests of this thesis. A standard electrophysiological metric of multisensory integration (MSI) was used to test the integrity of auditory–somatosensory integration in children with autism (N=17, aged 6–16 years), compared to age- and IQ-matched typically developing (TD) children. High-density electrophysiology was recorded while participants were presented with either auditory or somatosensory stimuli alone (unisensory conditions), or as a combined auditory–somatosensory stimulus (multisensory condition), in randomized order. Participants watched a silent movie during testing, ignoring concurrent stimulation. Significant differences between neural responses to the multisensory auditory–somatosensory stimulus and the unisensory stimuli (the sum of the responses to the auditory and somatosensory stimuli when presented alone) served as the dependent measure. The data revealed group differences in the integration of auditory and somatosensory information that appeared at around 175 ms, and were characterized by the presence of MSI for the TD but not the autism spectrum disorder (ASD) children. Overall, MSI was less extensive in the ASD group. These findings are discussed within the framework of current knowledge of MSI in typical development as well as in relation to theories of ASD. En ligne : http://dx.doi.org/10.1002/aur.152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.253-267[article] Multisensory processing in children with autism: high-density electrical mapping of auditory–somatosensory integration [Texte imprimé et/ou numérique] / Natalie RUSSO, Auteur ; John J. FOXE, Auteur ; Alice B. BRANDWEIN, Auteur ; Ted ALTSCHULER, Auteur ; Hilary GOMES, Auteur ; Sophie MOLHOLM, Auteur . - 2010 . - p.253-267.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.253-267
Mots-clés : autism spectrum disorders electrophysiology multisensory integration auditory processing somatosensory processing development Index. décimale : PER Périodiques Résumé : Successful integration of signals from the various sensory systems is crucial for normal sensory–perceptual functioning, allowing for the perception of coherent objects rather than a disconnected cluster of fragmented features. Several prominent theories of autism suggest that automatic integration is impaired in this population, but there have been few empirical tests of this thesis. A standard electrophysiological metric of multisensory integration (MSI) was used to test the integrity of auditory–somatosensory integration in children with autism (N=17, aged 6–16 years), compared to age- and IQ-matched typically developing (TD) children. High-density electrophysiology was recorded while participants were presented with either auditory or somatosensory stimuli alone (unisensory conditions), or as a combined auditory–somatosensory stimulus (multisensory condition), in randomized order. Participants watched a silent movie during testing, ignoring concurrent stimulation. Significant differences between neural responses to the multisensory auditory–somatosensory stimulus and the unisensory stimuli (the sum of the responses to the auditory and somatosensory stimuli when presented alone) served as the dependent measure. The data revealed group differences in the integration of auditory and somatosensory information that appeared at around 175 ms, and were characterized by the presence of MSI for the TD but not the autism spectrum disorder (ASD) children. Overall, MSI was less extensive in the ASD group. These findings are discussed within the framework of current knowledge of MSI in typical development as well as in relation to theories of ASD. En ligne : http://dx.doi.org/10.1002/aur.152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Is there a role for routinely screening children with autism spectrum disorder for creatine deficiency syndrome? / Lv WANG in Autism Research, 3-5 (October 2010)
![]()
[article]
Titre : Is there a role for routinely screening children with autism spectrum disorder for creatine deficiency syndrome? Type de document : Texte imprimé et/ou numérique Auteurs : Lv WANG, Auteur ; Manya T. ANGLEY, Auteur ; Michael J. SORICH, Auteur ; Robyn L. YOUNG, Auteur ; Ross A. MCKINNON, Auteur ; Jacobus P. GERBER, Auteur Année de publication : 2010 Article en page(s) : p.268-272 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD) creatine deficiency syndrome (CDS) creatine (CR) guanidinoacetate (GAA) liquid chromatography tandem mass spectrometry (LC-MS/MS) diagnostic biomarkers Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that presents in the first three years of life. Currently, diagnosis of ASD is based on its behavioural manifestations, as laboratory diagnostic tests do not exist. Creatine deficiency syndrome (CDS) is one form of inborn error of metabolism where affected individuals have similar clinical features to individuals with ASD. Abnormal urinary creatine (CR) and guanidinoacetate (GAA) levels have been reported as biomarkers of CDS. We hypothesized that screening for abnormal levels of urinary CR and GAA in children with ASD may assist in identifying a subgroup of ASD individuals who can be managed with dietary interventions. Morning urine samples were collected from children with and without autism and analyzed for CR and GAA levels. Results showed there was no statistically significant difference in urinary CR:creatinine and GAA:creatinine between the children with ASD and sibling or unrelated controls. In conclusion, routine screening for abnormal urinary CR and GAA could be considered in ASD diagnostic protocols; however, individuals positive for CDS are likely to be rare in an ASD cohort. En ligne : http://dx.doi.org/10.1002/aur.145 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.268-272[article] Is there a role for routinely screening children with autism spectrum disorder for creatine deficiency syndrome? [Texte imprimé et/ou numérique] / Lv WANG, Auteur ; Manya T. ANGLEY, Auteur ; Michael J. SORICH, Auteur ; Robyn L. YOUNG, Auteur ; Ross A. MCKINNON, Auteur ; Jacobus P. GERBER, Auteur . - 2010 . - p.268-272.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.268-272
Mots-clés : autism spectrum disorder (ASD) creatine deficiency syndrome (CDS) creatine (CR) guanidinoacetate (GAA) liquid chromatography tandem mass spectrometry (LC-MS/MS) diagnostic biomarkers Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that presents in the first three years of life. Currently, diagnosis of ASD is based on its behavioural manifestations, as laboratory diagnostic tests do not exist. Creatine deficiency syndrome (CDS) is one form of inborn error of metabolism where affected individuals have similar clinical features to individuals with ASD. Abnormal urinary creatine (CR) and guanidinoacetate (GAA) levels have been reported as biomarkers of CDS. We hypothesized that screening for abnormal levels of urinary CR and GAA in children with ASD may assist in identifying a subgroup of ASD individuals who can be managed with dietary interventions. Morning urine samples were collected from children with and without autism and analyzed for CR and GAA levels. Results showed there was no statistically significant difference in urinary CR:creatinine and GAA:creatinine between the children with ASD and sibling or unrelated controls. In conclusion, routine screening for abnormal urinary CR and GAA could be considered in ASD diagnostic protocols; however, individuals positive for CDS are likely to be rare in an ASD cohort. En ligne : http://dx.doi.org/10.1002/aur.145 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Cortical underconnectivity coupled with preserved visuospatial cognition in autism: Evidence from an fMRI study of an embedded figures task / Saudamini Roy DAMARLA in Autism Research, 3-5 (October 2010)
![]()
[article]
Titre : Cortical underconnectivity coupled with preserved visuospatial cognition in autism: Evidence from an fMRI study of an embedded figures task Type de document : Texte imprimé et/ou numérique Auteurs : Saudamini Roy DAMARLA, Auteur ; Timothy A. KELLER, Auteur ; Rajesh K. KANA, Auteur ; Vladimir L. CHERKASSKY, Auteur ; Diane L. WILLIAMS, Auteur ; Nancy J. MINSHEW, Auteur ; Marcel Adam JUST, Auteur Année de publication : 2010 Article en page(s) : p.273-279 Langues : Anglais (eng) Mots-clés : embedded figures task functional connectivity corpus callosum functional MRI Index. décimale : PER Périodiques Résumé : Individuals with high-functioning autism sometimes exhibit intact or superior performance on visuospatial tasks, in contrast to impaired functioning in other domains such as language comprehension, executive tasks, and social functions. The goal of the current study was to investigate the neural bases of preserved visuospatial processing in high-functioning autism from the perspective of the cortical underconnectivity theory. We used a combination of behavioral, functional magnetic resonance imaging, functional connectivity, and corpus callosum morphometric methodological tools. Thirteen participants with high-functioning autism and 13 controls (age-, IQ-, and gender-matched) were scanned while performing an Embedded Figures Task. Despite the ability of the autism group to attain behavioral performance comparable to the control group, the brain imaging results revealed several group differences consistent with the cortical underconnectivity account of autism. First, relative to controls, the autism group showed less activation in the left dorsolateral prefrontal and inferior parietal areas and more activation in visuospatial (bilateral superior parietal extending to inferior parietal and right occipital) areas. Second, the autism group demonstrated lower functional connectivity between higher-order working memory/executive areas and visuospatial regions (between frontal and parietal-occipital). Third, the size of the corpus callosum (an index of anatomical connectivity) was positively correlated with frontal–posterior (parietal and occipital) functional connectivity in the autism group. Thus, even in the visuospatial domain, where preserved performance among people with autism is observed, the neuroimaging signatures of cortical underconnectivity persist. En ligne : http://dx.doi.org/10.1002/aur.153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.273-279[article] Cortical underconnectivity coupled with preserved visuospatial cognition in autism: Evidence from an fMRI study of an embedded figures task [Texte imprimé et/ou numérique] / Saudamini Roy DAMARLA, Auteur ; Timothy A. KELLER, Auteur ; Rajesh K. KANA, Auteur ; Vladimir L. CHERKASSKY, Auteur ; Diane L. WILLIAMS, Auteur ; Nancy J. MINSHEW, Auteur ; Marcel Adam JUST, Auteur . - 2010 . - p.273-279.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.273-279
Mots-clés : embedded figures task functional connectivity corpus callosum functional MRI Index. décimale : PER Périodiques Résumé : Individuals with high-functioning autism sometimes exhibit intact or superior performance on visuospatial tasks, in contrast to impaired functioning in other domains such as language comprehension, executive tasks, and social functions. The goal of the current study was to investigate the neural bases of preserved visuospatial processing in high-functioning autism from the perspective of the cortical underconnectivity theory. We used a combination of behavioral, functional magnetic resonance imaging, functional connectivity, and corpus callosum morphometric methodological tools. Thirteen participants with high-functioning autism and 13 controls (age-, IQ-, and gender-matched) were scanned while performing an Embedded Figures Task. Despite the ability of the autism group to attain behavioral performance comparable to the control group, the brain imaging results revealed several group differences consistent with the cortical underconnectivity account of autism. First, relative to controls, the autism group showed less activation in the left dorsolateral prefrontal and inferior parietal areas and more activation in visuospatial (bilateral superior parietal extending to inferior parietal and right occipital) areas. Second, the autism group demonstrated lower functional connectivity between higher-order working memory/executive areas and visuospatial regions (between frontal and parietal-occipital). Third, the size of the corpus callosum (an index of anatomical connectivity) was positively correlated with frontal–posterior (parietal and occipital) functional connectivity in the autism group. Thus, even in the visuospatial domain, where preserved performance among people with autism is observed, the neuroimaging signatures of cortical underconnectivity persist. En ligne : http://dx.doi.org/10.1002/aur.153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Enhanced connectivity between visual cortex and other regions of the brain in autism: a REM sleep EEG coherence study / Cathy LEVEILLE in Autism Research, 3-5 (October 2010)
![]()
[article]
Titre : Enhanced connectivity between visual cortex and other regions of the brain in autism: a REM sleep EEG coherence study Type de document : Texte imprimé et/ou numérique Auteurs : Cathy LEVEILLE, Auteur ; Elise B. BARBEAU, Auteur ; Christianne BOLDUC, Auteur ; Elyse LIMOGES, Auteur ; Claude BERTHIAUME, Auteur ; Elyse CHEVRIER, Auteur ; Laurent MOTTRON, Auteur ; Roger GODBOUT, Auteur Année de publication : 2010 Article en page(s) : p.280-285 Langues : Anglais (eng) Mots-clés : autism occipital cortex REM sleep EEG EEG coherence visual perception neural coupling Index. décimale : PER Périodiques Résumé : Functional interregional neural coupling was measured as EEG coherence during REM sleep, a state of endogenous cortical activation, in 9 adult autistic individuals (21.1±4.0 years) and 13 typically developed controls (21.5±4.3 years) monitored for two consecutive nights in a sleep laboratory. Spectral analysis was performed on 60 s of artefact-free EEG samples distributed equally throughout the first four REM sleep periods of the second night. EEG coherence was calculated for six frequency bands (delta, theta, alpha, sigma, beta, and total spectrum) using a 22-electrode montage. The magnitude of coherence function was computed for intra- and interhemispheric pairs of recording sites. Results were compared by Multivariate Analysis of Variance (MANOVA). Each time the autistic group showed a greater EEG coherence than the controls; it involved intrahemispheric communication among the left visual cortex (O1) and other regions either close to or distant from the occipital cortex. In contrast, lower coherence values involved frontal electrodes in the right hemisphere. No significant differences between groups were found for interhemispheric EEG coherence. These results show that the analysis of EEG coherence during REM sleep can disclose patterns of cortical connectivity that can be reduced or increased in adults with autism compared to typically developed individuals, depending of the cortical areas studied. Superior coherence involving visual perceptual areas in autism is consistent with an enhanced role of perception in autistic brain organization. En ligne : http://dx.doi.org/10.1002/aur.155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.280-285[article] Enhanced connectivity between visual cortex and other regions of the brain in autism: a REM sleep EEG coherence study [Texte imprimé et/ou numérique] / Cathy LEVEILLE, Auteur ; Elise B. BARBEAU, Auteur ; Christianne BOLDUC, Auteur ; Elyse LIMOGES, Auteur ; Claude BERTHIAUME, Auteur ; Elyse CHEVRIER, Auteur ; Laurent MOTTRON, Auteur ; Roger GODBOUT, Auteur . - 2010 . - p.280-285.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.280-285
Mots-clés : autism occipital cortex REM sleep EEG EEG coherence visual perception neural coupling Index. décimale : PER Périodiques Résumé : Functional interregional neural coupling was measured as EEG coherence during REM sleep, a state of endogenous cortical activation, in 9 adult autistic individuals (21.1±4.0 years) and 13 typically developed controls (21.5±4.3 years) monitored for two consecutive nights in a sleep laboratory. Spectral analysis was performed on 60 s of artefact-free EEG samples distributed equally throughout the first four REM sleep periods of the second night. EEG coherence was calculated for six frequency bands (delta, theta, alpha, sigma, beta, and total spectrum) using a 22-electrode montage. The magnitude of coherence function was computed for intra- and interhemispheric pairs of recording sites. Results were compared by Multivariate Analysis of Variance (MANOVA). Each time the autistic group showed a greater EEG coherence than the controls; it involved intrahemispheric communication among the left visual cortex (O1) and other regions either close to or distant from the occipital cortex. In contrast, lower coherence values involved frontal electrodes in the right hemisphere. No significant differences between groups were found for interhemispheric EEG coherence. These results show that the analysis of EEG coherence during REM sleep can disclose patterns of cortical connectivity that can be reduced or increased in adults with autism compared to typically developed individuals, depending of the cortical areas studied. Superior coherence involving visual perceptual areas in autism is consistent with an enhanced role of perception in autistic brain organization. En ligne : http://dx.doi.org/10.1002/aur.155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Multiparameter Classification Approach to Structural Neuroimaging Data; Heterogeneity of 16p11.2 Microdeletion Clinical Presentation / Edwin H. Jr COOK in Autism Research, 3-5 (October 2010)
![]()
[article]
Titre : Multiparameter Classification Approach to Structural Neuroimaging Data; Heterogeneity of 16p11.2 Microdeletion Clinical Presentation Type de document : Texte imprimé et/ou numérique Auteurs : Edwin H. Jr COOK, Auteur Année de publication : 2010 Article en page(s) : p.286-287 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.166 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.286-287[article] Multiparameter Classification Approach to Structural Neuroimaging Data; Heterogeneity of 16p11.2 Microdeletion Clinical Presentation [Texte imprimé et/ou numérique] / Edwin H. Jr COOK, Auteur . - 2010 . - p.286-287.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.286-287
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.166 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
[article]
Titre : Lay abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2010 Article en page(s) : p.288-290 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.167 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.288-290[article] Lay abstracts [Texte imprimé et/ou numérique] . - 2010 . - p.288-290.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.288-290
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.167 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
[article]
Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Année de publication : 2010 Article en page(s) : p.291 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-5 (October 2010) . - p.291[article] International Society for Autism Research News [Texte imprimé et/ou numérique] . - 2010 . - p.291.
Langues : Anglais (eng)
in Autism Research > 3-5 (October 2010) . - p.291
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115