[article] 
inJournal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1541-1548

Titre :	Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Armando BERTONE, Auteur ; Julie HANCK, Auteur ; Cary KOGAN, Auteur ; Avi CHAUDHURI, Auteur ; Kim CORNISH, Auteur
Année de publication :	2010
Article en page(s) :	p.1541-1548
Langues :	Anglais (eng)
Mots-clés :	Autism  Fragile X syndrome  Vision  Neural networks  Causal model  Genetics
Index. décimale :	PER Périodiques
Résumé :	We have previously described (see companion paper, this issue) the utility of using perceptual signatures for defining and dissociating condition-specific neural functioning underlying early visual processes in autism and FXS. These perceptually-driven hypotheses are based on differential performance evidenced only at the earliest stages of visual information processing, mediated by local neural network functioning. In this paper, we first review how most large-scale neural models are unable to address atypical low-level perceptual functioning in autism, and then suggest how condition-specific, local neural endophenotypes (described in our companion paper) can be incorporated into causal models to infer target candidate gene or gene clusters that are implicated in autism’s pathogenesis. The usefulness of such a translational research approach is discussed.
En ligne :	http://dx.doi.org/10.1007/s10803-010-1110-z
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

[article] Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling [Texte imprimé et/ou numérique] / Armando BERTONE, Auteur ; Julie HANCK, Auteur ; Cary KOGAN, Auteur ; Avi CHAUDHURI, Auteur ; Kim CORNISH, Auteur . - 2010 . - p.1541-1548.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1541-1548

Mots-clés :	Autism  Fragile X syndrome  Vision  Neural networks  Causal model  Genetics
Index. décimale :	PER Périodiques
Résumé :	We have previously described (see companion paper, this issue) the utility of using perceptual signatures for defining and dissociating condition-specific neural functioning underlying early visual processes in autism and FXS. These perceptually-driven hypotheses are based on differential performance evidenced only at the earliest stages of visual information processing, mediated by local neural network functioning. In this paper, we first review how most large-scale neural models are unable to address atypical low-level perceptual functioning in autism, and then suggest how condition-specific, local neural endophenotypes (described in our companion paper) can be incorporated into causal models to infer target candidate gene or gene clusters that are implicated in autism’s pathogenesis. The usefulness of such a translational research approach is discussed.
En ligne :	http://dx.doi.org/10.1007/s10803-010-1110-z
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114