Brief Report: Parental Age and the Sex Ratio in Autism / Alene ANELLO in Journal of Autism and Developmental Disorders, 39-10 (October 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-10 (October 2009) . - p.1487-1492 Titre : Brief Report: Parental Age and the Sex Ratio in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Alene ANELLO, Auteur ; Eric HOLLANDER, Auteur ; Christopher J. SMITH, Auteur ; Lauren KRYZAK, Auteur ; Abraham REICHENBERG, Auteur ; Jeremy M. SILVERMAN, Auteur ; Xiaodong LUO, Auteur ; James SCHMEIDLER, Auteur ; Connor M. PULEO, Auteur Année de publication : 2009 Article en page(s) : p.1487-1492 Langues : Anglais (eng) Mots-clés : Paternal-age Maternal-age Sex-ratio Genetics Genomic-anomalies Copy-number-variants Index. décimale : PER Périodiques Résumé : The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30–34, 35–39, 40–44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children. En ligne : http://dx.doi.org/10.1007/s10803-009-0755-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=840 [article] Brief Report: Parental Age and the Sex Ratio in Autism [Texte imprimé et/ou numérique] / Alene ANELLO, Auteur ; Eric HOLLANDER, Auteur ; Christopher J. SMITH, Auteur ; Lauren KRYZAK, Auteur ; Abraham REICHENBERG, Auteur ; Jeremy M. SILVERMAN, Auteur ; Xiaodong LUO, Auteur ; James SCHMEIDLER, Auteur ; Connor M. PULEO, Auteur . - 2009 . - p.1487-1492. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-10 (October 2009) . - p.1487-1492 Mots-clés : Paternal-age Maternal-age Sex-ratio Genetics Genomic-anomalies Copy-number-variants Index. décimale : PER Périodiques Résumé : The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30–34, 35–39, 40–44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children. En ligne : http://dx.doi.org/10.1007/s10803-009-0755-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=840

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