An Exploratory Analysis of the Impact of Family Functioning on Treatment for Depression in Adolescents / Norah C. FEENY in Journal of Clinical Child & Adolescent Psychology, 38-6 (November-December 2009)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 38-6 (November-December 2009) . - p.814-825 Titre : An Exploratory Analysis of the Impact of Family Functioning on Treatment for Depression in Adolescents Type de document : texte imprimé Auteurs : Norah C. FEENY, Auteur ; John S. MARCH, Auteur ; Anne D. SIMONS, Auteur ; Diane E. MAY, Auteur ; Paul ROHDE, Auteur ; Robert L. FINDLING, Auteur ; Steven MCNULTY, Auteur ; David R. ROSENBERG, Auteur ; Sanjeev PATHAK, Auteur ; Christopher J. KRATOCHVIL, Auteur ; Betsy KENNARD, Auteur ; Susan G. SILVA, Auteur ; Golda S. GINSBURG, Auteur ; Mark A. REINECKE, Auteur ; John F. CURRY, Auteur ; Karen WELLS, Auteur ; Michele ROBINS, Auteur Année de publication : 2009 Article en page(s) : p.814-825 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This article explores aspects of family environment and parent-child conflict that may predict or moderate response to acute treatments among depressed adolescents (N = 439) randomly assigned to fluoxetine, cognitive behavioral therapy, their combination, or placebo. Outcomes were Week 12 scores on measures of depression and global impairment. Of 20 candidate variables, one predictor emerged: Across treatments, adolescents with mothers who reported less parent-child conflict were more likely to benefit than their counterparts. When family functioning moderated outcome, adolescents who endorsed more negative environments were more likely to benefit from fluoxetine. Similarly, when moderating effects were seen on cognitive behavioral therapy conditions, they were in the direction of being less effective among teens reporting poorer family environments. En ligne : http://dx.doi.org/10.1080/15374410903297148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=881 [article] An Exploratory Analysis of the Impact of Family Functioning on Treatment for Depression in Adolescents [texte imprimé] / Norah C. FEENY, Auteur ; John S. MARCH, Auteur ; Anne D. SIMONS, Auteur ; Diane E. MAY, Auteur ; Paul ROHDE, Auteur ; Robert L. FINDLING, Auteur ; Steven MCNULTY, Auteur ; David R. ROSENBERG, Auteur ; Sanjeev PATHAK, Auteur ; Christopher J. KRATOCHVIL, Auteur ; Betsy KENNARD, Auteur ; Susan G. SILVA, Auteur ; Golda S. GINSBURG, Auteur ; Mark A. REINECKE, Auteur ; John F. CURRY, Auteur ; Karen WELLS, Auteur ; Michele ROBINS, Auteur . - 2009 . - p.814-825. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 38-6 (November-December 2009) . - p.814-825 Index. décimale : PER Périodiques Résumé : This article explores aspects of family environment and parent-child conflict that may predict or moderate response to acute treatments among depressed adolescents (N = 439) randomly assigned to fluoxetine, cognitive behavioral therapy, their combination, or placebo. Outcomes were Week 12 scores on measures of depression and global impairment. Of 20 candidate variables, one predictor emerged: Across treatments, adolescents with mothers who reported less parent-child conflict were more likely to benefit than their counterparts. When family functioning moderated outcome, adolescents who endorsed more negative environments were more likely to benefit from fluoxetine. Similarly, when moderating effects were seen on cognitive behavioral therapy conditions, they were in the direction of being less effective among teens reporting poorer family environments. En ligne : http://dx.doi.org/10.1080/15374410903297148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=881

The Dysfunctional Attitudes Scale: Psychometric Properties in Depressed Adolescents / Gregory M. ROGERS in Journal of Clinical Child & Adolescent Psychology, 38-6 (November-December 2009)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 38-6 (November-December 2009) . - p.781-789 Titre : The Dysfunctional Attitudes Scale: Psychometric Properties in Depressed Adolescents Type de document : texte imprimé Auteurs : Gregory M. ROGERS, Auteur ; John S. MARCH, Auteur ; David R. ROSENBERG, Auteur ; Sanjeev PATHAK, Auteur ; Christopher J. KRATOCHVIL, Auteur ; Betsy KENNARD, Auteur ; Norah C. FEENY, Auteur ; Rick H. HOYLE, Auteur ; Susan G. SILVA, Auteur ; Mark A. REINECKE, Auteur ; Marjorie H. KLEIN, Auteur ; Marilyn J. ESSEX, Auteur ; Jong-Hyo PARK, Auteur ; John F. CURRY, Auteur ; Elizabeth B. WELLER, Auteur Année de publication : 2009 Article en page(s) : p.781-789 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The psychometric properties and factor structure of the Dysfunctional Attitudes Scale were examined in a sample of 422 male and female adolescents (ages 12-17) with current major depressive disorder. The scale demonstrated high internal consistency ( = .93) and correlated significantly with self-report and interview-based measures of depression. Confirmatory factor analysis indicated that a correlated 2-factor model, with scales corresponding to perfectionism and need for social approval, provided a satisfactory fit to the data. The goodness-of-fit was equivalent across sexes and age groups. The findings support the use of the Dysfunctional Attitudes Scale and its subscales in the assessment of clinically depressed adolescents. En ligne : http://dx.doi.org/10.1080/15374410903259007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=880 [article] The Dysfunctional Attitudes Scale: Psychometric Properties in Depressed Adolescents [texte imprimé] / Gregory M. ROGERS, Auteur ; John S. MARCH, Auteur ; David R. ROSENBERG, Auteur ; Sanjeev PATHAK, Auteur ; Christopher J. KRATOCHVIL, Auteur ; Betsy KENNARD, Auteur ; Norah C. FEENY, Auteur ; Rick H. HOYLE, Auteur ; Susan G. SILVA, Auteur ; Mark A. REINECKE, Auteur ; Marjorie H. KLEIN, Auteur ; Marilyn J. ESSEX, Auteur ; Jong-Hyo PARK, Auteur ; John F. CURRY, Auteur ; Elizabeth B. WELLER, Auteur . - 2009 . - p.781-789. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 38-6 (November-December 2009) . - p.781-789 Index. décimale : PER Périodiques Résumé : The psychometric properties and factor structure of the Dysfunctional Attitudes Scale were examined in a sample of 422 male and female adolescents (ages 12-17) with current major depressive disorder. The scale demonstrated high internal consistency ( = .93) and correlated significantly with self-report and interview-based measures of depression. Confirmatory factor analysis indicated that a correlated 2-factor model, with scales corresponding to perfectionism and need for social approval, provided a satisfactory fit to the data. The goodness-of-fit was equivalent across sexes and age groups. The findings support the use of the Dysfunctional Attitudes Scale and its subscales in the assessment of clinically depressed adolescents. En ligne : http://dx.doi.org/10.1080/15374410903259007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=880

Uncovering obsessive-compulsive disorder risk genes in a pediatric cohort by high-resolution analysis of copy number variation / MatthewJ GAZZELLONE in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.36 Titre : Uncovering obsessive-compulsive disorder risk genes in a pediatric cohort by high-resolution analysis of copy number variation Type de document : texte imprimé Auteurs : MatthewJ GAZZELLONE, Auteur ; Mehdi ZARREI, Auteur ; Christie L. BURTON, Auteur ; Susan WALKER, Auteur ; Mohammed UDDIN, Auteur ; S.M. SHAHEEN, Auteur ; Julie COSTE, Auteur ; Rageen RAJENDRAM, Auteur ; Reva J. SCHACHTER, Auteur ; Marlena COLASANTO, Auteur ; Gregory L. HANNA, Auteur ; David R. ROSENBERG, Auteur ; Noam SORENI, Auteur ; Kate D. FITZGERALD, Auteur ; Christian R. MARSHALL, Auteur ; Janet A. BUCHANAN, Auteur ; Daniele MERICO, Auteur ; Paul D. ARNOLD, Auteur ; Stephen SCHERER, Auteur Article en page(s) : p.36 Langues : Anglais (eng) Mots-clés : Copy number variation  Obsessive-compulsive disorder  Pediatrics  Whole-exome sequencing Index. décimale : PER Périodiques Résumé : BACKGROUND: Obsessive-compulsive disorder (OCD) is a heterogeneous neuropsychiatric condition, thought to have a significant genetic component. When onset occurs in childhood, affected individuals generally exhibit different characteristics from adult-onset OCD, including higher prevalence in males and increased heritability. Since neuropsychiatric conditions are associated with copy number variations (CNVs), we considered their potential role in the etiology of OCD. METHODS: We genotyped 307 unrelated pediatric probands with idiopathic OCD (including 174 that were part of complete parent-child trios) and compared their genotypes with those of 3861 population controls, to identify rare CNVs (<0.5 % frequency) of at least 15 kb in size that might contribute to OCD. RESULTS: We uncovered de novo CNVs in 4/174 probands (2.3 %). Our case cohort was enriched for CNVs in genes that encode targets of the fragile X mental retardation protein (nominal p = 1.85 x 10(-03); FDR=0.09), similar to previous findings in autism and schizophrenia. These results also identified deletions or duplications of exons in genes involved in neuronal migration (ASTN2), synapse formation (NLGN1 and PTPRD), and postsynaptic scaffolding (DLGAP1 and DLGAP2), which may be relevant to the pathogenesis of OCD. Four cases had CNVs involving known genomic disorder loci (1q21.1-21.2, 15q11.2-q13.1, 16p13.11, and 17p12). Further, we identified BTBD9 as a candidate gene for OCD. We also sequenced exomes of ten "CNV positive" trios and identified in one an additional plausibly relevant mutation: a 13 bp exonic deletion in DRD4. CONCLUSIONS: Our findings suggest that rare CNVs may contribute to the etiology of OCD. En ligne : http://dx.doi.org/10.1186/s11689-016-9170-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 [article] Uncovering obsessive-compulsive disorder risk genes in a pediatric cohort by high-resolution analysis of copy number variation [texte imprimé] / MatthewJ GAZZELLONE, Auteur ; Mehdi ZARREI, Auteur ; Christie L. BURTON, Auteur ; Susan WALKER, Auteur ; Mohammed UDDIN, Auteur ; S.M. SHAHEEN, Auteur ; Julie COSTE, Auteur ; Rageen RAJENDRAM, Auteur ; Reva J. SCHACHTER, Auteur ; Marlena COLASANTO, Auteur ; Gregory L. HANNA, Auteur ; David R. ROSENBERG, Auteur ; Noam SORENI, Auteur ; Kate D. FITZGERALD, Auteur ; Christian R. MARSHALL, Auteur ; Janet A. BUCHANAN, Auteur ; Daniele MERICO, Auteur ; Paul D. ARNOLD, Auteur ; Stephen SCHERER, Auteur . - p.36. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.36 Mots-clés : Copy number variation  Obsessive-compulsive disorder  Pediatrics  Whole-exome sequencing Index. décimale : PER Périodiques Résumé : BACKGROUND: Obsessive-compulsive disorder (OCD) is a heterogeneous neuropsychiatric condition, thought to have a significant genetic component. When onset occurs in childhood, affected individuals generally exhibit different characteristics from adult-onset OCD, including higher prevalence in males and increased heritability. Since neuropsychiatric conditions are associated with copy number variations (CNVs), we considered their potential role in the etiology of OCD. METHODS: We genotyped 307 unrelated pediatric probands with idiopathic OCD (including 174 that were part of complete parent-child trios) and compared their genotypes with those of 3861 population controls, to identify rare CNVs (<0.5 % frequency) of at least 15 kb in size that might contribute to OCD. RESULTS: We uncovered de novo CNVs in 4/174 probands (2.3 %). Our case cohort was enriched for CNVs in genes that encode targets of the fragile X mental retardation protein (nominal p = 1.85 x 10(-03); FDR=0.09), similar to previous findings in autism and schizophrenia. These results also identified deletions or duplications of exons in genes involved in neuronal migration (ASTN2), synapse formation (NLGN1 and PTPRD), and postsynaptic scaffolding (DLGAP1 and DLGAP2), which may be relevant to the pathogenesis of OCD. Four cases had CNVs involving known genomic disorder loci (1q21.1-21.2, 15q11.2-q13.1, 16p13.11, and 17p12). Further, we identified BTBD9 as a candidate gene for OCD. We also sequenced exomes of ten "CNV positive" trios and identified in one an additional plausibly relevant mutation: a 13 bp exonic deletion in DRD4. CONCLUSIONS: Our findings suggest that rare CNVs may contribute to the etiology of OCD. En ligne : http://dx.doi.org/10.1186/s11689-016-9170-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349

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