MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism / Timothy P.L. ROBERTS in Autism Research, 3-1 (February 2010)  

Public ISBD [article]  inAutism Research > 3-1 (February 2010) . - p.8-18 Titre : MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism Type de document : Texte imprimé et/ou numérique Auteurs : Timothy P.L. ROBERTS, Auteur ; Susan E. LEVY, Auteur ; Gwenda L. SCHMIDT, Auteur ; J. Christopher EDGAR, Auteur ; Deborah M. ZARNOW, Auteur ; Mike GANDAL, Auteur ; Saba QASMIEH, Auteur ; Sarah WOLDOFF, Auteur ; Lisa BLASKEY, Auteur ; Justin F. MONROE, Auteur ; Mike REY, Auteur ; Sarah Y. KHAN, Auteur ; Katelyn M. CANNON, Auteur Année de publication : 2010 Article en page(s) : p.8-18 Langues : Anglais (eng) Mots-clés : autism-spectrum-disorders M50 M100 magnetoencephalography language-impairment auditory-evoked-response Index. décimale : PER Périodiques Résumé : Motivated by auditory and speech deficits in autism spectrum disorders (ASD), the frequency dependence of superior temporal gyrus (STG) 50 msec (M50) and 100 msec (M100) neuromagnetic auditory evoked field responses in children with ASD and typically developing controls were evaluated. Whole-cortex magnetoencephalography (MEG) was obtained from 17 typically developing children and 25 children with ASD. Subjects were presented tones with frequencies of 200, 300, 500, and 1,000 Hz, and left and right STG M50 and M100 STG activity was examined. No M50 latency or amplitude Group differences were observed. In the right hemisphere, a Group×Frequency ANOVA on M100 latency produced a main effect for Group (P=0.01), with an average M100 latency delay of 11 msec in children with ASD. In addition, only in the control group was the expected association of earlier M100 latencies in older than younger children observed. Group latency differences remained significant when hierarchical regression analyses partialed out M100 variance associated with age, IQ, and language ability (all P-values <0.05). Examining the right-hemisphere 500 Hz condition (where the largest latency differences were observed), a sensitivity of 75%, a specificity of 81%, and a positive predictive value (PPV) of 86% was obtained at a threshold of 116 msec. The M100 latency delay indicates disruption of encoding simple sensory information. Given similar findings in language impaired and nonlanguage impaired ASD subjects, a right-hemisphere M100 latency delay appears to be an electrophysiological endophenotype for autism. En ligne : http://dx.doi.org/10.1002/aur.111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993 [article] MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism [Texte imprimé et/ou numérique] / Timothy P.L. ROBERTS, Auteur ; Susan E. LEVY, Auteur ; Gwenda L. SCHMIDT, Auteur ; J. Christopher EDGAR, Auteur ; Deborah M. ZARNOW, Auteur ; Mike GANDAL, Auteur ; Saba QASMIEH, Auteur ; Sarah WOLDOFF, Auteur ; Lisa BLASKEY, Auteur ; Justin F. MONROE, Auteur ; Mike REY, Auteur ; Sarah Y. KHAN, Auteur ; Katelyn M. CANNON, Auteur . - 2010 . - p.8-18. Langues : Anglais (eng) in Autism Research > 3-1 (February 2010) . - p.8-18 Mots-clés : autism-spectrum-disorders M50 M100 magnetoencephalography language-impairment auditory-evoked-response Index. décimale : PER Périodiques Résumé : Motivated by auditory and speech deficits in autism spectrum disorders (ASD), the frequency dependence of superior temporal gyrus (STG) 50 msec (M50) and 100 msec (M100) neuromagnetic auditory evoked field responses in children with ASD and typically developing controls were evaluated. Whole-cortex magnetoencephalography (MEG) was obtained from 17 typically developing children and 25 children with ASD. Subjects were presented tones with frequencies of 200, 300, 500, and 1,000 Hz, and left and right STG M50 and M100 STG activity was examined. No M50 latency or amplitude Group differences were observed. In the right hemisphere, a Group×Frequency ANOVA on M100 latency produced a main effect for Group (P=0.01), with an average M100 latency delay of 11 msec in children with ASD. In addition, only in the control group was the expected association of earlier M100 latencies in older than younger children observed. Group latency differences remained significant when hierarchical regression analyses partialed out M100 variance associated with age, IQ, and language ability (all P-values <0.05). Examining the right-hemisphere 500 Hz condition (where the largest latency differences were observed), a sensitivity of 75%, a specificity of 81%, and a positive predictive value (PPV) of 86% was obtained at a threshold of 116 msec. The M100 latency delay indicates disruption of encoding simple sensory information. Given similar findings in language impaired and nonlanguage impaired ASD subjects, a right-hemisphere M100 latency delay appears to be an electrophysiological endophenotype for autism. En ligne : http://dx.doi.org/10.1002/aur.111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993

Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders / J. Christopher EDGAR in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.395-405 Titre : Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : J. Christopher EDGAR, Auteur ; Sarah Y. KHAN, Auteur ; Lisa BLASKEY, Auteur ; Vivian Y. CHOW, Auteur ; Michael REY, Auteur ; William GAETZ, Auteur ; Katelyn M. CANNON, Auteur ; Justin F. MONROE, Auteur ; Lauren CORNEW, Auteur ; Saba QASMIEH, Auteur ; Song LIU, Auteur ; John P. WELSH, Auteur ; Susan E. LEVY, Auteur ; Timothy P. L. ROBERTS, Auteur Article en page(s) : p.395-405 Langues : Anglais (eng) Mots-clés : Auditory  Autism spectrum disorders  M100  Gamma  Evoked  Inter-trial coherence  Phase-locking  Magnetoencephalography Index. décimale : PER Périodiques Résumé : Previous studies have observed evoked response latency as well as gamma band superior temporal gyrus (STG) auditory abnormalities in individuals with autism spectrum disorders (ASD). A limitation of these studies is that associations between these two abnormalities, as well as the full extent of oscillatory phenomena in ASD in terms of frequency and time, have not been examined. Subjects were presented pure tones at 200, 300, 500, and 1,000 Hz while magnetoencephalography assessed activity in STG auditory areas in a sample of 105 children with ASD and 36 typically developing controls (TD). Findings revealed a profile such that auditory STG processes in ASD were characterized by pre-stimulus abnormalities across multiple frequencies, then early high-frequency abnormalities followed by low-frequency abnormalities. Increased pre-stimulus activity was a ‘core’ abnormality, with pre-stimulus activity predicting post-stimulus neural abnormalities, group membership, and clinical symptoms (CELF-4 Core Language Index). Deficits in synaptic integration in the auditory cortex are associated with oscillatory abnormalities in ASD as well as patient symptoms. Increased pre-stimulus activity in ASD likely demonstrates a fundamental signal-to-noise deficit in individuals with ASD, with elevations in oscillatory activity suggesting an inability to maintain an appropriate ‘neural tone’ and an inability to rapidly return to a resting state prior to the next stimulus. En ligne : http://dx.doi.org/10.1007/s10803-013-1904-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / J. Christopher EDGAR, Auteur ; Sarah Y. KHAN, Auteur ; Lisa BLASKEY, Auteur ; Vivian Y. CHOW, Auteur ; Michael REY, Auteur ; William GAETZ, Auteur ; Katelyn M. CANNON, Auteur ; Justin F. MONROE, Auteur ; Lauren CORNEW, Auteur ; Saba QASMIEH, Auteur ; Song LIU, Auteur ; John P. WELSH, Auteur ; Susan E. LEVY, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.395-405. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.395-405 Mots-clés : Auditory  Autism spectrum disorders  M100  Gamma  Evoked  Inter-trial coherence  Phase-locking  Magnetoencephalography Index. décimale : PER Périodiques Résumé : Previous studies have observed evoked response latency as well as gamma band superior temporal gyrus (STG) auditory abnormalities in individuals with autism spectrum disorders (ASD). A limitation of these studies is that associations between these two abnormalities, as well as the full extent of oscillatory phenomena in ASD in terms of frequency and time, have not been examined. Subjects were presented pure tones at 200, 300, 500, and 1,000 Hz while magnetoencephalography assessed activity in STG auditory areas in a sample of 105 children with ASD and 36 typically developing controls (TD). Findings revealed a profile such that auditory STG processes in ASD were characterized by pre-stimulus abnormalities across multiple frequencies, then early high-frequency abnormalities followed by low-frequency abnormalities. Increased pre-stimulus activity was a ‘core’ abnormality, with pre-stimulus activity predicting post-stimulus neural abnormalities, group membership, and clinical symptoms (CELF-4 Core Language Index). Deficits in synaptic integration in the auditory cortex are associated with oscillatory abnormalities in ASD as well as patient symptoms. Increased pre-stimulus activity in ASD likely demonstrates a fundamental signal-to-noise deficit in individuals with ASD, with elevations in oscillatory activity suggesting an inability to maintain an appropriate ‘neural tone’ and an inability to rapidly return to a resting state prior to the next stimulus. En ligne : http://dx.doi.org/10.1007/s10803-013-1904-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

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