Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers / Olga EGOROVA in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 7 p. Titre : Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers Type de document : Texte imprimé et/ou numérique Auteurs : Olga EGOROVA, Auteur ; Robin MYTE, Auteur ; Jörn SCHNEEDE, Auteur ; Bruno HAGGLOF, Auteur ; Sven BÖLTE, Auteur ; Erik DOMELLÖF, Auteur ; Barbro IVARS A'ROCH, Auteur ; Fredrik ELGH, Auteur ; Per Magne UELAND, Auteur ; Sven-Arne SILFVERDAL, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : Autism  Folate  Inflammation  One-carbon metabolism  Pregnancy  Vitamin A  Vitamin B  Vitamin D  that he has in the last 5 years acted as an author, consultant, or lecturer for  Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic,  Kompetento, Expo Medica, and Prophase. He receives royalties for text books and  diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Erik Domellöf is supported  by a grant from the Knut and Alice Wallenberg Foundation (KAW 2015.0192). There are  no other financial disclosures or conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis. METHODS: Serum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B(9)) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation. RESULTS: We found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22-2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D(3) levels, all hypothesized to be involved in ASD etiology, displayed associations with ASD occurrence in the offspring. CONCLUSIONS: Our findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted. En ligne : http://dx.doi.org/10.1186/s13229-020-0315-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers [Texte imprimé et/ou numérique] / Olga EGOROVA, Auteur ; Robin MYTE, Auteur ; Jörn SCHNEEDE, Auteur ; Bruno HAGGLOF, Auteur ; Sven BÖLTE, Auteur ; Erik DOMELLÖF, Auteur ; Barbro IVARS A'ROCH, Auteur ; Fredrik ELGH, Auteur ; Per Magne UELAND, Auteur ; Sven-Arne SILFVERDAL, Auteur . - 7 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 7 p. Mots-clés : Autism  Folate  Inflammation  One-carbon metabolism  Pregnancy  Vitamin A  Vitamin B  Vitamin D  that he has in the last 5 years acted as an author, consultant, or lecturer for  Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic,  Kompetento, Expo Medica, and Prophase. He receives royalties for text books and  diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Erik Domellöf is supported  by a grant from the Knut and Alice Wallenberg Foundation (KAW 2015.0192). There are  no other financial disclosures or conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis. METHODS: Serum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B(9)) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation. RESULTS: We found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22-2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D(3) levels, all hypothesized to be involved in ASD etiology, displayed associations with ASD occurrence in the offspring. CONCLUSIONS: Our findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted. En ligne : http://dx.doi.org/10.1186/s13229-020-0315-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

The prevalence of mental health problems in Ethiopian child laborers / Daniel FEKADU in Journal of Child Psychology and Psychiatry, 47-9 (September 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-9 (September 2006) . - p.954–959 Titre : The prevalence of mental health problems in Ethiopian child laborers Type de document : Texte imprimé et/ou numérique Auteurs : Daniel FEKADU, Auteur ; Alem ATALAY, Auteur ; Bruno HAGGLOF, Auteur Année de publication : 2006 Article en page(s) : p.954–959 Langues : Anglais (eng) Mots-clés : Child-labor emotional-disorders prevalence DICA Ethiopia Index. décimale : PER Périodiques Résumé : Background: Child labor refers to a state when a child is involved in exploitative economical activities that are mentally, physically, and socially hazardous. There are no prevalence studies on the magnitude of psychiatric disorders among child laborers. Methods: A cross-sectional population survey was conducted in Addis Ababa using the Diagnostic Interview for Children and Adolescents (DICA). Subjects were a random sample of 528 child laborers aged between 5 and 15 years and comprising child domestics, street-workers and private enterprise workers. These were compared with 472 non-economically active controls. Results: The aggregate prevalence of any DSM-III-R childhood emotional and behavioral disorders was found to be 16.5%, with 20.1% and 12.5% among child laborers and controls respectively, OR = 1.89 (95% CI, 1.34–2.67, p < .01). Internalizing disorders such as mood disorders were significantly higher among the laborers than the non-laborers, OR = 6.65 (95% CI, 2.20–22.52, p = .0001). Anxiety disorder was seen over twofold among child laborers while psychosocial stressors were one and half times more likely among the study subjects than controls. When all factors were taken into account, child labor status was the only significant factor in determining DSM-III-R diagnosis. Conclusion: In this study childhood emotional and behavioral disorders are found to be more common among child laborers than among non-laborers. We recommend a larger study to look into childhood disorders and risk factors in child labor. As part of the concerted effort, government, NGOs, and the public should at least view child labor as a menace in a child's development, with risk of psychosocial difficulties. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01617.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782 [article] The prevalence of mental health problems in Ethiopian child laborers [Texte imprimé et/ou numérique] / Daniel FEKADU, Auteur ; Alem ATALAY, Auteur ; Bruno HAGGLOF, Auteur . - 2006 . - p.954–959. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-9 (September 2006) . - p.954–959 Mots-clés : Child-labor emotional-disorders prevalence DICA Ethiopia Index. décimale : PER Périodiques Résumé : Background: Child labor refers to a state when a child is involved in exploitative economical activities that are mentally, physically, and socially hazardous. There are no prevalence studies on the magnitude of psychiatric disorders among child laborers. Methods: A cross-sectional population survey was conducted in Addis Ababa using the Diagnostic Interview for Children and Adolescents (DICA). Subjects were a random sample of 528 child laborers aged between 5 and 15 years and comprising child domestics, street-workers and private enterprise workers. These were compared with 472 non-economically active controls. Results: The aggregate prevalence of any DSM-III-R childhood emotional and behavioral disorders was found to be 16.5%, with 20.1% and 12.5% among child laborers and controls respectively, OR = 1.89 (95% CI, 1.34–2.67, p < .01). Internalizing disorders such as mood disorders were significantly higher among the laborers than the non-laborers, OR = 6.65 (95% CI, 2.20–22.52, p = .0001). Anxiety disorder was seen over twofold among child laborers while psychosocial stressors were one and half times more likely among the study subjects than controls. When all factors were taken into account, child labor status was the only significant factor in determining DSM-III-R diagnosis. Conclusion: In this study childhood emotional and behavioral disorders are found to be more common among child laborers than among non-laborers. We recommend a larger study to look into childhood disorders and risk factors in child labor. As part of the concerted effort, government, NGOs, and the public should at least view child labor as a menace in a child's development, with risk of psychosocial difficulties. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01617.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782

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