26 recherche sur le mot-clé 'Inflammation'

Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood / L. J. H. RASMUSSEN in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.199-208 Titre : Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood Type de document : Texte imprimé et/ou numérique Auteurs : L. J. H. RASMUSSEN, Auteur ; T. E. MOFFITT, Auteur ; J. EUGEN-OLSEN, Auteur ; Daniel W. BELSKY, Auteur ; A. DANESE, Auteur ; H. HARRINGTON, Auteur ; R. M. HOUTS, Auteur ; R. POULTON, Auteur ; K. SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur Article en page(s) : p.199-208 Langues : Anglais (eng) Mots-clés : Adverse childhood experiences  inflammation  physical health  risk factors  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP). METHODS: Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP). RESULTS: Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001). CONCLUSIONS: Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden. En ligne : http://dx.doi.org/10.1111/jcpp.12928 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 [article] Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood [Texte imprimé et/ou numérique] / L. J. H. RASMUSSEN, Auteur ; T. E. MOFFITT, Auteur ; J. EUGEN-OLSEN, Auteur ; Daniel W. BELSKY, Auteur ; A. DANESE, Auteur ; H. HARRINGTON, Auteur ; R. M. HOUTS, Auteur ; R. POULTON, Auteur ; K. SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur . - p.199-208. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.199-208 Mots-clés : Adverse childhood experiences  inflammation  physical health  risk factors  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP). METHODS: Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP). RESULTS: Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001). CONCLUSIONS: Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden. En ligne : http://dx.doi.org/10.1111/jcpp.12928 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381

Early life adversity, inflammation, and immune function: An initial test of adaptive response models of immunological programming / Katja CUNNINGHAM in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 539-555 Titre : Early life adversity, inflammation, and immune function: An initial test of adaptive response models of immunological programming Type de document : Texte imprimé et/ou numérique Auteurs : Katja CUNNINGHAM, Auteur ; Summer MENGELKOCH, Auteur ; Jeffrey GASSEN, Auteur ; Sarah E. HILL, Auteur Article en page(s) : 539-555 Langues : Anglais (eng) Mots-clés : early life adversity  immunological programming  inflammation  socioeconomic status Index. décimale : PER Périodiques Résumé : Much research indicates that exposure to early life adversity (ELA) predicts chronic inflammatory activity, increasing one?s risk of developing diseases of aging later in life. Despite its costs, researchers have proposed that chronic inflammation may be favored in this context because it would help promote immunological vigilance in environments with an elevated risk of infection and injury. Although intuitively appealing, the assumption that exaggerated inflammatory activity predicts favorable immunological outcomes among those exposed to ELA has not been tested. Here, we seek to address this gap, examining the links between exposure to ELA, inflammation, and immune function. Consistent with others? work, results revealed that those from low socioeconomic status (SES) childhood environments exhibited exaggerated unstimulated inflammatory activity relative to what was observed among those from higher SES childhood environments. Further, results revealed that ? although levels of inflammation predicted the magnitude of immunological responses in those from higher SES backgrounds ? for those who grew up in low SES environments, higher levels of inflammation were unrelated to the magnitude of immunological responses. Results suggest that exaggerated inflammatory activity in the context of ELA may not predict improved ability to manage acute immunological threats. En ligne : http://dx.doi.org/10.1017/s095457942100170x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Early life adversity, inflammation, and immune function: An initial test of adaptive response models of immunological programming [Texte imprimé et/ou numérique] / Katja CUNNINGHAM, Auteur ; Summer MENGELKOCH, Auteur ; Jeffrey GASSEN, Auteur ; Sarah E. HILL, Auteur . - 539-555. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 539-555 Mots-clés : early life adversity  immunological programming  inflammation  socioeconomic status Index. décimale : PER Périodiques Résumé : Much research indicates that exposure to early life adversity (ELA) predicts chronic inflammatory activity, increasing one?s risk of developing diseases of aging later in life. Despite its costs, researchers have proposed that chronic inflammation may be favored in this context because it would help promote immunological vigilance in environments with an elevated risk of infection and injury. Although intuitively appealing, the assumption that exaggerated inflammatory activity predicts favorable immunological outcomes among those exposed to ELA has not been tested. Here, we seek to address this gap, examining the links between exposure to ELA, inflammation, and immune function. Consistent with others? work, results revealed that those from low socioeconomic status (SES) childhood environments exhibited exaggerated unstimulated inflammatory activity relative to what was observed among those from higher SES childhood environments. Further, results revealed that ? although levels of inflammation predicted the magnitude of immunological responses in those from higher SES backgrounds ? for those who grew up in low SES environments, higher levels of inflammation were unrelated to the magnitude of immunological responses. Results suggest that exaggerated inflammatory activity in the context of ELA may not predict improved ability to manage acute immunological threats. En ligne : http://dx.doi.org/10.1017/s095457942100170x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence / Nathalie MICHELS ; George M. SLAVICH ; Matteo GILETTA in Journal of Child Psychology and Psychiatry, 66-3 (March 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.311-321 Titre : Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Nathalie MICHELS, Auteur ; George M. SLAVICH, Auteur ; Matteo GILETTA, Auteur Article en page(s) : p.311-321 Langues : Anglais (eng) Mots-clés : Adolescence  depression  inflammation  interleukin-6  peer victimization  social stress Index. décimale : PER Périodiques Résumé : Background Adolescents exposed to victimization are at an increased risk for a variety of adverse mental health outcomes, including depressive symptoms. Yet, the biological pathways underlying these associations remain poorly understood. Focusing on within-person processes, we examined whether low-grade systemic inflammation mediated the longitudinal associations between peer victimization and depressive symptoms in adolescence. Methods 207 adolescents (at baseline Mage?=?12.69?years; SD?=?0.49; 43.5% female) participated in a multi-wave longitudinal study, with assessments repeated every 6?months over 1.5?years. At each assessment wave, participants self-reported their peer victimization experiences and depressive symptoms. Dried blood spots were collected at each wave using a finger prick procedure to assay a key marker of low-grade systemic inflammation, interkeukin-6 (IL-6). Data were analyzed using random-intercept cross-lagged panel models. Results The cross-lagged paths from IL-6 to depressive symptoms were significant across all models and waves (?12?=?.13; ?23?=?.12; ?34?=?.08), indicating that when adolescents' levels of low-grade systemic inflammation were above their person-specific average, they reported increased levels of depressive symptoms in the subsequent months. However, no significant cross-lagged within-person associations emerged between peer victimization and either IL-6 or depressive symptoms. Conclusions The findings provide no evidence for the hypothesized mediating role of inflammation in the within-person associations between peer victimization and depressive symptoms. Nevertheless, they extend prior research by indicating that elevated levels of low-grade systemic inflammation predict the development of depressive symptoms in adolescence. En ligne : https://doi.org/10.1111/jcpp.14060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Examining systemic inflammation as a pathway linking peer victimization to depressive symptoms in adolescence [Texte imprimé et/ou numérique] / Nathalie MICHELS, Auteur ; George M. SLAVICH, Auteur ; Matteo GILETTA, Auteur . - p.311-321. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.311-321 Mots-clés : Adolescence  depression  inflammation  interleukin-6  peer victimization  social stress Index. décimale : PER Périodiques Résumé : Background Adolescents exposed to victimization are at an increased risk for a variety of adverse mental health outcomes, including depressive symptoms. Yet, the biological pathways underlying these associations remain poorly understood. Focusing on within-person processes, we examined whether low-grade systemic inflammation mediated the longitudinal associations between peer victimization and depressive symptoms in adolescence. Methods 207 adolescents (at baseline Mage?=?12.69?years; SD?=?0.49; 43.5% female) participated in a multi-wave longitudinal study, with assessments repeated every 6?months over 1.5?years. At each assessment wave, participants self-reported their peer victimization experiences and depressive symptoms. Dried blood spots were collected at each wave using a finger prick procedure to assay a key marker of low-grade systemic inflammation, interkeukin-6 (IL-6). Data were analyzed using random-intercept cross-lagged panel models. Results The cross-lagged paths from IL-6 to depressive symptoms were significant across all models and waves (?12?=?.13; ?23?=?.12; ?34?=?.08), indicating that when adolescents' levels of low-grade systemic inflammation were above their person-specific average, they reported increased levels of depressive symptoms in the subsequent months. However, no significant cross-lagged within-person associations emerged between peer victimization and either IL-6 or depressive symptoms. Conclusions The findings provide no evidence for the hypothesized mediating role of inflammation in the within-person associations between peer victimization and depressive symptoms. Nevertheless, they extend prior research by indicating that elevated levels of low-grade systemic inflammation predict the development of depressive symptoms in adolescence. En ligne : https://doi.org/10.1111/jcpp.14060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Immediate and longitudinal effects of maltreatment on systemic inflammation in young children / Sonja ENTRINGER in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Titre : Immediate and longitudinal effects of maltreatment on systemic inflammation in young children Type de document : Texte imprimé et/ou numérique Auteurs : Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur Article en page(s) : p.1725-1731 Langues : Anglais (eng) Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Immediate and longitudinal effects of maltreatment on systemic inflammation in young children [Texte imprimé et/ou numérique] / Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur . - p.1725-1731. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation / Rafail I. KUSHAK in Autism, 15-3 (May 2011)  

Public ISBD [article]  inAutism > 15-3 (May 2011) . - p.285-294 Titre : Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation Type de document : Texte imprimé et/ou numérique Auteurs : Rafail I. KUSHAK, Auteur ; Gregory Y. LAUWERS, Auteur ; Harland S. WINTER, Auteur ; Timothy M. BUIE, Auteur Année de publication : 2011 Article en page(s) : p.285-294 Langues : Anglais (eng) Mots-clés : autism  disaccharidases  inflammation  intestine Index. décimale : PER Périodiques Résumé : Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history. En ligne : http://dx.doi.org/10.1177/1362361310369142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130 [article] Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation [Texte imprimé et/ou numérique] / Rafail I. KUSHAK, Auteur ; Gregory Y. LAUWERS, Auteur ; Harland S. WINTER, Auteur ; Timothy M. BUIE, Auteur . - 2011 . - p.285-294. Langues : Anglais (eng) in Autism > 15-3 (May 2011) . - p.285-294 Mots-clés : autism  disaccharidases  inflammation  intestine Index. décimale : PER Périodiques Résumé : Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history. En ligne : http://dx.doi.org/10.1177/1362361310369142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130

Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children / A. E. RUSSELL in Journal of Child Psychology and Psychiatry, 60-10 (October 2019)  

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The prospective association between stressful life events and inflammation among adolescents with a history of early institutional rearing / Alva TANG in Development and Psychopathology, 32-5 (December 2020)  

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The search for gastrointestinal inflammation in autism: a systematic review and meta-analysis of non-invasive gastrointestinal markers / Nisha E. MATHEW in Molecular Autism, 15 (2024)  

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Vinpocetine amended prenatal valproic acid induced features of ASD possibly by altering markers of neuronal function, inflammation, and oxidative stress / K. LUHACH in Autism Research, 14-11 (November 2021)  

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From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition / A. M. YOUNG in Molecular Autism, 7 (2016)  

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