25 recherche sur le mot-clé 'Inflammation'

Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood / L. J. H. RASMUSSEN in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.199-208 Titre : Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood Type de document : Texte imprimé et/ou numérique Auteurs : L. J. H. RASMUSSEN, Auteur ; T. E. MOFFITT, Auteur ; J. EUGEN-OLSEN, Auteur ; Daniel W. BELSKY, Auteur ; A. DANESE, Auteur ; H. HARRINGTON, Auteur ; R. M. HOUTS, Auteur ; R. POULTON, Auteur ; K. SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur Article en page(s) : p.199-208 Langues : Anglais (eng) Mots-clés : Adverse childhood experiences  inflammation  physical health  risk factors  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP). METHODS: Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP). RESULTS: Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001). CONCLUSIONS: Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden. En ligne : http://dx.doi.org/10.1111/jcpp.12928 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 [article] Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood [Texte imprimé et/ou numérique] / L. J. H. RASMUSSEN, Auteur ; T. E. MOFFITT, Auteur ; J. EUGEN-OLSEN, Auteur ; Daniel W. BELSKY, Auteur ; A. DANESE, Auteur ; H. HARRINGTON, Auteur ; R. M. HOUTS, Auteur ; R. POULTON, Auteur ; K. SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur . - p.199-208. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.199-208 Mots-clés : Adverse childhood experiences  inflammation  physical health  risk factors  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP). METHODS: Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP). RESULTS: Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001). CONCLUSIONS: Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden. En ligne : http://dx.doi.org/10.1111/jcpp.12928 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381

Early life adversity, inflammation, and immune function: An initial test of adaptive response models of immunological programming / Katja CUNNINGHAM in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 539-555 Titre : Early life adversity, inflammation, and immune function: An initial test of adaptive response models of immunological programming Type de document : Texte imprimé et/ou numérique Auteurs : Katja CUNNINGHAM, Auteur ; Summer MENGELKOCH, Auteur ; Jeffrey GASSEN, Auteur ; Sarah E. HILL, Auteur Article en page(s) : 539-555 Langues : Anglais (eng) Mots-clés : early life adversity  immunological programming  inflammation  socioeconomic status Index. décimale : PER Périodiques Résumé : Much research indicates that exposure to early life adversity (ELA) predicts chronic inflammatory activity, increasing one?s risk of developing diseases of aging later in life. Despite its costs, researchers have proposed that chronic inflammation may be favored in this context because it would help promote immunological vigilance in environments with an elevated risk of infection and injury. Although intuitively appealing, the assumption that exaggerated inflammatory activity predicts favorable immunological outcomes among those exposed to ELA has not been tested. Here, we seek to address this gap, examining the links between exposure to ELA, inflammation, and immune function. Consistent with others? work, results revealed that those from low socioeconomic status (SES) childhood environments exhibited exaggerated unstimulated inflammatory activity relative to what was observed among those from higher SES childhood environments. Further, results revealed that ? although levels of inflammation predicted the magnitude of immunological responses in those from higher SES backgrounds ? for those who grew up in low SES environments, higher levels of inflammation were unrelated to the magnitude of immunological responses. Results suggest that exaggerated inflammatory activity in the context of ELA may not predict improved ability to manage acute immunological threats. En ligne : http://dx.doi.org/10.1017/s095457942100170x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Early life adversity, inflammation, and immune function: An initial test of adaptive response models of immunological programming [Texte imprimé et/ou numérique] / Katja CUNNINGHAM, Auteur ; Summer MENGELKOCH, Auteur ; Jeffrey GASSEN, Auteur ; Sarah E. HILL, Auteur . - 539-555. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 539-555 Mots-clés : early life adversity  immunological programming  inflammation  socioeconomic status Index. décimale : PER Périodiques Résumé : Much research indicates that exposure to early life adversity (ELA) predicts chronic inflammatory activity, increasing one?s risk of developing diseases of aging later in life. Despite its costs, researchers have proposed that chronic inflammation may be favored in this context because it would help promote immunological vigilance in environments with an elevated risk of infection and injury. Although intuitively appealing, the assumption that exaggerated inflammatory activity predicts favorable immunological outcomes among those exposed to ELA has not been tested. Here, we seek to address this gap, examining the links between exposure to ELA, inflammation, and immune function. Consistent with others? work, results revealed that those from low socioeconomic status (SES) childhood environments exhibited exaggerated unstimulated inflammatory activity relative to what was observed among those from higher SES childhood environments. Further, results revealed that ? although levels of inflammation predicted the magnitude of immunological responses in those from higher SES backgrounds ? for those who grew up in low SES environments, higher levels of inflammation were unrelated to the magnitude of immunological responses. Results suggest that exaggerated inflammatory activity in the context of ELA may not predict improved ability to manage acute immunological threats. En ligne : http://dx.doi.org/10.1017/s095457942100170x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Immediate and longitudinal effects of maltreatment on systemic inflammation in young children / Sonja ENTRINGER in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Titre : Immediate and longitudinal effects of maltreatment on systemic inflammation in young children Type de document : Texte imprimé et/ou numérique Auteurs : Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur Article en page(s) : p.1725-1731 Langues : Anglais (eng) Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Immediate and longitudinal effects of maltreatment on systemic inflammation in young children [Texte imprimé et/ou numérique] / Sonja ENTRINGER, Auteur ; Karin DE PUNDER, Auteur ; Judith OVERFELD, Auteur ; Gergana KARABOYCHEVA, Auteur ; Katja DITTRICH, Auteur ; Claudia BUSS, Auteur ; Sibylle Maria WINTER, Auteur ; Elisabeth B. BINDER, Auteur ; Christine HEIM, Auteur . - p.1725-1731. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1725-1731 Mots-clés : C-Reactive Protein  Child  *Child Abuse  Child, Preschool  Cross-Sectional Studies  Female  Humans  Infant  Inflammation  Male  Retrospective Studies  *crp  *early life stress  *inflammation  *maltreatment  *sex differences Index. décimale : PER Périodiques Résumé : Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period. En ligne : http://dx.doi.org/10.1017/s0954579420001686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation / Rafail I. KUSHAK in Autism, 15-3 (May 2011)  

Public ISBD [article]  inAutism > 15-3 (May 2011) . - p.285-294 Titre : Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation Type de document : Texte imprimé et/ou numérique Auteurs : Rafail I. KUSHAK, Auteur ; Gregory Y. LAUWERS, Auteur ; Harland S. WINTER, Auteur ; Timothy M. BUIE, Auteur Année de publication : 2011 Article en page(s) : p.285-294 Langues : Anglais (eng) Mots-clés : autism  disaccharidases  inflammation  intestine Index. décimale : PER Périodiques Résumé : Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history. En ligne : http://dx.doi.org/10.1177/1362361310369142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130 [article] Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation [Texte imprimé et/ou numérique] / Rafail I. KUSHAK, Auteur ; Gregory Y. LAUWERS, Auteur ; Harland S. WINTER, Auteur ; Timothy M. BUIE, Auteur . - 2011 . - p.285-294. Langues : Anglais (eng) in Autism > 15-3 (May 2011) . - p.285-294 Mots-clés : autism  disaccharidases  inflammation  intestine Index. décimale : PER Périodiques Résumé : Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history. En ligne : http://dx.doi.org/10.1177/1362361310369142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130

Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children / A. E. RUSSELL in Journal of Child Psychology and Psychiatry, 60-10 (October 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-10 (October 2019) . - p.1094-1103 Titre : Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children Type de document : Texte imprimé et/ou numérique Auteurs : A. E. RUSSELL, Auteur ; J. HERON, Auteur ; D. GUNNELL, Auteur ; T. FORD, Auteur ; G. HEMANI, Auteur ; C. JOINSON, Auteur ; P. MORAN, Auteur ; C. RELTON, Auteur ; M. SUDERMAN, Auteur ; B. MARS, Auteur Article en page(s) : p.1094-1103 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children  C-reactive protein  Inflammation  Self-harm  adverse childhood experiences  interleukin-6  mediation  suicide Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse childhood experiences (ACEs) such as physical and emotional abuse are strongly associated with self-harm, but mechanisms underlying this relationship are unclear. Inflammation has been linked to both the experience of ACEs and self-harm or suicide in prior research. This is the first study to examine whether inflammatory markers mediate the association between exposure to ACEs and self-harm. METHODS: Participants were 4,308 young people from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort in the United Kingdom. A structural equation modelling approach was used to fit a mediation model with the number of ACEs experienced between ages 0 and 9 years old (yo), levels of the inflammatory markers interleukin-6 and C-reactive protein measured at 9.5 yo, and self-harm reported at 16 yo. RESULTS: The mean number of ACEs young people experienced was 1.41 (SE 0.03). Higher ACE scores were associated with an increased risk of self-harm at 16 yo (direct effect relative risk (RR) per additional ACE 1.11, 95% CI 1.05, 1.18, p < 0.001). We did not find evidence of an indirect effect of ACEs on self-harm via inflammation (RR 1.00, 95% CI 1.00, 1.01, p = 0.38). CONCLUSIONS: Young people who have been exposed to ACEs are a group at high risk of self-harm. The association between ACEs and self-harm does not appear to be mediated by an inflammatory process in childhood, as indexed by peripheral levels of circulating inflammatory markers measured in childhood. Further research is needed to identify alternative psychological and biological mechanisms underlying this relationship. En ligne : http://dx.doi.org/10.1111/jcpp.13100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children [Texte imprimé et/ou numérique] / A. E. RUSSELL, Auteur ; J. HERON, Auteur ; D. GUNNELL, Auteur ; T. FORD, Auteur ; G. HEMANI, Auteur ; C. JOINSON, Auteur ; P. MORAN, Auteur ; C. RELTON, Auteur ; M. SUDERMAN, Auteur ; B. MARS, Auteur . - p.1094-1103. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-10 (October 2019) . - p.1094-1103 Mots-clés : Avon Longitudinal Study of Parents and Children  C-reactive protein  Inflammation  Self-harm  adverse childhood experiences  interleukin-6  mediation  suicide Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse childhood experiences (ACEs) such as physical and emotional abuse are strongly associated with self-harm, but mechanisms underlying this relationship are unclear. Inflammation has been linked to both the experience of ACEs and self-harm or suicide in prior research. This is the first study to examine whether inflammatory markers mediate the association between exposure to ACEs and self-harm. METHODS: Participants were 4,308 young people from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort in the United Kingdom. A structural equation modelling approach was used to fit a mediation model with the number of ACEs experienced between ages 0 and 9 years old (yo), levels of the inflammatory markers interleukin-6 and C-reactive protein measured at 9.5 yo, and self-harm reported at 16 yo. RESULTS: The mean number of ACEs young people experienced was 1.41 (SE 0.03). Higher ACE scores were associated with an increased risk of self-harm at 16 yo (direct effect relative risk (RR) per additional ACE 1.11, 95% CI 1.05, 1.18, p < 0.001). We did not find evidence of an indirect effect of ACEs on self-harm via inflammation (RR 1.00, 95% CI 1.00, 1.01, p = 0.38). CONCLUSIONS: Young people who have been exposed to ACEs are a group at high risk of self-harm. The association between ACEs and self-harm does not appear to be mediated by an inflammatory process in childhood, as indexed by peripheral levels of circulating inflammatory markers measured in childhood. Further research is needed to identify alternative psychological and biological mechanisms underlying this relationship. En ligne : http://dx.doi.org/10.1111/jcpp.13100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

The prospective association between stressful life events and inflammation among adolescents with a history of early institutional rearing / Alva TANG in Development and Psychopathology, 32-5 (December 2020)  

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The search for gastrointestinal inflammation in autism: a systematic review and meta-analysis of non-invasive gastrointestinal markers / Nisha E. MATHEW in Molecular Autism, 15 (2024)  

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Vinpocetine amended prenatal valproic acid induced features of ASD possibly by altering markers of neuronal function, inflammation, and oxidative stress / K. LUHACH in Autism Research, 14-11 (November 2021)  

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From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition / A. M. YOUNG in Molecular Autism, 7 (2016)  

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Brief Report: “Allergic Symptoms” in Children with Autism Spectrum Disorders. More than Meets the Eye? / Asimenia ANGELIDOU in Journal of Autism and Developmental Disorders, 41-11 (November 2011)  

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