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Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations? / Joseph M. BRAUN in Journal of Autism and Developmental Disorders, 44-10 (October 2014)
[article]
Titre : Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations? Type de document : Texte imprimé et/ou numérique Auteurs : Joseph M. BRAUN, Auteur ; Tanya FROEHLICH, Auteur ; Amy E. KALKBRENNER, Auteur ; Christine M. PFEIFFER, Auteur ; Zia FAZILI, Auteur ; Kimberly YOLTON, Auteur ; Bruce P. LANPHEAR, Auteur Article en page(s) : p.2602-2607 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Folate Pregnancy Prenatal vitamins Index. décimale : PER Périodiques Résumé : Prenatal multivitamin/folic acid supplement use may reduce the risk of autism spectrum disorders. We investigated whether 2nd trimester prenatal vitamin use and maternal whole blood folate (WBF) concentrations were associated with Social Responsiveness Scale (SRS) scores at 4–5 years of age in a prospective cohort of 209 mother–child pairs. After confounder adjustment, children born to women taking prenatal vitamins weekly/daily (n = 179) had lower odds of clinically elevated SRS scores (odds ratio 0.26; 95 % confidence interval 0.08, 0.89) than those who rarely/never took them (n = 30). WBF concentrations were not associated with SRS scores. The lack of association between WBF and autistic-behaviors may be due to the timing of biomarker measures relative to critical periods of brain development, confounding, or other modifying factors. En ligne : http://dx.doi.org/10.1007/s10803-014-2114-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240
in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2602-2607[article] Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations? [Texte imprimé et/ou numérique] / Joseph M. BRAUN, Auteur ; Tanya FROEHLICH, Auteur ; Amy E. KALKBRENNER, Auteur ; Christine M. PFEIFFER, Auteur ; Zia FAZILI, Auteur ; Kimberly YOLTON, Auteur ; Bruce P. LANPHEAR, Auteur . - p.2602-2607.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2602-2607
Mots-clés : Autism spectrum disorders Folate Pregnancy Prenatal vitamins Index. décimale : PER Périodiques Résumé : Prenatal multivitamin/folic acid supplement use may reduce the risk of autism spectrum disorders. We investigated whether 2nd trimester prenatal vitamin use and maternal whole blood folate (WBF) concentrations were associated with Social Responsiveness Scale (SRS) scores at 4–5 years of age in a prospective cohort of 209 mother–child pairs. After confounder adjustment, children born to women taking prenatal vitamins weekly/daily (n = 179) had lower odds of clinically elevated SRS scores (odds ratio 0.26; 95 % confidence interval 0.08, 0.89) than those who rarely/never took them (n = 30). WBF concentrations were not associated with SRS scores. The lack of association between WBF and autistic-behaviors may be due to the timing of biomarker measures relative to critical periods of brain development, confounding, or other modifying factors. En ligne : http://dx.doi.org/10.1007/s10803-014-2114-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240 Identification of likely associations between cerebral folate deficiency and complex genetic- and metabolic pathogenesis of autism spectrum disorders by utilization of a pilot interaction modeling approach / Daniel KRSI?KA in Autism Research, 10-8 (August 2017)
[article]
Titre : Identification of likely associations between cerebral folate deficiency and complex genetic- and metabolic pathogenesis of autism spectrum disorders by utilization of a pilot interaction modeling approach Type de document : Texte imprimé et/ou numérique Auteurs : Daniel KRSI?KA, Auteur ; Jan GERYK, Auteur ; Markéta VL?KOVÁ, Auteur ; Marketa HAVLOVICOVA, Auteur ; Milan MACEK, Auteur ; Radka POUROVÁ, Auteur Article en page(s) : p.1424-1435 Langues : Anglais (eng) Mots-clés : autism spectrum disorders cerebral folate deficiency knowledge databases folate genetic variation interaction modeling metabolic pathways Index. décimale : PER Périodiques Résumé : Recently, cerebral folate deficiency (CFD) was suggested to be involved in the pathogenesis of autism spectrum disorders (ASD). However, the exact role of folate metabolism in the pathogenesis of ASD, identification of underlying pathogenic mechanisms and impaired metabolic pathways remain unexplained. The aim of our study was to develop and test a novel, unbiased, bioinformatics approach in order to identify links between ASD and disturbed cerebral metabolism by focusing on abnormal folate metabolism, which could foster patient stratification and novel therapeutic interventions. An unbiased, automatable, computational workflow interaction model was developed using available data from public databases. The interaction network model of ASD-associated genes with known cerebral expression and function (SFARI) and metabolic networks (MetScape), including connections to known metabolic substrates, metabolites and cofactors involving folates, was established. Intersection of bioinformatically created networks resulted in a limited amount of interaction modules pointing to common disturbed metabolic pathways, linking ASD to CFD. Two independent interaction modules (comprising three pathways) covering enzymes encoded by ASD-related genes and folate cofactors utilizing enzymes were generated. Module 1 suggested possible interference of CFD with serine and lysine metabolism, while module 2 identified correlations with purine metabolism and inosine monophosphate production. Since our approach was primarily conceived as a proof of principle, further amendments of the presented initial model are necessary to obtain additional actionable outcomes. Our modelling strategy identified not only previously known interactions supported by evidence-based analyses, but also novel plausible interactions, which could be validated in subsequent functional and/or clinical studies. En ligne : http://dx.doi.org/10.1002/aur.1780 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310
in Autism Research > 10-8 (August 2017) . - p.1424-1435[article] Identification of likely associations between cerebral folate deficiency and complex genetic- and metabolic pathogenesis of autism spectrum disorders by utilization of a pilot interaction modeling approach [Texte imprimé et/ou numérique] / Daniel KRSI?KA, Auteur ; Jan GERYK, Auteur ; Markéta VL?KOVÁ, Auteur ; Marketa HAVLOVICOVA, Auteur ; Milan MACEK, Auteur ; Radka POUROVÁ, Auteur . - p.1424-1435.
Langues : Anglais (eng)
in Autism Research > 10-8 (August 2017) . - p.1424-1435
Mots-clés : autism spectrum disorders cerebral folate deficiency knowledge databases folate genetic variation interaction modeling metabolic pathways Index. décimale : PER Périodiques Résumé : Recently, cerebral folate deficiency (CFD) was suggested to be involved in the pathogenesis of autism spectrum disorders (ASD). However, the exact role of folate metabolism in the pathogenesis of ASD, identification of underlying pathogenic mechanisms and impaired metabolic pathways remain unexplained. The aim of our study was to develop and test a novel, unbiased, bioinformatics approach in order to identify links between ASD and disturbed cerebral metabolism by focusing on abnormal folate metabolism, which could foster patient stratification and novel therapeutic interventions. An unbiased, automatable, computational workflow interaction model was developed using available data from public databases. The interaction network model of ASD-associated genes with known cerebral expression and function (SFARI) and metabolic networks (MetScape), including connections to known metabolic substrates, metabolites and cofactors involving folates, was established. Intersection of bioinformatically created networks resulted in a limited amount of interaction modules pointing to common disturbed metabolic pathways, linking ASD to CFD. Two independent interaction modules (comprising three pathways) covering enzymes encoded by ASD-related genes and folate cofactors utilizing enzymes were generated. Module 1 suggested possible interference of CFD with serine and lysine metabolism, while module 2 identified correlations with purine metabolism and inosine monophosphate production. Since our approach was primarily conceived as a proof of principle, further amendments of the presented initial model are necessary to obtain additional actionable outcomes. Our modelling strategy identified not only previously known interactions supported by evidence-based analyses, but also novel plausible interactions, which could be validated in subsequent functional and/or clinical studies. En ligne : http://dx.doi.org/10.1002/aur.1780 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers / Olga EGOROVA in Molecular Autism, 11 (2020)
[article]
Titre : Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers Type de document : Texte imprimé et/ou numérique Auteurs : Olga EGOROVA, Auteur ; Robin MYTE, Auteur ; Jörn SCHNEEDE, Auteur ; Bruno HAGGLOF, Auteur ; Sven BÖLTE, Auteur ; Erik DOMELLÖF, Auteur ; Barbro IVARS A'ROCH, Auteur ; Fredrik ELGH, Auteur ; Per Magne UELAND, Auteur ; Sven-Arne SILFVERDAL, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : Autism Folate Inflammation One-carbon metabolism Pregnancy Vitamin A Vitamin B Vitamin D that he has in the last 5 years acted as an author, consultant, or lecturer for Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic, Kompetento, Expo Medica, and Prophase. He receives royalties for text books and diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Erik Domellöf is supported by a grant from the Knut and Alice Wallenberg Foundation (KAW 2015.0192). There are no other financial disclosures or conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis. METHODS: Serum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B(9)) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation. RESULTS: We found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22-2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D(3) levels, all hypothesized to be involved in ASD etiology, displayed associations with ASD occurrence in the offspring. CONCLUSIONS: Our findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted. En ligne : http://dx.doi.org/10.1186/s13229-020-0315-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 7 p.[article] Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers [Texte imprimé et/ou numérique] / Olga EGOROVA, Auteur ; Robin MYTE, Auteur ; Jörn SCHNEEDE, Auteur ; Bruno HAGGLOF, Auteur ; Sven BÖLTE, Auteur ; Erik DOMELLÖF, Auteur ; Barbro IVARS A'ROCH, Auteur ; Fredrik ELGH, Auteur ; Per Magne UELAND, Auteur ; Sven-Arne SILFVERDAL, Auteur . - 7 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 7 p.
Mots-clés : Autism Folate Inflammation One-carbon metabolism Pregnancy Vitamin A Vitamin B Vitamin D that he has in the last 5 years acted as an author, consultant, or lecturer for Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic, Kompetento, Expo Medica, and Prophase. He receives royalties for text books and diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Erik Domellöf is supported by a grant from the Knut and Alice Wallenberg Foundation (KAW 2015.0192). There are no other financial disclosures or conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis. METHODS: Serum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B(9)) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation. RESULTS: We found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22-2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D(3) levels, all hypothesized to be involved in ASD etiology, displayed associations with ASD occurrence in the offspring. CONCLUSIONS: Our findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted. En ligne : http://dx.doi.org/10.1186/s13229-020-0315-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Serum vitamin D and folate levels in children with autism spectrum disorders / Ça?atay U?UR in Research in Autism Spectrum Disorders, 8-12 (December 2014)
[article]
Titre : Serum vitamin D and folate levels in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ça?atay U?UR, Auteur ; Cihat Ka?an GÜRKAN, Auteur Article en page(s) : p.1641-1647 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Vitamin D Calcium Folate Index. décimale : PER Périodiques Résumé : Abstract It has recently proposed that vitamin D and folate may be involved in the aetiology of autism. We investigated the serum levels of vitamin D, calcium (Ca), phosphorus (P), alkaline phosphatase (ALP) and folate in 54 young children, aged 3–8 years, with autism spectrum disorders (ASD) and in 54 age and gender matched normal controls. Vitamin D, Ca, P, ALP and folate levels in children with ASD were not different from control group. The correlational analysis in children with ASD revealed that Aberrant Behaviour Checklist, Autism Behaviour Checklist, and Childhood Autism Rating Scale scores and the level of cognitive development were not correlated with these laboratory findings. Our findings do not support the idea that serum levels of vitamin D and folate might be low in children with ASD. Nevertheless, it is possible that vitamin D and folate deficiency may be playing a role in development of ASD at earlier ages or during prenatal period. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Research in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1641-1647[article] Serum vitamin D and folate levels in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Ça?atay U?UR, Auteur ; Cihat Ka?an GÜRKAN, Auteur . - p.1641-1647.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1641-1647
Mots-clés : Autism spectrum disorders Vitamin D Calcium Folate Index. décimale : PER Périodiques Résumé : Abstract It has recently proposed that vitamin D and folate may be involved in the aetiology of autism. We investigated the serum levels of vitamin D, calcium (Ca), phosphorus (P), alkaline phosphatase (ALP) and folate in 54 young children, aged 3–8 years, with autism spectrum disorders (ASD) and in 54 age and gender matched normal controls. Vitamin D, Ca, P, ALP and folate levels in children with ASD were not different from control group. The correlational analysis in children with ASD revealed that Aberrant Behaviour Checklist, Autism Behaviour Checklist, and Childhood Autism Rating Scale scores and the level of cognitive development were not correlated with these laboratory findings. Our findings do not support the idea that serum levels of vitamin D and folate might be low in children with ASD. Nevertheless, it is possible that vitamin D and folate deficiency may be playing a role in development of ASD at earlier ages or during prenatal period. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome / Kathryn HOLLOWOOD in Research in Autism Spectrum Disorders, 56 (December 2018)
[article]
Titre : Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn HOLLOWOOD, Auteur ; Stepan MELNYK, Auteur ; Oleksandra PAVLIV, Auteur ; Teresa EVANS, Auteur ; Ashley SIDES, Auteur ; Rebecca J. SCHMIDT, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; William ELMS, Auteur ; Elizabeth GUERRERO, Auteur ; Uwe KRUGER, Auteur ; Juergen HAHN, Auteur ; S. Jill JAMES, Auteur Article en page(s) : p.72-82 Langues : Anglais (eng) Mots-clés : Autism Pregnancy Metabolic profile Folate Transmethylation Transsulfuration Fisher discriminant analysis Index. décimale : PER Périodiques Résumé : Background Currently there is no test for pregnant mothers that can predict the probability of having a child that will be diagnosed with autism spectrum disorder (ASD). Recent estimates indicate that if a mother has previously had a child with ASD, the risk of having a second child with ASD is ?18.7% (High Risk) whereas the risk of ASD in the general population is ?1.7% (Low Risk). Methods In this study, metabolites of the folate-dependent transmethylation and transsulfuration biochemical pathways of pregnant mothers were measured to determine whether or not the risk of having a child with autism could be predicted by her metabolic profile. Pregnant mothers who have had a child with autism before were separated into two groups based on the diagnosis of their child whether the child had autism (ASD) or not (TD). Then these mothers were compared to a group of control mothers who have not had a child with autism before. A total of 107 mothers were in the High Risk category and 25 mothers in the Low Risk category. The High Risk category was further separated into 29 mothers in the ASD group and 78 mothers in the TD group. Results The metabolic results indicated that among High Risk mothers, it was not possible to predict an autism pregnancy outcome. However, the metabolic profile was able to predict with approximately 90% sensitivity and specificity whether a mother fell into the High Risk group (18.7% risk) or Low Risk group (1.7% risk). Conclusions Based upon these measurements it is not possible to determine during a pregnancy if a child will be diagnosed with ASD by age 3. However, differences in the folate-dependent transmethylation and transsulfuration metabolites are indicative of the risk level (High Risk of 18.7% vs. Low Risk of 1.7%) of the mother for having a child with ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.09.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Research in Autism Spectrum Disorders > 56 (December 2018) . - p.72-82[article] Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome [Texte imprimé et/ou numérique] / Kathryn HOLLOWOOD, Auteur ; Stepan MELNYK, Auteur ; Oleksandra PAVLIV, Auteur ; Teresa EVANS, Auteur ; Ashley SIDES, Auteur ; Rebecca J. SCHMIDT, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; William ELMS, Auteur ; Elizabeth GUERRERO, Auteur ; Uwe KRUGER, Auteur ; Juergen HAHN, Auteur ; S. Jill JAMES, Auteur . - p.72-82.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 56 (December 2018) . - p.72-82
Mots-clés : Autism Pregnancy Metabolic profile Folate Transmethylation Transsulfuration Fisher discriminant analysis Index. décimale : PER Périodiques Résumé : Background Currently there is no test for pregnant mothers that can predict the probability of having a child that will be diagnosed with autism spectrum disorder (ASD). Recent estimates indicate that if a mother has previously had a child with ASD, the risk of having a second child with ASD is ?18.7% (High Risk) whereas the risk of ASD in the general population is ?1.7% (Low Risk). Methods In this study, metabolites of the folate-dependent transmethylation and transsulfuration biochemical pathways of pregnant mothers were measured to determine whether or not the risk of having a child with autism could be predicted by her metabolic profile. Pregnant mothers who have had a child with autism before were separated into two groups based on the diagnosis of their child whether the child had autism (ASD) or not (TD). Then these mothers were compared to a group of control mothers who have not had a child with autism before. A total of 107 mothers were in the High Risk category and 25 mothers in the Low Risk category. The High Risk category was further separated into 29 mothers in the ASD group and 78 mothers in the TD group. Results The metabolic results indicated that among High Risk mothers, it was not possible to predict an autism pregnancy outcome. However, the metabolic profile was able to predict with approximately 90% sensitivity and specificity whether a mother fell into the High Risk group (18.7% risk) or Low Risk group (1.7% risk). Conclusions Based upon these measurements it is not possible to determine during a pregnancy if a child will be diagnosed with ASD by age 3. However, differences in the folate-dependent transmethylation and transsulfuration metabolites are indicative of the risk level (High Risk of 18.7% vs. Low Risk of 1.7%) of the mother for having a child with ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.09.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369