Neuropsychological functioning in childhood-onset psychosis and attention-deficit/hyperactivity disorder / Kimberly BRODSKY in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.811-818 Titre : Neuropsychological functioning in childhood-onset psychosis and attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kimberly BRODSKY, Auteur ; Erik G. WILLCUTT, Auteur ; Deana B. DAVALOS, Auteur ; Randal G. ROSS, Auteur Article en page(s) : p.811-818 Langues : Anglais (eng) Mots-clés : Psychosis  schizophrenia  ADHD  neuropsychology  cognition  comorbidity Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) and childhood-onset psychosis (COP) are chronic, heterogeneous disorders with symptoms that frequently co-occur, but the etiology of their comorbidity is unknown. Studies of each disorder indicate that both ADHD and COP are associated with a range of neuropsychological weaknesses, but few neuropsychological studies have directly compared groups with ADHD and COP. Methods Groups with ADHD only (32 F, 48 M), COP only (5 F, 5 M), ADHD + COP (9 F, 21 M), and a control group with neither disorder (25 F, 44 M) completed a neuropsychological battery that included measures of verbal working memory, response inhibition, response speed and variability, and selective attention. Results All three clinical groups exhibited significantly lower performance versus the control group on all neuropsychological measures, whereas the only significant difference between the clinical groups was a significantly larger weakness in verbal working memory in the groups with COP. Conclusions The frequent co-occurrence between COP and ADHD may reflect shared neuropsychological weaknesses that are most pronounced on measures of working memory and response variability. En ligne : http://dx.doi.org/10.1111/jcpp.12199 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235 [article] Neuropsychological functioning in childhood-onset psychosis and attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Kimberly BRODSKY, Auteur ; Erik G. WILLCUTT, Auteur ; Deana B. DAVALOS, Auteur ; Randal G. ROSS, Auteur . - p.811-818. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.811-818 Mots-clés : Psychosis  schizophrenia  ADHD  neuropsychology  cognition  comorbidity Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) and childhood-onset psychosis (COP) are chronic, heterogeneous disorders with symptoms that frequently co-occur, but the etiology of their comorbidity is unknown. Studies of each disorder indicate that both ADHD and COP are associated with a range of neuropsychological weaknesses, but few neuropsychological studies have directly compared groups with ADHD and COP. Methods Groups with ADHD only (32 F, 48 M), COP only (5 F, 5 M), ADHD + COP (9 F, 21 M), and a control group with neither disorder (25 F, 44 M) completed a neuropsychological battery that included measures of verbal working memory, response inhibition, response speed and variability, and selective attention. Results All three clinical groups exhibited significantly lower performance versus the control group on all neuropsychological measures, whereas the only significant difference between the clinical groups was a significantly larger weakness in verbal working memory in the groups with COP. Conclusions The frequent co-occurrence between COP and ADHD may reflect shared neuropsychological weaknesses that are most pronounced on measures of working memory and response variability. En ligne : http://dx.doi.org/10.1111/jcpp.12199 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235

Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia / Randal G. ROSS in Journal of Child Psychology and Psychiatry, 51-5 (May 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.535-549 Titre : Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Randal G. ROSS, Auteur ; Catherine ADAMS, Auteur ; Karen E. STEVENS, Auteur ; William R. PROCTOR, Auteur ; Sherry LEONARD, Auteur ; Michael A. KISLEY, Auteur ; Sharon K. HUNTER, Auteur ; Robert FREEDMAN, Auteur Année de publication : 2010 Article en page(s) : p.535-549 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The onset of diagnostic symptomology for neuropsychiatric diseases is often the end result of a decades-long process of aberrant brain development. Identification of novel treatment strategies aimed at normalizing early brain development and preventing mental illness should be a major therapeutic goal. However, there are few models for how this goal might be achieved. This review uses the development of a psychophysiological correlate of attentional deficits in schizophrenia to propose a developmental model with translational primary prevention implications. Review of genetic and neurobiological studies suggests that an early interaction between α7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits. Therapeutic implications, including perinatal dietary choline supplementation, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02187.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia [Texte imprimé et/ou numérique] / Randal G. ROSS, Auteur ; Catherine ADAMS, Auteur ; Karen E. STEVENS, Auteur ; William R. PROCTOR, Auteur ; Sherry LEONARD, Auteur ; Michael A. KISLEY, Auteur ; Sharon K. HUNTER, Auteur ; Robert FREEDMAN, Auteur . - 2010 . - p.535-549. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.535-549 Index. décimale : PER Périodiques Résumé : The onset of diagnostic symptomology for neuropsychiatric diseases is often the end result of a decades-long process of aberrant brain development. Identification of novel treatment strategies aimed at normalizing early brain development and preventing mental illness should be a major therapeutic goal. However, there are few models for how this goal might be achieved. This review uses the development of a psychophysiological correlate of attentional deficits in schizophrenia to propose a developmental model with translational primary prevention implications. Review of genetic and neurobiological studies suggests that an early interaction between α7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits. Therapeutic implications, including perinatal dietary choline supplementation, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02187.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

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