Downregulation of GABAA Receptor Protein Subunits ?6, ?2, ?, ?, ?2, ?, and ?2 in Superior Frontal Cortex of Subjects with Autism / S. Hossein FATEMI in Journal of Autism and Developmental Disorders, 44-8 (August 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.1833-1845 Titre : Downregulation of GABAA Receptor Protein Subunits ?6, ?2, ?, ?, ?2, ?, and ?2 in Superior Frontal Cortex of Subjects with Autism Type de document : Texte imprimé et/ou numérique Auteurs : S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Oyvind G. RUSTAN, Auteur ; Robert J. ROONEY, Auteur ; Paul D. THURAS, Auteur Article en page(s) : p.1833-1845 Langues : Anglais (eng) Mots-clés : Autism  GABA  Brain  GABR?6  Frontal cortex  GABR?2 Index. décimale : PER Périodiques Résumé : We measured protein and mRNA levels for nine gamma-aminobutyric acid A (GABAA) receptor subunits in three brain regions (cerebellum, superior frontal cortex, and parietal cortex) in subjects with autism versus matched controls. We observed changes in mRNA for a number of GABAA and GABAB subunits and overall reduced protein expression for GABAA receptor alpha 6 (GABR?6), GABAA receptor beta 2 (GABR?2), GABAA receptor delta (GABR?), GABAA receptor epsilon (GABR?), GABAA receptor gamma 2 (GABR?2), GABAA receptor theta (GABR?), and GABAA receptor rho 2 (GABR?2) in superior frontal cortex from subjects with autism. Our data demonstrate systematic changes in GABAAB subunit expression in brains of subjects with autism, which may help explain the presence of cognitive abnormalities in subjects with autism. En ligne : http://dx.doi.org/10.1007/s10803-014-2078-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] Downregulation of GABAA Receptor Protein Subunits ?6, ?2, ?, ?, ?2, ?, and ?2 in Superior Frontal Cortex of Subjects with Autism [Texte imprimé et/ou numérique] / S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Oyvind G. RUSTAN, Auteur ; Robert J. ROONEY, Auteur ; Paul D. THURAS, Auteur . - p.1833-1845. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.1833-1845 Mots-clés : Autism  GABA  Brain  GABR?6  Frontal cortex  GABR?2 Index. décimale : PER Périodiques Résumé : We measured protein and mRNA levels for nine gamma-aminobutyric acid A (GABAA) receptor subunits in three brain regions (cerebellum, superior frontal cortex, and parietal cortex) in subjects with autism versus matched controls. We observed changes in mRNA for a number of GABAA and GABAB subunits and overall reduced protein expression for GABAA receptor alpha 6 (GABR?6), GABAA receptor beta 2 (GABR?2), GABAA receptor delta (GABR?), GABAA receptor epsilon (GABR?), GABAA receptor gamma 2 (GABR?2), GABAA receptor theta (GABR?), and GABAA receptor rho 2 (GABR?2) in superior frontal cortex from subjects with autism. Our data demonstrate systematic changes in GABAAB subunit expression in brains of subjects with autism, which may help explain the presence of cognitive abnormalities in subjects with autism. En ligne : http://dx.doi.org/10.1007/s10803-014-2078-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism / S. Hossein FATEMI in Journal of Autism and Developmental Disorders, 40-6 (June 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-6 (June 2010) . - p.743-750 Titre : mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism Type de document : Texte imprimé et/ou numérique Auteurs : S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Paul D. THURAS, Auteur ; Robert J. ROONEY, Auteur ; Diven H. PATEL, Auteur Année de publication : 2010 Article en page(s) : p.743-750 Langues : Anglais (eng) Mots-clés : GABBR1 GABRα4 GABRα5 GABRβ1 Autism Brain Index. décimale : PER Périodiques Résumé : We have shown altered expression of gamma-aminobutyric acid A (GABAA) and gamma-aminobutyric acid B (GABAB) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABAA subunits previously associated with autism (GABRα4; GABRα5; GABRβ1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRα4, GABRα5, GABRβ1) and one demonstrated concordance in cerebellum (GABΒR1). These results provide further evidence of impairment of GABAergic signaling in autism. En ligne : http://dx.doi.org/10.1007/s10803-009-0924-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism [Texte imprimé et/ou numérique] / S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Paul D. THURAS, Auteur ; Robert J. ROONEY, Auteur ; Diven H. PATEL, Auteur . - 2010 . - p.743-750. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-6 (June 2010) . - p.743-750 Mots-clés : GABBR1 GABRα4 GABRα5 GABRβ1 Autism Brain Index. décimale : PER Périodiques Résumé : We have shown altered expression of gamma-aminobutyric acid A (GABAA) and gamma-aminobutyric acid B (GABAB) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABAA subunits previously associated with autism (GABRα4; GABRα5; GABRβ1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRα4, GABRα5, GABRβ1) and one demonstrated concordance in cerebellum (GABΒR1). These results provide further evidence of impairment of GABAergic signaling in autism. En ligne : http://dx.doi.org/10.1007/s10803-009-0924-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

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