56 recherche sur le mot-clé 'Brain'

Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder / H. BOZKURT in Autism Research, 14-10 (October 2021)  

Public ISBD [article]  inAutism Research > 14-10 (October 2021) . - p.2078-2084 Titre : Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : H. BOZKURT, Auteur ; ? ?IM?EK, Auteur ; S. ?AHIN, Auteur Article en page(s) : p.2078-2084 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Biomarkers  Brain  Brain-Derived Neurotrophic Factor  Child  Child, Preschool  Humans  Hydrocortisone  Male  Tissue Plasminogen Activator  autism  brain-derived neurotrophic factor  cortisol Index. décimale : PER Périodiques Résumé : Several studies demonstrated biological effects of cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) on human metabolism and central nervous system. Our study investigated the serum levels of tPA along with BDNF and cortisol in children with autism spectrum disorder (ASD). Thirty three male children with ASD ranging in age from 2 to 15?years were selected for the study group and 27 age-matched healthy male children were selected for the control group. The ASD severity was determined by the score on the Autism Behavior Checklist (ABC). The mean cortisol levels for the study group and the control group were 79.1?±?30.2 ng/ml and 60.0?±?25.1 ng/ml, respectively. The mean BDNF levels for the study group and the control group were 5.9?±?2.8 ng/ml and 3.7?±?1.8 ng/ml, respectively. The mean tPA levels for the study group and the control group were 32.9?±?18.5 ng/ml and 25.5?±?15.1 ng/ml, respectively. Cortisol, BDNF and tPA levels were significantly higher in the study group compared to the control group (p??0.05). It may be suggested that elevations may indicate a role in the pathogenesis of ASD or it may be the case that ASD may alter the levels or pathways of these metabolic factors. LAY SUMMARY: The underlying mechanism or a specific metabolic target relevant to autism spectrum disorder (ASD) has not yet been identified. Cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) have biological effects on neuroplasticity but little is known about the role of cortisol and tPA-BDNF pathway in ASD. In the present study focused on male children with ASD, we have found higher blood levels of cortisol, BDNF and tPA than their healthy peers. This is the first clinical study to evaluate the serum tPA levels along with BDNF and cortisol in ASD. The results suggest that several neurotrophic and other related markers should be born in mind while examining children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2582 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder [Texte imprimé et/ou numérique] / H. BOZKURT, Auteur ; ? ?IM?EK, Auteur ; S. ?AHIN, Auteur . - p.2078-2084. Langues : Anglais (eng) in Autism Research > 14-10 (October 2021) . - p.2078-2084 Mots-clés : Adolescent  Autism Spectrum Disorder  Biomarkers  Brain  Brain-Derived Neurotrophic Factor  Child  Child, Preschool  Humans  Hydrocortisone  Male  Tissue Plasminogen Activator  autism  brain-derived neurotrophic factor  cortisol Index. décimale : PER Périodiques Résumé : Several studies demonstrated biological effects of cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) on human metabolism and central nervous system. Our study investigated the serum levels of tPA along with BDNF and cortisol in children with autism spectrum disorder (ASD). Thirty three male children with ASD ranging in age from 2 to 15?years were selected for the study group and 27 age-matched healthy male children were selected for the control group. The ASD severity was determined by the score on the Autism Behavior Checklist (ABC). The mean cortisol levels for the study group and the control group were 79.1?±?30.2 ng/ml and 60.0?±?25.1 ng/ml, respectively. The mean BDNF levels for the study group and the control group were 5.9?±?2.8 ng/ml and 3.7?±?1.8 ng/ml, respectively. The mean tPA levels for the study group and the control group were 32.9?±?18.5 ng/ml and 25.5?±?15.1 ng/ml, respectively. Cortisol, BDNF and tPA levels were significantly higher in the study group compared to the control group (p??0.05). It may be suggested that elevations may indicate a role in the pathogenesis of ASD or it may be the case that ASD may alter the levels or pathways of these metabolic factors. LAY SUMMARY: The underlying mechanism or a specific metabolic target relevant to autism spectrum disorder (ASD) has not yet been identified. Cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) have biological effects on neuroplasticity but little is known about the role of cortisol and tPA-BDNF pathway in ASD. In the present study focused on male children with ASD, we have found higher blood levels of cortisol, BDNF and tPA than their healthy peers. This is the first clinical study to evaluate the serum tPA levels along with BDNF and cortisol in ASD. The results suggest that several neurotrophic and other related markers should be born in mind while examining children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2582 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children / Olivia SURGENT in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 48 p. Titre : Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Olivia SURGENT, Auteur ; Ali RIAZ, Auteur ; Karla K. AUSDERAU, Auteur ; Nagesh ADLURU, Auteur ; Gregory R. KIRK, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Emily C. SKALETSKI, Auteur ; Steven R. KECSKEMETI, Auteur ; Douglas C. DEAN III, Auteur ; Susan ELLIS WEISMER, Auteur ; Andrew L. ALEXANDER, Auteur ; Brittany G. TRAVERS, Auteur Article en page(s) : 48 p. Langues : Anglais (eng) Mots-clés : Humans  Child  White Matter  Brain  Quality of Life  Autistic Disorder  Brain Stem  Autism  Brainstem  Dti  Sensory features  Voxel-based analysis  White matter  TherVoyant). While both companies are involved in developing MRI-based surgery  techniques, neither are associated with any current areas of his research,  including the present publication. All other authors report no biomedical  financial interests of potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Elevated or reduced responses to sensory stimuli, known as sensory features, are common in autistic individuals and often impact quality of life. Little is known about the neurobiological basis of sensory features in autistic children. However, the brainstem may offer critical insights as it has been associated with both basic sensory processing and core features of autism. METHODS: Diffusion-weighted imaging (DWI) and parent-report of sensory features were acquired from 133 children (61 autistic children with and 72 non-autistic children, 6-11 years-old). Leveraging novel DWI processing techniques, we investigated the relationship between sensory features and white matter microstructure properties (free-water-elimination-corrected fractional anisotropy [FA] and mean diffusivity [MD]) in precisely delineated brainstem white matter tracts. Follow-up analyses assessed relationships between microstructure and sensory response patterns/modalities and analyzed whole brain white matter using voxel-based analysis. RESULTS: Results revealed distinct relationships between brainstem microstructure and sensory features in autistic children compared to non-autistic children. In autistic children, more prominent sensory features were generally associated with lower MD. Further, in autistic children, sensory hyporesponsiveness and tactile responsivity were strongly associated with white matter microstructure in nearly all brainstem tracts. Follow-up voxel-based analyses confirmed that these relationships were more prominent in the brainstem/cerebellum, with additional sensory-brain findings in the autistic group in the white matter of the primary motor and somatosensory cortices, the occipital lobe, the inferior parietal lobe, and the thalamic projections. LIMITATIONS: All participants communicated via spoken language and acclimated to the sensory environment of an MRI session, which should be considered when assessing the generalizability of this work to the whole of the autism spectrum. CONCLUSIONS: These findings suggest unique brainstem white matter contributions to sensory features in autistic children compared to non-autistic children. The brainstem correlates of sensory features underscore the potential reflex-like nature of behavioral responses to sensory stimuli in autism and have implications for how we conceptualize and address sensory features in autistic populations. En ligne : http://dx.doi.org/10.1186/s13229-022-00524-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children [Texte imprimé et/ou numérique] / Olivia SURGENT, Auteur ; Ali RIAZ, Auteur ; Karla K. AUSDERAU, Auteur ; Nagesh ADLURU, Auteur ; Gregory R. KIRK, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Emily C. SKALETSKI, Auteur ; Steven R. KECSKEMETI, Auteur ; Douglas C. DEAN III, Auteur ; Susan ELLIS WEISMER, Auteur ; Andrew L. ALEXANDER, Auteur ; Brittany G. TRAVERS, Auteur . - 48 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 48 p. Mots-clés : Humans  Child  White Matter  Brain  Quality of Life  Autistic Disorder  Brain Stem  Autism  Brainstem  Dti  Sensory features  Voxel-based analysis  White matter  TherVoyant). While both companies are involved in developing MRI-based surgery  techniques, neither are associated with any current areas of his research,  including the present publication. All other authors report no biomedical  financial interests of potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Elevated or reduced responses to sensory stimuli, known as sensory features, are common in autistic individuals and often impact quality of life. Little is known about the neurobiological basis of sensory features in autistic children. However, the brainstem may offer critical insights as it has been associated with both basic sensory processing and core features of autism. METHODS: Diffusion-weighted imaging (DWI) and parent-report of sensory features were acquired from 133 children (61 autistic children with and 72 non-autistic children, 6-11 years-old). Leveraging novel DWI processing techniques, we investigated the relationship between sensory features and white matter microstructure properties (free-water-elimination-corrected fractional anisotropy [FA] and mean diffusivity [MD]) in precisely delineated brainstem white matter tracts. Follow-up analyses assessed relationships between microstructure and sensory response patterns/modalities and analyzed whole brain white matter using voxel-based analysis. RESULTS: Results revealed distinct relationships between brainstem microstructure and sensory features in autistic children compared to non-autistic children. In autistic children, more prominent sensory features were generally associated with lower MD. Further, in autistic children, sensory hyporesponsiveness and tactile responsivity were strongly associated with white matter microstructure in nearly all brainstem tracts. Follow-up voxel-based analyses confirmed that these relationships were more prominent in the brainstem/cerebellum, with additional sensory-brain findings in the autistic group in the white matter of the primary motor and somatosensory cortices, the occipital lobe, the inferior parietal lobe, and the thalamic projections. LIMITATIONS: All participants communicated via spoken language and acclimated to the sensory environment of an MRI session, which should be considered when assessing the generalizability of this work to the whole of the autism spectrum. CONCLUSIONS: These findings suggest unique brainstem white matter contributions to sensory features in autistic children compared to non-autistic children. The brainstem correlates of sensory features underscore the potential reflex-like nature of behavioral responses to sensory stimuli in autism and have implications for how we conceptualize and address sensory features in autistic populations. En ligne : http://dx.doi.org/10.1186/s13229-022-00524-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Sex differentiation of brain structures in autism: Findings from a gray matter asymmetry study / Z. DENG in Autism Research, 14-6 (June 2021)  

Public ISBD [article]  inAutism Research > 14-6 (June 2021) . - p.1115-1126 Titre : Sex differentiation of brain structures in autism: Findings from a gray matter asymmetry study Type de document : Texte imprimé et/ou numérique Auteurs : Z. DENG, Auteur ; S. WANG, Auteur Article en page(s) : p.1115-1126 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Autistic Disorder/diagnostic imaging  Brain/diagnostic imaging  Female  Gray Matter/diagnostic imaging  Humans  Magnetic Resonance Imaging  Male  Sex Differentiation  Mri  autism  brain  gray matter  gray matter asymmetry  sex differences Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is diagnosed much more often in males than females. This male predominance has prompted a number of studies to examine how sex differences are related to the neural expression of ASD. Different theories, such as the "extreme male brain" theory, the "female protective effect" (FPE) theory, and the gender incoherence (GI) theory, provide different explanations for the mixed findings of sex-related neural expression of ASD. This study sought to clarify whether either theory applies to the brain structure in individuals with ASD by analyzing a selective high-quality data subset from an open data resource (Autism Brain Imaging Data Exchange I and II) including 35 males/35 females with ASD and 86 male/86 female typical-controls (TCs). We examined the sex-related changes in ASD in gray matter asymmetry measures (i.e., asymmetry index, AI) derived from voxel-based morphometry using a 2 (diagnosis: ASD vs. TC)?× ?2 (sex: female vs. male) factorial design. A diagnosis-by-sex interaction effect was identified in the planum temporale/Heschl's gyrus: (i) compared to females, males exhibited decreased AI (indicating more leftward brain asymmetry) in the TC group, whereas AI was greater (indicating less leftward brain asymmetry) for males than for females in the ASD group; and (ii) females with ASD showed reduced AI (indicating more leftward brain asymmetry) compared to female TCs, whereas there were no differences between ASDs and TCs in the male group. This interaction pattern supports the FPE theory in showing greater brain structure changes (masculinization) in females with ASD. LAY SUMMARY: To understand the neural mechanisms underlying male predominance in autism spectrum disorder (ASD), we investigated the sex differences in ASD-related alterations in brain asymmetry. We found greater changes in females with ASD compared with males with ASD, revealing a female protective effect. These findings provide novel insights into the neurobiology of sex differences in ASD. En ligne : http://dx.doi.org/10.1002/aur.2506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Sex differentiation of brain structures in autism: Findings from a gray matter asymmetry study [Texte imprimé et/ou numérique] / Z. DENG, Auteur ; S. WANG, Auteur . - p.1115-1126. Langues : Anglais (eng) in Autism Research > 14-6 (June 2021) . - p.1115-1126 Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Autistic Disorder/diagnostic imaging  Brain/diagnostic imaging  Female  Gray Matter/diagnostic imaging  Humans  Magnetic Resonance Imaging  Male  Sex Differentiation  Mri  autism  brain  gray matter  gray matter asymmetry  sex differences Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is diagnosed much more often in males than females. This male predominance has prompted a number of studies to examine how sex differences are related to the neural expression of ASD. Different theories, such as the "extreme male brain" theory, the "female protective effect" (FPE) theory, and the gender incoherence (GI) theory, provide different explanations for the mixed findings of sex-related neural expression of ASD. This study sought to clarify whether either theory applies to the brain structure in individuals with ASD by analyzing a selective high-quality data subset from an open data resource (Autism Brain Imaging Data Exchange I and II) including 35 males/35 females with ASD and 86 male/86 female typical-controls (TCs). We examined the sex-related changes in ASD in gray matter asymmetry measures (i.e., asymmetry index, AI) derived from voxel-based morphometry using a 2 (diagnosis: ASD vs. TC)?× ?2 (sex: female vs. male) factorial design. A diagnosis-by-sex interaction effect was identified in the planum temporale/Heschl's gyrus: (i) compared to females, males exhibited decreased AI (indicating more leftward brain asymmetry) in the TC group, whereas AI was greater (indicating less leftward brain asymmetry) for males than for females in the ASD group; and (ii) females with ASD showed reduced AI (indicating more leftward brain asymmetry) compared to female TCs, whereas there were no differences between ASDs and TCs in the male group. This interaction pattern supports the FPE theory in showing greater brain structure changes (masculinization) in females with ASD. LAY SUMMARY: To understand the neural mechanisms underlying male predominance in autism spectrum disorder (ASD), we investigated the sex differences in ASD-related alterations in brain asymmetry. We found greater changes in females with ASD compared with males with ASD, revealing a female protective effect. These findings provide novel insights into the neurobiology of sex differences in ASD. En ligne : http://dx.doi.org/10.1002/aur.2506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

The relationship between brain structure and general psychopathology in preadolescents / Louise MEWTON in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.734-744 Titre : The relationship between brain structure and general psychopathology in preadolescents Type de document : Texte imprimé et/ou numérique Auteurs : Louise MEWTON, Auteur ; Briana LEES, Auteur ; Lindsay M. SQUEGLIA, Auteur ; Miriam K. FORBES, Auteur ; Matthew SUNDERLAND, Auteur ; Robert F. KRUEGER, Auteur ; Forrest C. KOCH, Auteur ; Andrew BAILLIE, Auteur ; Tim SLADE, Auteur ; Nicholas HOY, Auteur ; Maree TEESSON, Auteur Article en page(s) : p.734-744 Langues : Anglais (eng) Mots-clés : Adolescent  Bayes Theorem  Brain  Child  Cognition  Humans  Male  Mental Disorders/psychology  Psychopathology  Generalized psychopathology  brain structure  externalizing  internalizing  preadolescence  interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: An emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging. METHODS: This study included baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study(®) (n=11,875; age range=9-10?years; male=52.2%). General psychopathology, externalizing, internalizing, and thought disorder dimensions were based on a higher-order model of psychopathology and estimated using Bayesian plausible values. Outcome variables included global and regional cortical volume, thickness, and surface area. RESULTS: Higher levels of psychopathology across all dimensions were associated with lower volume and surface area globally, as well as widespread and pervasive alterations across the majority of cortical and subcortical regions studied, after adjusting for sex, race/ethnicity, parental education, income, and maternal psychopathology. The relationships between general psychopathology and brain structure were attenuated when adjusting for cognitive functioning. There were no statistically significant relationships between psychopathology and cortical thickness in this sample of preadolescents. CONCLUSIONS: The current study identified lower cortical volume and surface area as transdiagnostic biomarkers for general psychopathology in preadolescence. Future research may focus on whether the widespread and pervasive relationships between general psychopathology and brain structure reflect cognitive dysfunction that is a feature across a range of mental illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.13513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] The relationship between brain structure and general psychopathology in preadolescents [Texte imprimé et/ou numérique] / Louise MEWTON, Auteur ; Briana LEES, Auteur ; Lindsay M. SQUEGLIA, Auteur ; Miriam K. FORBES, Auteur ; Matthew SUNDERLAND, Auteur ; Robert F. KRUEGER, Auteur ; Forrest C. KOCH, Auteur ; Andrew BAILLIE, Auteur ; Tim SLADE, Auteur ; Nicholas HOY, Auteur ; Maree TEESSON, Auteur . - p.734-744. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.734-744 Mots-clés : Adolescent  Bayes Theorem  Brain  Child  Cognition  Humans  Male  Mental Disorders/psychology  Psychopathology  Generalized psychopathology  brain structure  externalizing  internalizing  preadolescence  interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: An emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging. METHODS: This study included baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study(®) (n=11,875; age range=9-10?years; male=52.2%). General psychopathology, externalizing, internalizing, and thought disorder dimensions were based on a higher-order model of psychopathology and estimated using Bayesian plausible values. Outcome variables included global and regional cortical volume, thickness, and surface area. RESULTS: Higher levels of psychopathology across all dimensions were associated with lower volume and surface area globally, as well as widespread and pervasive alterations across the majority of cortical and subcortical regions studied, after adjusting for sex, race/ethnicity, parental education, income, and maternal psychopathology. The relationships between general psychopathology and brain structure were attenuated when adjusting for cognitive functioning. There were no statistically significant relationships between psychopathology and cortical thickness in this sample of preadolescents. CONCLUSIONS: The current study identified lower cortical volume and surface area as transdiagnostic biomarkers for general psychopathology in preadolescence. Future research may focus on whether the widespread and pervasive relationships between general psychopathology and brain structure reflect cognitive dysfunction that is a feature across a range of mental illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.13513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Brief Report: Antibodies Reacting to Brain Tissue in Basque Spanish Children with Autism Spectrum Disorder and Their Mothers / Christy C. ROSSI in Journal of Autism and Developmental Disorders, 44-2 (February 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-2 (February 2014) . - p.459-465 Titre : Brief Report: Antibodies Reacting to Brain Tissue in Basque Spanish Children with Autism Spectrum Disorder and Their Mothers Type de document : Texte imprimé et/ou numérique Auteurs : Christy C. ROSSI, Auteur ; Joaquin FUENTES, Auteur ; Judy WATER, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.459-465 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Autoantibody  Brain  International Index. décimale : PER Périodiques Résumé : Previous investigations found that a subset of children with autism spectrum disorder (ASD) in California possessed plasma autoantibodies that reacted intensely with brain interneurons or other neural profiles. Moreover, for several cohorts of American women, maternal autoantibody reactivity to specific fetal brain proteins was highly specific to mothers of children with ASD. We sought to determine whether children and their mothers from a regionally specific cohort from the Basque Country of Spain demonstrated similar reactivity. Some children’s plasma reacted to interneurons, beaded axons or other neural profiles with no difference in the occurrence of these antibodies in children with or without ASD. Findings on the maternal antibodies confirmed previous research; plasma reactivity to fetal brain a combination of proteins at 37 and 73 kDa or 39 and 73 kDa was found exclusively in mothers of children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1859-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223 [article] Brief Report: Antibodies Reacting to Brain Tissue in Basque Spanish Children with Autism Spectrum Disorder and Their Mothers [Texte imprimé et/ou numérique] / Christy C. ROSSI, Auteur ; Joaquin FUENTES, Auteur ; Judy WATER, Auteur ; David G. AMARAL, Auteur . - p.459-465. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-2 (February 2014) . - p.459-465 Mots-clés : Autism spectrum disorders  Autoantibody  Brain  International Index. décimale : PER Périodiques Résumé : Previous investigations found that a subset of children with autism spectrum disorder (ASD) in California possessed plasma autoantibodies that reacted intensely with brain interneurons or other neural profiles. Moreover, for several cohorts of American women, maternal autoantibody reactivity to specific fetal brain proteins was highly specific to mothers of children with ASD. We sought to determine whether children and their mothers from a regionally specific cohort from the Basque Country of Spain demonstrated similar reactivity. Some children’s plasma reacted to interneurons, beaded axons or other neural profiles with no difference in the occurrence of these antibodies in children with or without ASD. Findings on the maternal antibodies confirmed previous research; plasma reactivity to fetal brain a combination of proteins at 37 and 73 kDa or 39 and 73 kDa was found exclusively in mothers of children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1859-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223

Cortical Synaptogenesis in the Human Brain in Conditions of Prenatal Alcoholization / T.V. SHUSHPANOVA in Autism - Open Access, 6-2 ([01/03/2016])  

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Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder / Chanaka N. KAHATHUDUWA in Journal of Autism and Developmental Disorders, 49-12 (December 2019)  

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Finding Endophenotypes for Autism Spectrum Disorders (ASD): cDNA Microarrays and Brain Transcripts / Patrice BOURGEOIS

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From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition / A. M. YOUNG in Molecular Autism, 7 (2016)  

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A genotype resource for postmortem brain samples from the Autism Tissue Program / Richard F. WINTLE in Autism Research, 4-2 (April 2011)  

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