An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions / Yu-Chun CHEN in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2287-2299 Titre : An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions Type de document : texte imprimé Auteurs : Yu-Chun CHEN, Auteur ; Chenyi CHEN, Auteur ; Róger Marcelo MARTÍNEZ, Auteur ; Yang-Teng FAN, Auteur ; Chia-Chien LIU, Auteur ; Chin-Yau CHEN, Auteur ; Yu-Chun CHENG, Auteur Année de publication : 2021 Article en page(s) : p.2287-2299 Langues : Anglais (eng) Mots-clés : Adolescent  Amygdala/diagnostic imaging  Anxiety/complications  Autism Spectrum Disorder/complications/diagnostic imaging  Autistic Disorder  Case-Control Studies  Facial Recognition  Humans  Magnetic Resonance Imaging  amygdala  autism spectrum condition (ASC)  explicit  implicit  threat Index. décimale : PER Périodiques Résumé : Anxiety is exceedingly prevalent among individuals with an autism spectrum condition (ASC). While recent literature postulates anxiety as a mechanism encompassing an underlying amygdala-related elevated baseline level of arousal even to nonthreatening cues, whether this same mechanism contributes to anxiety in those with an ASC and supports the transdiagnostic nature of anxiety remains elusive. In this case-control study of 51 youths (26 ASC), we assessed autism and anxiety via the Autism-Spectrum Quotient and the State-Trait Anxiety Inventory, respectively. Hemodynamic responses, including amygdala reactivity, to explicit and implicit (backwardly masked) perception of threatening faces were acquired using functional Magnetic Resonance Imaging (fMRI). For explicit fear, ASC individuals showed significantly greater negative correlations between the amygdala and the attentional deployment-parietal network. For implicit fear, ASC individuals showed significantly stronger correlations of the amygdala with the prefrontal networks, temporal pole, and hippocampus. Additionally, an fMRI-based neurologic signature for anxiety in ASCs was identified via the LibSVM machine learning model using amygdala-centered functional connectivity during the emotional processing of explicit and implicit stimuli. Hypervigilance to implicit threat in ASCs comorbid with anxiety might exacerbate explicit threat reactivity; hence the use of attentional avoidance patterns to restrict affective hyperarousal for explicitly perceived socioemotional stimuli. Consequently, developing an attention-independent behavioral/neural marker identifying anxiety in ASCs is highly warranted. LAY SUMMARY: This study identifies a dissociation of amygdala reactivity dependent on explicit and implicit threat processing. Implicit anxiety in individuals with an autism spectrum condition (ASC) could outweigh explicitly induced threat. When explicitly perceiving socioemotional stimuli, ASC individuals with anxiety might use attentional avoidance patterns to restrict affective hyperarousal. En ligne : http://dx.doi.org/10.1002/aur.2595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions [texte imprimé] / Yu-Chun CHEN, Auteur ; Chenyi CHEN, Auteur ; Róger Marcelo MARTÍNEZ, Auteur ; Yang-Teng FAN, Auteur ; Chia-Chien LIU, Auteur ; Chin-Yau CHEN, Auteur ; Yu-Chun CHENG, Auteur . - 2021 . - p.2287-2299. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2287-2299 Mots-clés : Adolescent  Amygdala/diagnostic imaging  Anxiety/complications  Autism Spectrum Disorder/complications/diagnostic imaging  Autistic Disorder  Case-Control Studies  Facial Recognition  Humans  Magnetic Resonance Imaging  amygdala  autism spectrum condition (ASC)  explicit  implicit  threat Index. décimale : PER Périodiques Résumé : Anxiety is exceedingly prevalent among individuals with an autism spectrum condition (ASC). While recent literature postulates anxiety as a mechanism encompassing an underlying amygdala-related elevated baseline level of arousal even to nonthreatening cues, whether this same mechanism contributes to anxiety in those with an ASC and supports the transdiagnostic nature of anxiety remains elusive. In this case-control study of 51 youths (26 ASC), we assessed autism and anxiety via the Autism-Spectrum Quotient and the State-Trait Anxiety Inventory, respectively. Hemodynamic responses, including amygdala reactivity, to explicit and implicit (backwardly masked) perception of threatening faces were acquired using functional Magnetic Resonance Imaging (fMRI). For explicit fear, ASC individuals showed significantly greater negative correlations between the amygdala and the attentional deployment-parietal network. For implicit fear, ASC individuals showed significantly stronger correlations of the amygdala with the prefrontal networks, temporal pole, and hippocampus. Additionally, an fMRI-based neurologic signature for anxiety in ASCs was identified via the LibSVM machine learning model using amygdala-centered functional connectivity during the emotional processing of explicit and implicit stimuli. Hypervigilance to implicit threat in ASCs comorbid with anxiety might exacerbate explicit threat reactivity; hence the use of attentional avoidance patterns to restrict affective hyperarousal for explicitly perceived socioemotional stimuli. Consequently, developing an attention-independent behavioral/neural marker identifying anxiety in ASCs is highly warranted. LAY SUMMARY: This study identifies a dissociation of amygdala reactivity dependent on explicit and implicit threat processing. Implicit anxiety in individuals with an autism spectrum condition (ASC) could outweigh explicitly induced threat. When explicitly perceiving socioemotional stimuli, ASC individuals with anxiety might use attentional avoidance patterns to restrict affective hyperarousal. En ligne : http://dx.doi.org/10.1002/aur.2595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Functional but Inefficient Kinesthetic Motor Imagery in Adolescents with Autism Spectrum Disorder / Yen-Tsz CHEN in Journal of Autism and Developmental Disorders, 48-3 (March 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-3 (March 2018) . - p.784-795 Titre : Functional but Inefficient Kinesthetic Motor Imagery in Adolescents with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Yen-Tsz CHEN, Auteur ; Kuo-Su TSOU, Auteur ; Hao-Ling CHEN, Auteur ; Ching-Ching WONG, Auteur ; Yang-Teng FAN, Auteur ; Chien-Te WU, Auteur Année de publication : 2018 Article en page(s) : p.784-795 Langues : Anglais (eng) Mots-clés : Action representation  Autism spectrum disorder  Motor cognition  Motor imagery Index. décimale : PER Périodiques Résumé : Whether action representation in individuals with autism spectrum disorder (ASD) is deficient remains controversial, as previous studies of action observation or imitation report conflicting results. Here we investigated the characteristics of action representation in adolescents with ASD through motor imagery (MI) using a hand rotation and an object rotation task. Comparable with the typically-developing group, the individuals with ASD were able to spontaneously use kinesthetic MI to perform the hand rotation task, as manifested by the significant biomechanical effects. However, the ASD group performed significantly slower only in the hand rotation task, but not in the object rotation task. The findings suggest that the adolescents with ASD showed inefficient but functional kinesthetic MI, implicating that their action representation might be preserved. En ligne : https://doi.org/10.1007/s10803-017-3367-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338 [article] Functional but Inefficient Kinesthetic Motor Imagery in Adolescents with Autism Spectrum Disorder [texte imprimé] / Yen-Tsz CHEN, Auteur ; Kuo-Su TSOU, Auteur ; Hao-Ling CHEN, Auteur ; Ching-Ching WONG, Auteur ; Yang-Teng FAN, Auteur ; Chien-Te WU, Auteur . - 2018 . - p.784-795. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-3 (March 2018) . - p.784-795 Mots-clés : Action representation  Autism spectrum disorder  Motor cognition  Motor imagery Index. décimale : PER Périodiques Résumé : Whether action representation in individuals with autism spectrum disorder (ASD) is deficient remains controversial, as previous studies of action observation or imitation report conflicting results. Here we investigated the characteristics of action representation in adolescents with ASD through motor imagery (MI) using a hand rotation and an object rotation task. Comparable with the typically-developing group, the individuals with ASD were able to spontaneously use kinesthetic MI to perform the hand rotation task, as manifested by the significant biomechanical effects. However, the ASD group performed significantly slower only in the hand rotation task, but not in the object rotation task. The findings suggest that the adolescents with ASD showed inefficient but functional kinesthetic MI, implicating that their action representation might be preserved. En ligne : https://doi.org/10.1007/s10803-017-3367-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338

Linkage between pain sensitivity and empathic response in adolescents with autism spectrum conditions and conduct disorder symptoms / Chenyi CHEN in Autism Research, 10-2 (February 2017)  

Public ISBD [article]  inAutism Research > 10-2 (February 2017) . - p.267-275 Titre : Linkage between pain sensitivity and empathic response in adolescents with autism spectrum conditions and conduct disorder symptoms Type de document : texte imprimé Auteurs : Chenyi CHEN, Auteur ; An-Yi HUNG, Auteur ; Yang-Teng FAN, Auteur ; Shuai TAN, Auteur ; Hua HONG, Auteur ; Yawei CHENG, Auteur Article en page(s) : p.267-275 Langues : Anglais (eng) Mots-clés : pain sensitivity  empathy  autism spectrum conditions  conduct disorder symptom Index. décimale : PER Périodiques Résumé : Lack of empathy is one of the behavioral hallmarks in individuals with autism spectrum conditions (ASC) as well as youth with conduct disorder symptoms (CDS). Previous research has reliably documented considerable overlap between the perception of others' pain and first-hand experience of pain. However, the linkage between empathy for pain and sensitivity to physical pain needs to be empirically determined, particularly in individuals with empathy deficits. This study measured the pressure pain threshold, which indexes sensitization of peripheral nociceptors, and assessed subjective ratings of unpleasantness and pain intensity in response to empathy-eliciting stimuli depicting physical bodily injuries in three age- and sex-matched participant groups: ASC, CDS, and typically developing controls (TDC). The results indicated that the pain threshold was lowest in the ASC group and highest in the CDS group. The ASC group displayed lower ratings of unpleasantness and pain intensity than did the TDC and CDS groups. Within the ASC and CDS, pain intensity ratings were significantly correlated with unpleasantness ratings to others' pain. Moreover, the ASC significantly differed from the TDC in the correlation between pain threshold values and unpleasantness ratings. These findings may cast some light on the linkage between atypical low-level sensory functioning, for instance altered pain sensitivity, and high-level empathic processing. En ligne : http://dx.doi.org/10.1002/aur.1653 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Linkage between pain sensitivity and empathic response in adolescents with autism spectrum conditions and conduct disorder symptoms [texte imprimé] / Chenyi CHEN, Auteur ; An-Yi HUNG, Auteur ; Yang-Teng FAN, Auteur ; Shuai TAN, Auteur ; Hua HONG, Auteur ; Yawei CHENG, Auteur . - p.267-275. Langues : Anglais (eng) in Autism Research > 10-2 (February 2017) . - p.267-275 Mots-clés : pain sensitivity  empathy  autism spectrum conditions  conduct disorder symptom Index. décimale : PER Périodiques Résumé : Lack of empathy is one of the behavioral hallmarks in individuals with autism spectrum conditions (ASC) as well as youth with conduct disorder symptoms (CDS). Previous research has reliably documented considerable overlap between the perception of others' pain and first-hand experience of pain. However, the linkage between empathy for pain and sensitivity to physical pain needs to be empirically determined, particularly in individuals with empathy deficits. This study measured the pressure pain threshold, which indexes sensitization of peripheral nociceptors, and assessed subjective ratings of unpleasantness and pain intensity in response to empathy-eliciting stimuli depicting physical bodily injuries in three age- and sex-matched participant groups: ASC, CDS, and typically developing controls (TDC). The results indicated that the pain threshold was lowest in the ASC group and highest in the CDS group. The ASC group displayed lower ratings of unpleasantness and pain intensity than did the TDC and CDS groups. Within the ASC and CDS, pain intensity ratings were significantly correlated with unpleasantness ratings to others' pain. Moreover, the ASC significantly differed from the TDC in the correlation between pain threshold values and unpleasantness ratings. These findings may cast some light on the linkage between atypical low-level sensory functioning, for instance altered pain sensitivity, and high-level empathic processing. En ligne : http://dx.doi.org/10.1002/aur.1653 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Unbroken mirror neurons in autism spectrum disorders / Yang-Teng FAN in Journal of Child Psychology and Psychiatry, 51-9 (September 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-9 (September 2010) . - p.981-988 Titre : Unbroken mirror neurons in autism spectrum disorders Type de document : texte imprimé Auteurs : Yang-Teng FAN, Auteur ; Jean DECETY, Auteur ; Chia-Yen YANG, Auteur ; Ji-Lin LIU, Auteur ; Yawei CHENG, Auteur Année de publication : 2010 Article en page(s) : p.981-988 Langues : Anglais (eng) Mots-clés : Mirror-neurons autism-spectrum-disorders mu-suppression Index. décimale : PER Périodiques Résumé : Background:  The ‘broken mirror’ theory of autism, which proposes that a dysfunction of the human mirror neuron system (MNS) is responsible for the core social and cognitive deficits in individuals with autism spectrum disorders (ASD), has received considerable attention despite weak empirical evidence. Methods:  In this electroencephalographic study, we examined mu suppression, as an indicator of sensorimotor resonance, concurrent with oculomotor performance while individuals (n = 20) with ASD and control participants (n = 20) either executed hand actions or observed hand actions or a moving dot. No difference in visual attention between groups was found as indicated by fixation duration and normalized fixation number on the presented stimuli. Results:  The mu suppression over the sensorimotor cortex was significantly affected by experimental conditions, but not by group membership, nor by the interaction between groups and conditions. Individuals with ASD, similar to the controls, exhibited stronger mu suppression when watching hand actions relative to a moving dot. Notably, participants with ASD failed to imitate the observed actions while their mu suppression indicating the MNS activity was intact. In addition, the mu suppression during the observation of hand actions was positively associated with the communication competence of individuals with ASD. Conclusion:  Our study clearly challenges the broken mirror theory of autism. The functioning of the mirror neuron system might be preserved in individuals with ASD to a certain degree. Less mu suppression to action observation coupled with more communicational severity can reflect the symptom heterogeneity of ASD. Additional research needs to be done, and more caution should be used when reaching out to the media. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02269.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Unbroken mirror neurons in autism spectrum disorders [texte imprimé] / Yang-Teng FAN, Auteur ; Jean DECETY, Auteur ; Chia-Yen YANG, Auteur ; Ji-Lin LIU, Auteur ; Yawei CHENG, Auteur . - 2010 . - p.981-988. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-9 (September 2010) . - p.981-988 Mots-clés : Mirror-neurons autism-spectrum-disorders mu-suppression Index. décimale : PER Périodiques Résumé : Background:  The ‘broken mirror’ theory of autism, which proposes that a dysfunction of the human mirror neuron system (MNS) is responsible for the core social and cognitive deficits in individuals with autism spectrum disorders (ASD), has received considerable attention despite weak empirical evidence. Methods:  In this electroencephalographic study, we examined mu suppression, as an indicator of sensorimotor resonance, concurrent with oculomotor performance while individuals (n = 20) with ASD and control participants (n = 20) either executed hand actions or observed hand actions or a moving dot. No difference in visual attention between groups was found as indicated by fixation duration and normalized fixation number on the presented stimuli. Results:  The mu suppression over the sensorimotor cortex was significantly affected by experimental conditions, but not by group membership, nor by the interaction between groups and conditions. Individuals with ASD, similar to the controls, exhibited stronger mu suppression when watching hand actions relative to a moving dot. Notably, participants with ASD failed to imitate the observed actions while their mu suppression indicating the MNS activity was intact. In addition, the mu suppression during the observation of hand actions was positively associated with the communication competence of individuals with ASD. Conclusion:  Our study clearly challenges the broken mirror theory of autism. The functioning of the mirror neuron system might be preserved in individuals with ASD to a certain degree. Less mu suppression to action observation coupled with more communicational severity can reflect the symptom heterogeneity of ASD. Additional research needs to be done, and more caution should be used when reaching out to the media. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02269.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

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