Birth weight and autism spectrum disorder: A population-based nested case-control study / Ziv TALMI in Autism Research, 13-4 (April 2020)  

Public ISBD [article]  inAutism Research > 13-4 (April 2020) . - p.655-665 Titre : Birth weight and autism spectrum disorder: A population-based nested case-control study Type de document : texte imprimé Auteurs : Ziv TALMI, Auteur ; David MANKUTA, Auteur ; Raanan RAZ, Auteur Article en page(s) : p.655-665 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  birth weight  case-control study  epidemiology  perinatal risk factors Index. décimale : PER Périodiques Résumé : Low birth weight (<2,500 g) and preterm birth (<37 weeks) were found to be associated with increased risk of autism spectrum disorder (ASD), however, the data regarding the entire birth weight (BW) and gestational age (GA) range are inconclusive. In this population nested case-control study, based on the Israeli National Insurance Institute records, we aimed to estimate the associations in the Israeli population. The study population included all children born between 2000 and 2012 and diagnosed with ASD (N = 12,635 cases), and a random 20% sample of children born in the same period who were not diagnosed with ASD (N = 369,548 controls). We used multiple logistic regression models to calculate the risk of ASD for each BW and GA category, adjusted for covariates (child sex, maternal age, paternal age, population group, maternal wage, paternal wage, having a sibling with ASD, multiple gestation and socioeconomic status). BW < 3,000 g and GA < 39 weeks were associated with higher risk of ASD, including BW of 2,500-3,000 g (adjusted odds ratio [AOR], 1.18; 95% CI, 1.12-1.24, in comparison to the 3,000-3,500 g category) and GA of 37 & 38 weeks (AOR, 1.35; 95% CI, 1.25-1.45 and AOR, 1.13; 95% CI 1.06-1.20, respectively; in comparison to GA of 40 weeks). To account for the high correlation between GA and BW, we modeled BW percentiles for gestational age and found that the BW < 20th percentile was associated with an increased risk of ASD (AOR, 1.10; 95% CI, 1.01-1.19). These results demonstrate that associations of ASD with BW and GA are not limited to commonly used clinical cutoffs. Autism Res 2020, 13: 655-665. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Autism spectrum disorder (ASD) has been associated with low birth weight (<2,500 g) in prior research. Our study aims to describe the relationship between birth weight (BW) and ASD in the Israeli population. We found that BW <3,000 g was associated with a higher risk of ASD. These results demonstrate that an increased risk of ASD is not confined to clinically defined cutoffs such as BW < 2,500 g. En ligne : http://dx.doi.org/10.1002/aur.2260 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Birth weight and autism spectrum disorder: A population-based nested case-control study [texte imprimé] / Ziv TALMI, Auteur ; David MANKUTA, Auteur ; Raanan RAZ, Auteur . - p.655-665. Langues : Anglais (eng) in Autism Research > 13-4 (April 2020) . - p.655-665 Mots-clés : autism spectrum disorder  birth weight  case-control study  epidemiology  perinatal risk factors Index. décimale : PER Périodiques Résumé : Low birth weight (<2,500 g) and preterm birth (<37 weeks) were found to be associated with increased risk of autism spectrum disorder (ASD), however, the data regarding the entire birth weight (BW) and gestational age (GA) range are inconclusive. In this population nested case-control study, based on the Israeli National Insurance Institute records, we aimed to estimate the associations in the Israeli population. The study population included all children born between 2000 and 2012 and diagnosed with ASD (N = 12,635 cases), and a random 20% sample of children born in the same period who were not diagnosed with ASD (N = 369,548 controls). We used multiple logistic regression models to calculate the risk of ASD for each BW and GA category, adjusted for covariates (child sex, maternal age, paternal age, population group, maternal wage, paternal wage, having a sibling with ASD, multiple gestation and socioeconomic status). BW < 3,000 g and GA < 39 weeks were associated with higher risk of ASD, including BW of 2,500-3,000 g (adjusted odds ratio [AOR], 1.18; 95% CI, 1.12-1.24, in comparison to the 3,000-3,500 g category) and GA of 37 & 38 weeks (AOR, 1.35; 95% CI, 1.25-1.45 and AOR, 1.13; 95% CI 1.06-1.20, respectively; in comparison to GA of 40 weeks). To account for the high correlation between GA and BW, we modeled BW percentiles for gestational age and found that the BW < 20th percentile was associated with an increased risk of ASD (AOR, 1.10; 95% CI, 1.01-1.19). These results demonstrate that associations of ASD with BW and GA are not limited to commonly used clinical cutoffs. Autism Res 2020, 13: 655-665. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Autism spectrum disorder (ASD) has been associated with low birth weight (<2,500 g) in prior research. Our study aims to describe the relationship between birth weight (BW) and ASD in the Israeli population. We found that BW <3,000 g was associated with a higher risk of ASD. These results demonstrate that an increased risk of ASD is not confined to clinically defined cutoffs such as BW < 2,500 g. En ligne : http://dx.doi.org/10.1002/aur.2260 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development / Edwa FRIEDLANDER in Autism Research, 12-7 (July 2019)  

Public ISBD [article]  inAutism Research > 12-7 (July 2019) . - p.1087-1100 Titre : Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development Type de document : texte imprimé Auteurs : Edwa FRIEDLANDER, Auteur ; Nurit YIRMIYA, Auteur ; Efrat LAIBA, Auteur ; Ayelet HAREL-GADASSI, Auteur ; Maya YAARI, Auteur ; Ohad FELDSTEIN, Auteur ; David MANKUTA, Auteur ; Salomon ISRAEL, Auteur Année de publication : 2019 Article en page(s) : p.1087-1100 Langues : Anglais (eng) Mots-clés : Oxtr  autism spectrum disorder  gene-environment interaction  oxytocin  oxytocin receptor antagonist  oxytocin receptor gene Index. décimale : PER Périodiques Résumé : Compelling evidence for the far-reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor (OXTR) gene and risk for autism spectrum disorder (ASD). In the current study, gene-environment interaction between OXTR and prenatal exposure to either OT or OXTR antagonist (OXTRA) in predicting early social communication development was examined. One hundred and fifty-three children (age: M = 4.32, SD = 1.07) were assigned to four groups based on prenatal history: children whose mothers prenatally received OXTRA and Nifedipine to delay preterm labor (n = 27); children whose mothers received Nifedipine only to delay preterm labor (n = 35); children whose mothers received OT for labor augmentation (n = 56), and a no intervention group (n = 35). Participants completed a developmental assessment of intelligence quotient (IQ), adaptive behavior, and social communication abilities. DNA was extracted via buccal swab. A genetic risk score was calculated based on four OXTR single nucleotide polymorphisms (rs53576, rs237887, rs1042778, and rs2254298) previously reported to be associated with ASD symptomatology. OXTRrisk-allele dosage was associated with more severe autism diagnostics observation schedule (ADOS) scores only in the OXTRA group. In contrast, in the Nifedipine, OT, and no intervention groups, OXTRrisk-allele dosage was not associated with children's ADOS scores. These findings highlight the importance of both genetic and environmental pathways of OT in signaling early social development and raise the need for further research in this field. Autism Res 2019, 12: 1087-1100. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In the current study, we examined if the association between prenatal exposure to an oxytocin receptor antagonist (OXTRA) and autism spectrum disorder (ASD) related impairments are dependent on an individual's genetic background for the oxytocin receptor gene (OXTR). Children who carried a greater number of risk alleles for the OXTR gene and whose mothers received OXTRA to delay preterm labor showed more ASD-related impairments. The results highlight the importance of both genetic and environmental pathways of oxytocin in shaping early social development. En ligne : http://dx.doi.org/10.1002/aur.2111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development [texte imprimé] / Edwa FRIEDLANDER, Auteur ; Nurit YIRMIYA, Auteur ; Efrat LAIBA, Auteur ; Ayelet HAREL-GADASSI, Auteur ; Maya YAARI, Auteur ; Ohad FELDSTEIN, Auteur ; David MANKUTA, Auteur ; Salomon ISRAEL, Auteur . - 2019 . - p.1087-1100. Langues : Anglais (eng) in Autism Research > 12-7 (July 2019) . - p.1087-1100 Mots-clés : Oxtr  autism spectrum disorder  gene-environment interaction  oxytocin  oxytocin receptor antagonist  oxytocin receptor gene Index. décimale : PER Périodiques Résumé : Compelling evidence for the far-reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor (OXTR) gene and risk for autism spectrum disorder (ASD). In the current study, gene-environment interaction between OXTR and prenatal exposure to either OT or OXTR antagonist (OXTRA) in predicting early social communication development was examined. One hundred and fifty-three children (age: M = 4.32, SD = 1.07) were assigned to four groups based on prenatal history: children whose mothers prenatally received OXTRA and Nifedipine to delay preterm labor (n = 27); children whose mothers received Nifedipine only to delay preterm labor (n = 35); children whose mothers received OT for labor augmentation (n = 56), and a no intervention group (n = 35). Participants completed a developmental assessment of intelligence quotient (IQ), adaptive behavior, and social communication abilities. DNA was extracted via buccal swab. A genetic risk score was calculated based on four OXTR single nucleotide polymorphisms (rs53576, rs237887, rs1042778, and rs2254298) previously reported to be associated with ASD symptomatology. OXTRrisk-allele dosage was associated with more severe autism diagnostics observation schedule (ADOS) scores only in the OXTRA group. In contrast, in the Nifedipine, OT, and no intervention groups, OXTRrisk-allele dosage was not associated with children's ADOS scores. These findings highlight the importance of both genetic and environmental pathways of OT in signaling early social development and raise the need for further research in this field. Autism Res 2019, 12: 1087-1100. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In the current study, we examined if the association between prenatal exposure to an oxytocin receptor antagonist (OXTRA) and autism spectrum disorder (ASD) related impairments are dependent on an individual's genetic background for the oxytocin receptor gene (OXTR). Children who carried a greater number of risk alleles for the OXTR gene and whose mothers received OXTRA to delay preterm labor showed more ASD-related impairments. The results highlight the importance of both genetic and environmental pathways of oxytocin in shaping early social development. En ligne : http://dx.doi.org/10.1002/aur.2111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study / Elad LERER in Autism Research, 3-6 (December 2010)  

Public ISBD [article]  inAutism Research > 3-6 (December 2010) . - p.293-302 Titre : Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study Type de document : texte imprimé Auteurs : Elad LERER, Auteur ; Shlomit LEVI, Auteur ; Salomon ISRAEL, Auteur ; Maya YAARI, Auteur ; Lubov NEMANOV, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2010 Article en page(s) : p.293-302 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD)  CD38;polymorphism  gene expression  real time PCR  haplotype Index. décimale : PER Périodiques Résumé : Background: Impairments in social processes characterize one of the core deficits in autism spectrum disorders (ASD) and accumulating evidence suggests that oxytocin neurotransmission is implicated in mediating social adaptation in ASD. Using a mouse model, CD38, a transmembrane protein expressed in immune cells but also in brain, was found to be critical for social behavior via regulation of oxytocin secretion. This prompted us to both examine CD38 expression in human lymphoblastoid cell lines (LBC) as well as to test association between SNPs across the CD38 gene and ASD. Methods: LBC's were derived from 44 ASD lines and 40 “unaffected” parents. Family-based association (UNPHASED) was examined by genotyping 11 tagging SNPs spanning the CD38 gene identified using HapMap data in 170 trios. An additional SNP (rs3796863) associated in a study by Munesue et al. with ASD was also genotyped. Results: A highly significant reduction in CD38 expression was observed in immortalized lymphocytes derived from ASD subjects compared to their “unaffected” parents (F = 17.2, P = 0.00024, df = 1). Haplotype analysis showed significant association (permutation corrected) between three and seven locus haplotypes and DSM IV ASD in low functioning (IQ<70) subjects. Conclusions: The current report supports a role for CD38 in conferring risk for ASD. Notably, our study shows that this gene is not only associated with low functioning ASD but that CD38 expression is markedly reduced in LBC derived from ASD subjects compared to “unaffected” parents, strengthening the connection between oxytocin and ASD. En ligne : http://dx.doi.org/10.1002/aur.156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study [texte imprimé] / Elad LERER, Auteur ; Shlomit LEVI, Auteur ; Salomon ISRAEL, Auteur ; Maya YAARI, Auteur ; Lubov NEMANOV, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur ; Richard P. EBSTEIN, Auteur . - 2010 . - p.293-302. Langues : Anglais (eng) in Autism Research > 3-6 (December 2010) . - p.293-302 Mots-clés : autism spectrum disorder (ASD)  CD38;polymorphism  gene expression  real time PCR  haplotype Index. décimale : PER Périodiques Résumé : Background: Impairments in social processes characterize one of the core deficits in autism spectrum disorders (ASD) and accumulating evidence suggests that oxytocin neurotransmission is implicated in mediating social adaptation in ASD. Using a mouse model, CD38, a transmembrane protein expressed in immune cells but also in brain, was found to be critical for social behavior via regulation of oxytocin secretion. This prompted us to both examine CD38 expression in human lymphoblastoid cell lines (LBC) as well as to test association between SNPs across the CD38 gene and ASD. Methods: LBC's were derived from 44 ASD lines and 40 “unaffected” parents. Family-based association (UNPHASED) was examined by genotyping 11 tagging SNPs spanning the CD38 gene identified using HapMap data in 170 trios. An additional SNP (rs3796863) associated in a study by Munesue et al. with ASD was also genotyped. Results: A highly significant reduction in CD38 expression was observed in immortalized lymphocytes derived from ASD subjects compared to their “unaffected” parents (F = 17.2, P = 0.00024, df = 1). Haplotype analysis showed significant association (permutation corrected) between three and seven locus haplotypes and DSM IV ASD in low functioning (IQ<70) subjects. Conclusions: The current report supports a role for CD38 in conferring risk for ASD. Notably, our study shows that this gene is not only associated with low functioning ASD but that CD38 expression is markedly reduced in LBC derived from ASD subjects compared to “unaffected” parents, strengthening the connection between oxytocin and ASD. En ligne : http://dx.doi.org/10.1002/aur.156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

Risk for ASD in Preterm Infants: A Three-Year Follow-Up Study / Ayelet HAREL-GADASSI in Autism Research and Treatment, 2018 (2018)  

Public ISBD [article]  inAutism Research and Treatment > 2018 (2018) . - 9p. Titre : Risk for ASD in Preterm Infants: A Three-Year Follow-Up Study Type de document : texte imprimé Auteurs : Ayelet HAREL-GADASSI, Auteur ; Edwa FRIEDLANDER, Auteur ; Maya YAARI, Auteur ; Benjamin BAR-OZ, Auteur ; Smadar EVENTOV-FRIEDMAN, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur Article en page(s) : 9p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: The aim of this study was to examine the long-term risk for autism spectrum disorders (ASD) in individuals who are born preterm and full-term using both observational instruments and parental reports. Neonatal risk factors and developmental characteristics associated with ASD risk were also examined. METHOD: Participants included 110 preterm children (born at a gestational age of ≤ 34 weeks) and 39 full-term children assessed at ages 18, 24, and 36 months. The Autism Diagnostic Observation Schedule, the Modified Checklist for Autism in Toddlers, the Autism Diagnostic Interview-Revised, the Social Communication Questionnaire, and the Mullen Scales of Early Learning were administered. RESULTS AND CONCLUSIONS: The long-term risk for ASD was higher when parental reports were employed compared to observational instruments. At 18 and 24 months, a higher long-term risk for ASD was found for preterm children compared to full-term children. At 36 months, only one preterm child and one full-term child met the cutoff for ASD based on the ADOS, yet clinical judgment and parental reports supported an ASD diagnosis for the preterm child only. Earlier gestational age and lower general developmental abilities were associated with elevated ASD risk among preterm children. En ligne : http://dx.doi.org/10.1155/2018/8316212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Risk for ASD in Preterm Infants: A Three-Year Follow-Up Study [texte imprimé] / Ayelet HAREL-GADASSI, Auteur ; Edwa FRIEDLANDER, Auteur ; Maya YAARI, Auteur ; Benjamin BAR-OZ, Auteur ; Smadar EVENTOV-FRIEDMAN, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur . - 9p. Langues : Anglais (eng) in Autism Research and Treatment > 2018 (2018) . - 9p. Index. décimale : PER Périodiques Résumé : BACKGROUND: The aim of this study was to examine the long-term risk for autism spectrum disorders (ASD) in individuals who are born preterm and full-term using both observational instruments and parental reports. Neonatal risk factors and developmental characteristics associated with ASD risk were also examined. METHOD: Participants included 110 preterm children (born at a gestational age of ≤ 34 weeks) and 39 full-term children assessed at ages 18, 24, and 36 months. The Autism Diagnostic Observation Schedule, the Modified Checklist for Autism in Toddlers, the Autism Diagnostic Interview-Revised, the Social Communication Questionnaire, and the Mullen Scales of Early Learning were administered. RESULTS AND CONCLUSIONS: The long-term risk for ASD was higher when parental reports were employed compared to observational instruments. At 18 and 24 months, a higher long-term risk for ASD was found for preterm children compared to full-term children. At 36 months, only one preterm child and one full-term child met the cutoff for ASD based on the ADOS, yet clinical judgment and parental reports supported an ASD diagnosis for the preterm child only. Earlier gestational age and lower general developmental abilities were associated with elevated ASD risk among preterm children. En ligne : http://dx.doi.org/10.1155/2018/8316212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Stability of early risk assessment for autism spectrum disorder in preterm infants / Maya YAARI in Autism, 20-7 (October 2016)  

Public ISBD [article]  inAutism > 20-7 (October 2016) . - p.856-867 Titre : Stability of early risk assessment for autism spectrum disorder in preterm infants Type de document : texte imprimé Auteurs : Maya YAARI, Auteur ; Neta YITZHAK, Auteur ; Ayelet HAREL, Auteur ; Edwa FRIEDLANDER, Auteur ; Benjamin BAR-OZ, Auteur ; Smadar EVENTOV-FRIEDMAN, Auteur ; David MANKUTA, Auteur ; Ifat GAMLIEL, Auteur ; Nurit YIRMIYA, Auteur Article en page(s) : p.856-867 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  development  early diagnosis  preterm  screening Index. décimale : PER Périodiques Résumé : Stability and change in early autism spectrum disorder risk were examined in a cohort of 99 preterm infants (⩽34 weeks of gestation) using the Autism Observation Scale for Infants at 8 and 12 months and the Autism Diagnostic Observation Schedule—Toddler Module at 18 months. A total of 21 infants were identified at risk by the Autism Observation Scale for Infants at 8 months, and 9 were identified at risk at 12 months, including 4 children who were not previously identified. At 18 months, eight children were identified at risk for autism spectrum disorder using the Autism Diagnostic Observation Schedule—Toddler Module, only half of whom had been identified using the original Autism Observation Scale for Infants cutoffs. Results are discussed in relation to early trajectories of autism spectrum disorder risk among preterm infants as well as identifying social-communication deficiencies associated with the early preterm behavioral phenotype. En ligne : http://dx.doi.org/10.1177/1362361315614758 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 [article] Stability of early risk assessment for autism spectrum disorder in preterm infants [texte imprimé] / Maya YAARI, Auteur ; Neta YITZHAK, Auteur ; Ayelet HAREL, Auteur ; Edwa FRIEDLANDER, Auteur ; Benjamin BAR-OZ, Auteur ; Smadar EVENTOV-FRIEDMAN, Auteur ; David MANKUTA, Auteur ; Ifat GAMLIEL, Auteur ; Nurit YIRMIYA, Auteur . - p.856-867. Langues : Anglais (eng) in Autism > 20-7 (October 2016) . - p.856-867 Mots-clés : autism spectrum disorders  development  early diagnosis  preterm  screening Index. décimale : PER Périodiques Résumé : Stability and change in early autism spectrum disorder risk were examined in a cohort of 99 preterm infants (⩽34 weeks of gestation) using the Autism Observation Scale for Infants at 8 and 12 months and the Autism Diagnostic Observation Schedule—Toddler Module at 18 months. A total of 21 infants were identified at risk by the Autism Observation Scale for Infants at 8 months, and 9 were identified at risk at 12 months, including 4 children who were not previously identified. At 18 months, eight children were identified at risk for autism spectrum disorder using the Autism Diagnostic Observation Schedule—Toddler Module, only half of whom had been identified using the original Autism Observation Scale for Infants cutoffs. Results are discussed in relation to early trajectories of autism spectrum disorder risk among preterm infants as well as identifying social-communication deficiencies associated with the early preterm behavioral phenotype. En ligne : http://dx.doi.org/10.1177/1362361315614758 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293

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