[article]
| Titre : |
The complementary role of high sensitivity C-reactive protein in the diagnosis and severity assessment of autism |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Mohammad Reza KHAKZAD, Auteur ; Maryam JAVANBAKHT, Auteur ; Mohammad Reza SHAYEGAN, Auteur ; Sina KIANOUSH, Auteur ; Fatemeh OMID, Auteur ; Maryam HOJATI, Auteur ; Mojtaba MESHKAT, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p.1032-1037 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autistic disorder C-reactive protein Inflammation Severity |
| Index. décimale : |
PER Périodiques |
| Résumé : |
C-reactive protein (CRP) is a beneficial diagnostic test for the evaluation of inflammatory response. Extremely low levels of CRP can be detected using high-sensitivity CRP (hs-CRP) test. A considerable body of evidence has demonstrated that inflammatory response has an important role in the pathophysiology of autism. In this study, we evaluated and compared hs-CRP levels between autistic and intellectually normal individuals. Clinical data of 39 autistic and 30 age-matched intellectually normal individuals (control group) were recorded. Patients were divided into two groups (mild-to-moderate and severe) according to childhood autism rating scale. Then serum hs-CRP concentrations were measured and compared between two groups. Also, the correlation between hs-CRP concentration and the severity of autism was determined. The mean concentration of hs-CRP in children with autism (540.1 ± 1125.5 ng/ml) was significantly (P < 0.0001) higher than control group (1.3 ± 1.0 ng/ml). In severe autism, the mean level of hs-CRP (985.1 ± 1432.1 ng/ml) was significantly (P = 0.008) higher than the mean level of hs-CRP in patients with mild-to-moderate autism (147.1 ± 60.4 ng/ml). There was a positive correlation between hs-CRP concentration and autism severity (r = 0.34; P = 0.039). These findings affirm the role of inflammation in autism. |
| En ligne : |
http://dx.doi.org/10.1016/j.rasd.2011.10.002 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 |
in Research in Autism Spectrum Disorders > 6-3 (July-September 2012) . - p.1032-1037
[article] The complementary role of high sensitivity C-reactive protein in the diagnosis and severity assessment of autism [Texte imprimé et/ou numérique] / Mohammad Reza KHAKZAD, Auteur ; Maryam JAVANBAKHT, Auteur ; Mohammad Reza SHAYEGAN, Auteur ; Sina KIANOUSH, Auteur ; Fatemeh OMID, Auteur ; Maryam HOJATI, Auteur ; Mojtaba MESHKAT, Auteur . - 2012 . - p.1032-1037. Langues : Anglais ( eng) in Research in Autism Spectrum Disorders > 6-3 (July-September 2012) . - p.1032-1037
| Mots-clés : |
Autistic disorder C-reactive protein Inflammation Severity |
| Index. décimale : |
PER Périodiques |
| Résumé : |
C-reactive protein (CRP) is a beneficial diagnostic test for the evaluation of inflammatory response. Extremely low levels of CRP can be detected using high-sensitivity CRP (hs-CRP) test. A considerable body of evidence has demonstrated that inflammatory response has an important role in the pathophysiology of autism. In this study, we evaluated and compared hs-CRP levels between autistic and intellectually normal individuals. Clinical data of 39 autistic and 30 age-matched intellectually normal individuals (control group) were recorded. Patients were divided into two groups (mild-to-moderate and severe) according to childhood autism rating scale. Then serum hs-CRP concentrations were measured and compared between two groups. Also, the correlation between hs-CRP concentration and the severity of autism was determined. The mean concentration of hs-CRP in children with autism (540.1 ± 1125.5 ng/ml) was significantly (P < 0.0001) higher than control group (1.3 ± 1.0 ng/ml). In severe autism, the mean level of hs-CRP (985.1 ± 1432.1 ng/ml) was significantly (P = 0.008) higher than the mean level of hs-CRP in patients with mild-to-moderate autism (147.1 ± 60.4 ng/ml). There was a positive correlation between hs-CRP concentration and autism severity (r = 0.34; P = 0.039). These findings affirm the role of inflammation in autism. |
| En ligne : |
http://dx.doi.org/10.1016/j.rasd.2011.10.002 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 |
|  |
The complementary role of high sensitivity C-reactive protein in the diagnosis and severity assessment of autism in Research in Autism Spectrum Disorders, 6-3 (July-September 2012)
