Hippocampal volume and sensitivity to maternal aggressive behavior: A prospective study of adolescent depressive symptoms / Sarah WHITTLE in Development and Psychopathology, 23-1 (January 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-1 (January 2011) . - p.115-129 Titre : Hippocampal volume and sensitivity to maternal aggressive behavior: A prospective study of adolescent depressive symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Sarah WHITTLE, Auteur ; Marie B.H. YAP, Auteur ; Lisa B. SHEEBER, Auteur ; Paul DUDGEON, Auteur ; Murat YUCEL, Auteur ; Christos PANTELIS, Auteur ; Julian G. SIMMONS, Auteur ; Nicholas B. ALLEN, Auteur Année de publication : 2011 Article en page(s) : p.115-129 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : It has been suggested that biological factors confer increased sensitivity to environmental influences on depressive symptoms during adolescence, a crucial time for the onset of depressive disorders. Given the critical role of the hippocampus in sensitivity to stress and processing of contextual aspects of the environment, investigation of its role in determining sensitivity to environmental context seems warranted. This study prospectively examined hippocampal volume as a measure of sensitivity to the influence of aggressive maternal behavior on change in depressive symptoms from early to midadolescence. The interaction between aggressive maternal behavior and hippocampal volume was found to predict change in depressive symptoms. Significant sex differences also emerged, whereby only for girls were larger bilateral hippocampal volumes more sensitive to the effects of maternal aggressive behavior, particularly with respect to experiencing the protective effects of low levels of maternal aggressiveness. These findings help elucidate the complex relationships between brain structure, environmental factors such as maternal parenting style, and sensitivity to (i.e., risk for, and protection from) the emergence of depression during this life stage. Given that family context risk factors are modifiable, our findings suggest the potential utility of targeted parenting interventions for the prevention and treatment of adolescent depressive disorder. En ligne : http://dx.doi.org/10.1017/S0954579410000684 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 [article] Hippocampal volume and sensitivity to maternal aggressive behavior: A prospective study of adolescent depressive symptoms [Texte imprimé et/ou numérique] / Sarah WHITTLE, Auteur ; Marie B.H. YAP, Auteur ; Lisa B. SHEEBER, Auteur ; Paul DUDGEON, Auteur ; Murat YUCEL, Auteur ; Christos PANTELIS, Auteur ; Julian G. SIMMONS, Auteur ; Nicholas B. ALLEN, Auteur . - 2011 . - p.115-129. Langues : Anglais (eng) in Development and Psychopathology > 23-1 (January 2011) . - p.115-129 Index. décimale : PER Périodiques Résumé : It has been suggested that biological factors confer increased sensitivity to environmental influences on depressive symptoms during adolescence, a crucial time for the onset of depressive disorders. Given the critical role of the hippocampus in sensitivity to stress and processing of contextual aspects of the environment, investigation of its role in determining sensitivity to environmental context seems warranted. This study prospectively examined hippocampal volume as a measure of sensitivity to the influence of aggressive maternal behavior on change in depressive symptoms from early to midadolescence. The interaction between aggressive maternal behavior and hippocampal volume was found to predict change in depressive symptoms. Significant sex differences also emerged, whereby only for girls were larger bilateral hippocampal volumes more sensitive to the effects of maternal aggressive behavior, particularly with respect to experiencing the protective effects of low levels of maternal aggressiveness. These findings help elucidate the complex relationships between brain structure, environmental factors such as maternal parenting style, and sensitivity to (i.e., risk for, and protection from) the emergence of depression during this life stage. Given that family context risk factors are modifiable, our findings suggest the potential utility of targeted parenting interventions for the prevention and treatment of adolescent depressive disorder. En ligne : http://dx.doi.org/10.1017/S0954579410000684 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117

Pituitary volume prospectively predicts internalizing symptoms in adolescence / Amy R. ZIPURSKY in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.315-323 Titre : Pituitary volume prospectively predicts internalizing symptoms in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Amy R. ZIPURSKY, Auteur ; Sarah WHITTLE, Auteur ; Murat YUCEL, Auteur ; Valentina LORENZETTI, Auteur ; Stephen J. WOOD, Auteur ; Dan I. LUBMAN, Auteur ; Julian G. SIMMONS, Auteur ; Nicholas B. ALLEN, Auteur Année de publication : 2011 Article en page(s) : p.315-323 Langues : Anglais (eng) Mots-clés : Pituitary volume  depression  anxiety  externalizing  adolescence  HPA axis Index. décimale : PER Périodiques Résumé : Background:  Early adolescence is a critical time for the development of both internalizing and externalizing disorders. We aimed to investigate whether pituitary volume, an index of hypothalamic–pituitary–adrenal (HPA) axis function, represents a vulnerability factor for the emergence of internalizing and externalizing symptoms during adolescence using a prospective, longitudinal design. Methods:  One hundred and fifty-five adolescents completed 3T structural magnetic resonance imaging (MRI), symptom rating scales and a diagnostic interview during early adolescence (M age 12.6 years, SD .5 years); symptom rating scales were re-administered approximately three years later (M age 15.2 years). The volume of the pituitary gland was estimated by manually delineating its structure on MR images. The degree to which pituitary volumes prospectively predicted change in internalizing and externalizing symptoms across the two time-points was assessed using hierarchal linear regression, after controlling for the influence of gender, age, pubertal stage and intracranial volume. Results:  Larger pituitary volumes prospectively predicted an increase in internalizing, but not externalizing, symptoms from early adolescence to mid-adolescence. Conclusions:  This study provides the first evidence that increased pituitary volume might represent a specific vulnerability marker for the development of internalizing symptoms during early to mid-adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02337.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Pituitary volume prospectively predicts internalizing symptoms in adolescence [Texte imprimé et/ou numérique] / Amy R. ZIPURSKY, Auteur ; Sarah WHITTLE, Auteur ; Murat YUCEL, Auteur ; Valentina LORENZETTI, Auteur ; Stephen J. WOOD, Auteur ; Dan I. LUBMAN, Auteur ; Julian G. SIMMONS, Auteur ; Nicholas B. ALLEN, Auteur . - 2011 . - p.315-323. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.315-323 Mots-clés : Pituitary volume  depression  anxiety  externalizing  adolescence  HPA axis Index. décimale : PER Périodiques Résumé : Background:  Early adolescence is a critical time for the development of both internalizing and externalizing disorders. We aimed to investigate whether pituitary volume, an index of hypothalamic–pituitary–adrenal (HPA) axis function, represents a vulnerability factor for the emergence of internalizing and externalizing symptoms during adolescence using a prospective, longitudinal design. Methods:  One hundred and fifty-five adolescents completed 3T structural magnetic resonance imaging (MRI), symptom rating scales and a diagnostic interview during early adolescence (M age 12.6 years, SD .5 years); symptom rating scales were re-administered approximately three years later (M age 15.2 years). The volume of the pituitary gland was estimated by manually delineating its structure on MR images. The degree to which pituitary volumes prospectively predicted change in internalizing and externalizing symptoms across the two time-points was assessed using hierarchal linear regression, after controlling for the influence of gender, age, pubertal stage and intracranial volume. Results:  Larger pituitary volumes prospectively predicted an increase in internalizing, but not externalizing, symptoms from early adolescence to mid-adolescence. Conclusions:  This study provides the first evidence that increased pituitary volume might represent a specific vulnerability marker for the development of internalizing symptoms during early to mid-adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02337.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

The relationship between hippocampal asymmetry and temperament in adolescent borderline and antisocial personality pathology / Martina JOVEV in Development and Psychopathology, 26-1 (February 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-1 (February 2014) . - p.275-285 Titre : The relationship between hippocampal asymmetry and temperament in adolescent borderline and antisocial personality pathology Type de document : Texte imprimé et/ou numérique Auteurs : Martina JOVEV, Auteur ; Sarah WHITTLE, Auteur ; Murat YUCEL, Auteur ; Julian Guy SIMMONS, Auteur ; Nicholas B. ALLEN, Auteur ; Andrew M. CHANEN, Auteur Article en page(s) : p.275-285 Langues : Français (fre) Index. décimale : PER Périodiques Résumé : Investigating etiological processes early in the life span represents an important step toward a better understanding of the development of personality pathology. The current study evaluated the interaction between an individual difference risk factor (i.e., temperament) and a biological risk factor for aggressive behavior (i.e., atypical [larger] rightward hippocampal asymmetry) in predicting the emergence of borderline personality disorder (BPD) and antisocial personality disorder symptoms during early adolescence. The sample consisted of 153 healthy adolescents (M = 12.6 years, SD = 0.4, range = 11.4–13.7) who were selected from a larger sample to maximize variation in temperament. Interactions between four temperament factors (effortful control, negative affectivity, surgency, and affiliativeness), based on the Early Adolescent Temperament Questionnaire—Revised, and volumetric measures of hippocampal asymmetry were examined as cross-sectional predictors of BPD and antisocial personality disorder symptoms. Boys were more likely to have elevated BPD symptoms if they were high on affiliation and had larger rightward hippocampal asymmetry. In boys, low affiliation was a significant predictor of BPD symptoms in the presence of low rightward hippocampal asymmetry. For girls, low effortful control was associated with elevated BPD symptoms in the presence of atypical rightward hippocampal asymmetry. This study builds on previous work reporting significant associations between atypical hippocampal asymmetry and poor behavioral regulation. En ligne : http://dx.doi.org/10.1017/S0954579413000886 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=224 [article] The relationship between hippocampal asymmetry and temperament in adolescent borderline and antisocial personality pathology [Texte imprimé et/ou numérique] / Martina JOVEV, Auteur ; Sarah WHITTLE, Auteur ; Murat YUCEL, Auteur ; Julian Guy SIMMONS, Auteur ; Nicholas B. ALLEN, Auteur ; Andrew M. CHANEN, Auteur . - p.275-285. Langues : Français (fre) in Development and Psychopathology > 26-1 (February 2014) . - p.275-285 Index. décimale : PER Périodiques Résumé : Investigating etiological processes early in the life span represents an important step toward a better understanding of the development of personality pathology. The current study evaluated the interaction between an individual difference risk factor (i.e., temperament) and a biological risk factor for aggressive behavior (i.e., atypical [larger] rightward hippocampal asymmetry) in predicting the emergence of borderline personality disorder (BPD) and antisocial personality disorder symptoms during early adolescence. The sample consisted of 153 healthy adolescents (M = 12.6 years, SD = 0.4, range = 11.4–13.7) who were selected from a larger sample to maximize variation in temperament. Interactions between four temperament factors (effortful control, negative affectivity, surgency, and affiliativeness), based on the Early Adolescent Temperament Questionnaire—Revised, and volumetric measures of hippocampal asymmetry were examined as cross-sectional predictors of BPD and antisocial personality disorder symptoms. Boys were more likely to have elevated BPD symptoms if they were high on affiliation and had larger rightward hippocampal asymmetry. In boys, low affiliation was a significant predictor of BPD symptoms in the presence of low rightward hippocampal asymmetry. For girls, low effortful control was associated with elevated BPD symptoms in the presence of atypical rightward hippocampal asymmetry. This study builds on previous work reporting significant associations between atypical hippocampal asymmetry and poor behavioral regulation. En ligne : http://dx.doi.org/10.1017/S0954579413000886 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=224

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