Increased Serum Levels of Epidermal Growth Factor in Children with Autism / Elvan ISERI in Journal of Autism and Developmental Disorders, 41-2 (February 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-2 (February 2011) . - p.237-241 Titre : Increased Serum Levels of Epidermal Growth Factor in Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Elvan ISERI, Auteur ; Esra GUNEY, Auteur ; Mehmet Fatih CEYLAN, Auteur ; Ayşegül YUCEL, Auteur ; Arzu ARAL, Auteur ; Sahin BODUR, Auteur ; Sahnur SENER, Auteur Année de publication : 2011 Article en page(s) : p.237-241 Langues : Anglais (eng) Mots-clés : Autism  Developmental disorders  Epidermal growth factor  Growth factors Index. décimale : PER Périodiques Résumé : The etiology of autism is unclear, however autism is considered as a multifactorial disorder that is influenced by neurological, environmental, immunological and genetic factors. Growth factors, including epidermal growth factor (EGF), play an important role in the celluler proliferation and the differentiation of the central and peripheral nervous system. In this study we hypothesized that EGF may play a role in the pathophysiology of autism and examined serum EGF levels in children with autism. We measured serum levels of EGF in the 27 autistic children and 28 age- matched normal controls. The serum levels of EGF in the subjects with autism were significantly higher than those of normal control subjects. However, there were no correlations between serum EGF levels and clinical variables in the subjects with autism. This is the first report demonstrating the increased serum levels of EGF in children with autism. This study suggests that increased levels of EGF might have an importance in the pathophysiology of autism. En ligne : http://dx.doi.org/10.1007/s10803-010-1046-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 [article] Increased Serum Levels of Epidermal Growth Factor in Children with Autism [Texte imprimé et/ou numérique] / Elvan ISERI, Auteur ; Esra GUNEY, Auteur ; Mehmet Fatih CEYLAN, Auteur ; Ayşegül YUCEL, Auteur ; Arzu ARAL, Auteur ; Sahin BODUR, Auteur ; Sahnur SENER, Auteur . - 2011 . - p.237-241. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-2 (February 2011) . - p.237-241 Mots-clés : Autism  Developmental disorders  Epidermal growth factor  Growth factors Index. décimale : PER Périodiques Résumé : The etiology of autism is unclear, however autism is considered as a multifactorial disorder that is influenced by neurological, environmental, immunological and genetic factors. Growth factors, including epidermal growth factor (EGF), play an important role in the celluler proliferation and the differentiation of the central and peripheral nervous system. In this study we hypothesized that EGF may play a role in the pathophysiology of autism and examined serum EGF levels in children with autism. We measured serum levels of EGF in the 27 autistic children and 28 age- matched normal controls. The serum levels of EGF in the subjects with autism were significantly higher than those of normal control subjects. However, there were no correlations between serum EGF levels and clinical variables in the subjects with autism. This is the first report demonstrating the increased serum levels of EGF in children with autism. This study suggests that increased levels of EGF might have an importance in the pathophysiology of autism. En ligne : http://dx.doi.org/10.1007/s10803-010-1046-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117

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