Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development / Tania L. ROTH in Journal of Child Psychology and Psychiatry, 52-4 (April 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.398-408 Titre : Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development Type de document : Texte imprimé et/ou numérique Auteurs : Tania L. ROTH, Auteur ; J. David SWEATT, Auteur Année de publication : 2011 Article en page(s) : p.398-408 Langues : Anglais (eng) Mots-clés : Early-life experience  maternal care  epigenetic  DNA methylation  histone modification Index. décimale : PER Périodiques Résumé : Experiences during early development profoundly affect development of the central nervous system (CNS) to impart either risk for or resilience to later psychopathology. Work in the developmental neuroscience field is providing compelling data that epigenetic marking of the genome may underlie aspects of this process. Experiments in rodents continue to show that experiences during sensitive periods of development influence DNA methylation patterns of several genes. These experience-induced DNA methylation patterns represent stable epigenetic modifications that alter gene transcription throughout the lifespan and promote specific behavioral outcomes. We discuss the relevance of these findings to humans, and also briefly discuss these findings in the broader contexts of cognition and psychiatric disorder. We conclude by discussing the implications of these observations for future research. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02282.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 [article] Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development [Texte imprimé et/ou numérique] / Tania L. ROTH, Auteur ; J. David SWEATT, Auteur . - 2011 . - p.398-408. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.398-408 Mots-clés : Early-life experience  maternal care  epigenetic  DNA methylation  histone modification Index. décimale : PER Périodiques Résumé : Experiences during early development profoundly affect development of the central nervous system (CNS) to impart either risk for or resilience to later psychopathology. Work in the developmental neuroscience field is providing compelling data that epigenetic marking of the genome may underlie aspects of this process. Experiments in rodents continue to show that experiences during sensitive periods of development influence DNA methylation patterns of several genes. These experience-induced DNA methylation patterns represent stable epigenetic modifications that alter gene transcription throughout the lifespan and promote specific behavioral outcomes. We discuss the relevance of these findings to humans, and also briefly discuss these findings in the broader contexts of cognition and psychiatric disorder. We conclude by discussing the implications of these observations for future research. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02282.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119

Caregiver maltreatment causes altered neuronal DNA methylation in female rodents / Jennifer BLAZE in Development and Psychopathology, 29-2 (May 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-2 (May 2017) . - p.477-489 Titre : Caregiver maltreatment causes altered neuronal DNA methylation in female rodents Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer BLAZE, Auteur ; Tania L. ROTH, Auteur Article en page(s) : p.477-489 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Negative experiences with a caregiver during infancy can result in long-term changes in brain function and behavior, but underlying mechanisms are not well understood. It is our central hypothesis that brain and behavior changes are conferred by early childhood adversity through epigenetic changes involving DNA methylation. Using a rodent model of early-life caregiver maltreatment (involving exposure to an adverse caregiving environment for postnatal days 1–7), we have previously demonstrated abnormal methylation of DNA associated with the brain-derived neurotrophic factor (Bdnf) gene in the medial prefrontal cortex (mPFC) of adult rats. The aim of the current study was to characterize Bdnf DNA methylation in specific cell populations within the mPFC. In the prefrontal cortex, there is approximately twice as many neurons as glia, and studies have recently shown differential and distinctive DNA methylation patterns in neurons versus nonneurons. Here, we extracted nuclei from the mPFC of adult animals that had experienced maltreatment and used fluorescence-activated cell sorting to isolate cell types before performing bisulfite sequencing to estimate methylation of cytosine–guanine sites. Our data indicate that early-life stress induced methylation of DNA associated with Bdnf IV in a cell-type and sex-specific manner. Specifically, females that experienced early-life maltreatment exhibited greater neuronal cytosine–guanine methylation compared to controls, while no changes were detected in Bdnf methylation in males regardless of cell type. These changes localize the specificity of our previous findings to mPFC neurons and highlight the capacity of maltreatment to cause methylation changes that are likely to have functional consequences for neuronal function. En ligne : http://dx.doi.org/10.1017/s0954579417000128 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Caregiver maltreatment causes altered neuronal DNA methylation in female rodents [Texte imprimé et/ou numérique] / Jennifer BLAZE, Auteur ; Tania L. ROTH, Auteur . - p.477-489. Langues : Anglais (eng) in Development and Psychopathology > 29-2 (May 2017) . - p.477-489 Index. décimale : PER Périodiques Résumé : Negative experiences with a caregiver during infancy can result in long-term changes in brain function and behavior, but underlying mechanisms are not well understood. It is our central hypothesis that brain and behavior changes are conferred by early childhood adversity through epigenetic changes involving DNA methylation. Using a rodent model of early-life caregiver maltreatment (involving exposure to an adverse caregiving environment for postnatal days 1–7), we have previously demonstrated abnormal methylation of DNA associated with the brain-derived neurotrophic factor (Bdnf) gene in the medial prefrontal cortex (mPFC) of adult rats. The aim of the current study was to characterize Bdnf DNA methylation in specific cell populations within the mPFC. In the prefrontal cortex, there is approximately twice as many neurons as glia, and studies have recently shown differential and distinctive DNA methylation patterns in neurons versus nonneurons. Here, we extracted nuclei from the mPFC of adult animals that had experienced maltreatment and used fluorescence-activated cell sorting to isolate cell types before performing bisulfite sequencing to estimate methylation of cytosine–guanine sites. Our data indicate that early-life stress induced methylation of DNA associated with Bdnf IV in a cell-type and sex-specific manner. Specifically, females that experienced early-life maltreatment exhibited greater neuronal cytosine–guanine methylation compared to controls, while no changes were detected in Bdnf methylation in males regardless of cell type. These changes localize the specificity of our previous findings to mPFC neurons and highlight the capacity of maltreatment to cause methylation changes that are likely to have functional consequences for neuronal function. En ligne : http://dx.doi.org/10.1017/s0954579417000128 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Epigenetic pathways through which experiences become linked with biology / Patrick O. MCGOWAN in Development and Psychopathology, 27-2 (May 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-2 (May 2015) . - p.637-648 Titre : Epigenetic pathways through which experiences become linked with biology Type de document : Texte imprimé et/ou numérique Auteurs : Patrick O. MCGOWAN, Auteur ; Tania L. ROTH, Auteur Article en page(s) : p.637-648 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This article highlights the defining principles, progress, and future directions in epigenetics research in relation to this Special Issue. Exciting studies in the fields of neuroscience, psychology, and psychiatry have provided new insights into the epigenetic factors (e.g., DNA methylation) that are responsive to environmental input and serve as biological pathways in behavioral development. Here we highlight the experimental evidence, mainly from animal models, that factors such as psychosocial stress and environmental adversity can become encoded within epigenetic factors with functional consequences for brain plasticity and behavior. We also highlight evidence that epigenetic marking of genes in one generation can have consequences for future generations (i.e., inherited), and work with humans linking epigenetics, cognitive dysfunction, and psychiatric disorder. Though epigenetics has offered more of a beginning than an answer to the centuries-old nature–nurture debate, continued research is certain to yield substantial information regarding biological determinants of central nervous system changes and behavior with relevance for the study of developmental psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579415000206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Epigenetic pathways through which experiences become linked with biology [Texte imprimé et/ou numérique] / Patrick O. MCGOWAN, Auteur ; Tania L. ROTH, Auteur . - p.637-648. Langues : Anglais (eng) in Development and Psychopathology > 27-2 (May 2015) . - p.637-648 Index. décimale : PER Périodiques Résumé : This article highlights the defining principles, progress, and future directions in epigenetics research in relation to this Special Issue. Exciting studies in the fields of neuroscience, psychology, and psychiatry have provided new insights into the epigenetic factors (e.g., DNA methylation) that are responsive to environmental input and serve as biological pathways in behavioral development. Here we highlight the experimental evidence, mainly from animal models, that factors such as psychosocial stress and environmental adversity can become encoded within epigenetic factors with functional consequences for brain plasticity and behavior. We also highlight evidence that epigenetic marking of genes in one generation can have consequences for future generations (i.e., inherited), and work with humans linking epigenetics, cognitive dysfunction, and psychiatric disorder. Though epigenetics has offered more of a beginning than an answer to the centuries-old nature–nurture debate, continued research is certain to yield substantial information regarding biological determinants of central nervous system changes and behavior with relevance for the study of developmental psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579415000206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain / Tiffany S. DOHERTY in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1229-1243 Titre : Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain Type de document : Texte imprimé et/ou numérique Auteurs : Tiffany S. DOHERTY, Auteur ; Tania L. ROTH, Auteur Article en page(s) : p.1229-1243 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The efforts of many neuroscientists are directed toward understanding the appreciable plasticity of the brain and behavior. In recent years, epigenetics has become a core of this focus as a prime mechanistic candidate for behavioral modifications. Animal models have been instrumental in advancing our understanding of environmentally driven changes to the epigenome in the developing and adult brain. This review focuses mainly on such discoveries driven by adverse environments along with their associated behavioral outcomes. While much of the evidence discussed focuses on epigenetics within the central nervous system, several peripheral studies in humans who have experienced significant adversity are also highlighted. As we continue to unravel the link between epigenetics and phenotype, discerning the complexity and specificity of epigenetic changes induced by environments is an important step toward understanding optimal development and how to prevent or ameliorate behavioral deficits bred by disruptive environments. En ligne : http://dx.doi.org/10.1017/s095457941600081x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain [Texte imprimé et/ou numérique] / Tiffany S. DOHERTY, Auteur ; Tania L. ROTH, Auteur . - p.1229-1243. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1229-1243 Index. décimale : PER Périodiques Résumé : The efforts of many neuroscientists are directed toward understanding the appreciable plasticity of the brain and behavior. In recent years, epigenetics has become a core of this focus as a prime mechanistic candidate for behavioral modifications. Animal models have been instrumental in advancing our understanding of environmentally driven changes to the epigenome in the developing and adult brain. This review focuses mainly on such discoveries driven by adverse environments along with their associated behavioral outcomes. While much of the evidence discussed focuses on epigenetics within the central nervous system, several peripheral studies in humans who have experienced significant adversity are also highlighted. As we continue to unravel the link between epigenetics and phenotype, discerning the complexity and specificity of epigenetic changes induced by environments is an important step toward understanding optimal development and how to prevent or ameliorate behavioral deficits bred by disruptive environments. En ligne : http://dx.doi.org/10.1017/s095457941600081x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

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