Relation of Melatonin to Sleep Architecture in Children with Autism / Roberta M. LEU in Journal of Autism and Developmental Disorders, 41-4 (April 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.427-433 Titre : Relation of Melatonin to Sleep Architecture in Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Roberta M. LEU, Auteur ; Liya BEYDERMAN, Auteur ; Emmanuel J. BOTZOLAKIS, Auteur ; Kyla SURDYKA, Auteur ; Lily WANG, Auteur ; Beth A. MALOW, Auteur Année de publication : 2011 Article en page(s) : p.427-433 Langues : Anglais (eng) Mots-clés : 6-Sulfatoxymelatonin  6-SM  Sleep stages  Children’s Sleep Habits Questionnaire  Parental Concerns Questionnaire  Polysomnography Index. décimale : PER Périodiques Résumé : Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM). We therefore investigated the relationship between 6-SM levels and sleep architecture in children with autism spectrum disorders (ASD). Twenty-three children, aged 4–10 years, completed two nights of polysomnography and one overnight urine collection for measurement of urinary 6-SM excretion rate. Parents completed the Children’s Sleep Habits Questionnaire. We found that higher urinary 6-SM excretion rates were associated with increased N3 sleep, decreased N2 sleep, and decreased daytime sleepiness. The results warrant further examination to examine the effects of supplemental melatonin on sleep architecture and daytime sleepiness. En ligne : http://dx.doi.org/10.1007/s10803-010-1072-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 [article] Relation of Melatonin to Sleep Architecture in Children with Autism [Texte imprimé et/ou numérique] / Roberta M. LEU, Auteur ; Liya BEYDERMAN, Auteur ; Emmanuel J. BOTZOLAKIS, Auteur ; Kyla SURDYKA, Auteur ; Lily WANG, Auteur ; Beth A. MALOW, Auteur . - 2011 . - p.427-433. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.427-433 Mots-clés : 6-Sulfatoxymelatonin  6-SM  Sleep stages  Children’s Sleep Habits Questionnaire  Parental Concerns Questionnaire  Polysomnography Index. décimale : PER Périodiques Résumé : Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM). We therefore investigated the relationship between 6-SM levels and sleep architecture in children with autism spectrum disorders (ASD). Twenty-three children, aged 4–10 years, completed two nights of polysomnography and one overnight urine collection for measurement of urinary 6-SM excretion rate. Parents completed the Children’s Sleep Habits Questionnaire. We found that higher urinary 6-SM excretion rates were associated with increased N3 sleep, decreased N2 sleep, and decreased daytime sleepiness. The results warrant further examination to examine the effects of supplemental melatonin on sleep architecture and daytime sleepiness. En ligne : http://dx.doi.org/10.1007/s10803-010-1072-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119

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