Editorial Perspective: Childhood maltreatment - the problematic unisex assumption / Jordon D. WHITE in Journal of Child Psychology and Psychiatry, 61-6 (June 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.732-734 Titre : Editorial Perspective: Childhood maltreatment - the problematic unisex assumption Type de document : Texte imprimé et/ou numérique Auteurs : Jordon D. WHITE, Auteur ; Arie KAFFMAN, Auteur Article en page(s) : p.732-734 Langues : Anglais (eng) Mots-clés : Sex differences  animal models  childhood maltreatment  early life stress  psychopathology Index. décimale : PER Périodiques Résumé : Childhood maltreatment (CM) is a heterogeneous group of childhood adversities that can range from different forms of abuse (physical, sexual, emotional) or neglect (physical, emotional, cognitive), to severe bullying by peers. With an annual estimated cost of $500 billion in the United States alone, CM is recognized as one of the most significant risk factors for a range of psychiatric and medical conditions (White and Kaffman, 2019). Further, rates of numerous psychiatric, neurological, and medical conditions differ significantly between males and females (Gillies and McArthur, 2010), inspiring decades of research on how sex moderates consequences of CM (Gershon et al., 2008). Although vulnerability to CM has been reported to vary by sex, very few findings have been consistent across studies. Moreover, most work to date has focused on how sex alters the frequencies of different psychopathologies in maltreated individuals, with little attention to whether different developmental processes may underlie these psychopathologies in males and females (White and Kaffman, 2019). The primary goal of this editorial was to advocate for more effective research strategies to address these questions. We first examine the rationale for studying sex as an important moderator of consequences of CM, briefly summarize some of the most consistent clinical findings, and discuss the implications of sex in treatment response. We then highlight important obstacles that contribute to the large number of inconsistent findings and make five recommendations on how to move forward. En ligne : http://dx.doi.org/10.1111/jcpp.13177 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Editorial Perspective: Childhood maltreatment - the problematic unisex assumption [Texte imprimé et/ou numérique] / Jordon D. WHITE, Auteur ; Arie KAFFMAN, Auteur . - p.732-734. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.732-734 Mots-clés : Sex differences  animal models  childhood maltreatment  early life stress  psychopathology Index. décimale : PER Périodiques Résumé : Childhood maltreatment (CM) is a heterogeneous group of childhood adversities that can range from different forms of abuse (physical, sexual, emotional) or neglect (physical, emotional, cognitive), to severe bullying by peers. With an annual estimated cost of $500 billion in the United States alone, CM is recognized as one of the most significant risk factors for a range of psychiatric and medical conditions (White and Kaffman, 2019). Further, rates of numerous psychiatric, neurological, and medical conditions differ significantly between males and females (Gillies and McArthur, 2010), inspiring decades of research on how sex moderates consequences of CM (Gershon et al., 2008). Although vulnerability to CM has been reported to vary by sex, very few findings have been consistent across studies. Moreover, most work to date has focused on how sex alters the frequencies of different psychopathologies in maltreated individuals, with little attention to whether different developmental processes may underlie these psychopathologies in males and females (White and Kaffman, 2019). The primary goal of this editorial was to advocate for more effective research strategies to address these questions. We first examine the rationale for studying sex as an important moderator of consequences of CM, briefly summarize some of the most consistent clinical findings, and discuss the implications of sex in treatment response. We then highlight important obstacles that contribute to the large number of inconsistent findings and make five recommendations on how to move forward. En ligne : http://dx.doi.org/10.1111/jcpp.13177 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights / Arie KAFFMAN in Journal of Child Psychology and Psychiatry, 48-3/4 (March/April 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-3/4 (March/April 2007) . - p.224–244 Titre : Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights Type de document : Texte imprimé et/ou numérique Auteurs : Arie KAFFMAN, Auteur ; Michael J. MEANEY, Auteur Année de publication : 2007 Article en page(s) : p.224–244 Langues : Anglais (eng) Mots-clés : Family-factors hormones parent–child-interaction maternal-care epigenetic DNA-methylation Index. décimale : PER Périodiques Résumé : Parental care plays an important role in the emotional and cognitive development of the offspring. Children who have been exposed to abuse or neglect are more likely to develop numerous psychopathologies, while good parent–infant bonding is associated with improved resiliency to stress. Similar observations have also been reported in non-human primates and rodents, suggesting that at least some neurodevelopmental aspects of parent–offspring interactions are conserved among mammals and could therefore be studied in animals. We present data to suggest that frequency of licking and grooming provided by the dam during a critical period in development plays an important role in modifying neurodevelopment. These findings are examined in the broader context in which exposure to other sensory modalities such as vision or hearing during a specific period in development shapes brain development with functional consequences that persist into adulthood. We also discuss recent rodent work showing that increased frequency of licking and grooming provided by the dam during the first week of life is associated with changes in DNA methylation of promoter elements that control expression of these genes and behavior. The stability of DNA methylation in postmitotic cells provides a possible molecular scaffold by which changes in gene expression and behavioral traits induced by postnatal maternal care are maintained throughout life. Finally, the relevance of findings reported in rodents to those noted in non-human primates and humans are assessed and the research and clinical implications of these observations for future work are explored. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01730.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=947 [article] Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights [Texte imprimé et/ou numérique] / Arie KAFFMAN, Auteur ; Michael J. MEANEY, Auteur . - 2007 . - p.224–244. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-3/4 (March/April 2007) . - p.224–244 Mots-clés : Family-factors hormones parent–child-interaction maternal-care epigenetic DNA-methylation Index. décimale : PER Périodiques Résumé : Parental care plays an important role in the emotional and cognitive development of the offspring. Children who have been exposed to abuse or neglect are more likely to develop numerous psychopathologies, while good parent–infant bonding is associated with improved resiliency to stress. Similar observations have also been reported in non-human primates and rodents, suggesting that at least some neurodevelopmental aspects of parent–offspring interactions are conserved among mammals and could therefore be studied in animals. We present data to suggest that frequency of licking and grooming provided by the dam during a critical period in development plays an important role in modifying neurodevelopment. These findings are examined in the broader context in which exposure to other sensory modalities such as vision or hearing during a specific period in development shapes brain development with functional consequences that persist into adulthood. We also discuss recent rodent work showing that increased frequency of licking and grooming provided by the dam during the first week of life is associated with changes in DNA methylation of promoter elements that control expression of these genes and behavior. The stability of DNA methylation in postmitotic cells provides a possible molecular scaffold by which changes in gene expression and behavioral traits induced by postnatal maternal care are maintained throughout life. Finally, the relevance of findings reported in rodents to those noted in non-human primates and humans are assessed and the research and clinical implications of these observations for future work are explored. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01730.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=947

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