Allostatic load and comorbidities: A mitochondrial, epigenetic, and evolutionary perspective / Robert-Paul JUSTER in Development and Psychopathology, 28-4 pt1 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt1 (November 2016) . - p.1117-1146 Titre : Allostatic load and comorbidities: A mitochondrial, epigenetic, and evolutionary perspective Type de document : Texte imprimé et/ou numérique Auteurs : Robert-Paul JUSTER, Auteur ; Jennifer J. RUSSELL, Auteur ; Daniel ALMEIDA, Auteur ; Martin PICARD, Auteur Article en page(s) : p.1117-1146 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Stress-related pathophysiology drives comorbid trajectories that elude precise prediction. Allostatic load algorithms that quantify biological “wear and tear” represent a comprehensive approach to detect multisystemic disease processes of the mind and body. However, the multiple morbidities directly or indirectly related to stress physiology remain enigmatic. Our aim in this article is to propose that biological comorbidities represent discrete pathophysiological processes captured by measuring allostatic load. This has applications in research and clinical settings to predict physical and psychiatric comorbidities alike. The reader will be introduced to the concepts of allostasis, allostasic states, allostatic load, and allostatic overload as they relate to stress-related diseases and the proposed prediction of biological comorbidities that extend rather to understanding psychopathologies. In our transdisciplinary discussion, we will integrate perspectives related to (a) mitochondrial biology as a key player in the allostatic load time course toward diseases that “get under the skin and skull”; (b) epigenetics related to child maltreatment and biological embedding that shapes stress perception throughout lifespan development; and (c) evolutionary drivers of distinct personality profiles and biobehavioral patterns that are linked to dimensions of psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579416000730 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Allostatic load and comorbidities: A mitochondrial, epigenetic, and evolutionary perspective [Texte imprimé et/ou numérique] / Robert-Paul JUSTER, Auteur ; Jennifer J. RUSSELL, Auteur ; Daniel ALMEIDA, Auteur ; Martin PICARD, Auteur . - p.1117-1146. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt1 (November 2016) . - p.1117-1146 Index. décimale : PER Périodiques Résumé : Stress-related pathophysiology drives comorbid trajectories that elude precise prediction. Allostatic load algorithms that quantify biological “wear and tear” represent a comprehensive approach to detect multisystemic disease processes of the mind and body. However, the multiple morbidities directly or indirectly related to stress physiology remain enigmatic. Our aim in this article is to propose that biological comorbidities represent discrete pathophysiological processes captured by measuring allostatic load. This has applications in research and clinical settings to predict physical and psychiatric comorbidities alike. The reader will be introduced to the concepts of allostasis, allostasic states, allostatic load, and allostatic overload as they relate to stress-related diseases and the proposed prediction of biological comorbidities that extend rather to understanding psychopathologies. In our transdisciplinary discussion, we will integrate perspectives related to (a) mitochondrial biology as a key player in the allostatic load time course toward diseases that “get under the skin and skull”; (b) epigenetics related to child maltreatment and biological embedding that shapes stress perception throughout lifespan development; and (c) evolutionary drivers of distinct personality profiles and biobehavioral patterns that are linked to dimensions of psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579416000730 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Early menarche predicts increased depressive symptoms and cortisol levels in Quebec girls ages 11 to 13 / Lyane TREPANIER in Development and Psychopathology, 25-4 (November 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-4 (November 2013) . - p.1017-1027 Titre : Early menarche predicts increased depressive symptoms and cortisol levels in Quebec girls ages 11 to 13 Type de document : Texte imprimé et/ou numérique Auteurs : Lyane TREPANIER, Auteur ; Robert-Paul JUSTER, Auteur ; Marie-France MARIN, Auteur ; Pierrich PLUSQUELLEC, Auteur ; Nathe FRANCOIS, Auteur ; Shireen SINDI, Auteur ; Nathalie WAN, Auteur ; Helen FINDLAY, Auteur ; Tania SCHRAMEK, Auteur ; Julie ANDREWS, Auteur ; Vincent CORBO, Auteur ; Katarina DEDOVIC, Auteur ; Sonia J. LUPIEN, Auteur Article en page(s) : p.1017-1027 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Earlier age of menarche is believed to confer greater vulnerability to depressive symptoms via increased reactivity to stressors associated with adolescence. In this longitudinal study, we measured depressive symptoms and salivary cortisol levels in 198 boys and 142 girls between the ages of 11 and 13 tested four times during Grade 7 as they transitioned from elementary school to secondary school as per Quebec's education system. Results showed that girls who had already reached menarche before starting secondary school had significantly higher depressive symptoms and salivary cortisol levels across the school year in comparison to girls who had not reached menarche, who in turn presented higher depressive scores than boys. When we divided menarcheal girls as a function of menarcheal timing in subanalyses, we found that girls with early menarche presented consistently elevated depressive symptoms across the school year while girls with on-time menarche presented transient depressive symptoms but no differences in salivary cortisol levels. Collectively, these results show that early menarche is associated with high depressive symptoms and cortisol levels in adolescent girls. This developmental milestone may render girls more vulnerable to environmental stressors and therefore represents a critical period to intervene to promote mental health. En ligne : http://dx.doi.org/10.1017/S0954579413000345 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Early menarche predicts increased depressive symptoms and cortisol levels in Quebec girls ages 11 to 13 [Texte imprimé et/ou numérique] / Lyane TREPANIER, Auteur ; Robert-Paul JUSTER, Auteur ; Marie-France MARIN, Auteur ; Pierrich PLUSQUELLEC, Auteur ; Nathe FRANCOIS, Auteur ; Shireen SINDI, Auteur ; Nathalie WAN, Auteur ; Helen FINDLAY, Auteur ; Tania SCHRAMEK, Auteur ; Julie ANDREWS, Auteur ; Vincent CORBO, Auteur ; Katarina DEDOVIC, Auteur ; Sonia J. LUPIEN, Auteur . - p.1017-1027. Langues : Anglais (eng) in Development and Psychopathology > 25-4 (November 2013) . - p.1017-1027 Index. décimale : PER Périodiques Résumé : Earlier age of menarche is believed to confer greater vulnerability to depressive symptoms via increased reactivity to stressors associated with adolescence. In this longitudinal study, we measured depressive symptoms and salivary cortisol levels in 198 boys and 142 girls between the ages of 11 and 13 tested four times during Grade 7 as they transitioned from elementary school to secondary school as per Quebec's education system. Results showed that girls who had already reached menarche before starting secondary school had significantly higher depressive symptoms and salivary cortisol levels across the school year in comparison to girls who had not reached menarche, who in turn presented higher depressive scores than boys. When we divided menarcheal girls as a function of menarcheal timing in subanalyses, we found that girls with early menarche presented consistently elevated depressive symptoms across the school year while girls with on-time menarche presented transient depressive symptoms but no differences in salivary cortisol levels. Collectively, these results show that early menarche is associated with high depressive symptoms and cortisol levels in adolescent girls. This developmental milestone may render girls more vulnerable to environmental stressors and therefore represents a critical period to intervene to promote mental health. En ligne : http://dx.doi.org/10.1017/S0954579413000345 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development / Robert-Paul JUSTER in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.725-776 Titre : A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development Type de document : Texte imprimé et/ou numérique Auteurs : Robert-Paul JUSTER, Auteur ; Gustav BIZIK, Auteur ; Martin PICARD, Auteur ; Genevieve ARSENAULT-LAPIERRE, Auteur ; Shireen SINDI, Auteur ; Lyane TREPANIER, Auteur ; Marie-France MARIN, Auteur ; Nathalie WAN, Auteur ; Zoran SEKEROVIC, Auteur ; Catherine LORD, Auteur ; Alexandra J. FIOCCO, Auteur ; Pierrich PLUSQUELLEC, Auteur ; Bruce S. MCEWEN, Auteur ; Sonia J. LUPIEN, Auteur Année de publication : 2011 Article en page(s) : p.725-776 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The allostatic load (AL) model represents an interdisciplinary approach to comprehensively conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle. This article first reviews the AL model, followed by interactions among early adversity, genetics, environmental toxins, as well as distinctions among sex, gender, and sex hormones as integral antecedents of AL. We next explore perspectives on severe mental illness, dementia, and caregiving as unique human models of AL that merit future investigations in the field of developmental psychopathology. A complimenting transdisciplinary perspective is applied throughout, whereby we argue that the AL model goes beyond traditional stress–disease theories toward the advancement of person-centered research and practice that promote not only physical health but also mental health. En ligne : http://dx.doi.org/10.1017/S0954579411000289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development [Texte imprimé et/ou numérique] / Robert-Paul JUSTER, Auteur ; Gustav BIZIK, Auteur ; Martin PICARD, Auteur ; Genevieve ARSENAULT-LAPIERRE, Auteur ; Shireen SINDI, Auteur ; Lyane TREPANIER, Auteur ; Marie-France MARIN, Auteur ; Nathalie WAN, Auteur ; Zoran SEKEROVIC, Auteur ; Catherine LORD, Auteur ; Alexandra J. FIOCCO, Auteur ; Pierrich PLUSQUELLEC, Auteur ; Bruce S. MCEWEN, Auteur ; Sonia J. LUPIEN, Auteur . - 2011 . - p.725-776. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.725-776 Index. décimale : PER Périodiques Résumé : The allostatic load (AL) model represents an interdisciplinary approach to comprehensively conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle. This article first reviews the AL model, followed by interactions among early adversity, genetics, environmental toxins, as well as distinctions among sex, gender, and sex hormones as integral antecedents of AL. We next explore perspectives on severe mental illness, dementia, and caregiving as unique human models of AL that merit future investigations in the field of developmental psychopathology. A complimenting transdisciplinary perspective is applied throughout, whereby we argue that the AL model goes beyond traditional stress–disease theories toward the advancement of person-centered research and practice that promote not only physical health but also mental health. En ligne : http://dx.doi.org/10.1017/S0954579411000289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

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