[article]
| Titre : |
Latent class analysis of early developmental trajectory in baby siblings of children with autism |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Rebecca LANDA, Auteur ; Alden L. GROSS, Auteur ; Elizabeth A. STUART, Auteur ; Margaret L. BAUMAN, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p.986-96 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism trajectories broader autism phenotype |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background: Siblings of children with autism (sibs-A) are at increased genetic risk for autism spectrum disorders (ASD) and milder impairments. To elucidate diversity and contour of early developmental trajectories exhibited by sibs-A, regardless of diagnostic classification, latent class modeling was used. Methods: Sibs-A (N = 204) were assessed with the Mullen Scales of Early Learning from age 6 to 36 months. Mullen T scores served as dependent variables. Outcome classifications at age 36 months included: ASD (N = 52); non-ASD social/communication delay (broader autism phenotype; BAP; N = 31); and unaffected (N = 121). Child-specific patterns of performance were studied using latent class growth analysis. Latent class membership was then related to diagnostic outcome through estimation of within-class proportions of children assigned to each diagnostic classification. Results: A 4-class model was favored. Class 1 represented accelerated development and consisted of 25.7% of the sample, primarily unaffected children. Class 2 (40.0% of the sample), was characterized by normative development with above-average nonverbal cognitive outcome. Class 3 (22.3% of the sample) was characterized by receptive language, and gross and fine motor delay. Class 4 (12.0% of the sample), was characterized by widespread delayed skill acquisition, reflected by declining trajectories. Children with an outcome diagnosis of ASD were spread across Classes 2, 3, and 4. Conclusions: Results support a category of ASD that involves slowing in early non-social development. Receptive language and motor development is vulnerable to early delay in sibs-A with and without ASD outcomes. Non-ASD sibs-A are largely distributed across classes depicting average or accelerated development. Developmental trajectories of motor, language, and cognition appear independent of communication and social delays in non-ASD sibs-A. |
| En ligne : |
http://dx.doi.org/10.1111/j.1469-7610.2012.02558.x |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 |
in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.986-96
[article] Latent class analysis of early developmental trajectory in baby siblings of children with autism [Texte imprimé et/ou numérique] / Rebecca LANDA, Auteur ; Alden L. GROSS, Auteur ; Elizabeth A. STUART, Auteur ; Margaret L. BAUMAN, Auteur . - 2012 . - p.986-96. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.986-96
| Mots-clés : |
Autism trajectories broader autism phenotype |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background: Siblings of children with autism (sibs-A) are at increased genetic risk for autism spectrum disorders (ASD) and milder impairments. To elucidate diversity and contour of early developmental trajectories exhibited by sibs-A, regardless of diagnostic classification, latent class modeling was used. Methods: Sibs-A (N = 204) were assessed with the Mullen Scales of Early Learning from age 6 to 36 months. Mullen T scores served as dependent variables. Outcome classifications at age 36 months included: ASD (N = 52); non-ASD social/communication delay (broader autism phenotype; BAP; N = 31); and unaffected (N = 121). Child-specific patterns of performance were studied using latent class growth analysis. Latent class membership was then related to diagnostic outcome through estimation of within-class proportions of children assigned to each diagnostic classification. Results: A 4-class model was favored. Class 1 represented accelerated development and consisted of 25.7% of the sample, primarily unaffected children. Class 2 (40.0% of the sample), was characterized by normative development with above-average nonverbal cognitive outcome. Class 3 (22.3% of the sample) was characterized by receptive language, and gross and fine motor delay. Class 4 (12.0% of the sample), was characterized by widespread delayed skill acquisition, reflected by declining trajectories. Children with an outcome diagnosis of ASD were spread across Classes 2, 3, and 4. Conclusions: Results support a category of ASD that involves slowing in early non-social development. Receptive language and motor development is vulnerable to early delay in sibs-A with and without ASD outcomes. Non-ASD sibs-A are largely distributed across classes depicting average or accelerated development. Developmental trajectories of motor, language, and cognition appear independent of communication and social delays in non-ASD sibs-A. |
| En ligne : |
http://dx.doi.org/10.1111/j.1469-7610.2012.02558.x |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 |
|  |
Latent class analysis of early developmental trajectory in baby siblings of children with autism in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)
