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A Two-Year Longitudinal MRI Study of the Corpus Callosum in Autism / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 42-11 (November 2012)

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inJournal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2312-2322

Titre :

A Two-Year Longitudinal MRI Study of the Corpus Callosum in Autism

Type de document :

texte imprimé

Auteurs :

Thomas W. FRAZIER, Auteur ; Matcheri S. KESHAVAN, Auteur ; Nancy J. MINSHEW, Auteur ; Antonio Y. HARDAN, Auteur

Article en page(s) :

p.2312-2322

Langues :

Anglais (eng)

Mots-clés :

Magnetic resonance imaging Autism Corpus callosum Rostral body

Index. décimale :

PER Périodiques

Résumé :

A growing body of literature has identified size reductions of the corpus callosum (CC) in autism. However, to our knowledge, no published studies have reported on the growth of CC volumes in youth with autism. Volumes of the total CC and its sub-divisions were obtained from 23 male children with autism and 23 age- and gender-matched controls at baseline and 2-year follow-up. Persistent reductions in total CC volume were observed in participants with autism relative to controls. Only the rostral body subdivision showed a normalization of size over time. Persistent reductions are consistent with the diagnostic stability and life-long impairment observed in many individuals with autism. Multi-modal imaging studies are needed to identify specific fiber tracks contributing to CC reductions.

En ligne :

http://dx.doi.org/10.1007/s10803-012-1478-z

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