Changes in the neural bases of emotion regulation associated with clinical improvement in children with behavior problems / Marc D. LEWIS in Development and Psychopathology, 20-3 (Summer 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-3 (Summer 2008) . - p.913-939 Titre : Changes in the neural bases of emotion regulation associated with clinical improvement in children with behavior problems Type de document : Texte imprimé et/ou numérique Auteurs : Marc D. LEWIS, Auteur ; Jim STIEBEN, Auteur ; Isabela GRANIC, Auteur ; Philip David ZELAZO, Auteur ; Debra PEPLER, Auteur ; Connie LAMM, Auteur ; Rebecca M. TODD, Auteur ; Ida MOADAB, Auteur Année de publication : 2008 Article en page(s) : p.913-939 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children's behavior problems may stem from ineffective cortical mechanisms for regulating negative emotions, and the success of interventions may depend on their impact on such mechanisms. We examined neurophysiological markers associated with emotion regulation in children comorbid for externalizing and internalizing problems before and after treatment. We hypothesized that treatment success would correspond with reduced ventral prefrontal activation, and increased dorsomedial prefrontal activation, at the time point of an event-related potential (ERP) associated with inhibitory control. Twenty-seven 8- to 12-year-old children (with usable data) were tested before and after a 14-week community-based treatment program and assessed as to improvement status. Fifteen 8- to 12-year-olds from the normal population (with usable data) were tested over the same interval. All children completed an emotion-induction go/no-go task while fitted with a 128-channel electrode net at each test session. ERP amplitudes, and estimates of cortical activation in prefrontal regions of interest, were measured at the peak of the “inhibitory” N2 and compared between improvers, nonimprovers, and nonclinical children. ERP amplitudes showed no group differences. However, improvers showed an overall reduction in ventral prefrontal activation from pretreatment to posttreatment, bringing them in line with nonclinical children, whereas ventral activation remained high for nonimprovers. Both improvers and nonimprovers showed high dorsal activation relative to nonclinical children. Supplementary analyses indicated that only ventral prefrontal regions, and only within the N2 time window, showed decreased activity from pre- to posttreatment, suggesting changes in regulatory processes rather than in overall emotional arousal. These cortically mediated changes may permit a reduction in the overengaged, rigid style of emotion regulation characteristic of children with behavior problems. En ligne : http://dx.doi.org/10.1017/s0954579408000448 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543 [article] Changes in the neural bases of emotion regulation associated with clinical improvement in children with behavior problems [Texte imprimé et/ou numérique] / Marc D. LEWIS, Auteur ; Jim STIEBEN, Auteur ; Isabela GRANIC, Auteur ; Philip David ZELAZO, Auteur ; Debra PEPLER, Auteur ; Connie LAMM, Auteur ; Rebecca M. TODD, Auteur ; Ida MOADAB, Auteur . - 2008 . - p.913-939. Langues : Anglais (eng) in Development and Psychopathology > 20-3 (Summer 2008) . - p.913-939 Index. décimale : PER Périodiques Résumé : Children's behavior problems may stem from ineffective cortical mechanisms for regulating negative emotions, and the success of interventions may depend on their impact on such mechanisms. We examined neurophysiological markers associated with emotion regulation in children comorbid for externalizing and internalizing problems before and after treatment. We hypothesized that treatment success would correspond with reduced ventral prefrontal activation, and increased dorsomedial prefrontal activation, at the time point of an event-related potential (ERP) associated with inhibitory control. Twenty-seven 8- to 12-year-old children (with usable data) were tested before and after a 14-week community-based treatment program and assessed as to improvement status. Fifteen 8- to 12-year-olds from the normal population (with usable data) were tested over the same interval. All children completed an emotion-induction go/no-go task while fitted with a 128-channel electrode net at each test session. ERP amplitudes, and estimates of cortical activation in prefrontal regions of interest, were measured at the peak of the “inhibitory” N2 and compared between improvers, nonimprovers, and nonclinical children. ERP amplitudes showed no group differences. However, improvers showed an overall reduction in ventral prefrontal activation from pretreatment to posttreatment, bringing them in line with nonclinical children, whereas ventral activation remained high for nonimprovers. Both improvers and nonimprovers showed high dorsal activation relative to nonclinical children. Supplementary analyses indicated that only ventral prefrontal regions, and only within the N2 time window, showed decreased activity from pre- to posttreatment, suggesting changes in regulatory processes rather than in overall emotional arousal. These cortically mediated changes may permit a reduction in the overengaged, rigid style of emotion regulation characteristic of children with behavior problems. En ligne : http://dx.doi.org/10.1017/s0954579408000448 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543

Emotion regulation in children with behavior problems: Linking behavioral and brain processes / Isabela GRANIC in Development and Psychopathology, 24-3 (August 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-3 (August 2012) . - p.1019-29 Titre : Emotion regulation in children with behavior problems: Linking behavioral and brain processes Type de document : Texte imprimé et/ou numérique Auteurs : Isabela GRANIC, Auteur ; Liesel-Ann MEUSEL, Auteur ; Connie LAMM, Auteur ; Steven WOLTERING, Auteur ; Marc D. LEWIS, Auteur Année de publication : 2012 Article en page(s) : p.1019-29 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Past studies have shown that aggressive children exhibit rigid (rather than flexible) parent–child interactions; these rigid repertoires may provide the context through which children fail to acquire emotion-regulation skills. Difficulties in regulating emotion are associated with minimal activity in dorsal systems in the cerebral cortex, for example, the anterior cingulate cortex. The current study aimed to integrate parent–child and neurocognitive indices of emotion regulation and examine their associations for the first time. Sixty children (8–12 years old) referred for treatment for aggression underwent two assessments. Brain processes related to emotion regulation were assessed using dense-array EEG with a computerized go/no-go task. The N2 amplitudes thought to tap inhibitory control were recorded, and a source analysis was conducted. In the second assessment, parents and children were videotaped while trying to solve a conflict topic. State space grids were used to derive two dynamic flexibility parameters from the coded videotapes: (a) the number of transitions between emotional states and (b) the dispersion of emotional states, based on proportional durations in each state. The regression results showed that flexibility measures were not related to N2 amplitudes. However, flexibility measures were significantly associated with the ratio of dorsal to ventral source activation: for transitions, ΔR2 = .27, F (1, 34) = 13.13, p = .001; for dispersion, ΔR2 = .29, F (1, 35) = 14.76, p < .001. Thus, in support of our main hypothesis, greater dyadic flexibility was associated with a higher ratio of dorsomedial to ventral activation, suggesting that children with more flexible parent–child interactions are able to recruit relatively more dorsomedial activity in challenging situations. En ligne : http://dx.doi.org/10.1017/S095457941200051X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Emotion regulation in children with behavior problems: Linking behavioral and brain processes [Texte imprimé et/ou numérique] / Isabela GRANIC, Auteur ; Liesel-Ann MEUSEL, Auteur ; Connie LAMM, Auteur ; Steven WOLTERING, Auteur ; Marc D. LEWIS, Auteur . - 2012 . - p.1019-29. Langues : Anglais (eng) in Development and Psychopathology > 24-3 (August 2012) . - p.1019-29 Index. décimale : PER Périodiques Résumé : Past studies have shown that aggressive children exhibit rigid (rather than flexible) parent–child interactions; these rigid repertoires may provide the context through which children fail to acquire emotion-regulation skills. Difficulties in regulating emotion are associated with minimal activity in dorsal systems in the cerebral cortex, for example, the anterior cingulate cortex. The current study aimed to integrate parent–child and neurocognitive indices of emotion regulation and examine their associations for the first time. Sixty children (8–12 years old) referred for treatment for aggression underwent two assessments. Brain processes related to emotion regulation were assessed using dense-array EEG with a computerized go/no-go task. The N2 amplitudes thought to tap inhibitory control were recorded, and a source analysis was conducted. In the second assessment, parents and children were videotaped while trying to solve a conflict topic. State space grids were used to derive two dynamic flexibility parameters from the coded videotapes: (a) the number of transitions between emotional states and (b) the dispersion of emotional states, based on proportional durations in each state. The regression results showed that flexibility measures were not related to N2 amplitudes. However, flexibility measures were significantly associated with the ratio of dorsal to ventral source activation: for transitions, ΔR2 = .27, F (1, 34) = 13.13, p = .001; for dispersion, ΔR2 = .29, F (1, 35) = 14.76, p < .001. Thus, in support of our main hypothesis, greater dyadic flexibility was associated with a higher ratio of dorsomedial to ventral activation, suggesting that children with more flexible parent–child interactions are able to recruit relatively more dorsomedial activity in challenging situations. En ligne : http://dx.doi.org/10.1017/S095457941200051X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

Neural mechanisms of emotion regulation in childhood anxiety / Kathryn M. HUM in Journal of Child Psychology and Psychiatry, 54-5 (May 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.552-564 Titre : Neural mechanisms of emotion regulation in childhood anxiety Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn M. HUM, Auteur ; Katharina MANASSIS, Auteur ; Marc D. LEWIS, Auteur Article en page(s) : p.552-564 Langues : Anglais (eng) Mots-clés : Childhood anxiety  event-related potentials  emotion faces  emotion regulation Index. décimale : PER Périodiques Résumé : Background: The present study was designed to examine the cortical processes that mediate cognitive regulation in response to emotion-eliciting stimuli in anxious children. Methods: Electroencephalographic (EEG) activity was recorded from clinically anxious children (n = 29) and typically developing children (n = 34). Event-related potential components were recorded while children performed a go/no-go task using facial stimuli depicting angry, calm, and happy expressions. Results: Anxious children had significantly greater posterior P1 and frontal N2 amplitudes, components associated with attention/arousal and cognitive control, respectively, than typically developing children. Anxious children also had significantly greater error-related negativities and correct-response negativities relative to typically developing children. For the anxious group only, there were no differences in neural activation between face (emotion) types or trial (Go vs. No-go) types. A regression analysis revealed that No-go N2 amplitudes for calm faces predicted self-reported anxiety levels. Conclusions: Anxious children appeared to show increased cortical activation regardless of the emotional content of the stimuli. Anxious children also showed greater medial-frontal activity regardless of task demands and response accuracy. Taken together, these findings suggest indiscriminate cortical processes that may underlie the hypervigilant regulatory style seen in clinically anxious individuals. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02609.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196 [article] Neural mechanisms of emotion regulation in childhood anxiety [Texte imprimé et/ou numérique] / Kathryn M. HUM, Auteur ; Katharina MANASSIS, Auteur ; Marc D. LEWIS, Auteur . - p.552-564. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.552-564 Mots-clés : Childhood anxiety  event-related potentials  emotion faces  emotion regulation Index. décimale : PER Périodiques Résumé : Background: The present study was designed to examine the cortical processes that mediate cognitive regulation in response to emotion-eliciting stimuli in anxious children. Methods: Electroencephalographic (EEG) activity was recorded from clinically anxious children (n = 29) and typically developing children (n = 34). Event-related potential components were recorded while children performed a go/no-go task using facial stimuli depicting angry, calm, and happy expressions. Results: Anxious children had significantly greater posterior P1 and frontal N2 amplitudes, components associated with attention/arousal and cognitive control, respectively, than typically developing children. Anxious children also had significantly greater error-related negativities and correct-response negativities relative to typically developing children. For the anxious group only, there were no differences in neural activation between face (emotion) types or trial (Go vs. No-go) types. A regression analysis revealed that No-go N2 amplitudes for calm faces predicted self-reported anxiety levels. Conclusions: Anxious children appeared to show increased cortical activation regardless of the emotional content of the stimuli. Anxious children also showed greater medial-frontal activity regardless of task demands and response accuracy. Taken together, these findings suggest indiscriminate cortical processes that may underlie the hypervigilant regulatory style seen in clinically anxious individuals. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02609.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196

Neurophysiological mechanisms of emotion regulation for subtypes of externalizing children / Jim STIEBEN in Development and Psychopathology, 19-2 (Spring 2007)  

Public ISBD [article]  inDevelopment and Psychopathology > 19-2 (Spring 2007) . - p.455-480 Titre : Neurophysiological mechanisms of emotion regulation for subtypes of externalizing children Type de document : Texte imprimé et/ou numérique Auteurs : Jim STIEBEN, Auteur ; Marc D. LEWIS, Auteur ; Isabela GRANIC, Auteur ; Philip David ZELAZO, Auteur ; Sidney SEGALOWITZ, Auteur ; Debra PEPLER, Auteur Année de publication : 2007 Article en page(s) : p.455-480 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children referred for externalizing behavior problems may not represent a homogeneous population. Our objective was to assess neural mechanisms of emotion regulation that might distinguish subtypes of externalizing children from each other and from their normal age mates. Children with pure externalizing (EXT) problems were compared with children comorbid for externalizing and internalizing (MIXED) problems and with age-matched controls. Only boys were included in the analysis because so few girls were referred for treatment. We used a go/no-go task with a negative emotion induction, and we examined dense-array EEG data together with behavioral measures of performance. We investigated two event-related potential (ERP) components tapping inhibitory control or self-monitoring—the inhibitory N2 and error-related negativity (ERN)—and we constructed source models estimating their cortical generators. The MIXED children's N2s increased in response to the emotion induction, resulting in greater amplitudes than EXT children in the following trial block. ERN amplitudes were greatest for control children and smallest for EXT children with MIXED children in between, but only prior to the emotion induction. These results were paralleled by behavioral differences in response time and performance monitoring. ERP activity was localized to cortical sources suggestive of the dorsal anterior cingulate for control children, posterior cingulate areas for the EXT children, and both posterior cingulate and ventral cingulate/prefrontal regions for the MIXED children. These findings highlight different mechanisms of self-regulation underlying externalizing subtypes and point toward distinct developmental pathways and treatment strategies. En ligne : http://dx.doi.org/10.1017/s0954579407070228 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=104 [article] Neurophysiological mechanisms of emotion regulation for subtypes of externalizing children [Texte imprimé et/ou numérique] / Jim STIEBEN, Auteur ; Marc D. LEWIS, Auteur ; Isabela GRANIC, Auteur ; Philip David ZELAZO, Auteur ; Sidney SEGALOWITZ, Auteur ; Debra PEPLER, Auteur . - 2007 . - p.455-480. Langues : Anglais (eng) in Development and Psychopathology > 19-2 (Spring 2007) . - p.455-480 Index. décimale : PER Périodiques Résumé : Children referred for externalizing behavior problems may not represent a homogeneous population. Our objective was to assess neural mechanisms of emotion regulation that might distinguish subtypes of externalizing children from each other and from their normal age mates. Children with pure externalizing (EXT) problems were compared with children comorbid for externalizing and internalizing (MIXED) problems and with age-matched controls. Only boys were included in the analysis because so few girls were referred for treatment. We used a go/no-go task with a negative emotion induction, and we examined dense-array EEG data together with behavioral measures of performance. We investigated two event-related potential (ERP) components tapping inhibitory control or self-monitoring—the inhibitory N2 and error-related negativity (ERN)—and we constructed source models estimating their cortical generators. The MIXED children's N2s increased in response to the emotion induction, resulting in greater amplitudes than EXT children in the following trial block. ERN amplitudes were greatest for control children and smallest for EXT children with MIXED children in between, but only prior to the emotion induction. These results were paralleled by behavioral differences in response time and performance monitoring. ERP activity was localized to cortical sources suggestive of the dorsal anterior cingulate for control children, posterior cingulate areas for the EXT children, and both posterior cingulate and ventral cingulate/prefrontal regions for the MIXED children. These findings highlight different mechanisms of self-regulation underlying externalizing subtypes and point toward distinct developmental pathways and treatment strategies. En ligne : http://dx.doi.org/10.1017/s0954579407070228 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=104

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