[article] 
inResearch in Autism Spectrum Disorders > 7-2 (February 2013) . - p.221-234

Titre :	Corpus callosum area in children and adults with autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Molly B. D. PRIGGE, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Tricia L. MERKLEY, Auteur ; E. Shannon NEELEY, Auteur ; Tracy J. ABILDSKOV, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Caitlin RAVICHANDRAN, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur
Année de publication :	2013
Article en page(s) :	p.221-234
Langues :	Anglais (eng)
Mots-clés :	Autism  Corpus callosum area  Development  MRI
Index. décimale :	PER Périodiques
Résumé :	Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with autism compared to a typically developing sample. Midsagittal corpus callosum area and the 7 Witelson subregions were examined in 68 males with autism (mean age 14.1 years; range 3'36 years) and 47 males with typical development (mean age 15.3 years; range 4'29 years). Controlling for total brain volume, increased variability in total corpus callosum area was found in autism. In autism, increased midsagittal areas were associated with reduced severity of autism behaviors, higher intelligence, and faster speed of processing (p = 0.003, p = 0.011, p = 0.013, respectively). A trend toward group differences in isthmus development was found (p = 0.029, uncorrected). These results suggest that individuals with autism benefit functionally from increased corpus callosum area. Our cross-sectional examination also shows potential maturational abnormalities in autism, a finding that should be examined further with longitudinal datasets.
En ligne :	http://dx.doi.org/10.1016/j.rasd.2012.09.007
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186

[article] Corpus callosum area in children and adults with autism [Texte imprimé et/ou numérique] / Molly B. D. PRIGGE, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Tricia L. MERKLEY, Auteur ; E. Shannon NEELEY, Auteur ; Tracy J. ABILDSKOV, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Caitlin RAVICHANDRAN, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - 2013 . - p.221-234.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 7-2 (February 2013) . - p.221-234

Mots-clés :	Autism  Corpus callosum area  Development  MRI
Index. décimale :	PER Périodiques
Résumé :	Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with autism compared to a typically developing sample. Midsagittal corpus callosum area and the 7 Witelson subregions were examined in 68 males with autism (mean age 14.1 years; range 3'36 years) and 47 males with typical development (mean age 15.3 years; range 4'29 years). Controlling for total brain volume, increased variability in total corpus callosum area was found in autism. In autism, increased midsagittal areas were associated with reduced severity of autism behaviors, higher intelligence, and faster speed of processing (p = 0.003, p = 0.011, p = 0.013, respectively). A trend toward group differences in isthmus development was found (p = 0.029, uncorrected). These results suggest that individuals with autism benefit functionally from increased corpus callosum area. Our cross-sectional examination also shows potential maturational abnormalities in autism, a finding that should be examined further with longitudinal datasets.
En ligne :	http://dx.doi.org/10.1016/j.rasd.2012.09.007
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186