Allostasis and the developing human brain: Explicit consideration of implicit models / Barbara L. GANZEL in Development and Psychopathology, 23-4 (November 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-4 (November 2011) . - p.955-974 Titre : Allostasis and the developing human brain: Explicit consideration of implicit models Type de document : Texte imprimé et/ou numérique Auteurs : Barbara L. GANZEL, Auteur ; Pamela A. MORRIS, Auteur Année de publication : 2011 Article en page(s) : p.955-974 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We previously used the theory of allostasis as the foundation for a model of the current stress process. This work highlighted the core emotional systems of the brain as the central mediator of the relationship between stress and health. In this paper, we extend this theoretical approach to consider the role of developmental timing. In doing so, we note that there are strong implicit models that underlie current developmental stress research in the social and life sciences. We endeavor to illustrate these models explicitly as we review the evidence behind each one and discuss their implications. We then extend these models to reflect recent findings from research in life span human neuroscience. The result is a new set of developmental allostatic models that provide fodder for future empirical research, as well as novel perspectives on intervention. En ligne : http://dx.doi.org/10.1017/S0954579411000447 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Allostasis and the developing human brain: Explicit consideration of implicit models [Texte imprimé et/ou numérique] / Barbara L. GANZEL, Auteur ; Pamela A. MORRIS, Auteur . - 2011 . - p.955-974. Langues : Anglais (eng) in Development and Psychopathology > 23-4 (November 2011) . - p.955-974 Index. décimale : PER Périodiques Résumé : We previously used the theory of allostasis as the foundation for a model of the current stress process. This work highlighted the core emotional systems of the brain as the central mediator of the relationship between stress and health. In this paper, we extend this theoretical approach to consider the role of developmental timing. In doing so, we note that there are strong implicit models that underlie current developmental stress research in the social and life sciences. We endeavor to illustrate these models explicitly as we review the evidence behind each one and discuss their implications. We then extend these models to reflect recent findings from research in life span human neuroscience. The result is a new set of developmental allostatic models that provide fodder for future empirical research, as well as novel perspectives on intervention. En ligne : http://dx.doi.org/10.1017/S0954579411000447 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene / Cynthia J. WILLNER in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 1) (November 2014) . - p.999-1019 Titre : Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene Type de document : Texte imprimé et/ou numérique Auteurs : Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur Année de publication : 2014 Article en page(s) : p.999-1019 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Building on research on cumulative risk and psychopathology, this study examines how cumulative risk exposure is associated with altered diurnal cortisol rhythms in an ethnically diverse, low-income sample of youth. In addition, consistent with a diathesis-stress perspective, this study explores whether the effect of environmental risk is moderated by allelic variation in the serotonin transporter linked polymorphic region (5-HTTLPR) gene. Results show that youth with greater cumulative risk exposure had flatter diurnal cortisol slopes, regardless of 5-HTTLPR genotype. However, the association of cumulative risk with average cortisol output (area under the curve [AUC]) was moderated by the 5-HTTLPR genotype. Among youth homozygous for the long allele, greater cumulative risk exposure was associated with lower cortisol AUC, driven by significant reductions in cortisol levels at waking. In contrast, there was a trend-level association between greater cumulative risk and higher cortisol AUC among youth carrying the short allele, driven by a trend-level increase in bedtime cortisol levels. Findings are discussed with regard to the relevance of dysregulated diurnal cortisol rhythms for the development of psychopathology and the implications of genetically mediated differences in psychophysiological adaptations to stress. En ligne : http://dx.doi.org/10.1017/S0954579414000558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242 [article] Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene [Texte imprimé et/ou numérique] / Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur . - 2014 . - p.999-1019. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 1) (November 2014) . - p.999-1019 Index. décimale : PER Périodiques Résumé : Building on research on cumulative risk and psychopathology, this study examines how cumulative risk exposure is associated with altered diurnal cortisol rhythms in an ethnically diverse, low-income sample of youth. In addition, consistent with a diathesis-stress perspective, this study explores whether the effect of environmental risk is moderated by allelic variation in the serotonin transporter linked polymorphic region (5-HTTLPR) gene. Results show that youth with greater cumulative risk exposure had flatter diurnal cortisol slopes, regardless of 5-HTTLPR genotype. However, the association of cumulative risk with average cortisol output (area under the curve [AUC]) was moderated by the 5-HTTLPR genotype. Among youth homozygous for the long allele, greater cumulative risk exposure was associated with lower cortisol AUC, driven by significant reductions in cortisol levels at waking. In contrast, there was a trend-level association between greater cumulative risk and higher cortisol AUC among youth carrying the short allele, driven by a trend-level increase in bedtime cortisol levels. Findings are discussed with regard to the relevance of dysregulated diurnal cortisol rhythms for the development of psychopathology and the implications of genetically mediated differences in psychophysiological adaptations to stress. En ligne : http://dx.doi.org/10.1017/S0954579414000558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242

Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene—ERRATUM / Cynthia J. WILLNER in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 1) (November 2014) . - p.1185-1188 Titre : Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene—ERRATUM Type de document : Texte imprimé et/ou numérique Auteurs : Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur Année de publication : 2014 Article en page(s) : p.1185-1188 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579414000819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene—ERRATUM [Texte imprimé et/ou numérique] / Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur . - 2014 . - p.1185-1188. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 1) (November 2014) . - p.1185-1188 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579414000819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

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