The neuroanatomy of the autistic phenotype / Cherine FAHIM in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.898-906 Titre : The neuroanatomy of the autistic phenotype Type de document : Texte imprimé et/ou numérique Auteurs : Cherine FAHIM, Auteur ; Nagwa A. MEGUID, Auteur ; Neveen H. NASHAAT, Auteur ; Uicheul YOON, Auteur ; Adham MANCINI-MARIE, Auteur ; Alan C. EVANS, Auteur Année de publication : 2012 Article en page(s) : p.898-906 Langues : Anglais (eng) Mots-clés : Autism  Fragile X syndrome  Williams syndrome  Gray matter  White matter  Neuroimaging Index. décimale : PER Périodiques Résumé : The autism phenotype is associated with an excess of brain volume due in part to decreased pruning during development. Here we aimed at assessing brain volume early in development to further elucidate previous findings in autism and determine whether this pattern is restricted to idiopathic autism or shared within the autistic phenotype (fragile X syndrome [FXS]). We investigated brain volume in 37 participants, using the fully automated Civet pipeline anatomical magnetic resonance imaging. 3 groups with intellectual deficiency: autism (AUT); its most associated FXS; and its most opposite Williams syndrome (WS) were compared with each other and with normal controls (NC). We report increased total and regional gray and white matter brain volume in AUT and FXS relative to WS and NC. These findings are discussed in light of the possibilities leading for the enlarged brain volume in children with the AUT phenotype. We speculate that this excess suggests reduced regression of neuronal processes “pruning” in cortical and subcortical regions in AUT/FXS, which may be due to a mutation in specific genes involved in pruning and/or a lack of socio-emotional environmental experience during a critical developmental period. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.11.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150 [article] The neuroanatomy of the autistic phenotype [Texte imprimé et/ou numérique] / Cherine FAHIM, Auteur ; Nagwa A. MEGUID, Auteur ; Neveen H. NASHAAT, Auteur ; Uicheul YOON, Auteur ; Adham MANCINI-MARIE, Auteur ; Alan C. EVANS, Auteur . - 2012 . - p.898-906. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.898-906 Mots-clés : Autism  Fragile X syndrome  Williams syndrome  Gray matter  White matter  Neuroimaging Index. décimale : PER Périodiques Résumé : The autism phenotype is associated with an excess of brain volume due in part to decreased pruning during development. Here we aimed at assessing brain volume early in development to further elucidate previous findings in autism and determine whether this pattern is restricted to idiopathic autism or shared within the autistic phenotype (fragile X syndrome [FXS]). We investigated brain volume in 37 participants, using the fully automated Civet pipeline anatomical magnetic resonance imaging. 3 groups with intellectual deficiency: autism (AUT); its most associated FXS; and its most opposite Williams syndrome (WS) were compared with each other and with normal controls (NC). We report increased total and regional gray and white matter brain volume in AUT and FXS relative to WS and NC. These findings are discussed in light of the possibilities leading for the enlarged brain volume in children with the AUT phenotype. We speculate that this excess suggests reduced regression of neuronal processes “pruning” in cortical and subcortical regions in AUT/FXS, which may be due to a mutation in specific genes involved in pruning and/or a lack of socio-emotional environmental experience during a critical developmental period. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.11.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150

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