32 recherche sur le mot-clé 'White matter'

White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies / Meghan R. SWANSON in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 33 Titre : White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies Type de document : texte imprimé Auteurs : Meghan R. SWANSON, Auteur ; Heather C. HAZLETT, Auteur Article en page(s) : 33 Langues : Anglais (eng) Mots-clés : Animals  Autism Spectrum Disorder/diagnostic imaging/pathology/therapy  Biomarkers  Brain/diagnostic imaging/growth & development/pathology  Early Medical Intervention  Fragile X Syndrome/diagnostic imaging/pathology/therapy  Humans  Neurodevelopmental Disorders/diagnostic imaging/pathology/therapy  White Matter/diagnostic imaging/growth & development/pathology  Autism spectrum disorder  Brain  Clinical trial  Fragile X syndrome  Intervention  Myelin  Neurodevelopment  Treatment  White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Early intervention is a valuable tool to support the development of toddlers with neurodevelopmental disorders. With recent research advances in early identification that allow for pre-symptomatic detection of autism in infancy, scientists are looking forward to intervention during infancy. These advances may be supported by the identification of biologically based treatment and outcome measures that are sensitive and dimensional. The purpose of this review is to evaluate white matter neurodevelopment as a monitoring biomarker for early treatment of neurodevelopmental disorders. Fragile X syndrome (FXS) and autism spectrum disorder (ASD) as used as exemplars. White matter has unique neurobiology, including a prolonged period of dynamic development. This developmental pattern may make white matter especially responsive to treatment. White matter develops aberrantly in children with ASD and FXS. Histologic studies in rodents have provided targets for FXS pharmacological intervention. However, pharmaceutical clinical trials in humans failed to garner positive clinical results. In this article, we argue that the use of neurobiological monitoring biomarkers may overcome some of these limitations, as they are objective, not susceptible to placebo effects, and are dimensional in nature. SHORT CONCLUSION: As the field moves towards earlier detection and early intervention for neurodevelopmental disorders, we encourage scientists to consider the advantages of using neurobiological features as monitoring biomarkers. En ligne : https://dx.doi.org/10.1186/s11689-019-9295-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies [texte imprimé] / Meghan R. SWANSON, Auteur ; Heather C. HAZLETT, Auteur . - 33. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 33 Mots-clés : Animals  Autism Spectrum Disorder/diagnostic imaging/pathology/therapy  Biomarkers  Brain/diagnostic imaging/growth & development/pathology  Early Medical Intervention  Fragile X Syndrome/diagnostic imaging/pathology/therapy  Humans  Neurodevelopmental Disorders/diagnostic imaging/pathology/therapy  White Matter/diagnostic imaging/growth & development/pathology  Autism spectrum disorder  Brain  Clinical trial  Fragile X syndrome  Intervention  Myelin  Neurodevelopment  Treatment  White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Early intervention is a valuable tool to support the development of toddlers with neurodevelopmental disorders. With recent research advances in early identification that allow for pre-symptomatic detection of autism in infancy, scientists are looking forward to intervention during infancy. These advances may be supported by the identification of biologically based treatment and outcome measures that are sensitive and dimensional. The purpose of this review is to evaluate white matter neurodevelopment as a monitoring biomarker for early treatment of neurodevelopmental disorders. Fragile X syndrome (FXS) and autism spectrum disorder (ASD) as used as exemplars. White matter has unique neurobiology, including a prolonged period of dynamic development. This developmental pattern may make white matter especially responsive to treatment. White matter develops aberrantly in children with ASD and FXS. Histologic studies in rodents have provided targets for FXS pharmacological intervention. However, pharmaceutical clinical trials in humans failed to garner positive clinical results. In this article, we argue that the use of neurobiological monitoring biomarkers may overcome some of these limitations, as they are objective, not susceptible to placebo effects, and are dimensional in nature. SHORT CONCLUSION: As the field moves towards earlier detection and early intervention for neurodevelopmental disorders, we encourage scientists to consider the advantages of using neurobiological features as monitoring biomarkers. En ligne : https://dx.doi.org/10.1186/s11689-019-9295-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

White matter microstructure of children with sensory over-responsivity is associated with affective behavior / Jamie WREN-JARVIS in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : White matter microstructure of children with sensory over-responsivity is associated with affective behavior Type de document : texte imprimé Auteurs : Jamie WREN-JARVIS, Auteur ; Rachel POWERS, Auteur ; Maia C. LAZERWITZ, Auteur ; Jaclyn XIAO, Auteur ; Lanya T. CAI, Auteur ; Hannah L. CHOI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Mikaela A. ROWE, Auteur ; Mary C. STEELE, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur Langues : Anglais (eng) Mots-clés : Male  Child  Female  Humans  White Matter/diagnostic imaging  Diffusion Tensor Imaging/methods  Diffusion Magnetic Resonance Imaging  Magnetic Resonance Imaging  Cerebellum  Dti  Depression  Mri  Sensory over-responsivity  Sensory processing disorder  Somatization  White matter  commercial or financial relationships that could be construed as a potential  conflict of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory over-responsivity (SOR), a form of SPD, affects at least 2.5% of all children and has substantial deleterious impact on learning and mental health. However, SOR has not been well studied using microstructural imaging such as diffusion MRI (dMRI). Since SOR involves hypersensitivity to external stimuli, we test the hypothesis that children with SOR require compensatory neuroplasticity in the form of superior WM microstructural integrity to protect against internalizing behavior, leaving those with impaired WM microstructure vulnerable to somatization and depression. METHODS: Children ages 8-12 years old with neurodevelopmental concerns were assessed for SOR using a comprehensive structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment, and underwent 3 Tesla MRI with multishell multiband dMRI. Tract-based spatial statistics was used to measure diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics from global WM and nineteen selected WM tracts. Correlations of DTI and NODDI measures with measures of somatization and emotional disturbance from the Behavioral Assessment System for Children, 3rd edition (BASC-3), were computed in the SOR group and in matched children with neurodevelopmental concerns but not SOR. RESULTS: Global WM fractional anisotropy (FA) is negatively correlated with somatization and with emotional disturbance in the SOR group but not the non-SOR group. Also observed in children with SOR are positive correlations of radial diffusivity (RD) and free water fraction (FISO) with somatization and, in most cases, emotional disturbance. These effects are significant in boys with SOR, whereas the study is underpowered for girls. The most affected white matter are medial lemniscus and internal capsule sensory tracts, although effects of SOR are observed in many cerebral, cerebellar, and brainstem tracts. CONCLUSION: White matter microstructure is related to affective behavior in children with SOR. En ligne : https://dx.doi.org/10.1186/s11689-023-09513-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] White matter microstructure of children with sensory over-responsivity is associated with affective behavior [texte imprimé] / Jamie WREN-JARVIS, Auteur ; Rachel POWERS, Auteur ; Maia C. LAZERWITZ, Auteur ; Jaclyn XIAO, Auteur ; Lanya T. CAI, Auteur ; Hannah L. CHOI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Mikaela A. ROWE, Auteur ; Mary C. STEELE, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Male  Child  Female  Humans  White Matter/diagnostic imaging  Diffusion Tensor Imaging/methods  Diffusion Magnetic Resonance Imaging  Magnetic Resonance Imaging  Cerebellum  Dti  Depression  Mri  Sensory over-responsivity  Sensory processing disorder  Somatization  White matter  commercial or financial relationships that could be construed as a potential  conflict of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory over-responsivity (SOR), a form of SPD, affects at least 2.5% of all children and has substantial deleterious impact on learning and mental health. However, SOR has not been well studied using microstructural imaging such as diffusion MRI (dMRI). Since SOR involves hypersensitivity to external stimuli, we test the hypothesis that children with SOR require compensatory neuroplasticity in the form of superior WM microstructural integrity to protect against internalizing behavior, leaving those with impaired WM microstructure vulnerable to somatization and depression. METHODS: Children ages 8-12 years old with neurodevelopmental concerns were assessed for SOR using a comprehensive structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment, and underwent 3 Tesla MRI with multishell multiband dMRI. Tract-based spatial statistics was used to measure diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics from global WM and nineteen selected WM tracts. Correlations of DTI and NODDI measures with measures of somatization and emotional disturbance from the Behavioral Assessment System for Children, 3rd edition (BASC-3), were computed in the SOR group and in matched children with neurodevelopmental concerns but not SOR. RESULTS: Global WM fractional anisotropy (FA) is negatively correlated with somatization and with emotional disturbance in the SOR group but not the non-SOR group. Also observed in children with SOR are positive correlations of radial diffusivity (RD) and free water fraction (FISO) with somatization and, in most cases, emotional disturbance. These effects are significant in boys with SOR, whereas the study is underpowered for girls. The most affected white matter are medial lemniscus and internal capsule sensory tracts, although effects of SOR are observed in many cerebral, cerebellar, and brainstem tracts. CONCLUSION: White matter microstructure is related to affective behavior in children with SOR. En ligne : https://dx.doi.org/10.1186/s11689-023-09513-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

White matter and development in children with an autism spectrum disorder / Kathleen M. MAK-FAN in Autism, 17-5 (September 2013)  

Public ISBD [article]  inAutism > 17-5 (September 2013) . - p.541-557 Titre : White matter and development in children with an autism spectrum disorder Type de document : texte imprimé Auteurs : Kathleen M. MAK-FAN, Auteur ; Drew MORRIS, Auteur ; Julie VIDAL, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Wendy ROBERTS, Auteur ; Margot J. TAYLOR, Auteur Article en page(s) : p.541-557 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  brain structure  development  white matter  diffusion tensor imaging  diffusivity Index. décimale : PER Périodiques Résumé : Recent research suggests that brain development follows an abnormal trajectory in children with autism spectrum disorders (ASD). The current study examined changes in diffusivity with age within defined white matter tracts in a group of typically developing children and a group of children with an ASD, aged 6 to 14 years. Age by group interactions were observed for frontal, long distant, interhemispheric and posterior tracts, for longitudinal, radial and mean diffusivity, but not for fractional anisotropy. In all cases, these measures of diffusivity decreased with age in the typically developing group, but showed little or no change in the ASD group. This supports the hypothesis of an abnormal developmental trajectory of white matter in this population, which could have profound effects on the development of neural connectivity and contribute to atypical cognitive development in children with ASD. En ligne : http://dx.doi.org/10.1177/1362361312442596 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] White matter and development in children with an autism spectrum disorder [texte imprimé] / Kathleen M. MAK-FAN, Auteur ; Drew MORRIS, Auteur ; Julie VIDAL, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Wendy ROBERTS, Auteur ; Margot J. TAYLOR, Auteur . - p.541-557. Langues : Anglais (eng) in Autism > 17-5 (September 2013) . - p.541-557 Mots-clés : autism spectrum disorder  brain structure  development  white matter  diffusion tensor imaging  diffusivity Index. décimale : PER Périodiques Résumé : Recent research suggests that brain development follows an abnormal trajectory in children with autism spectrum disorders (ASD). The current study examined changes in diffusivity with age within defined white matter tracts in a group of typically developing children and a group of children with an ASD, aged 6 to 14 years. Age by group interactions were observed for frontal, long distant, interhemispheric and posterior tracts, for longitudinal, radial and mean diffusivity, but not for fractional anisotropy. In all cases, these measures of diffusivity decreased with age in the typically developing group, but showed little or no change in the ASD group. This supports the hypothesis of an abnormal developmental trajectory of white matter in this population, which could have profound effects on the development of neural connectivity and contribute to atypical cognitive development in children with ASD. En ligne : http://dx.doi.org/10.1177/1362361312442596 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

White matter compromise in autism? Differentiating motion confounds from true differences in diffusion tensor imaging / Seraphina K. SOLDERS in Autism Research, 10-10 (October 2017)  

Public ISBD [article]  inAutism Research > 10-10 (October 2017) . - p.1606-1620 Titre : White matter compromise in autism? Differentiating motion confounds from true differences in diffusion tensor imaging Type de document : texte imprimé Auteurs : Seraphina K. SOLDERS, Auteur ; Ruth A. CARPER, Auteur ; Ralph-Axel MULLER, Auteur Article en page(s) : p.1606-1620 Langues : Anglais (eng) Mots-clés : diffusion  autism  motion  MRI  white matter  artifact Index. décimale : PER Périodiques Résumé : Common findings from diffusion tensor imaging (DTI) in autism spectrum disorder (ASD) include reduced fractional anisotropy (FA), and increased mean and radial diffusivity (MD, RD) of white matter tracts. However, findings may be confounded by head motion. We examined how group-level motion matching affects DTI comparisons between ASD and typically developing (TD) groups. We included 57 ASD and 50 TD participants, comparing three subsets at increasing levels of motion-matching stringency: full sample (FS); quality-controlled (QC); and quantitatively-matched (QM). Groups were compared on diffusivity measures using Tract-Based Spatial Statistics (TBSS) and probabilistic tractography. Two methods for estimating diffusivity were compared: dti-fit and restore. TBSS: In set FS, FA was reduced in the ASD compared to the TD group throughout the right hemisphere. This effect was less extensive in set QC and absent in set QM. However, effect sizes remained stable or increased with better quality-control in some regions. Tractography: In set QM, MD was significantly higher in ASD overall and RD was higher in bilateral ILF. Effects were more robust in QM than in FS or QC sets. Effect sizes in several tracts increased with stringent quality matching. Restore improved tensor estimates, with some increases in effect sizes, but did not fully compensate for reduced quality. Findings suggest that some previously reported DTI findings for ASD may have been confounded by motion. However, effects in the tightly matched subset indicate that tract-specific anomalies probably do exist in ASD. Our results highlight the need for careful quality-control and motion-matching. Autism Res 2017, 10: 1606–1620. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1807 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 [article] White matter compromise in autism? Differentiating motion confounds from true differences in diffusion tensor imaging [texte imprimé] / Seraphina K. SOLDERS, Auteur ; Ruth A. CARPER, Auteur ; Ralph-Axel MULLER, Auteur . - p.1606-1620. Langues : Anglais (eng) in Autism Research > 10-10 (October 2017) . - p.1606-1620 Mots-clés : diffusion  autism  motion  MRI  white matter  artifact Index. décimale : PER Périodiques Résumé : Common findings from diffusion tensor imaging (DTI) in autism spectrum disorder (ASD) include reduced fractional anisotropy (FA), and increased mean and radial diffusivity (MD, RD) of white matter tracts. However, findings may be confounded by head motion. We examined how group-level motion matching affects DTI comparisons between ASD and typically developing (TD) groups. We included 57 ASD and 50 TD participants, comparing three subsets at increasing levels of motion-matching stringency: full sample (FS); quality-controlled (QC); and quantitatively-matched (QM). Groups were compared on diffusivity measures using Tract-Based Spatial Statistics (TBSS) and probabilistic tractography. Two methods for estimating diffusivity were compared: dti-fit and restore. TBSS: In set FS, FA was reduced in the ASD compared to the TD group throughout the right hemisphere. This effect was less extensive in set QC and absent in set QM. However, effect sizes remained stable or increased with better quality-control in some regions. Tractography: In set QM, MD was significantly higher in ASD overall and RD was higher in bilateral ILF. Effects were more robust in QM than in FS or QC sets. Effect sizes in several tracts increased with stringent quality matching. Restore improved tensor estimates, with some increases in effect sizes, but did not fully compensate for reduced quality. Findings suggest that some previously reported DTI findings for ASD may have been confounded by motion. However, effects in the tightly matched subset indicate that tract-specific anomalies probably do exist in ASD. Our results highlight the need for careful quality-control and motion-matching. Autism Res 2017, 10: 1606–1620. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1807 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322

White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults / Oswald J.N. BLOEMEN in Autism Research, 3-5 (October 2010)  

Public ISBD [article]  inAutism Research > 3-5 (October 2010) . - p.203-213 Titre : White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults Type de document : texte imprimé Auteurs : Oswald J.N. BLOEMEN, Auteur ; Quinton DEELEY, Auteur ; Fred SUNDRAM, Auteur ; Eileen DALY, Auteur ; Gareth J. BARKER, Auteur ; Derek K. JONES, Auteur ; Therese A.M.J. VAN AMELSVOORT, Auteur ; Nicole SCHMITZ, Auteur ; Dene ROBERTSON, Auteur ; Kieran C. MURPHY, Auteur ; Declan G.M. MURPHY, Auteur Année de publication : 2010 Article en page(s) : p.203-213 Langues : Anglais (eng) Mots-clés : autism  Asperger syndrome  white matter  DTI  connectivity Index. décimale : PER Périodiques Résumé : Background: Autistic Spectrum Disorder (ASD), including Asperger syndrome and autism, is a highly genetic neurodevelopmental disorder. There is a consensus that ASD has a biological basis, and it has been proposed that it is a “connectivity” disorder. Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) allows measurement of the microstructural integrity of white matter (a proxy measure of “connectivity”). However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome. Methods: We measured the fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) of white matter, using DT-MRI, in 13 adults with Asperger syndrome and 13 controls. The groups did not differ significantly in overall intelligence and age. FA, MD and RD were assessed using whole brain voxel-based techniques. Results: Adults with Asperger syndrome had a significantly lower FA than controls in 13 clusters. These were largely bilateral and included white matter in the internal capsule, frontal, temporal, parietal and occipital lobes, cingulum and corpus callosum. Conclusions: Adults with Asperger syndrome have widespread significant differences from controls in white matter microstructural integrity. En ligne : http://dx.doi.org/10.1002/aur.146 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults [texte imprimé] / Oswald J.N. BLOEMEN, Auteur ; Quinton DEELEY, Auteur ; Fred SUNDRAM, Auteur ; Eileen DALY, Auteur ; Gareth J. BARKER, Auteur ; Derek K. JONES, Auteur ; Therese A.M.J. VAN AMELSVOORT, Auteur ; Nicole SCHMITZ, Auteur ; Dene ROBERTSON, Auteur ; Kieran C. MURPHY, Auteur ; Declan G.M. MURPHY, Auteur . - 2010 . - p.203-213. Langues : Anglais (eng) in Autism Research > 3-5 (October 2010) . - p.203-213 Mots-clés : autism  Asperger syndrome  white matter  DTI  connectivity Index. décimale : PER Périodiques Résumé : Background: Autistic Spectrum Disorder (ASD), including Asperger syndrome and autism, is a highly genetic neurodevelopmental disorder. There is a consensus that ASD has a biological basis, and it has been proposed that it is a “connectivity” disorder. Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) allows measurement of the microstructural integrity of white matter (a proxy measure of “connectivity”). However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome. Methods: We measured the fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) of white matter, using DT-MRI, in 13 adults with Asperger syndrome and 13 controls. The groups did not differ significantly in overall intelligence and age. FA, MD and RD were assessed using whole brain voxel-based techniques. Results: Adults with Asperger syndrome had a significantly lower FA than controls in 13 clusters. These were largely bilateral and included white matter in the internal capsule, frontal, temporal, parietal and occipital lobes, cingulum and corpus callosum. Conclusions: Adults with Asperger syndrome have widespread significant differences from controls in white matter microstructural integrity. En ligne : http://dx.doi.org/10.1002/aur.146 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

White matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder / Winke FRANCX in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)  

Permalink

White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study / Austin BAZYDLO in Journal of Neurodevelopmental Disorders, 13 (2021)  

Permalink

White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder / Miriam COOPER in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

Permalink

White matter volume in the brainstem and inferior parietal lobule is related to motor performance in children with autism spectrum disorder: A voxel-based morphometry study / Ryuzo HANAIE in Autism Research, 9-9 (September 2016)  

Permalink

Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children / Olivia SURGENT in Molecular Autism, 13 (2022)  

Permalink