Interaction of serotonin transporter linked polymorphic region and childhood neglect on criminal behavior and substance use for males and females / Jamie VASKE in Development and Psychopathology, 24-1 (January 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-1 (January 2012) . - p.181-193 Titre : Interaction of serotonin transporter linked polymorphic region and childhood neglect on criminal behavior and substance use for males and females Type de document : Texte imprimé et/ou numérique Auteurs : Jamie VASKE, Auteur ; Jamie NEWSOME, Auteur ; John Paul WRIGHT, Auteur Année de publication : 2012 Article en page(s) : p.181-193 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Childhood neglect has been cited as a risk factor for later substance abuse and criminal behavior. However, a large body of literature shows that a substantial percentage of neglected and abused individuals do not go on to abuse substances or engage in criminal behavior. The current study investigates whether a genetic variant (serotonin transporter linked polymorphic region [5-HTTLPR]) in the 5-hydroxytryptamine (5-HTT) gene moderates the effect of childhood neglect on alcohol use problems, marijuana use, and criminal behavior. Data from the National Longitudinal Study of Adolescent Health shows that 5-HTTLPR conditions the effect of neglect on marijuana use for females, but not for males. Findings also reveal a significant gene–environment correlation between 5-HTTLPR and neglect for females only. These results suggest that 5-HTTLPR is associated with an increased risk of neglect for females, and it also increases neglected females’ risk of abusing marijuana. En ligne : http://dx.doi.org/10.1017/S0954579411000769 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Interaction of serotonin transporter linked polymorphic region and childhood neglect on criminal behavior and substance use for males and females [Texte imprimé et/ou numérique] / Jamie VASKE, Auteur ; Jamie NEWSOME, Auteur ; John Paul WRIGHT, Auteur . - 2012 . - p.181-193. Langues : Anglais (eng) in Development and Psychopathology > 24-1 (January 2012) . - p.181-193 Index. décimale : PER Périodiques Résumé : Childhood neglect has been cited as a risk factor for later substance abuse and criminal behavior. However, a large body of literature shows that a substantial percentage of neglected and abused individuals do not go on to abuse substances or engage in criminal behavior. The current study investigates whether a genetic variant (serotonin transporter linked polymorphic region [5-HTTLPR]) in the 5-hydroxytryptamine (5-HTT) gene moderates the effect of childhood neglect on alcohol use problems, marijuana use, and criminal behavior. Data from the National Longitudinal Study of Adolescent Health shows that 5-HTTLPR conditions the effect of neglect on marijuana use for females, but not for males. Findings also reveal a significant gene–environment correlation between 5-HTTLPR and neglect for females only. These results suggest that 5-HTTLPR is associated with an increased risk of neglect for females, and it also increases neglected females’ risk of abusing marijuana. En ligne : http://dx.doi.org/10.1017/S0954579411000769 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

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