The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood / Daniel E. ADKINS in Development and Psychopathology, 24-1 (January 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-1 (January 2012) . - p.267-285 Titre : The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Daniel E. ADKINS, Auteur ; Jonathan K. DAW, Auteur ; Joseph L. MCCLAY, Auteur ; Edwin J. C. G. VAN DEN OORD, Auteur Année de publication : 2012 Article en page(s) : p.267-285 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The influence of five monoamine candidate genes on depressive symptom trajectories in adolescence and young adulthood were examined in the Add Health genetic sample. Results indicated that, for all respondents, carriers of the dopamine receptor D4 5-repeat allele were characterized by distinct depressive symptom trajectories across adolescence and early adulthood. Similarly, for males, individuals with the monoamine oxidase A 3.5-repeat allele exhibited unique depressive symptom trajectories. Specifically, the trajectories of those with the dopamine receptor D4 5-repeat allele were characterized by rising levels in the transition to adulthood, while their peers were experiencing a normative drop in depressive symptom frequency. Conversely, males with the monoamine oxidase A 3.5-repeat allele were shown to experience increased distress in late adolescence. An empirical method for examining a wide array of allelic combinations was employed, and false discovery rate methods were used to control the risk of false positives due to multiple testing. Special attention was given to thoroughly interrogate the robustness of the putative genetic effects. These results demonstrate the value of combining dynamic developmental perspectives with statistical genetic methods to optimize the search for genetic influences on psychopathology across the life course. En ligne : http://dx.doi.org/10.1017/S0954579411000824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood [Texte imprimé et/ou numérique] / Daniel E. ADKINS, Auteur ; Jonathan K. DAW, Auteur ; Joseph L. MCCLAY, Auteur ; Edwin J. C. G. VAN DEN OORD, Auteur . - 2012 . - p.267-285. Langues : Anglais (eng) in Development and Psychopathology > 24-1 (January 2012) . - p.267-285 Index. décimale : PER Périodiques Résumé : The influence of five monoamine candidate genes on depressive symptom trajectories in adolescence and young adulthood were examined in the Add Health genetic sample. Results indicated that, for all respondents, carriers of the dopamine receptor D4 5-repeat allele were characterized by distinct depressive symptom trajectories across adolescence and early adulthood. Similarly, for males, individuals with the monoamine oxidase A 3.5-repeat allele exhibited unique depressive symptom trajectories. Specifically, the trajectories of those with the dopamine receptor D4 5-repeat allele were characterized by rising levels in the transition to adulthood, while their peers were experiencing a normative drop in depressive symptom frequency. Conversely, males with the monoamine oxidase A 3.5-repeat allele were shown to experience increased distress in late adolescence. An empirical method for examining a wide array of allelic combinations was employed, and false discovery rate methods were used to control the risk of false positives due to multiple testing. Special attention was given to thoroughly interrogate the robustness of the putative genetic effects. These results demonstrate the value of combining dynamic developmental perspectives with statistical genetic methods to optimize the search for genetic influences on psychopathology across the life course. En ligne : http://dx.doi.org/10.1017/S0954579411000824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

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