Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status / Richard E. FRYE in Autism Research and Treatment, (November 2013)  

Public ISBD [article]  inAutism Research and Treatment > (November 2013) . - 9 p. Titre : Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status Type de document : Texte imprimé et/ou numérique Auteurs : Richard E. FRYE, Auteur ; Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Tyra REID, Auteur ; Stefanie JERNIGAN, Auteur ; Oleksandra PAVLIV, Auteur ; Amanda HUBANKS, Auteur ; David W. GAYLOR, Auteur ; Laura WALTERS, Auteur ; S. Jill JAMES, Auteur Année de publication : 2013 Article en page(s) : 9 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Treatments targeting metabolic abnormalities in children with autism are limited. Previously we reported that a nutritional treatment significantly improved glutathione metabolism in children with autistic disorder. In this study we evaluated changes in adaptive behaviors in this cohort and determined whether such changes are related to changes in glutathione metabolism. Thirty-seven children diagnosed with autistic disorder and abnormal glutathione and methylation metabolism were treated with twice weekly 75?µg/Kg methylcobalamin and twice daily 400?µg folinic acid for 3 months in an open-label fashion. The Vineland Adaptive Behavior Scale (VABS) and glutathione redox metabolites were measured at baseline and at the end of the treatment period. Over the treatment period, all VABS subscales significantly improved with an average effect size of 0.59, and an average improvement in skills of 7.7 months. A greater improvement in glutathione redox status was associated with a greater improvement in expressive communication, personal and domestic daily living skills, and interpersonal, play-leisure, and coping social skills. Age, gender, and history of regression did not influence treatment response. The significant behavioral improvements observed and the relationship between these improvements to glutathione redox status suggest that nutritional interventions targeting redox metabolism may benefit some children with autism. En ligne : http://dx.doi.org/10.1155/2013/609705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status [Texte imprimé et/ou numérique] / Richard E. FRYE, Auteur ; Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Tyra REID, Auteur ; Stefanie JERNIGAN, Auteur ; Oleksandra PAVLIV, Auteur ; Amanda HUBANKS, Auteur ; David W. GAYLOR, Auteur ; Laura WALTERS, Auteur ; S. Jill JAMES, Auteur . - 2013 . - 9 p. Langues : Anglais (eng) in Autism Research and Treatment > (November 2013) . - 9 p. Index. décimale : PER Périodiques Résumé : Treatments targeting metabolic abnormalities in children with autism are limited. Previously we reported that a nutritional treatment significantly improved glutathione metabolism in children with autistic disorder. In this study we evaluated changes in adaptive behaviors in this cohort and determined whether such changes are related to changes in glutathione metabolism. Thirty-seven children diagnosed with autistic disorder and abnormal glutathione and methylation metabolism were treated with twice weekly 75?µg/Kg methylcobalamin and twice daily 400?µg folinic acid for 3 months in an open-label fashion. The Vineland Adaptive Behavior Scale (VABS) and glutathione redox metabolites were measured at baseline and at the end of the treatment period. Over the treatment period, all VABS subscales significantly improved with an average effect size of 0.59, and an average improvement in skills of 7.7 months. A greater improvement in glutathione redox status was associated with a greater improvement in expressive communication, personal and domestic daily living skills, and interpersonal, play-leisure, and coping social skills. Age, gender, and history of regression did not influence treatment response. The significant behavioral improvements observed and the relationship between these improvements to glutathione redox status suggest that nutritional interventions targeting redox metabolism may benefit some children with autism. En ligne : http://dx.doi.org/10.1155/2013/609705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

Gastroenterology / Sylvia Y. OFEI

Public ISBD in Handbook of Interdisciplinary Treatments for Autism Spectrum Disorder / Robert D. RIESKE Titre : Gastroenterology Type de document : Texte imprimé et/ou numérique Auteurs : Sylvia Y. OFEI, Auteur ; George J. FUCHS, Auteur Année de publication : 2019 Importance : p.297-307 Langues : Anglais (eng) Index. décimale : AUT-F AUT-F - L'Autisme - Soins Résumé : Gastrointestinal (GI) disturbances are among the most frequent comorbidities associated with autism spectrum disorder (ASD). The extent to which GI issues are causally related to autism or are strictly comorbid conditions of ASD remains to be defined. Clinical and research experience indicates an important role for GI conditions in autism and their impact on children with ASD and their families. While the reported prevalence of GI symptoms among children with ASD varies widely, consensus exists that GI problems including constipation, diarrhea, and abdominal pain are frequent and manifest in common as well as unusual symptoms compared to symptoms in neurotypical children. The microbiome-gut-brain axis in children with ASD is an emerging area of interest and research, although the exact mechanisms and clinical implications in the context of ASD remain to be defined. Intestinal microbial dysbiosis is currently being evaluated in children with ASD yielding conflicting results. Some studies have shown improvement in behavior and decreased severity of GI symptoms in children with ASD with the use of prebiotics, probiotics, and other dietary interventions. Studies using rigorous methodology to better characterize GI pathophysiology and repercussions in children with ASD can be expected to result in more effective interventions. Effective management of specific GI issues and potential underlying causes is often best achieved through a multidisciplinary, coordinated approach in which the primary care provider or gastroenterologist interacts closely with other disciplines such as psychology, neurology, dietetics, child development, and social work. It is important for the clinic environment to be welcoming and supportive, with individualized accommodations made as needed. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=418 in Handbook of Interdisciplinary Treatments for Autism Spectrum Disorder / Robert D. RIESKE Gastroenterology [Texte imprimé et/ou numérique] / Sylvia Y. OFEI, Auteur ; George J. FUCHS, Auteur . - 2019 . - p.297-307. Langues : Anglais (eng) Index. décimale : AUT-F AUT-F - L'Autisme - Soins Résumé : Gastrointestinal (GI) disturbances are among the most frequent comorbidities associated with autism spectrum disorder (ASD). The extent to which GI issues are causally related to autism or are strictly comorbid conditions of ASD remains to be defined. Clinical and research experience indicates an important role for GI conditions in autism and their impact on children with ASD and their families. While the reported prevalence of GI symptoms among children with ASD varies widely, consensus exists that GI problems including constipation, diarrhea, and abdominal pain are frequent and manifest in common as well as unusual symptoms compared to symptoms in neurotypical children. The microbiome-gut-brain axis in children with ASD is an emerging area of interest and research, although the exact mechanisms and clinical implications in the context of ASD remain to be defined. Intestinal microbial dysbiosis is currently being evaluated in children with ASD yielding conflicting results. Some studies have shown improvement in behavior and decreased severity of GI symptoms in children with ASD with the use of prebiotics, probiotics, and other dietary interventions. Studies using rigorous methodology to better characterize GI pathophysiology and repercussions in children with ASD can be expected to result in more effective interventions. Effective management of specific GI issues and potential underlying causes is often best achieved through a multidisciplinary, coordinated approach in which the primary care provider or gastroenterologist interacts closely with other disciplines such as psychology, neurology, dietetics, child development, and social work. It is important for the clinic environment to be welcoming and supportive, with individualized accommodations made as needed. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=418

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Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism / Stepan MELNYK in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.367-377 Titre : Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Eldon SCHULZ, Auteur ; Maya LOPEZ, Auteur ; Stephen G. KAHLER, Auteur ; Jill J. FUSSELL, Auteur ; Jayne BELLANDO, Auteur ; Oleksandra PAVLIV, Auteur ; Shannon ROSE, Auteur ; Lisa SEIDEL, Auteur ; David W. GAYLOR, Auteur ; S. Jill JAMES, Auteur Année de publication : 2012 Article en page(s) : p.367-377 Langues : Anglais (eng) Mots-clés : Autism  Oxidative stress  Metabolic  Epigenetics  Glutathione  DNA methylation Index. décimale : PER Périodiques Résumé : Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1260-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism [Texte imprimé et/ou numérique] / Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Eldon SCHULZ, Auteur ; Maya LOPEZ, Auteur ; Stephen G. KAHLER, Auteur ; Jill J. FUSSELL, Auteur ; Jayne BELLANDO, Auteur ; Oleksandra PAVLIV, Auteur ; Shannon ROSE, Auteur ; Lisa SEIDEL, Auteur ; David W. GAYLOR, Auteur ; S. Jill JAMES, Auteur . - 2012 . - p.367-377. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.367-377 Mots-clés : Autism  Oxidative stress  Metabolic  Epigenetics  Glutathione  DNA methylation Index. décimale : PER Périodiques Résumé : Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1260-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

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