Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism / Stepan MELNYK in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.367-377 Titre : Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Eldon SCHULZ, Auteur ; Maya LOPEZ, Auteur ; Stephen G. KAHLER, Auteur ; Jill J. FUSSELL, Auteur ; Jayne BELLANDO, Auteur ; Oleksandra PAVLIV, Auteur ; Shannon ROSE, Auteur ; Lisa SEIDEL, Auteur ; David W. GAYLOR, Auteur ; S. Jill JAMES, Auteur Année de publication : 2012 Article en page(s) : p.367-377 Langues : Anglais (eng) Mots-clés : Autism  Oxidative stress  Metabolic  Epigenetics  Glutathione  DNA methylation Index. décimale : PER Périodiques Résumé : Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1260-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism [Texte imprimé et/ou numérique] / Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Eldon SCHULZ, Auteur ; Maya LOPEZ, Auteur ; Stephen G. KAHLER, Auteur ; Jill J. FUSSELL, Auteur ; Jayne BELLANDO, Auteur ; Oleksandra PAVLIV, Auteur ; Shannon ROSE, Auteur ; Lisa SEIDEL, Auteur ; David W. GAYLOR, Auteur ; S. Jill JAMES, Auteur . - 2012 . - p.367-377. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.367-377 Mots-clés : Autism  Oxidative stress  Metabolic  Epigenetics  Glutathione  DNA methylation Index. décimale : PER Périodiques Résumé : Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1260-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

---

1 (1 - 1 / 1)