Association of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness / Triin KURRIKOFF in Development and Psychopathology, 24-4 (November 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-4 (November 2012) . - p.1225-1235 Titre : Association of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness Type de document : Texte imprimé et/ou numérique Auteurs : Triin KURRIKOFF, Auteur ; Klaus-Peter LESCH, Auteur ; Evelyn KIIVE, Auteur ; Kenn KONSTABEL, Auteur ; Sabine HERTERICH, Auteur ; Toomas VEIDEBAUM, Auteur ; Andreas REIF, Auteur ; Jaanus HARRO, Auteur Année de publication : 2012 Article en page(s) : p.1225-1235 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A functional promoter polymorphism of the nitric oxide synthase 1 gene first exon 1f variable number tandem repeat (NOS1 ex1f-VNTR) is associated with impulsivity and related psychopathology. Facets of impulsivity are strongly associated with personality traits; maladaptive impulsivity with neuroticism; and adaptive impulsivity with extraversion. Both high neuroticism and low extraversion predict anxiety and depressive symptoms. The aim of the present study was to evaluate the effect of the NOS1 ex1f-VNTR genotype and possible interaction with environmental factors on personality, anxiety, and depressiveness in a population-representative sample. Short allele carriers had higher neuroticism and anxiety than individuals with the long/long (l/l) genotype. Male short/short homozygotes also had higher extraversion. In the face of environmental adversity, females with a short allele had higher scores of neuroticism, anxiety, and depressiveness compared to the l/l genotype. Males were more sensitive to environmental conditions when they had the l/l genotype and low extraversion. In conclusion, the NOS1 ex1f-VNTR influences personality and emotional regulation dependent on gender and environment. Together with previous findings on the effect of the NOS1 genotype on impulse control, these data suggest that NOS1 should be considered another plasticity gene, because its variants are associated with different coping strategies. En ligne : http://dx.doi.org/10.1017/S0954579412000661 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Association of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness [Texte imprimé et/ou numérique] / Triin KURRIKOFF, Auteur ; Klaus-Peter LESCH, Auteur ; Evelyn KIIVE, Auteur ; Kenn KONSTABEL, Auteur ; Sabine HERTERICH, Auteur ; Toomas VEIDEBAUM, Auteur ; Andreas REIF, Auteur ; Jaanus HARRO, Auteur . - 2012 . - p.1225-1235. Langues : Anglais (eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1225-1235 Index. décimale : PER Périodiques Résumé : A functional promoter polymorphism of the nitric oxide synthase 1 gene first exon 1f variable number tandem repeat (NOS1 ex1f-VNTR) is associated with impulsivity and related psychopathology. Facets of impulsivity are strongly associated with personality traits; maladaptive impulsivity with neuroticism; and adaptive impulsivity with extraversion. Both high neuroticism and low extraversion predict anxiety and depressive symptoms. The aim of the present study was to evaluate the effect of the NOS1 ex1f-VNTR genotype and possible interaction with environmental factors on personality, anxiety, and depressiveness in a population-representative sample. Short allele carriers had higher neuroticism and anxiety than individuals with the long/long (l/l) genotype. Male short/short homozygotes also had higher extraversion. In the face of environmental adversity, females with a short allele had higher scores of neuroticism, anxiety, and depressiveness compared to the l/l genotype. Males were more sensitive to environmental conditions when they had the l/l genotype and low extraversion. In conclusion, the NOS1 ex1f-VNTR influences personality and emotional regulation dependent on gender and environment. Together with previous findings on the effect of the NOS1 genotype on impulse control, these data suggest that NOS1 should be considered another plasticity gene, because its variants are associated with different coping strategies. En ligne : http://dx.doi.org/10.1017/S0954579412000661 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

Future of Neuropeptides in Biological Psychiatry and Emotional Psychopharmacology: Goals and Strategies / Jaak PANKSEPP

Public ISBD in Textbook of Biological Psychiatry / Jaak PANKSEPP Titre : Future of Neuropeptides in Biological Psychiatry and Emotional Psychopharmacology: Goals and Strategies Type de document : Texte imprimé et/ou numérique Auteurs : Jaak PANKSEPP, Auteur ; Jaanus HARRO, Auteur Année de publication : 2004 Importance : p. 627–659 Langues : Anglais (eng) Index. décimale : SCI-E SCI-E - Psychiatrie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177 in Textbook of Biological Psychiatry / Jaak PANKSEPP Future of Neuropeptides in Biological Psychiatry and Emotional Psychopharmacology: Goals and Strategies [Texte imprimé et/ou numérique] / Jaak PANKSEPP, Auteur ; Jaanus HARRO, Auteur . - 2004 . - p. 627–659. Langues : Anglais (eng) Index. décimale : SCI-E SCI-E - Psychiatrie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177

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Genome-wide DNA methylation analysis of aggressive behaviour: a longitudinal population-based study / Ehsan PISHVA in Journal of Child Psychology and Psychiatry, 64-7 (July 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.998-1006 Titre : Genome-wide DNA methylation analysis of aggressive behaviour: a longitudinal population-based study Type de document : Texte imprimé et/ou numérique Auteurs : Ehsan PISHVA, Auteur ; Daniel L. A. VAN DEN HOVE, Auteur ; Valentin LAROCHE, Auteur ; Aneth LVOVS, Auteur ; Arunima ROY, Auteur ; Gabriela ORTEGA, Auteur ; Joe BURRAGE, Auteur ; Toomas VEIDEBAUM, Auteur ; Margus KANARIK, Auteur ; Jonathan MILL, Auteur ; Klaus-Peter LESCH, Auteur ; Jaanus HARRO, Auteur Article en page(s) : p.998-1006 Langues : Anglais (eng) Mots-clés : Aggression  DNA methylation  epigenetics  genetics Index. décimale : PER Périodiques Résumé : Background Human aggression is influenced by an interplay between genetic predisposition and experience across the life span. This interaction is thought to occur through epigenetic mechanisms, inducing differential gene expression, thereby moderating neuronal cell and circuit function, and thus shaping aggressive behaviour. Methods Genome-wide DNA methylation (DNAm) levels were measured in peripheral blood obtained from 95 individuals participating in the Estonian Children Personality Behaviours and Health Study (ECPBHS) at 15 and 25years of age. We examined the association between aggressive behaviour, as measured by Life History of Aggression (LHA) total score and DNAm levels both assessed at age 25. We further examined the pleiotropic effect of genetic variants regulating LHA-associated differentially methylated positions (DMPs) and multiple traits related to aggressive behaviours. Lastly, we tested whether the DNA methylomic loci identified in association with LHA at age 25 were also present at age 15. Results We found one differentially methylated position (DMP) (cg17815886; p =1.12108) and five differentially methylated regions (DMRs) associated with LHA after multiple testing adjustments. The DMP annotated to the PDLIM5 gene, and DMRs resided in the vicinity of four protein-encoding genes (TRIM10, GTF2H4, SLC45A4, B3GALT4) and a long intergenic non-coding RNA (LINC02068). We observed evidence for the colocalization of genetic variants associated with top DMPs and general cognitive function, educational attainment and cholesterol levels. Notably, a subset of the DMPs associated with LHA at age 25 also displayed altered DNAm patterns at age 15 with high accuracy in predicting aggression. Conclusions Our findings highlight the potential role of DNAm in the development of aggressive behaviours. We observed pleiotropic genetic variants associated with identified DMPs, and various traits previously established to be relevant in shaping aggression in humans. The concordance of DNAm signatures in adolescents and young adults may have predictive value for inappropriate and maladaptive aggression later in life. En ligne : https://doi.org/10.1111/jcpp.13782 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Genome-wide DNA methylation analysis of aggressive behaviour: a longitudinal population-based study [Texte imprimé et/ou numérique] / Ehsan PISHVA, Auteur ; Daniel L. A. VAN DEN HOVE, Auteur ; Valentin LAROCHE, Auteur ; Aneth LVOVS, Auteur ; Arunima ROY, Auteur ; Gabriela ORTEGA, Auteur ; Joe BURRAGE, Auteur ; Toomas VEIDEBAUM, Auteur ; Margus KANARIK, Auteur ; Jonathan MILL, Auteur ; Klaus-Peter LESCH, Auteur ; Jaanus HARRO, Auteur . - p.998-1006. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.998-1006 Mots-clés : Aggression  DNA methylation  epigenetics  genetics Index. décimale : PER Périodiques Résumé : Background Human aggression is influenced by an interplay between genetic predisposition and experience across the life span. This interaction is thought to occur through epigenetic mechanisms, inducing differential gene expression, thereby moderating neuronal cell and circuit function, and thus shaping aggressive behaviour. Methods Genome-wide DNA methylation (DNAm) levels were measured in peripheral blood obtained from 95 individuals participating in the Estonian Children Personality Behaviours and Health Study (ECPBHS) at 15 and 25years of age. We examined the association between aggressive behaviour, as measured by Life History of Aggression (LHA) total score and DNAm levels both assessed at age 25. We further examined the pleiotropic effect of genetic variants regulating LHA-associated differentially methylated positions (DMPs) and multiple traits related to aggressive behaviours. Lastly, we tested whether the DNA methylomic loci identified in association with LHA at age 25 were also present at age 15. Results We found one differentially methylated position (DMP) (cg17815886; p =1.12108) and five differentially methylated regions (DMRs) associated with LHA after multiple testing adjustments. The DMP annotated to the PDLIM5 gene, and DMRs resided in the vicinity of four protein-encoding genes (TRIM10, GTF2H4, SLC45A4, B3GALT4) and a long intergenic non-coding RNA (LINC02068). We observed evidence for the colocalization of genetic variants associated with top DMPs and general cognitive function, educational attainment and cholesterol levels. Notably, a subset of the DMPs associated with LHA at age 25 also displayed altered DNAm patterns at age 15 with high accuracy in predicting aggression. Conclusions Our findings highlight the potential role of DNAm in the development of aggressive behaviours. We observed pleiotropic genetic variants associated with identified DMPs, and various traits previously established to be relevant in shaping aggression in humans. The concordance of DNAm signatures in adolescents and young adults may have predictive value for inappropriate and maladaptive aggression later in life. En ligne : https://doi.org/10.1111/jcpp.13782 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Pharmacodynamics and Pharmacokinetics / Jaanus HARRO

Public ISBD in Textbook of Biological Psychiatry / Jaak PANKSEPP Titre : Pharmacodynamics and Pharmacokinetics Type de document : Texte imprimé et/ou numérique Auteurs : Jaanus HARRO, Auteur Année de publication : 2004 Importance : p.661–681 Langues : Anglais (eng) Index. décimale : SCI-E SCI-E - Psychiatrie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177 in Textbook of Biological Psychiatry / Jaak PANKSEPP Pharmacodynamics and Pharmacokinetics [Texte imprimé et/ou numérique] / Jaanus HARRO, Auteur . - 2004 . - p.661–681. Langues : Anglais (eng) Index. décimale : SCI-E SCI-E - Psychiatrie Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177

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