Is Autism a Member of a Family of Diseases Resulting from Genetic/Cultural Mismatches? Implications for Treatment and Prevention / Staci D. BILBO in Autism Research and Treatment, (April 2012)  

Public ISBD [article]  inAutism Research and Treatment > (April 2012) . - 11 p. Titre : Is Autism a Member of a Family of Diseases Resulting from Genetic/Cultural Mismatches? Implications for Treatment and Prevention Type de document : Texte imprimé et/ou numérique Auteurs : Staci D. BILBO, Auteur ; John P. JONES, Auteur ; William PARKER, Auteur Année de publication : 2012 Article en page(s) : 11 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Several lines of evidence support the view that autism is a typical member of a large family of immune-related, noninfectious, chronic diseases associated with postindustrial society. This family of diseases includes a wide range of inflammatory, allergic, and autoimmune diseases and results from consequences of genetic/culture mismatches which profoundly destabilize the immune system. Principle among these consequences is depletion of important components, particularly helminths, from the ecosystem of the human body, the human biome. Autism shares a wide range of features in common with this family of diseases, including the contribution of genetics/epigenetics, the identification of disease-inducing triggers, the apparent role of immunity in pathogenesis, high prevalence, complex etiologies and manifestations, and potentially some aspects of epidemiology. Fortunately, using available resources and technology, modern medicine has the potential to effectively reconstitute the human biome, thus treating or even avoiding altogether the consequences of genetic/cultural mismatches which underpin this entire family of disease. Thus, if indeed autism is an epidemic of postindustrial society associated with immune hypersensitivity, we can expect that the disease is readily preventable. En ligne : http://dx.doi.org/10.1155/2012/910946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Is Autism a Member of a Family of Diseases Resulting from Genetic/Cultural Mismatches? Implications for Treatment and Prevention [Texte imprimé et/ou numérique] / Staci D. BILBO, Auteur ; John P. JONES, Auteur ; William PARKER, Auteur . - 2012 . - 11 p. Langues : Anglais (eng) in Autism Research and Treatment > (April 2012) . - 11 p. Index. décimale : PER Périodiques Résumé : Several lines of evidence support the view that autism is a typical member of a large family of immune-related, noninfectious, chronic diseases associated with postindustrial society. This family of diseases includes a wide range of inflammatory, allergic, and autoimmune diseases and results from consequences of genetic/culture mismatches which profoundly destabilize the immune system. Principle among these consequences is depletion of important components, particularly helminths, from the ecosystem of the human body, the human biome. Autism shares a wide range of features in common with this family of diseases, including the contribution of genetics/epigenetics, the identification of disease-inducing triggers, the apparent role of immunity in pathogenesis, high prevalence, complex etiologies and manifestations, and potentially some aspects of epidemiology. Fortunately, using available resources and technology, modern medicine has the potential to effectively reconstitute the human biome, thus treating or even avoiding altogether the consequences of genetic/cultural mismatches which underpin this entire family of disease. Thus, if indeed autism is an epidemic of postindustrial society associated with immune hypersensitivity, we can expect that the disease is readily preventable. En ligne : http://dx.doi.org/10.1155/2012/910946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder / C. J. SMITH in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.3036-3044 Titre : A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : C. J. SMITH, Auteur ; A. BHANOT, Auteur ; E. NORMAN, Auteur ; J. E. MULLETT, Auteur ; Staci D. BILBO, Auteur ; C. J. MCDOUGLE, Auteur ; N. R. ZURCHER, Auteur ; J. M. HOOKER, Auteur Article en page(s) : p.3036-3044 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Magnetic resonance imaging  Neuroimaging  Positron emission tomography  Training protocols Index. décimale : PER Périodiques Résumé : Imaging technologies such as positron emission tomography (PET) and magnetic resonance imaging (MRI) present unparalleled opportunities to investigate the neural basis of autism spectrum disorder (ASD). However, challenges such as deficits in social interaction, anxiety around new experiences, impaired language abilities, and hypersensitivity to sensory stimuli make participating in neuroimaging studies challenging for individuals with ASD. In this commentary, we describe the existent training protocols for preparing individuals with ASD for PET/MRI scans and our own experience developing a training protocol to facilitate the inclusion of low-functioning adults with ASD in PET-MRI studies. We hope to raise awareness of the need for more information exchange between research groups about lessons learned in this context in order to include the entire disease spectrum in neuroimaging studies. En ligne : http://dx.doi.org/10.1007/s10803-019-04010-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / C. J. SMITH, Auteur ; A. BHANOT, Auteur ; E. NORMAN, Auteur ; J. E. MULLETT, Auteur ; Staci D. BILBO, Auteur ; C. J. MCDOUGLE, Auteur ; N. R. ZURCHER, Auteur ; J. M. HOOKER, Auteur . - p.3036-3044. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.3036-3044 Mots-clés : Autism spectrum disorder  Magnetic resonance imaging  Neuroimaging  Positron emission tomography  Training protocols Index. décimale : PER Périodiques Résumé : Imaging technologies such as positron emission tomography (PET) and magnetic resonance imaging (MRI) present unparalleled opportunities to investigate the neural basis of autism spectrum disorder (ASD). However, challenges such as deficits in social interaction, anxiety around new experiences, impaired language abilities, and hypersensitivity to sensory stimuli make participating in neuroimaging studies challenging for individuals with ASD. In this commentary, we describe the existent training protocols for preparing individuals with ASD for PET/MRI scans and our own experience developing a training protocol to facilitate the inclusion of low-functioning adults with ASD in PET-MRI studies. We hope to raise awareness of the need for more information exchange between research groups about lessons learned in this context in order to include the entire disease spectrum in neuroimaging studies. En ligne : http://dx.doi.org/10.1007/s10803-019-04010-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

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